ENSMUSG00000034320


Mus musculus
transportSlc26a2transportermembraneactivityanionsulfatedomainplasmaslcsulpstasossificationbicarbonateoxalateregulationchlorideintegralcomponentlongbonedecreasedcellsulphateconservedsitesolutecarrierfamilymember

Features
Gene ID: ENSMUSG00000034320
  
Biological name :Slc26a2
  
Synonyms : Q62273 / Slc26a2 / Sulfate transporter
  
Possible biological names infered from orthology : P50443 / solute carrier family 26 member 2
  
Species: Mus musculus
  
Chr. number: 18
Strand: -1
Band: E1
Gene start: 61192919
Gene end: 61211612
  
Corresponding Affymetrix probe sets: 10459183 (MoGene1.0st)   1421145_at (Mouse Genome 430 2.0 Array)   1427195_at (Mouse Genome 430 2.0 Array)   1443882_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000114419
Ensembl peptide - ENSMUSP00000119447
Ensembl peptide - ENSMUSP00000040163
NCBI entrez gene - 13521     See in Manteia.
MGI - MGI:892977
RefSeq - NM_007885
RefSeq Peptide - NP_031911
swissprot - Q62273
swissprot - E9PZ06
swissprot - F8WI08
Ensembl - ENSMUSG00000034320
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 slc26a2ENSDARG00000011618Danio rerio
 SLC26A2ENSGALG00000001239Gallus gallus
 P50443ENSG00000155850Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
P58735 / Slc26a1 / solute carrier family 26 (sulfate transporter), member 1 / Q9H2B4* / solute carrier family 26 member 1*ENSMUSG0000004695944
Q99NH7 / Slc26a5 / Prestin / P58743* / solute carrier family 26 member 5*ENSMUSG0000002901533
Q9R155 / Slc26a4 / Pendrin / O43511* / solute carrier family 26 member 4*ENSMUSG0000002065130
Q9WVC8 / Slc26a3 / Chloride anion exchanger / P40879* / solute carrier family 26 member 3*ENSMUSG0000000122529
Slc26a6 / solute carrier family 26, member 6 / Q9BXS9*ENSMUSG0000002325929
Slc26a10 / solute carrier family 26 member 10 / Q8NG04*ENSMUSG0000004044129
Slc26a9 / solute carrier family 26 member 9 / Q7LBE3*ENSMUSG0000004226829
Q8R2Z3 / Slc26a7 / Anion exchange transporter / Q8TE54* / solute carrier family 26 member 7*ENSMUSG0000004056926
Q8R0C3 / Slc26a8 / Testis anion transporter 1 / Q96RN1* / solute carrier family 26 member 8*ENSMUSG0000003619622


Protein motifs (from Interpro)
Interpro ID Name
 IPR001902  SLC26A/SulP transporter
 IPR002645  STAS domain
 IPR011547  SLC26A/SulP transporter domain
 IPR018045  Sulphate anion transporter, conserved site
 IPR030280  Solute carrier family 26 member 2
 IPR036513  STAS domain superfamily


Gene Ontology (GO)
ossificationestablishment of localizationregulation of biological qualityossificationestablishment of localizationregulation of biological qualityossificationestablishment of localizationregulation of biological qualityossificationestablishment of localizationregulation of biological qualityossificationestablishment of localizationregulation of biological qualityossificationestablishment of localizationregulation of biological qualityossificationestablishment of localizationregulation of biological qualityossificationestablishment of localizationregulation of biological qualityossificationestablishment of localizationregulation of biological qualityossificationestablishment of localizationregulation of biological qualityossificationossificationestablishment of localizationestablishment of localizationregulation of biological qualityregulation of biological quality
transmembrane transporter activitytransmembrane transporter activitytransmembrane transporter activitytransmembrane transporter activitytransmembrane transporter activitytransmembrane transporter activitytransmembrane transporter activitytransmembrane transporter activitytransmembrane transporter activitytransmembrane transporter activitytransmembrane transporter activitytransmembrane transporter activity
cellmembranecellmembranecellmembranecellmembranecellmembranecellmembranecellmembranecellmembranecellmembranecellmembranecellcellmembranemembrane
TypeGO IDTermEv.Code
 biological_processGO:0001503 ossification IEA
 biological_processGO:0006811 ion transport IEA
 biological_processGO:0008272 sulfate transport IEA
 biological_processGO:0015701 bicarbonate transport IBA
 biological_processGO:0019532 oxalate transport IEA
 biological_processGO:0042391 regulation of membrane potential IBA
 biological_processGO:0051453 regulation of intracellular pH IBA
 biological_processGO:0055085 transmembrane transport IEA
 biological_processGO:1902358 sulfate transmembrane transport IEA
 biological_processGO:1902476 chloride transmembrane transport IBA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0005887 integral component of plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0016324 apical plasma membrane IEA
 cellular_componentGO:0031528 microvillus membrane IEA
 molecular_functionGO:0005254 chloride channel activity IBA
 molecular_functionGO:0008271 secondary active sulfate transmembrane transporter activity IEA
 molecular_functionGO:0015106 bicarbonate transmembrane transporter activity IBA
 molecular_functionGO:0015116 sulfate transmembrane transporter activity IEA
 molecular_functionGO:0015301 anion:anion antiporter activity IBA
 molecular_functionGO:0019531 oxalate transmembrane transporter activity IBA


Pathways (from Reactome)
Pathway description
Transport and synthesis of PAPS
Multifunctional anion exchangers


Phenotype (from MGI, Zfin or HPO)
skeleton phenotypecellular phenotypegrowth/size phenotypemortality/aginglimbs/digits/tail phenotypecraniofacial phenotypeskeleton phenotypecellular phenotypegrowth/size phenotypemortality/aginglimbs/digits/tail phenotypecraniofacial phenotypeskeleton phenotypecellular phenotypegrowth/size phenotypemortality/aginglimbs/digits/tail phenotypecraniofacial phenotypeskeleton phenotypecellular phenotypegrowth/size phenotypemortality/aginglimbs/digits/tail phenotypecraniofacial phenotypeskeleton phenotypecellular phenotypegrowth/size phenotypemortality/aginglimbs/digits/tail phenotypecraniofacial phenotypeskeleton phenotypecellular phenotypegrowth/size phenotypemortality/aginglimbs/digits/tail phenotypecraniofacial phenotypeskeleton phenotypecellular phenotypegrowth/size phenotypemortality/aginglimbs/digits/tail phenotypecraniofacial phenotypeskeleton phenotypecellular phenotypegrowth/size phenotypemortality/aginglimbs/digits/tail phenotypecraniofacial phenotypeskeleton phenotypecellular phenotypegrowth/size phenotypemortality/aginglimbs/digits/tail phenotypecraniofacial phenotypeskeleton phenotypecellular phenotypegrowth/size phenotypemortality/aginglimbs/digits/tail phenotypecraniofacial phenotypeskeleton phenotypeskeleton phenotypecellular phenotypecellular phenotypegrowth/size phenotypegrowth/size phenotypemortality/agingmortality/aginglimbs/digits/tail phenolimbs/digits/tail phenotypecraniofacial phenotypecraniofacial phenotype
IDPhenotypeDefinition Genetic BG
 MP:0000066 osteoporosis "reduction in bone mass or atrophy of skeletal tissue; may lead to skeletal fragility" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:57315]
Show

Allelic Composition: Ltbtm1Kpf/Ltbtm1Kpf
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0000131 abnormal long bone epiphysis morphology "the head of a developing long bone that is separated from the shaft by the epiphyseal plate" [J:61509]
Show

Allelic Composition: Ltbtm1Kpf/Ltbtm1Kpf
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0000160 kyphosis "forward curvature of the spine, characterized by extensive flexion. " [J:62023, J:66943, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, cml:Cathleen M. Lutz , Mouse Genome Informatics Curator]
Show

Allelic Composition: Ltbtm1Kpf/Ltbtm1Kpf
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0000165 abnormal hypertrophic chondrocyte zone "anomaly of the cartilage cell matrix layer " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:58795]
Show

Allelic Composition: Ltbtm1Kpf/Ltbtm1Kpf
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0000352 decreased cell proliferation "less than the normal growth and reproduction of similar cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Ltbtm1Kpf/Ltbtm1Kpf
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001732 postnatal growth retardation "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Ltbtm1Kpf/Ltbtm1Kpf
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Ltbtm1Kpf/Ltbtm1Kpf
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002932 abnormal joint "defect in the articulation point of two or more bones" [RGD:Rat Genome Database submission, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Ltbtm1Kpf/Ltbtm1Kpf
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0003419 delayed endochondral bone ossification "late onset of bone formation in bones that form from cartilage" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:94631]
Show

Allelic Composition: Ltbtm1Kpf/Ltbtm1Kpf
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0004358 bowed tibia "increased curvature of the medial and larger of the two bones of the lower leg" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Ltbtm1Kpf/Ltbtm1Kpf
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0004686 decreased length of long bones "reduced end-to-end length of the several elongated bones of the extremities" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ltbtm1Kpf/Ltbtm1Kpf
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0005621 abnormal cell physiology "aberration in the vital processes of the cell " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, hdene:Howard Dene , Mouse Genome Informatics Curator]
Show

Allelic Composition: Ltbtm1Kpf/Ltbtm1Kpf
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0030223 mandibular hyperostosis "hyperostosis (bony overgrowth) of the mandible" [HP:0004472]
Show

Allelic Composition: Ltbtm1Kpf/Ltbtm1Kpf
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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