ENSMUSG00000030474


Mus musculus

Features
Gene ID: ENSMUSG00000030474
  
Biological name :Siglece
  
Synonyms : Q91Y57 / Sialic acid-binding Ig-like lectin 12 / Siglece
  
Possible biological names infered from orthology : Q96PQ1 / Q9NYZ4 / Q9Y286 / Q9Y336 / sialic acid binding Ig like lectin 12 (gene/pseudogene) / sialic acid binding Ig like lectin 7 / sialic acid binding Ig like lectin 8 / sialic acid binding Ig like lectin 9 / SIGLEC12 / SIGLEC7 / SIGLEC8 / SIGLEC9
  
Species: Mus musculus
  
Chr. number: 7
Strand: -1
Band: B3
Gene start: 43651070
Gene end: 43660161
  
Corresponding Affymetrix probe sets: 10562720 (MoGene1.0st)   1421463_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000032667
Ensembl peptide - ENSMUSP00000146072
NCBI entrez gene - 83382     See in Manteia.
MGI - MGI:1932475
RefSeq - XM_006541321
RefSeq - NM_031181
RefSeq - XM_006541318
RefSeq - XM_006541319
RefSeq - XM_006541320
RefSeq Peptide - NP_112458
swissprot - Q91Y57
swissprot - A0A0U1RPP9
Ensembl - ENSMUSG00000030474
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 si:dkey-24p1.7ENSDARG00000089404Danio rerio
 Q96PQ1ENSG00000254521Homo sapiens
 Q9NYZ4ENSG00000105366Homo sapiens
 Q9Y286ENSG00000168995Homo sapiens
 Q9Y336ENSG00000129450Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q920G3 / Siglec5 / Sialic acid-binding Ig-like lectin 5 ENSMUSG0000003901340
Q80ZE3 / Siglecg / Sialic acid-binding Ig-like lectin 10 / Q96RL6* / Q96LC7* / SIGLEC10* / SIGLEC11* / sialic acid binding Ig like lectin 11*ENSMUSG0000003046838
Cd33 / Q63994 / Myeloid cell surface antigen CD33 ENSMUSG0000000460929
Siglech / sialic acid binding Ig-like lectin H / CD33* / P20138* / CD33 molecule*ENSMUSG0000005150427
Mag / P20917 / Mus musculus myelin-associated glycoprotein (Mag), transcript variant 5, mRNA. / P20916* / myelin associated glycoprotein*ENSMUSG0000003663419


Protein motifs (from Interpro)
Interpro ID Name
 IPR003006  Immunoglobulin/major histocompatibility complex, conserved site
 IPR003598  Immunoglobulin subtype 2
 IPR003599  Immunoglobulin subtype
 IPR007110  Immunoglobulin-like domain
 IPR013106  Immunoglobulin V-set domain
 IPR013783  Immunoglobulin-like fold
 IPR036179  Immunoglobulin-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007155 cell adhesion IDA
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0050728 negative regulation of inflammatory response IMP
 biological_processGO:0060101 negative regulation of phagocytosis, engulfment IMP
 cellular_componentGO:0009897 external side of plasma membrane IDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0005057 obsolete signal transducer activity, downstream of receptor IPI
 molecular_functionGO:0030246 carbohydrate binding IEA
 molecular_functionGO:0033691 sialic acid binding IDA
 molecular_functionGO:0048029 monosaccharide binding IDA


Pathways (from Reactome)
Pathway description
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
Neutrophil degranulation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0002451 abnormal macrophage physiology "abnormal function or response of the phagocytic leukocytes involved in innate immunity, early non-adaptive phases of host-defense, antigen presentation, and which act as effector cells in humoral and cell-mediated immunity" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Sun1tm1.1Ktj/Sun1tm1.1Ktj
Genetic Background: Not Specified

Allelic Composition: Siglecetm1Croc/Siglecetm1Croc
Genetic Background: B6.129P2-Siglecetm1Croc

 MP:0002463 abnormal neutrophil physiology "abnormal function of these granular leukocytes, which stain with neutral dyes" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Sun1tm1.1Ktj/Sun1tm1.1Ktj
Genetic Background: Not Specified

Allelic Composition: Siglecetm1Croc/Siglecetm1Croc
Genetic Background: B6.129P2-Siglecetm1Croc

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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