ENSMUSG00000047109


Mus musculus

Features
Gene ID: ENSMUSG00000047109
  
Biological name :Cldn14
  
Synonyms : Claudin-14 / Cldn14 / Q9Z0S3
  
Possible biological names infered from orthology : O95500
  
Species: Mus musculus
  
Chr. number: 16
Strand: -1
Band: C4
Gene start: 93919031
Gene end: 94008837
  
Corresponding Affymetrix probe sets: 10441032 (MoGene1.0st)   1420345_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000062045
Ensembl peptide - ENSMUSP00000126455
Ensembl peptide - ENSMUSP00000136156
NCBI entrez gene - 56173     See in Manteia.
MGI - MGI:1860425
RefSeq - XM_006523067
RefSeq - NM_001165925
RefSeq - NM_001165926
RefSeq - NM_019500
RefSeq Peptide - NP_001159397
RefSeq Peptide - NP_001159398
RefSeq Peptide - NP_062373
swissprot - Q9Z0S3
swissprot - A2RSP0
Ensembl - ENSMUSG00000047109
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 CLDN14ENSGALG00000016043Gallus gallus
 CLDN14ENSG00000159261Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Cldn2 / O88552 / Claudin-2 / P57739*ENSMUSG0000004723044
Cldn4 / O35054 / Claudin-4 / O14493*ENSMUSG0000004750141
Cldn7 / Q9Z261 / Claudin-7 / O95471*ENSMUSG0000001856940
Cldn1 / O88551 / Claudin-1 / O95832*ENSMUSG0000002251240
Cldn3 / Q9Z0G9 / Claudin-3 / O15551*ENSMUSG0000007047340
Cldn19 / Q9ET38 / Claudin-19 / Q8N6F1*ENSMUSG0000006605839
Cldn9 / Q9Z0S7 / Claudin-9 / O95484*ENSMUSG0000006672039
Cldn6 / Q9Z262 / Claudin-6 / P56747*ENSMUSG0000002390637
Cldn5 / O54942 / Claudin-5 / O00501*ENSMUSG0000004137837
Cldn8 / Q9Z260 / Claudin-8 / P56748*ENSMUSG0000005052033


Protein motifs (from Interpro)
Interpro ID Name
 IPR003556  Claudin-14
 IPR004031  PMP-22/EMP/MP20/Claudin superfamily
 IPR006187  Claudin
 IPR017974  Claudin, conserved site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0016338 calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules ISS
 cellular_componentGO:0005886 plasma membrane IDA
 cellular_componentGO:0005923 bicellular tight junction ISS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0030054 cell junction IEA
 molecular_functionGO:0005198 structural molecule activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0042802 identical protein binding ISS


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001967 deafness "inability to hear" [J:57651]
Show

Allelic Composition: H1f0tm1Ais/H1f0tm1Ais,Hist1h1ctm2Ais/Hist1h1ctm2Ais,Hist1h1etm2Ais/Hist1h1etm2Ais
Genetic Background: involves: 129/Sv * C57BL/6 * SJL

 MP:0004362 cochlear hair cell degeneration "degeneration or loss of the sensory epithelial cells of the cochlea; these cells are in synaptic contact with the auditory nerve" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: H1f0tm1Ais/H1f0tm1Ais,Hist1h1ctm2Ais/Hist1h1ctm2Ais,Hist1h1etm2Ais/Hist1h1etm2Ais
Genetic Background: involves: 129/Sv * C57BL/6 * SJL

 MP:0004398 cochlear inner hair cell degeneration "degeneration or loss of the single row of flask-shaped inner hair sensory cells of the organ of Corti" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: H1f0tm1Ais/H1f0tm1Ais,Hist1h1ctm2Ais/Hist1h1ctm2Ais,Hist1h1etm2Ais/Hist1h1etm2Ais
Genetic Background: involves: 129/Sv * C57BL/6 * SJL

 MP:0004404 cochlear outer hair cell degeneration "degeneration or loss of the columnar outer hair sensory cells of the organ of Corti" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: H1f0tm1Ais/H1f0tm1Ais,Hist1h1ctm2Ais/Hist1h1ctm2Ais,Hist1h1etm2Ais/Hist1h1etm2Ais
Genetic Background: involves: 129/Sv * C57BL/6 * SJL

 MP:0004530 absent outer hair cell stereocilia "complete absence of the nonmotile, actin-filled specialized microvilli (stereocilia) which are normally arrayed on cochlear outer hair cells" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: H1f0tm1Ais/H1f0tm1Ais,Hist1h1ctm2Ais/Hist1h1ctm2Ais,Hist1h1etm2Ais/Hist1h1etm2Ais
Genetic Background: involves: 129/Sv * C57BL/6 * SJL

 MP:0004532 abnormal inner hair cell stereociliary bundle morphology "any structural anomaly or disruption of the typically linear or U-shaped pattern of arrangement of mechanosensitive hair bundles located at the apical end of cochlear IHCs; each hair bundle is normally composed of ~100 nonmotile, actin-filled microvilli (stereocilia) arranged in rows of increasing height and coupled to one another by morphologically distinct links: tip links, horizontal top connectors, shaft connectors, and ankle links; most hair bundles also possess a single motile kinocilium immediately adjacent to the tallest row of stereocilia; a fifth link type, the kinocilial link, connects the kinocilium to its neighboring stereocilia" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: H1f0tm1Ais/H1f0tm1Ais,Hist1h1ctm2Ais/Hist1h1ctm2Ais,Hist1h1etm2Ais/Hist1h1etm2Ais
Genetic Background: involves: 129/Sv * C57BL/6 * SJL

 MP:0011967 increased or absent threshold for auditory brainstem response "increase in the value at which one or more sound frequencies or broadband clicks first elicits a recordable response generated by electrical activity of neurons in the ascending auditory system, or complete lack of a recordable response at any frequency or broadband click" [MGI:csmith]
Show

Allelic Composition: H1f0tm1Ais/H1f0tm1Ais,Hist1h1ctm2Ais/Hist1h1ctm2Ais,Hist1h1etm2Ais/Hist1h1etm2Ais
Genetic Background: involves: 129/Sv * C57BL/6 * SJL

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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