ENSMUSG00000036196


Mus musculus

Features
Gene ID: ENSMUSG00000036196
  
Biological name :Slc26a8
  
Synonyms : Q8R0C3 / Slc26a8 / Testis anion transporter 1
  
Possible biological names infered from orthology : Q96RN1 / solute carrier family 26 member 8
  
Species: Mus musculus
  
Chr. number: 17
Strand: -1
Band: A3.3
Gene start: 28637783
Gene end: 28689987
  
Corresponding Affymetrix probe sets: 10449487 (MoGene1.0st)   1425915_at (Mouse Genome 430 2.0 Array)   1439281_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000110412
NCBI entrez gene - 224661     See in Manteia.
MGI - MGI:2385046
RefSeq - XM_011246390
RefSeq - NM_001290320
RefSeq - XM_011246388
RefSeq - XM_011246389
RefSeq - XM_011246384
RefSeq - XM_011246385
RefSeq - XM_011246387
RefSeq Peptide - NP_001277249
swissprot - Q8R0C3
Ensembl - ENSMUSG00000036196
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 SLC26A8ENSGALG00000040498Gallus gallus
 Q96RN1ENSG00000112053Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q9WVC8 / Slc26a3 / Chloride anion exchanger / P40879* / solute carrier family 26 member 3*ENSMUSG0000000122521
Slc26a6 / solute carrier family 26, member 6 / Q9BXS9*ENSMUSG0000002325921
Q9R155 / Slc26a4 / Pendrin / O43511* / solute carrier family 26 member 4*ENSMUSG0000002065120
Q99NH7 / Slc26a5 / Prestin / P58743* / solute carrier family 26 member 5*ENSMUSG0000002901520
Slc26a9 / solute carrier family 26 member 9 / Q7LBE3*ENSMUSG0000004226820
Slc26a10 / solute carrier family 26 member 10 / Q8NG04*ENSMUSG0000004044117
Q62273 / Slc26a2 / Sulfate transporter / P50443* / solute carrier family 26 member 2*ENSMUSG0000003432016
P58735 / Slc26a1 / solute carrier family 26 (sulfate transporter), member 1 / Q9H2B4* / solute carrier family 26 member 1*ENSMUSG0000004695916
Q8R2Z3 / Slc26a7 / Anion exchange transporter / Q8TE54* / solute carrier family 26 member 7*ENSMUSG0000004056915


Protein motifs (from Interpro)
Interpro ID Name
 IPR001902  SLC26A/SulP transporter
 IPR002645  STAS domain
 IPR011547  SLC26A/SulP transporter domain
 IPR030303  Solute carrier family 26 member 8 (testis anion transporter 1)
 IPR036513  STAS domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006811 ion transport IEA
 biological_processGO:0006820 anion transport ISO
 biological_processGO:0006821 chloride transport IEA
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0007283 spermatogenesis IEA
 biological_processGO:0008272 sulfate transport ISO
 biological_processGO:0015701 bicarbonate transport IBA
 biological_processGO:0019532 oxalate transport IEA
 biological_processGO:0030154 cell differentiation IEA
 biological_processGO:0030317 flagellated sperm motility IEA
 biological_processGO:0042391 regulation of membrane potential IBA
 biological_processGO:0048240 sperm capacitation IEA
 biological_processGO:0051321 meiotic cell cycle IEA
 biological_processGO:0051453 regulation of intracellular pH IBA
 biological_processGO:0055085 transmembrane transport IEA
 biological_processGO:1902358 sulfate transmembrane transport IEA
 biological_processGO:1902476 chloride transmembrane transport IBA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0005887 integral component of plasma membrane IBA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0005254 chloride channel activity IEA
 molecular_functionGO:0008271 secondary active sulfate transmembrane transporter activity IEA
 molecular_functionGO:0008509 anion transmembrane transporter activity IEA
 molecular_functionGO:0015106 bicarbonate transmembrane transporter activity IBA
 molecular_functionGO:0015116 sulfate transmembrane transporter activity IBA
 molecular_functionGO:0015301 anion:anion antiporter activity IBA
 molecular_functionGO:0019531 oxalate transmembrane transporter activity IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001925 male infertility "inability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]
Show

Allelic Composition: Hace1tm1Pngr/Hace1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002675 asthenozoospermia "loss or reduction of the mobility of the spermatozoa, frequently associated with infertility" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Hace1tm1Pngr/Hace1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0004542 impaired acrosome reaction "abnormality in the cellular exocytosis that allows sperm to penetrate the zona pellucida of ovulated eggs" [MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Hace1tm1Pngr/Hace1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0004543 abnormal sperm physiology "anomaly in the normal function of spermatozoa" [MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Hace1tm1Pngr/Hace1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0009237 kinked sperm flagellum "a sharp bend or zigzag in the sperm tail" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Hace1tm1Pngr/Hace1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0009242 thin sperm flagellum "reduced thickness of the whiplike posterior filiform portion of the spermatozoon that provides sperm motility" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Hace1tm1Pngr/Hace1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0009243 hairpin sperm flagellum "a structural alteration where the sperm flagellum becomes bent back (folded) on itself to form a hairpin (loop) structure; a sharp hairpin-like bend formation can disrupt the axial structures and cause the sperm tail to become kinked" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Hace1tm1Pngr/Hace1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0009831 abnormal sperm midpiece morphology "any structural abnormality of the highly organized segment of the sperm flagellum which begins at the connecting piece and is characterized by the presence of 9 outer dense fibers (ODFs) that lie outside each of the 9 outer axonemal microtubule doublets and by a sheath of mitochondria that encloses the ODFs and the axoneme; the midpiece terminates about one-fourth of the way down the sperm flagellum at the annulus, which marks the beginning of the principal piece" [PMID:14581499]
Show

Allelic Composition: Hace1tm1Pngr/Hace1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0009832 abnormal sperm mitochondrial sheath morphology "any structural anomaly or impairment of the tightly packed helical sheath of ATP-producing mitochondria restricted to the midpiece of the sperm flagellum" [PMID:14581499]
Show

Allelic Composition: Hace1tm1Pngr/Hace1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0009834 abnormal sperm annulus morphology "any structural anomaly of the ring-like, filamentous structure located at the distal end of the midpiece of the sperm flagellum; the annulus is thought to form a diffusion barrier between the midpiece and the principal piece and serve as a stabilizing structure for tail rigidity" [PMID:14581499]
Show

Allelic Composition: Hace1tm1Pngr/Hace1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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