ENSMUSG00000022512


Mus musculus

Features
Gene ID: ENSMUSG00000022512
  
Biological name :Cldn1
  
Synonyms : Claudin-1 / Cldn1 / O88551
  
Possible biological names infered from orthology : O95832
  
Species: Mus musculus
  
Chr. number: 16
Strand: -1
Band: B2
Gene start: 26356642
Gene end: 26371841
  
Corresponding Affymetrix probe sets: 10438769 (MoGene1.0st)   1437932_a_at (Mouse Genome 430 2.0 Array)   1438850_at (Mouse Genome 430 2.0 Array)   1438851_x_at (Mouse Genome 430 2.0 Array)   1450014_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000023154
NCBI entrez gene - 12737     See in Manteia.
MGI - MGI:1276109
RefSeq - NM_016674
RefSeq Peptide - NP_057883
swissprot - O88551
swissprot - Q4FJV3
Ensembl - ENSMUSG00000022512
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 cldn1ENSDARG00000040045Danio rerio
 CLDN1ENSGALG00000026862Gallus gallus
 CLDN1ENSG00000163347Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Cldn7 / Q9Z261 / Claudin-7 / O95471*ENSMUSG0000001856960
Cldn19 / Q9ET38 / Claudin-19 / Q8N6F1*ENSMUSG0000006605855
Cldn6 / Q9Z262 / Claudin-6 / P56747*ENSMUSG0000002390648
Cldn9 / Q9Z0S7 / Claudin-9 / O95484*ENSMUSG0000006672047
Cldn3 / Q9Z0G9 / Claudin-3 / O15551*ENSMUSG0000007047347
Cldn14 / Q9Z0S3 / Claudin-14 / O95500*ENSMUSG0000004710945
Cldn4 / O35054 / Claudin-4 / O14493*ENSMUSG0000004750145
Cldn5 / O54942 / Claudin-5 / O00501*ENSMUSG0000004137842
Cldn8 / Q9Z260 / Claudin-8 / P56748*ENSMUSG0000005052037
Cldn2 / O88552 / Claudin-2 / P57739*ENSMUSG0000004723036


Protein motifs (from Interpro)
Interpro ID Name
 IPR003548  Claudin-1
 IPR004031  PMP-22/EMP/MP20/Claudin superfamily
 IPR006187  Claudin
 IPR017974  Claudin, conserved site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007568 aging IEA
 biological_processGO:0008065 establishment of blood-nerve barrier IEA
 biological_processGO:0009636 response to toxic substance IEA
 biological_processGO:0016338 calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules IDA
 biological_processGO:0032496 response to lipopolysaccharide IEA
 biological_processGO:0042538 hyperosmotic salinity response IEA
 biological_processGO:0045216 cell-cell junction organization IEA
 biological_processGO:0045471 response to ethanol IEA
 biological_processGO:0046718 viral entry into host cell IEA
 biological_processGO:0051260 protein homooligomerization IEA
 biological_processGO:0051291 protein heterooligomerization IEA
 biological_processGO:0061436 establishment of skin barrier IEA
 biological_processGO:0061772 drug transport across blood-nerve barrier IEA
 biological_processGO:0070673 response to interleukin-18 IEA
 biological_processGO:0070830 bicellular tight junction assembly IEA
 biological_processGO:0071284 cellular response to lead ion IEA
 biological_processGO:0071346 cellular response to interferon-gamma IEA
 biological_processGO:0071356 cellular response to tumor necrosis factor IEA
 biological_processGO:0071548 response to dexamethasone IEA
 biological_processGO:0071560 cellular response to transforming growth factor beta stimulus IEA
 biological_processGO:0090557 establishment of endothelial intestinal barrier IEA
 biological_processGO:0097421 liver regeneration IEA
 biological_processGO:1903348 positive regulation of bicellular tight junction assembly IEA
 biological_processGO:1903545 cellular response to butyrate IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0005887 integral component of plasma membrane IEA
 cellular_componentGO:0005923 bicellular tight junction ISO
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane NAS
 cellular_componentGO:0016323 basolateral plasma membrane IEA
 cellular_componentGO:0016324 apical plasma membrane IEA
 cellular_componentGO:0016328 lateral plasma membrane IEA
 cellular_componentGO:0030054 cell junction TAS
 molecular_functionGO:0001618 virus receptor activity IEA
 molecular_functionGO:0005198 structural molecule activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0042802 identical protein binding IPI


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001211 wrinkled skin "irregular folds and/or indentations on the skin" [J:19212]
Show

Allelic Composition: Ercc8tm1Jhjh/Ercc8tm1Jhjh,Xpctm1Ecf/Xpc+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0001219 thickened epidermis "increase in the width of the epidermal cell layer in the skin" [J:65146]
Show

Allelic Composition: Ercc8tm1Jhjh/Ercc8tm1Jhjh,Xpctm1Ecf/Xpc+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0001242 hyperkeratosis "increased depth of the corneal layer of the epidermis; thickening of the horny layer of the epidermis" [J:1133]
Show

Allelic Composition: Ercc8tm1Jhjh/Ercc8tm1Jhjh,Xpctm1Ecf/Xpc+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0001263 weight loss "progressive reduction of body weight below normal average for age" [J:45400]
Show

Allelic Composition: Ercc8tm1Jhjh/Ercc8tm1Jhjh,Xpctm1Ecf/Xpc+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0001429 dehydration "excessive water loss from the body or from an organ or bodily part" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:50053]
Show

Allelic Composition: Ercc8tm1Jhjh/Ercc8tm1Jhjh,Xpctm1Ecf/Xpc+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0002073 abnormal hair growth "absence or reduced amount of hair or abnormal onset of hair growth cycle or development" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Ercc8tm1Jhjh/Ercc8tm1Jhjh,Xpctm1Ecf/Xpc+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0002796 impaired skin barrier function "impaired ability of the skin to regulate water loss; frequently leads to dehydration" [J:56641]
Show

Allelic Composition: Ercc8tm1Jhjh/Ercc8tm1Jhjh,Xpctm1Ecf/Xpc+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0011087 complete neonatal lethality "death of all organisms of a given genotype in a population within the neonatal period after birth (Mus: P0)" [MGI:csmith]
Show

Allelic Composition: Ercc8tm1Jhjh/Ercc8tm1Jhjh,Xpctm1Ecf/Xpc+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0011100 complete preweaning lethality "death of all organisms of a given genotype in a population between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Cecr2tm2b(EUCOMM)Hmgu/Cecr2+
Genetic Background: C57BL/6N-Cecr2tm2b(EUCOMM)Hmgu/Tcp

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000022512 Cldn1 / O88551 / Claudin-1 / O95832*  / complex / reaction






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2025
contact: otassy@igbmc.fr