ENSMUSG00000040569


Mus musculus

Features
Gene ID: ENSMUSG00000040569
  
Biological name :Slc26a7
  
Synonyms : Anion exchange transporter / Q8R2Z3 / Slc26a7
  
Possible biological names infered from orthology : Q8TE54 / solute carrier family 26 member 7
  
Species: Mus musculus
  
Chr. number: 4
Strand: -1
Band: A1
Gene start: 14502430
Gene end: 14621805
  
Corresponding Affymetrix probe sets: 10511631 (MoGene1.0st)   1425841_at (Mouse Genome 430 2.0 Array)   1436279_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000116157
Ensembl peptide - ENSMUSP00000122870
Ensembl peptide - ENSMUSP00000041789
NCBI entrez gene - 208890     See in Manteia.
MGI - MGI:2384791
RefSeq - XM_006537722
RefSeq - XM_006537723
RefSeq - NM_145947
RefSeq Peptide - NP_666059
swissprot - Q8R2Z3
swissprot - A2AJZ6
swissprot - A2AJZ5
Ensembl - ENSMUSG00000040569
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 SLC26A7ENSGALG00000033638Gallus gallus
 Q8TE54ENSG00000147606Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Slc26a10 / solute carrier family 26 member 10 / Q8NG04*ENSMUSG0000004044131
Q9WVC8 / Slc26a3 / Chloride anion exchanger / P40879* / solute carrier family 26 member 3*ENSMUSG0000000122530
Q9R155 / Slc26a4 / Pendrin / O43511* / solute carrier family 26 member 4*ENSMUSG0000002065130
Q99NH7 / Slc26a5 / Prestin / P58743* / solute carrier family 26 member 5*ENSMUSG0000002901530
Q62273 / Slc26a2 / Sulfate transporter / P50443* / solute carrier family 26 member 2*ENSMUSG0000003432029
Slc26a9 / solute carrier family 26 member 9 / Q7LBE3*ENSMUSG0000004226828
Slc26a6 / solute carrier family 26, member 6 / Q9BXS9*ENSMUSG0000002325927
P58735 / Slc26a1 / solute carrier family 26 (sulfate transporter), member 1 / Q9H2B4* / solute carrier family 26 member 1*ENSMUSG0000004695927
Q8R0C3 / Slc26a8 / Testis anion transporter 1 / Q96RN1* / solute carrier family 26 member 8*ENSMUSG0000003619622


Protein motifs (from Interpro)
Interpro ID Name
 IPR001902  SLC26A/SulP transporter
 IPR002645  STAS domain
 IPR011547  SLC26A/SulP transporter domain
 IPR030329  Solute carrier family 26 member 7
 IPR036513  STAS domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001696 gastric acid secretion IEA
 biological_processGO:0006811 ion transport IEA
 biological_processGO:0006820 anion transport IEA
 biological_processGO:0006821 chloride transport IEA
 biological_processGO:0008272 sulfate transport IEA
 biological_processGO:0015701 bicarbonate transport IMP
 biological_processGO:0019532 oxalate transport IEA
 biological_processGO:0042391 regulation of membrane potential IBA
 biological_processGO:0051453 regulation of intracellular pH IBA
 biological_processGO:0055085 transmembrane transport IEA
 biological_processGO:0098656 anion transmembrane transport IEA
 biological_processGO:1902358 sulfate transmembrane transport IEA
 biological_processGO:1902476 chloride transmembrane transport IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005768 endosome IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0005887 integral component of plasma membrane IBA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0016323 basolateral plasma membrane IEA
 cellular_componentGO:0055038 recycling endosome membrane IEA
 molecular_functionGO:0005253 anion channel activity IMP
 molecular_functionGO:0005254 chloride channel activity IEA
 molecular_functionGO:0008271 secondary active sulfate transmembrane transporter activity IEA
 molecular_functionGO:0008509 anion transmembrane transporter activity IEA
 molecular_functionGO:0015106 bicarbonate transmembrane transporter activity IMP
 molecular_functionGO:0015116 sulfate transmembrane transporter activity IEA
 molecular_functionGO:0015301 anion:anion antiporter activity IBA
 molecular_functionGO:0019531 oxalate transmembrane transporter activity IEA


Pathways (from Reactome)
Pathway description
Multifunctional anion exchangers


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000525 renal tubular acidosis "a clinical syndrome characterized by the inability to acidify urine" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:19268]
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Allelic Composition: Cux1tm2Ejn/Cux1tm2Ejn,Cux2tm1.1Nieto/Cux2tm1.1Nieto
Genetic Background: involves: 129S4/SvJae * C57BL6 * FVB/N * Swiss Webster

 MP:0001663 abnormal digestive system physiology "altered function of the organ system that converts ingested food to nutrients and energy" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Cux1tm2Ejn/Cux1tm2Ejn,Cux2tm1.1Nieto/Cux2tm1.1Nieto
Genetic Background: involves: 129S4/SvJae * C57BL6 * FVB/N * Swiss Webster

 MP:0003017 decreased circulating bicarbonate level "reduced concentration of inorganic salts that contain the -HCO3 radical in the circulation, which are an important factor in regulating the pH of the blood " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, RGD:Rat Genome Database submission]
Show

Allelic Composition: Cux1tm2Ejn/Cux1tm2Ejn,Cux2tm1.1Nieto/Cux2tm1.1Nieto
Genetic Background: involves: 129S4/SvJae * C57BL6 * FVB/N * Swiss Webster

 MP:0003030 acidemia "increased concentration of H-ion in the blood or a fall below normal in pH" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, RGD:Rat Genome Database submission]
Show

Allelic Composition: Cux1tm2Ejn/Cux1tm2Ejn,Cux2tm1.1Nieto/Cux2tm1.1Nieto
Genetic Background: involves: 129S4/SvJae * C57BL6 * FVB/N * Swiss Webster

 MP:0003620 decreased urine output "decreased volume of urine produced and excreted" [ncbi:Matthew Mailman, NCBI request]
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Allelic Composition: Cux1tm2Ejn/Cux1tm2Ejn,Cux2tm1.1Nieto/Cux2tm1.1Nieto
Genetic Background: involves: 129S4/SvJae * C57BL6 * FVB/N * Swiss Webster

 MP:0008055 increased urine osmolality "increase in the concentration of ions in the urine compared to the normal state" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cux1tm2Ejn/Cux1tm2Ejn,Cux2tm1.1Nieto/Cux2tm1.1Nieto
Genetic Background: involves: 129S4/SvJae * C57BL6 * FVB/N * Swiss Webster

 MP:0009349 increased urine pH "increased urine alkalinity" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cux1tm2Ejn/Cux1tm2Ejn,Cux2tm1.1Nieto/Cux2tm1.1Nieto
Genetic Background: involves: 129S4/SvJae * C57BL6 * FVB/N * Swiss Webster

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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