ENSMUSG00000066720


Mus musculus

Features
Gene ID: ENSMUSG00000066720
  
Biological name :Cldn9
  
Synonyms : Claudin-9 / Cldn9 / Q9Z0S7
  
Possible biological names infered from orthology : O95484
  
Species: Mus musculus
  
Chr. number: 17
Strand: -1
Band: A3.3
Gene start: 23682584
Gene end: 23684018
  
Corresponding Affymetrix probe sets: 10448312 (MoGene1.0st)   1439427_at (Mouse Genome 430 2.0 Array)   1450524_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000093236
NCBI entrez gene - 56863     See in Manteia.
MGI - MGI:1913100
RefSeq - NM_020293
RefSeq Peptide - NP_064689
swissprot - Q9Z0S7
Ensembl - ENSMUSG00000066720
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 CLDN9ENSG00000213937Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Cldn6 / Q9Z262 / Claudin-6 / P56747*ENSMUSG0000002390671
Cldn3 / Q9Z0G9 / Claudin-3 / O15551*ENSMUSG0000007047365
Cldn4 / O35054 / Claudin-4 / O14493*ENSMUSG0000004750159
Cldn5 / O54942 / Claudin-5 / O00501*ENSMUSG0000004137853
Cldn8 / Q9Z260 / Claudin-8 / P56748*ENSMUSG0000005052047
Cldn1 / O88551 / Claudin-1 / O95832*ENSMUSG0000002251246
Cldn7 / Q9Z261 / Claudin-7 / O95471*ENSMUSG0000001856945
Cldn19 / Q9ET38 / Claudin-19 / Q8N6F1*ENSMUSG0000006605844
Cldn14 / Q9Z0S3 / Claudin-14 / O95500*ENSMUSG0000004710943
Cldn2 / O88552 / Claudin-2 / P57739*ENSMUSG0000004723038


Protein motifs (from Interpro)
Interpro ID Name
 IPR003553  Claudin-9
 IPR004031  PMP-22/EMP/MP20/Claudin superfamily
 IPR006187  Claudin
 IPR017974  Claudin, conserved site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0016338 calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules ISS
 biological_processGO:0045216 cell-cell junction organization IDA
 biological_processGO:0046718 viral entry into host cell IEA
 cellular_componentGO:0005886 plasma membrane ISO
 cellular_componentGO:0005923 bicellular tight junction ISS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0030054 cell junction ISO
 cellular_componentGO:0043231 intracellular membrane-bounded organelle IEA
 molecular_functionGO:0001618 virus receptor activity IEA
 molecular_functionGO:0005198 structural molecule activity IDA
 molecular_functionGO:0042802 identical protein binding ISS


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000042 abnormal organ of Corti "abnormalities associated with the highly specialized epithelium in the floor of the ductus cochlearis; also referred to a spiral organ (organum spirale), or acoustic papilla" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Slc4a1tm1Phsl/Slc4a1+
Genetic Background: involves: 129 * 129S6/SvEvTac * Black Swiss

 MP:0001967 deafness "inability to hear" [J:57651]
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Allelic Composition: Slc4a1tm1Phsl/Slc4a1+
Genetic Background: involves: 129 * 129S6/SvEvTac * Black Swiss

 MP:0004402 decreased cochlear outer hair cell number "decreased number (or less than the expected 3 rows) of the columnar outer hair sensory cells of the organ of Corti" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Slc4a1tm1Phsl/Slc4a1+
Genetic Background: involves: 129 * 129S6/SvEvTac * Black Swiss

 MP:0004404 cochlear outer hair cell degeneration "degeneration or loss of the columnar outer hair sensory cells of the organ of Corti" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Slc4a1tm1Phsl/Slc4a1+
Genetic Background: involves: 129 * 129S6/SvEvTac * Black Swiss

 MP:0004529 decreased outer hair cell stereocilia number "decreased number (or less than the expected 100 or so) of the nonmotile, actin-filled specialized microvilli (stereocilia) normally arrayed on cochlear outer hair cells" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Slc4a1tm1Phsl/Slc4a1+
Genetic Background: involves: 129 * 129S6/SvEvTac * Black Swiss

 MP:0004888 abnormal perilymph "change in the normal production (volume) or ionic homeostasis of the fluid contained within the osseous labyrinth, surrounding and protecting the membranous labyrinth; perilymph resembles extracellular fluid in composition, has a high concentration of sodium ion and a low concentration of potassium ion and, through the perilymphatic duct, is in continuity with cerebrospinal fluid" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Slc4a1tm1Phsl/Slc4a1+
Genetic Background: involves: 129 * 129S6/SvEvTac * Black Swiss

 MP:0006359 absent startle reflex "failure to respond to variable stimuli, often auditory; usually measured by amplitude of whole body flinch" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Slc4a1tm1Phsl/Slc4a1+
Genetic Background: involves: 129 * 129S6/SvEvTac * Black Swiss

 MP:0011967 increased or absent threshold for auditory brainstem response "increase in the value at which one or more sound frequencies or broadband clicks first elicits a recordable response generated by electrical activity of neurons in the ascending auditory system, or complete lack of a recordable response at any frequency or broadband click" [MGI:csmith]
Show

Allelic Composition: Slc4a1tm1Phsl/Slc4a1+
Genetic Background: involves: 129 * 129S6/SvEvTac * Black Swiss

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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