ENSMUSG00000036196


Mus musculus

Features
Gene ID: ENSMUSG00000036196
  
Biological name :Slc26a8
  
Synonyms : Q8R0C3 / Slc26a8 / Testis anion transporter 1
  
Possible biological names infered from orthology : Q96RN1 / solute carrier family 26 member 8
  
Species: Mus musculus
  
Chr. number: 17
Strand: -1
Band: A3.3
Gene start: 28637783
Gene end: 28689987
  
Corresponding Affymetrix probe sets: 10449487 (MoGene1.0st)   1425915_at (Mouse Genome 430 2.0 Array)   1439281_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000110412
NCBI entrez gene - 224661     See in Manteia.
MGI - MGI:2385046
RefSeq - XM_011246390
RefSeq - NM_001290320
RefSeq - XM_011246388
RefSeq - XM_011246389
RefSeq - XM_011246384
RefSeq - XM_011246385
RefSeq - XM_011246387
RefSeq Peptide - NP_001277249
swissprot - Q8R0C3
Ensembl - ENSMUSG00000036196
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 SLC26A8ENSGALG00000040498Gallus gallus
 Q96RN1ENSG00000112053Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q9WVC8 / Slc26a3 / Chloride anion exchanger / P40879* / solute carrier family 26 member 3*ENSMUSG0000000122521
Slc26a6 / solute carrier family 26, member 6 / Q9BXS9*ENSMUSG0000002325921
Q9R155 / Slc26a4 / Pendrin / O43511* / solute carrier family 26 member 4*ENSMUSG0000002065120
Q99NH7 / Slc26a5 / Prestin / P58743* / solute carrier family 26 member 5*ENSMUSG0000002901520
Slc26a9 / solute carrier family 26 member 9 / Q7LBE3*ENSMUSG0000004226820
Slc26a10 / solute carrier family 26 member 10 / Q8NG04*ENSMUSG0000004044117
Q62273 / Slc26a2 / Sulfate transporter / P50443* / solute carrier family 26 member 2*ENSMUSG0000003432016
P58735 / Slc26a1 / solute carrier family 26 (sulfate transporter), member 1 / Q9H2B4* / solute carrier family 26 member 1*ENSMUSG0000004695916
Q8R2Z3 / Slc26a7 / Anion exchange transporter / Q8TE54* / solute carrier family 26 member 7*ENSMUSG0000004056915


Protein motifs (from Interpro)
Interpro ID Name
 IPR001902  SLC26A/SulP transporter
 IPR002645  STAS domain
 IPR011547  SLC26A/SulP transporter domain
 IPR030303  Solute carrier family 26 member 8 (testis anion transporter 1)
 IPR036513  STAS domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006811 ion transport IEA
 biological_processGO:0006820 anion transport ISO
 biological_processGO:0006821 chloride transport IEA
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0007283 spermatogenesis IEA
 biological_processGO:0008272 sulfate transport ISO
 biological_processGO:0015701 bicarbonate transport IBA
 biological_processGO:0019532 oxalate transport IEA
 biological_processGO:0030154 cell differentiation IEA
 biological_processGO:0030317 flagellated sperm motility IEA
 biological_processGO:0042391 regulation of membrane potential IBA
 biological_processGO:0048240 sperm capacitation IEA
 biological_processGO:0051321 meiotic cell cycle IEA
 biological_processGO:0051453 regulation of intracellular pH IBA
 biological_processGO:0055085 transmembrane transport IEA
 biological_processGO:1902358 sulfate transmembrane transport IEA
 biological_processGO:1902476 chloride transmembrane transport IBA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0005887 integral component of plasma membrane IBA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0005254 chloride channel activity IEA
 molecular_functionGO:0008271 secondary active sulfate transmembrane transporter activity IEA
 molecular_functionGO:0008509 anion transmembrane transporter activity IEA
 molecular_functionGO:0015106 bicarbonate transmembrane transporter activity IBA
 molecular_functionGO:0015116 sulfate transmembrane transporter activity IBA
 molecular_functionGO:0015301 anion:anion antiporter activity IBA
 molecular_functionGO:0019531 oxalate transmembrane transporter activity IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001925 male infertility "inability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]
Show

Allelic Composition: Hace1tm1Pngr/Hace1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002675 asthenozoospermia "loss or reduction of the mobility of the spermatozoa, frequently associated with infertility" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Hace1tm1Pngr/Hace1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0004542 impaired acrosome reaction "abnormality in the cellular exocytosis that allows sperm to penetrate the zona pellucida of ovulated eggs" [MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Hace1tm1Pngr/Hace1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0004543 abnormal sperm physiology "anomaly in the normal function of spermatozoa" [MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Hace1tm1Pngr/Hace1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0009237 kinked sperm flagellum "a sharp bend or zigzag in the sperm tail" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Hace1tm1Pngr/Hace1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0009242 thin sperm flagellum "reduced thickness of the whiplike posterior filiform portion of the spermatozoon that provides sperm motility" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Hace1tm1Pngr/Hace1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0009243 hairpin sperm flagellum "a structural alteration where the sperm flagellum becomes bent back (folded) on itself to form a hairpin (loop) structure; a sharp hairpin-like bend formation can disrupt the axial structures and cause the sperm tail to become kinked" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Hace1tm1Pngr/Hace1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0009831 abnormal sperm midpiece morphology "any structural abnormality of the highly organized segment of the sperm flagellum which begins at the connecting piece and is characterized by the presence of 9 outer dense fibers (ODFs) that lie outside each of the 9 outer axonemal microtubule doublets and by a sheath of mitochondria that encloses the ODFs and the axoneme; the midpiece terminates about one-fourth of the way down the sperm flagellum at the annulus, which marks the beginning of the principal piece" [PMID:14581499]
Show

Allelic Composition: Hace1tm1Pngr/Hace1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0009832 abnormal sperm mitochondrial sheath morphology "any structural anomaly or impairment of the tightly packed helical sheath of ATP-producing mitochondria restricted to the midpiece of the sperm flagellum" [PMID:14581499]
Show

Allelic Composition: Hace1tm1Pngr/Hace1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0009834 abnormal sperm annulus morphology "any structural anomaly of the ring-like, filamentous structure located at the distal end of the midpiece of the sperm flagellum; the annulus is thought to form a diffusion barrier between the midpiece and the principal piece and serve as a stabilizing structure for tail rigidity" [PMID:14581499]
Show

Allelic Composition: Hace1tm1Pngr/Hace1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2025
contact: otassy@igbmc.fr