ENSMUSG00000037892


Mus musculus

Features
Gene ID: ENSMUSG00000037892
  
Biological name :Pcdh18
  
Synonyms : Pcdh18 / Protocadherin 18 / Q8VHR0
  
Possible biological names infered from orthology : Q9HCL0
  
Species: Mus musculus
  
Chr. number: 3
Strand: -1
Band: C
Gene start: 49743296
Gene end: 49757325
  
Corresponding Affymetrix probe sets: 10498018 (MoGene1.0st)   1422889_at (Mouse Genome 430 2.0 Array)   1422890_at (Mouse Genome 430 2.0 Array)   1430427_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000039245
Ensembl peptide - ENSMUSP00000142135
Ensembl peptide - ENSMUSP00000141995
NCBI entrez gene - 73173     See in Manteia.
MGI - MGI:1920423
RefSeq - NM_130448
RefSeq - XM_006500789
RefSeq Peptide - NP_569715
swissprot - A0A0A6YXT8
swissprot - Q8VHR0
swissprot - A0A0A6YXH7
Ensembl - ENSMUSG00000037892
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 pcdh18aENSDARG00000089805Danio rerio
 pcdh18bENSDARG00000052494Danio rerio
 PCDH18ENSGALG00000009732Gallus gallus
 PCDH18ENSG00000189184Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Pcdh17 / protocadherin 17 / O14917*ENSMUSG0000003556635
O55134 / Pcdh12 / Protocadherin-12 / Q9NPG4*ENSMUSG0000002444034
Pcdh19 / Q80TF3 / Protocadherin-19 / Q8TAB3*ENSMUSG0000005132333
Pcdh8 / Q7TSK3 / Protocadherin-8 / O95206*ENSMUSG0000003642232
Pcdh10 / protocadherin 10 / Q9P2E7*ENSMUSG0000004910032
Pcdhga10 / protocadherin gamma subfamily A, 10 / Q9Y5H3*ENSMUSG0000010222226
Pcdhga11 / protocadherin gamma subfamily A, 11 / Q9Y5H2*ENSMUSG0000010274226
Pcdhga7 / protocadherin gamma subfamily A, 7 / Q9Y5G6*ENSMUSG0000010347226
Q91XY4 / Pcdhga4 / Protocadherin gamma-A4 / Q9Y5G9* / protocadherin gamma subfamily A, 4*ENSMUSG0000010367726
Pcdhga8 / protocadherin gamma subfamily A, 8 / Q9Y5G5*ENSMUSG0000010389726
Pcdha3 / protocadherin alpha 3ENSMUSG0000010231225
Pcdhac2ENSMUSG0000010269725
Pcdhga5 / protocadherin gamma subfamily A, 5 / Q9Y5G8*ENSMUSG0000010356725
Pcdha2 / protocadherin alpha 2ENSMUSG0000010414825
Pcdhga3 / protocadherin gamma subfamily A, 3 / Q9Y5H0*ENSMUSG0000010434625
Pcdhga6 / protocadherin gamma subfamily A, 6 / Q9Y5G7*ENSMUSG0000010379324


Protein motifs (from Interpro)
Interpro ID Name
 IPR002126  Cadherin
 IPR013164  Cadherin, N-terminal
 IPR015919  Cadherin-like
 IPR020894  Cadherin conserved site
 IPR030714  Protocadherin-18


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007155 cell adhesion IEA
 biological_processGO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules IEA
 biological_processGO:0007267 cell-cell signaling IBA
 biological_processGO:0007399 nervous system development IEA
 biological_processGO:0007420 brain development IEP
 biological_processGO:0016339 calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules ISO
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0005887 integral component of plasma membrane IBA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0005509 calcium ion binding IEA
 molecular_functionGO:0005515 protein binding IPI


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001314 corneal opacity "complete or partial clouding of the cornea" [jte:Janan T. Eppig , Mouse Genome Informatics, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Dixdc1tm1.1(KOMP)Vlcg/Dixdc1tm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Dixdc1tm1.1(KOMP)Vlcg/J

 MP:0002574 increased vertical activity "greater than average time spent jumping or rearing " [J:72576, cwg:Carroll W. Goldsmith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Dixdc1tm1.1(KOMP)Vlcg/Dixdc1tm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Dixdc1tm1.1(KOMP)Vlcg/J

 MP:0002727 decreased circulating insulin level "less than normal levels of insulin in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, dlb:Donna Burkart , Mouse Genome Informatics Curator]
Show

Allelic Composition: Dixdc1tm1.1(KOMP)Vlcg/Dixdc1tm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Dixdc1tm1.1(KOMP)Vlcg/J

 MP:0002764 short tibia " reduced length of the medial and larger bone of the lower leg" [J:12736, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Dixdc1tm1.1(KOMP)Vlcg/Dixdc1tm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Dixdc1tm1.1(KOMP)Vlcg/J

 MP:0003960 increased lean body mass "more than average fat-free physical bulk or volume of the body including all its components except adipose tissue" [honda:Hiraoki Onda, Mouse GEnome Informatics Curator]
Show

Allelic Composition: Dixdc1tm1.1(KOMP)Vlcg/Dixdc1tm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Dixdc1tm1.1(KOMP)Vlcg/J

 MP:0004924 abnormal behavior "anomalies in the actions, reactions, or performance of an organism in response to external or internal stimuli compared to controls" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Dixdc1tm1.1(KOMP)Vlcg/Dixdc1tm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Dixdc1tm1.1(KOMP)Vlcg/J

 MP:0010025 decreased total body fat amount "less than the normal total amount of connective tissue composed of fat cells within the entire body" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Dixdc1tm1.1(KOMP)Vlcg/Dixdc1tm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Dixdc1tm1.1(KOMP)Vlcg/J

 MP:0010123 increased bone mineral content "elevation in the amount (usually in grams/cm) of bone mineral divided by a bone-scanned area" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Dixdc1tm1.1(KOMP)Vlcg/Dixdc1tm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Dixdc1tm1.1(KOMP)Vlcg/J

 MP:0010571 shortened ST segment "reduction in the length of time between the end of S-wave and the beginning of T-wave; reflects the amount of time the ventricles remain electrically depolarized" [MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Dixdc1tm1.1(KOMP)Vlcg/Dixdc1tm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Dixdc1tm1.1(KOMP)Vlcg/J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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