ENSMUSG00000030921


Mus musculus

Features
Gene ID: ENSMUSG00000030921
  
Biological name :Trim30a
  
Synonyms : Mus musculus tripartite motif-containing 30A (Trim30a), transcript variant 2, mRNA. / P15533 / Trim30a
  
Possible biological names infered from orthology : Q9C035 / TRIM5 / tripartite motif containing 5
  
Species: Mus musculus
  
Chr. number: 7
Strand: -1
Band: E3
Gene start: 104409025
Gene end: 104465193
  
Corresponding Affymetrix probe sets: 10566358 (MoGene1.0st)   1417961_a_at (Mouse Genome 430 2.0 Array)   1451860_a_at (Mouse Genome 430 2.0 Array)   1456494_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000076189
NCBI entrez gene - 20128     See in Manteia.
MGI - MGI:98178
RefSeq - XM_006507471
RefSeq - NM_001357467
RefSeq - NM_009099
RefSeq Peptide - NP_033125
RefSeq Peptide - NP_001344396
swissprot - P15533
Ensembl - ENSMUSG00000030921
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 TRIM5ENSG00000132256Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Trim30d / tripartite motif-containing 30D / TRIM5* / Q9C035* / tripartite motif containing 5*ENSMUSG0000005759683
Trim30c / TRIM5* / Q9C035* / tripartite motif containing 5*ENSMUSG0000007861672
Trim12c / tripartite motif-containing 12C / TRIM5* / Q9C035* / tripartite motif containing 5*ENSMUSG0000005714357
Trim5 / Q9C035* / tripartite motif containing 5*ENSMUSG0000006044156
Trim6 / Q8BGE7 / Tripartite motif-containing protein 6 / Q9C030* / tripartite motif containing 6*ENSMUSG0000007224443
Trim34a / tripartite motif-containing 34A / TRIM34* / Q9BYJ4* / TRIM6-TRIM34* / TRIM6-TRIM34 readthrough* / tripartite motif containing 34*ENSMUSG0000005614439
Trim34b / TRIM34* / Q9BYJ4* / TRIM6-TRIM34* / TRIM6-TRIM34 readthrough* / tripartite motif containing 34*ENSMUSG0000009021539
Q99PQ1 / Trim12a / Tripartite motif-containing protein 12A / TRIM5* / Q9C035* / tripartite motif containing 5*ENSMUSG0000006625834
Trim21 / tripartite motif-containing 21 / P19474*ENSMUSG0000003096631
Trim68 / tripartite motif-containing 68 / Q6AZZ1*ENSMUSG0000007396829
Q99PQ2 / Trim11 / E3 ubiquitin-protein ligase TRIM11 / Q96F44* / tripartite motif containing 11*ENSMUSG0000002045528
Q7TPM3 / Trim17 / E3 ubiquitin-protein ligase TRIM17 / Q9Y577* / tripartite motif containing 17*ENSMUSG0000003696426
Q5NCC9 / Trim58 / tripartite motif-containing 58 / Q8NG06*ENSMUSG0000003712426
Trim39 / tripartite motif-containing 39 / Q9HCM9* / TRIM39-RPP21* / TRIM39-RPP21 readthrough*ENSMUSG0000004540926
Trim38 / tripartite motif-containing 38 / O00635*ENSMUSG0000006414026
Q3UWZ0 / Trim75 / tripartite motif-containing 75 / A6NK02* / TRIM75P* / tripartite motif containing 75, pseudogene*ENSMUSG0000007108924
Q8VI40 / Trim60 / tripartite motif-containing 60 / Q495X7*ENSMUSG0000005349023
Trim61 / tripartite motif-containing 61ENSMUSG0000010971821


Protein motifs (from Interpro)
Interpro ID Name
 IPR000315  B-box-type zinc finger
 IPR001841  Zinc finger, RING-type
 IPR001870  B30.2/SPRY domain
 IPR003877  SPRY domain
 IPR003879  Butyrophylin-like, SPRY domain
 IPR013083  Zinc finger, RING/FYVE/PHD-type
 IPR013320  Concanavalin A-like lectin/glucanase domain superfamily
 IPR017907  Zinc finger, RING-type, conserved site
 IPR027370  RING-type zinc-finger, LisH dimerisation motif
 IPR032917  Tripartite motif-containing protein 5


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006914 autophagy IEA
 biological_processGO:0032715 negative regulation of interleukin-6 production IMP
 biological_processGO:0032720 negative regulation of tumor necrosis factor production IMP
 biological_processGO:0034122 negative regulation of toll-like receptor signaling pathway IMP
 biological_processGO:0045087 innate immune response IEA
 biological_processGO:0045732 positive regulation of protein catabolic process IMP
 biological_processGO:0046598 positive regulation of viral entry into host cell IDA
 biological_processGO:0051607 defense response to virus IEA
 biological_processGO:0051865 protein autoubiquitination IMP
 biological_processGO:1900226 negative regulation of NLRP3 inflammasome complex assembly IMP
 biological_processGO:2000378 negative regulation of reactive oxygen species metabolic process IMP
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005737 cytoplasm IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0004842 ubiquitin-protein transferase activity IEA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0008270 zinc ion binding IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0003944 abnormal T cell subpopulation ratio "deviation from the standard ratios of T cell subpopulations (e.g. double positive to single positive ratio) compared to control samples" [mberry:Melissa Berry, Genetics Resources Curator]
Show

Allelic Composition: Ryr2tm1Krbr/Ryr2tm3.1Swch,A1cfTg(Myh6-cre/Esr1*)1Jmk/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB/N

 MP:0005348 increased T cell proliferation "increased clonal expansion of naive T cells in response to stimuli" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Ryr2tm1Krbr/Ryr2tm3.1Swch,A1cfTg(Myh6-cre/Esr1*)1Jmk/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB/N

Allelic Composition: Tg(TcraTcrb)425Cbn/0,Trim30atm1Yjk/Trim30atm1Yjk
Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6

 MP:0005463 abnormal CD4+ T cell physiology "anomalous response of the subset of T lymphocytes that carry the CD4 marker, recognize intravesicular peptides bound to MHC class-II molecules, and turn on antibody production" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Ryr2tm1Krbr/Ryr2tm3.1Swch,A1cfTg(Myh6-cre/Esr1*)1Jmk/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB/N

 MP:0008074 increased CD4-positive T cell number "greater number of the subset of T lymphocytes that carry the CD4 marker, recognize intravesicular peptides bound to MHC class-II molecules, and turn on antibody production" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ryr2tm1Krbr/Ryr2tm3.1Swch,A1cfTg(Myh6-cre/Esr1*)1Jmk/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB/N

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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