ENSMUSG00000028834


Mus musculus

Features
Gene ID: ENSMUSG00000028834
  
Biological name :Trim63
  
Synonyms : Trim63 / tripartite motif-containing 63
  
Possible biological names infered from orthology : Q969Q1
  
Species: Mus musculus
  
Chr. number: 4
Strand: 1
Band: D3
Gene start: 134315120
Gene end: 134329629
  
Corresponding Affymetrix probe sets: 10508953 (MoGene1.0st)   1438704_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000030638
Ensembl peptide - ENSMUSP00000101501
NCBI entrez gene - 433766     See in Manteia.
MGI - MGI:2447992
RefSeq - NM_001039048
RefSeq Peptide - NP_001034137
swissprot - F8VPZ1
swissprot - A2A9L4
Ensembl - ENSMUSG00000028834
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 trim63aENSDARG00000028027Danio rerio
 trim63bENSDARG00000086685Danio rerio
 TRIM63ENSGALG00000034107Gallus gallus
 Q969Q1ENSG00000158022Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Trim55 / tripartite motif-containing 55 / Q9BYV6*ENSMUSG0000006091361
Q9ERP3 / Trim54 / Tripartite motif-containing protein 54 / Q9BYV2* / tripartite motif containing 54*ENSMUSG0000006207759
Q7TNM2 / Trim46 / tripartite motif-containing 46 / Q7Z4K8*ENSMUSG0000004276631
Q80WG7 / Trim36 / E3 ubiquitin-protein ligase Trim36 / Q9NQ86* / tripartite motif containing 36*ENSMUSG0000003394930
Mid2 / Mus musculus midline 2 (Mid2), transcript variant 2, mRNA. / Q9UJV3* / midline 2*ENSMUSG0000000026628
Mid1 / O70583 / E3 ubiquitin-protein ligase Midline-1 / O15344* / midline 1*ENSMUSG0000003529928
Q505D9 / Trim67 / Tripartite motif-containing protein 67 / Q6ZTA4* / tripartite motif containing 67*ENSMUSG0000003691327
Trim9 / Q8C7M3 / E3 ubiquitin-protein ligase TRIM9 / Q9C026* / tripartite motif containing 9*ENSMUSG0000002107126
Fsd1l / Q8BYN5 / Mus musculus fibronectin type III and SPRY domain containing 1-like (Fsd1l), transcript variant 3, mRNA. / Q9BXM9* / fibronectin type III and SPRY domain containing 1 like*ENSMUSG0000005475215
Fsd1 / Q7TPM6 / Fibronectin type III and SPRY domain-containing protein 1 / Q9BTV5* / fibronectin type III and SPRY domain containing 1*ENSMUSG0000001158914


Protein motifs (from Interpro)
Interpro ID Name
 IPR000315  B-box-type zinc finger
 IPR001841  Zinc finger, RING-type
 IPR013083  Zinc finger, RING/FYVE/PHD-type
 IPR017903  COS domain
 IPR017907  Zinc finger, RING-type, conserved site
 IPR027370  RING-type zinc-finger, LisH dimerisation motif


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006936 muscle contraction IEA
 biological_processGO:0010614 negative regulation of cardiac muscle hypertrophy IEA
 biological_processGO:0014732 skeletal muscle atrophy IEA
 biological_processGO:0014878 response to electrical stimulus involved in regulation of muscle adaptation IEA
 biological_processGO:0016567 protein ubiquitination IEA
 biological_processGO:0051384 response to glucocorticoid IEA
 biological_processGO:0070555 response to interleukin-1 IEA
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0043292 contractile fiber IEA
 molecular_functionGO:0004842 ubiquitin-protein transferase activity IEA
 molecular_functionGO:0008270 zinc ion binding IEA
 molecular_functionGO:0031432 titin binding IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Antigen processing: Ubiquitination & Proteasome degradation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000274 enlarged heart "increase over normal size of the heart" [J:29971]
Show

Allelic Composition: Ramp2tm1.1Tash/Ramp2tm1.1Tash
Genetic Background: involves: C57BL/6

 MP:0000278 abnormal myocardial fiber morphology "malformed or poorly developed cardiac muscle fibers, the multinucleated muscle cells of the heart" [J:18048]
Show

Allelic Composition: Ramp2tm1.1Tash/Ramp2tm1.1Tash
Genetic Background: involves: C57BL/6

 MP:0000598 abnormal liver morphology "malformation or absence of this bile-secreting exocrine gland, which is important for detoxification; for fat, carbohydrate, and protein metabolism; and for glycogen storage " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:23170]
Show

Allelic Composition: Ramp2tm1.1Tash/Ramp2tm1.1Tash
Genetic Background: involves: C57BL/6

 MP:0001175 abnormal lung morphology "malformed organ of respiration" [J:35802]
Show

Allelic Composition: Ramp2tm1.1Tash/Ramp2tm1.1Tash
Genetic Background: involves: C57BL/6

 MP:0001625 cardiac hypertrophy "an increase in size of the cardiac tissue, not due to increased cell number " [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Ramp2tm1.1Tash/Ramp2tm1.1Tash
Genetic Background: involves: C57BL/6

Allelic Composition: Trim63tm1Slbt/Trim63tm1Slbt
Genetic Background: involves: 129 * C57BL/6

Allelic Composition: Trim63tm1Glas/Trim63tm1Glas
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0001914 hemorrhage "loss of blood from the vascular compartment to the exterior or into nonvascular body space as a result of rupture or severance of the blood vessels" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Ramp2tm1.1Tash/Ramp2tm1.1Tash
Genetic Background: involves: C57BL/6

 MP:0002625 left ventricle hypertrophy "increased size of the left ventricle" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Enpp2tm1Vart/Enpp2tm1Vart
Genetic Background: B6.Cg-Enpp2tm1Vart/Flmg

 MP:0002833 increased heart weight "greater than average weight of the heart compared to the average for a particular strain" [RGD:Rat Genome Database submission]
Show

Allelic Composition: Ramp2tm1.1Tash/Ramp2tm1.1Tash
Genetic Background: involves: C57BL/6

Allelic Composition: Trim63tm1Slbt/Trim63tm1Slbt
Genetic Background: involves: 129 * C57BL/6

 MP:0003828 pulmonary edema "an accumulation of an excessive amount of watery fluid in the lung " [J:44108, anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
Show

Allelic Composition: Ramp2tm1.1Tash/Ramp2tm1.1Tash
Genetic Background: involves: C57BL/6

 MP:0004064 resistance to induced muscular atrophy "less than expected wasting of muscle tissue after experimental manipulation (starvation, neurectomy, immobilization, etc)" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Brca1tm2.1Cxd/Brca1tm2.1Cxd
Genetic Background: involves: 129S6/SvEvTac

Allelic Composition: Trim63tm2.1Vlcg/Trim63tm2.1Vlcg
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0004091 abnormal Z lines "any structural abnormality in the cross-striation bisecting the I band of striated muscle myofibrils and serving as the anchoring point of actin filaments at either end of the sarcomere" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
Show

Allelic Composition: Ramp2tm1.1Tash/Ramp2tm1.1Tash
Genetic Background: involves: C57BL/6

 MP:0005140 decreased cardiac muscle contractility "inability or reduced ability of the heart muscle to shorten or to develop increased tension" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Ramp2tm1.1Tash/Ramp2tm1.1Tash
Genetic Background: involves: C57BL/6

 MP:0005329 abnormal cardiac muscle morphology "anomalous structure of the involuntary muscle comprising the myocardium " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Ramp2tm1.1Tash/Ramp2tm1.1Tash
Genetic Background: involves: C57BL/6

 MP:0008489 postnatal slow weight gain "the weight gain over a span of postnatal developmental time is slower than controls, with or without ever attaining a similar weight to controls as adults" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ramp2tm1.1Tash/Ramp2tm1.1Tash
Genetic Background: involves: C57BL/6

 MP:0009399 increased skeletal muscle fiber size "increase in the size of the large multinucleated cells that make up the skeletal muscles" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Trim63tm1Slbt/Trim63tm1Slbt
Genetic Background: involves: 129 * C57BL/6

 MP:0010025 decreased total body fat amount "less than the normal total amount of connective tissue composed of fat cells within the entire body" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ramp2tm1.1Tash/Ramp2tm1.1Tash
Genetic Background: involves: C57BL/6

 MP:0010226 increased quadriceps weight "increase in the weight of the group of four muscles (rectus femoris, vastus intermedius, vastus lateralis, and vastus medialis) which extend down the front of the thigh and are the major extensors of the knee joint" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ramp2tm1.1Tash/Ramp2tm1.1Tash
Genetic Background: involves: C57BL/6

Allelic Composition: Trim63tm1Slbt/Trim63tm1Slbt
Genetic Background: involves: 129 * C57BL/6

 MP:0011086 partial postnatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Ramp2tm1.1Tash/Ramp2tm1.1Tash
Genetic Background: involves: C57BL/6

 MP:0011952 decreased cardiac stroke volume "reduction in the volume of blood pushed into the aorta with each beat of the heart" [MGI:csmith]
Show

Allelic Composition: Ramp2tm1.1Tash/Ramp2tm1.1Tash
Genetic Background: involves: C57BL/6

 MP:0020409 abnormal cardiac thrombosis "any anomaly in the formation or presence of thrombi in the heart" [PMID:15870284]
Show

Allelic Composition: Ramp2tm1.1Tash/Ramp2tm1.1Tash
Genetic Background: involves: C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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