ENSMUSG00000060913


Mus musculus

Features
Gene ID: ENSMUSG00000060913
  
Biological name :Trim55
  
Synonyms : Trim55 / tripartite motif-containing 55
  
Possible biological names infered from orthology : Q9BYV6
  
Species: Mus musculus
  
Chr. number: 3
Strand: 1
Band: A2
Gene start: 19644474
Gene end: 19692421
  
Corresponding Affymetrix probe sets: 10490972 (MoGene1.0st)   
  
Cross references: Ensembl peptide - ENSMUSP00000029139
NCBI entrez gene - 381485     See in Manteia.
MGI - MGI:3036269
RefSeq - XM_006535491
RefSeq - NM_001081281
RefSeq - XM_006535489
RefSeq - XM_006535490
RefSeq Peptide - NP_001074750
swissprot - G3X8Y1
Ensembl - ENSMUSG00000060913
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 trim55aENSDARG00000029596Danio rerio
 trim55bENSDARG00000058158Danio rerio
 TRIM55ENSGALG00000041327Gallus gallus
 Q9BYV6ENSG00000147573Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q9ERP3 / Trim54 / Tripartite motif-containing protein 54 / Q9BYV2* / tripartite motif containing 54*ENSMUSG0000006207741
Trim63 / tripartite motif-containing 63 / Q969Q1*ENSMUSG0000002883440
Q80WG7 / Trim36 / E3 ubiquitin-protein ligase Trim36 / Q9NQ86* / tripartite motif containing 36*ENSMUSG0000003394926
Q7TNM2 / Trim46 / tripartite motif-containing 46 / Q7Z4K8*ENSMUSG0000004276625
Mid1 / O70583 / E3 ubiquitin-protein ligase Midline-1 / O15344* / midline 1*ENSMUSG0000003529923
Mid2 / Mus musculus midline 2 (Mid2), transcript variant 2, mRNA. / Q9UJV3* / midline 2*ENSMUSG0000000026622
Q505D9 / Trim67 / Tripartite motif-containing protein 67 / Q6ZTA4* / tripartite motif containing 67*ENSMUSG0000003691319
Trim9 / Q8C7M3 / E3 ubiquitin-protein ligase TRIM9 / Q9C026* / tripartite motif containing 9*ENSMUSG0000002107118
Fsd1 / Q7TPM6 / Fibronectin type III and SPRY domain-containing protein 1 / Q9BTV5* / fibronectin type III and SPRY domain containing 1*ENSMUSG0000001158911
Fsd1l / Q8BYN5 / Mus musculus fibronectin type III and SPRY domain containing 1-like (Fsd1l), transcript variant 3, mRNA. / Q9BXM9* / fibronectin type III and SPRY domain containing 1 like*ENSMUSG0000005475211


Protein motifs (from Interpro)
Interpro ID Name
 IPR000315  B-box-type zinc finger
 IPR001841  Zinc finger, RING-type
 IPR013083  Zinc finger, RING/FYVE/PHD-type
 IPR017903  COS domain
 IPR017907  Zinc finger, RING-type, conserved site
 IPR027370  RING-type zinc-finger, LisH dimerisation motif


Gene Ontology (GO)
TypeGO IDTermEv.Code
 cellular_componentGO:0005622 intracellular IEA
 molecular_functionGO:0008270 zinc ion binding IEA
 molecular_functionGO:0042802 identical protein binding IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000274 enlarged heart "increase over normal size of the heart" [J:29971]
Show

Allelic Composition: Ramp2tm1.1Tash/Ramp2tm1.1Tash
Genetic Background: involves: C57BL/6

 MP:0000278 abnormal myocardial fiber morphology "malformed or poorly developed cardiac muscle fibers, the multinucleated muscle cells of the heart" [J:18048]
Show

Allelic Composition: Ramp2tm1.1Tash/Ramp2tm1.1Tash
Genetic Background: involves: C57BL/6

 MP:0000598 abnormal liver morphology "malformation or absence of this bile-secreting exocrine gland, which is important for detoxification; for fat, carbohydrate, and protein metabolism; and for glycogen storage " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:23170]
Show

Allelic Composition: Ramp2tm1.1Tash/Ramp2tm1.1Tash
Genetic Background: involves: C57BL/6

 MP:0001175 abnormal lung morphology "malformed organ of respiration" [J:35802]
Show

Allelic Composition: Ramp2tm1.1Tash/Ramp2tm1.1Tash
Genetic Background: involves: C57BL/6

 MP:0001625 cardiac hypertrophy "an increase in size of the cardiac tissue, not due to increased cell number " [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Ramp2tm1.1Tash/Ramp2tm1.1Tash
Genetic Background: involves: C57BL/6

Allelic Composition: Trim55tm1Slbt/Trim55tm1Slbt
Genetic Background: involves: 129 * C57BL/6

 MP:0001914 hemorrhage "loss of blood from the vascular compartment to the exterior or into nonvascular body space as a result of rupture or severance of the blood vessels" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Ramp2tm1.1Tash/Ramp2tm1.1Tash
Genetic Background: involves: C57BL/6

 MP:0002833 increased heart weight "greater than average weight of the heart compared to the average for a particular strain" [RGD:Rat Genome Database submission]
Show

Allelic Composition: Ramp2tm1.1Tash/Ramp2tm1.1Tash
Genetic Background: involves: C57BL/6

Allelic Composition: Trim55tm1Slbt/Trim55tm1Slbt
Genetic Background: involves: 129 * C57BL/6

 MP:0003828 pulmonary edema "an accumulation of an excessive amount of watery fluid in the lung " [J:44108, anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
Show

Allelic Composition: Ramp2tm1.1Tash/Ramp2tm1.1Tash
Genetic Background: involves: C57BL/6

 MP:0004091 abnormal Z lines "any structural abnormality in the cross-striation bisecting the I band of striated muscle myofibrils and serving as the anchoring point of actin filaments at either end of the sarcomere" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
Show

Allelic Composition: Ramp2tm1.1Tash/Ramp2tm1.1Tash
Genetic Background: involves: C57BL/6

 MP:0005140 decreased cardiac muscle contractility "inability or reduced ability of the heart muscle to shorten or to develop increased tension" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Ramp2tm1.1Tash/Ramp2tm1.1Tash
Genetic Background: involves: C57BL/6

 MP:0005329 abnormal cardiac muscle morphology "anomalous structure of the involuntary muscle comprising the myocardium " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Ramp2tm1.1Tash/Ramp2tm1.1Tash
Genetic Background: involves: C57BL/6

 MP:0008489 postnatal slow weight gain "the weight gain over a span of postnatal developmental time is slower than controls, with or without ever attaining a similar weight to controls as adults" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ramp2tm1.1Tash/Ramp2tm1.1Tash
Genetic Background: involves: C57BL/6

 MP:0009399 increased skeletal muscle fiber size "increase in the size of the large multinucleated cells that make up the skeletal muscles" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Trim55tm1Slbt/Trim55tm1Slbt
Genetic Background: involves: 129 * C57BL/6

 MP:0009461 skeletal muscle hypertrophy "increase in the bulk size of the skeletal muscle due to cell enlargement" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Trim55tm1Slbt/Trim55tm1Slbt
Genetic Background: involves: 129 * C57BL/6

 MP:0010025 decreased total body fat amount "less than the normal total amount of connective tissue composed of fat cells within the entire body" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ramp2tm1.1Tash/Ramp2tm1.1Tash
Genetic Background: involves: C57BL/6

 MP:0010226 increased quadriceps weight "increase in the weight of the group of four muscles (rectus femoris, vastus intermedius, vastus lateralis, and vastus medialis) which extend down the front of the thigh and are the major extensors of the knee joint" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ramp2tm1.1Tash/Ramp2tm1.1Tash
Genetic Background: involves: C57BL/6

Allelic Composition: Trim55tm1Slbt/Trim55tm1Slbt
Genetic Background: involves: 129 * C57BL/6

 MP:0011086 partial postnatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Ramp2tm1.1Tash/Ramp2tm1.1Tash
Genetic Background: involves: C57BL/6

 MP:0011952 decreased cardiac stroke volume "reduction in the volume of blood pushed into the aorta with each beat of the heart" [MGI:csmith]
Show

Allelic Composition: Ramp2tm1.1Tash/Ramp2tm1.1Tash
Genetic Background: involves: C57BL/6

 MP:0020409 abnormal cardiac thrombosis "any anomaly in the formation or presence of thrombi in the heart" [PMID:15870284]
Show

Allelic Composition: Ramp2tm1.1Tash/Ramp2tm1.1Tash
Genetic Background: involves: C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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