ENSMUSG00000031845


Mus musculus

Features
Gene ID: ENSMUSG00000031845
  
Biological name :Bco1
  
Synonyms : Bco1 / Beta,beta-carotene 15,15-dioxygenase / Q9JJS6
  
Possible biological names infered from orthology : beta-carotene oxygenase 1 / Q9HAY6
  
Species: Mus musculus
  
Chr. number: 8
Strand: 1
Band: E1
Gene start: 117095854
Gene end: 117133720
  
Corresponding Affymetrix probe sets: 10575750 (MoGene1.0st)   1449907_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000034308
Ensembl peptide - ENSMUSP00000132042
Ensembl peptide - ENSMUSP00000134815
NCBI entrez gene - 63857     See in Manteia.
MGI - MGI:1926923
RefSeq - XM_011248481
RefSeq - NM_001163028
RefSeq - NM_021486
RefSeq Peptide - NP_001156500
RefSeq Peptide - NP_067461
swissprot - Q05AC0
swissprot - Q9JJS6
swissprot - E9Q321
Ensembl - ENSMUSG00000031845
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 bco1ENSDARG00000104256Danio rerio
 bco1lENSDARG00000103659Danio rerio
 BCO1ENSGALG00000005408Gallus gallus
 BCO1ENSG00000135697Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Bco2 / Q99NF1 / Beta,beta-carotene 9,10-oxygenase / Q9BYV7* / beta-carotene oxygenase 2*ENSMUSG0000003206639
Rpe65 / Q91ZQ5 / Retinoid isomerohydrolase / Q16518* / RPE65, retinoid isomerohydrolase*ENSMUSG0000002817432


Protein motifs (from Interpro)
Interpro ID Name
 IPR004294  Carotenoid oxygenase


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001523 retinoid metabolic process IDA
 biological_processGO:0042572 retinol metabolic process IEA
 biological_processGO:0042574 retinal metabolic process IGI
 biological_processGO:0055114 oxidation-reduction process IEA
 biological_processGO:1901810 beta-carotene metabolic process IMP
 molecular_functionGO:0003834 beta-carotene 15,15"-monooxygenase activity IDA
 molecular_functionGO:0004497 monooxygenase activity IEA
 molecular_functionGO:0016491 oxidoreductase activity IEA
 molecular_functionGO:0016702 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen IEA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0051213 dioxygenase activity IEA


Pathways (from Reactome)
Pathway description
Retinoid metabolism and transport


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001554 increased circulating free fatty acid level "higher than normal levels of unesterified fatty acids in the blood" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:65146]
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Allelic Composition: Pax6Sey/Pax6Sey-H
Genetic Background: involves: 101/H * C3H/HeH * C57BL/10

 MP:0002628 fatty liver "an accumulation of fat deposits in the liver " [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Pax6Sey/Pax6Sey-H
Genetic Background: involves: 101/H * C3H/HeH * C57BL/10

 MP:0002941 increased circulating alanine transaminase level "increased concentration in the blood of this enzyme, which transfers amino groups from l-alanine to 2 ketoglutarate, or the reverse (from l-glutamate to pyruvate); serum concentration is increased in viral hepatitis and myocardial infarction" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Pax6Sey/Pax6Sey-H
Genetic Background: involves: 101/H * C3H/HeH * C57BL/10

 MP:0004019 abnormal vitamin homeostasis "anomaly in the state of equilibrium in the body of organic substances found in food and are not synthesized by the body and are necessary in trace amounts for normal metabolic function" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Pax6Sey/Pax6Sey-H
Genetic Background: involves: 101/H * C3H/HeH * C57BL/10

 MP:0005178 increased total circulating cholesterol level "greater than the normal concentration in the blood of these most abundant steroids in animal tissues, and precursors to steroid hormones and bile salts; also components of plasma membranes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Pax6Sey/Pax6Sey-H
Genetic Background: involves: 101/H * C3H/HeH * C57BL/10

 MP:0005658 susceptibility to diet-induced obesity "more likely to become excessively fat or to increase fat in the subcutaneous connective tissue as a result of consuming a diet geared to increase body fat " [cwg:Carroll-Ann W. Goldsmith, Mouse Genome Informatics curator]
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Allelic Composition: Pax6Sey/Pax6Sey-H
Genetic Background: involves: 101/H * C3H/HeH * C57BL/10

 MP:0011232 abnormal vitamin A level "any anomaly in the concentration of any of the vitamin A compounds, retinol, retinal (retinaldehyde) and retinoic acid; animals can not synthesize vitamin A de novo, but form it through oxidative cleavage of carotenoids supplied in the diet" [GO:0035238]
Show

Allelic Composition: Pax6Sey/Pax6Sey-H
Genetic Background: involves: 101/H * C3H/HeH * C57BL/10

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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