ENSMUSG00000047230


Mus musculus

Features
Gene ID: ENSMUSG00000047230
  
Biological name :Cldn2
  
Synonyms : Claudin-2 / Cldn2 / O88552
  
Possible biological names infered from orthology : P57739
  
Species: Mus musculus
  
Chr. number: X
Strand: 1
Band: F1
Gene start: 139800828
Gene end: 139811386
  
Corresponding Affymetrix probe sets: 10602033 (MoGene1.0st)   1417231_at (Mouse Genome 430 2.0 Array)   1417232_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000054219
Ensembl peptide - ENSMUSP00000121152
Ensembl peptide - ENSMUSP00000134644
NCBI entrez gene - 12738     See in Manteia.
MGI - MGI:1276110
RefSeq - XM_006528490
RefSeq - NM_016675
RefSeq - XM_006528486
RefSeq - XM_006528487
RefSeq Peptide - NP_057884
swissprot - A3KGB5
swissprot - O88552
Ensembl - ENSMUSG00000047230
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 cldn2ENSDARG00000044387Danio rerio
 CLDN2ENSGALG00000007311Gallus gallus
 CLDN2ENSG00000165376Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Cldn14 / Q9Z0S3 / Claudin-14 / O95500*ENSMUSG0000004710945
Cldn3 / Q9Z0G9 / Claudin-3 / O15551*ENSMUSG0000007047337
Cldn6 / Q9Z262 / Claudin-6 / P56747*ENSMUSG0000002390636
Cldn4 / O35054 / Claudin-4 / O14493*ENSMUSG0000004750136
Cldn19 / Q9ET38 / Claudin-19 / Q8N6F1*ENSMUSG0000006605836
Cldn9 / Q9Z0S7 / Claudin-9 / O95484*ENSMUSG0000006672036
Cldn7 / Q9Z261 / Claudin-7 / O95471*ENSMUSG0000001856934
Cldn1 / O88551 / Claudin-1 / O95832*ENSMUSG0000002251233
Cldn8 / Q9Z260 / Claudin-8 / P56748*ENSMUSG0000005052032
Cldn5 / O54942 / Claudin-5 / O00501*ENSMUSG0000004137830


Protein motifs (from Interpro)
Interpro ID Name
 IPR004031  PMP-22/EMP/MP20/Claudin superfamily
 IPR005411  Claudin-2
 IPR006187  Claudin
 IPR017974  Claudin, conserved site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0016338 calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules IDA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0005923 bicellular tight junction IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0030054 cell junction IEA
 molecular_functionGO:0005198 structural molecule activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0042802 identical protein binding IPI


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001762 polyuria "increased volume of urine produced and excreted" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Galnt4tm1Tabk/Galnt4tm1Tabk,Galnt5tm1Tabk/Galnt5tm1Tabk
Genetic Background: B6;129S-Galnt5tm1Tabk Galnt4tm1Tabk/Mmucd

 MP:0002988 decreased urine osmolarity "reduction in the concentration of ions in the urine compared to normal" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:83000]
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Allelic Composition: Galnt4tm1Tabk/Galnt4tm1Tabk,Galnt5tm1Tabk/Galnt5tm1Tabk
Genetic Background: B6;129S-Galnt5tm1Tabk Galnt4tm1Tabk/Mmucd

 MP:0004041 increased susceptibility to kidney reperfusion injury "an increased likelihood or extent of damage to the kidney when the blood supply is restored after a period of ischemia " [brs:Beverly Richards-Smith, Mouse Genome Informatics Curator]
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Allelic Composition: Cacna1atm2.1Maag/Cacna1atm2.1Maag,Tg(Pcp2-cre)2Mpin/0
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ

 MP:0005039 hypoxia "reduced concentration of O2 in the blood, alveoli or other tissues resulting in the decreased pressure of this component of body gases" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Cacna1atm2.1Maag/Cacna1atm2.1Maag,Tg(Pcp2-cre)2Mpin/0
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ

 MP:0005289 increased oxygen consumption "greater than the normal rate at which oxygen enters the blood from alveolar gas; this is equal in the steady state to the consumption of oxygen by tissue metabolism throughout the body" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Cacna1atm2.1Maag/Cacna1atm2.1Maag,Tg(Pcp2-cre)2Mpin/0
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ

 MP:0005319 abnormal enzyme/ coenzyme level "altered concentration of any of these proteins, or their cofactors, that act as catalysts to induce chemical changes in other substances" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Cacna1atm2.1Maag/Cacna1atm2.1Maag,Tg(Pcp2-cre)2Mpin/0
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ

 MP:0005441 hypercalciuria "excretion of abnormally large amounts of calcium in the urine" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:86949]
Show

Allelic Composition: Galnt4tm1Tabk/Galnt4tm1Tabk,Galnt5tm1Tabk/Galnt5tm1Tabk
Genetic Background: B6;129S-Galnt5tm1Tabk Galnt4tm1Tabk/Mmucd

 MP:0005553 increased circulating creatinine level "greater than the normal blood concentration of this product of creatine catabolism; abnormal levels indicative of renal dysfunction" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, RGD:Rat Genome Database submission]
Show

Allelic Composition: Cacna1atm2.1Maag/Cacna1atm2.1Maag,Tg(Pcp2-cre)2Mpin/0
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ

 MP:0005565 increased blood urea nitrogen level "high circulating concentration of nitrogen, in the form of urea; commonly used to measure renal function" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Cacna1atm2.1Maag/Cacna1atm2.1Maag,Tg(Pcp2-cre)2Mpin/0
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ

 MP:0006316 increased urine sodium level "higher than normal concentration of sodium in the urine" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Galnt4tm1Tabk/Galnt4tm1Tabk,Galnt5tm1Tabk/Galnt5tm1Tabk
Genetic Background: B6;129S-Galnt5tm1Tabk Galnt4tm1Tabk/Mmucd

Allelic Composition: Cldn2tm1Lex/Y
Genetic Background: B6J.129S5-Cldn2tm1Lex

 MP:0010107 abnormal renal reabsorption "any anomaly in the two-step process beginning with the active or passive extraction of substances (such as water, glucose, oligopeptides, amino acids, sodium (Na+) and other ions) from the renal tubule fluid into the renal interstitium, and the subsequent transport of these substances out of the renal interstitium back into the bloodstream; reabsorption begins in the proximal convoluted tubules and continues in the loop of Henle, distal convoluted tubules, and collecting tubules" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Galnt4tm1Tabk/Galnt4tm1Tabk,Galnt5tm1Tabk/Galnt5tm1Tabk
Genetic Background: B6;129S-Galnt5tm1Tabk Galnt4tm1Tabk/Mmucd

 MP:0010108 abnormal renal water reabsorption "any anomaly in the process by which water is passively transported out of the renal tubules back into the bloodstream" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Galnt4tm1Tabk/Galnt4tm1Tabk,Galnt5tm1Tabk/Galnt5tm1Tabk
Genetic Background: B6;129S-Galnt5tm1Tabk Galnt4tm1Tabk/Mmucd

 MP:0010109 abnormal renal sodium reabsorption "any anomaly in the process by which sodium ions are transported out of the renal tubules back into the bloodstream" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Galnt4tm1Tabk/Galnt4tm1Tabk,Galnt5tm1Tabk/Galnt5tm1Tabk
Genetic Background: B6;129S-Galnt5tm1Tabk Galnt4tm1Tabk/Mmucd

Allelic Composition: Cldn2tm1Lex/Y
Genetic Background: B6J.129S5-Cldn2tm1Lex

 MP:0011442 abnormal renal sodium ion transport "any anomaly in the directed movement of sodium ions (Na+) by the kidney" [GO:0003096]
Show

Allelic Composition: Cldn2tm1Lex/Y
Genetic Background: B6J.129S5-Cldn2tm1Lex

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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