ENSMUSG00000056427


Mus musculus
domainSlit3leucine-richrepeategf-likeaxonregulationsignalingbindingherniateddiaphragmsitesuperfamilydevelopmentguidancecellrightventriclecysteine-richregionc-terminalcalcium-bindinggrowthreceptorconservedproliferationresponseroundaboutpathwayinvolvedextracellular

Features
Gene ID: ENSMUSG00000056427
  
Biological name :Slit3
  
Synonyms : Q9WVB4 / Slit3 / Slit homolog 3 protein
  
Possible biological names infered from orthology : O75094 / slit guidance ligand 3
  
Species: Mus musculus
  
Chr. number: 11
Strand: 1
Band: A4
Gene start: 35121224
Gene end: 35708507
  
Corresponding Affymetrix probe sets: 10375175 (MoGene1.0st)   1427086_at (Mouse Genome 430 2.0 Array)   1452296_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000066857
NCBI entrez gene - 20564     See in Manteia.
MGI - MGI:1315202
RefSeq - NM_011412
RefSeq Peptide - NP_035542
swissprot - Q9WVB4
Ensembl - ENSMUSG00000056427
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 slit3ENSDARG00000034268Danio rerio
 SLIT3ENSGALG00000001916Gallus gallus
 SLIT3ENSG00000184347Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Slit2 / Q9R1B9 / slit guidance ligand 2 / O94813*ENSMUSG0000003155866
Slit1 / Q80TR4 / Slit homolog 1 protein / O75093* / slit guidance ligand 1*ENSMUSG0000002502060
2 / Crb2 / Q80YA8 / Q5IJ48* / crumbs 2, cell polarity complex component*ENSMUSG0000003540315
1 / Crb1 / Q8VHS2 / P82279* / crumbs 1, cell polarity complex component*ENSMUSG0000006368115
Dner / Q8JZM4 / Delta and Notch-like epidermal growth factor-related receptor / Q8NFT8* / delta/notch like EGF repeat containing*ENSMUSG0000003676610
Dll3 / O88516 / Delta-like protein 3 / Q9NYJ7* / delta like canonical Notch ligand 3*ENSMUSG000000034368
2 / Dlk2 / Q8K1E3 / Q6UY11* / delta like non-canonical Notch ligand 2*ENSMUSG000000474287
Dlk1 / delta like non-canonical Notch ligand 1 / P80370*ENSMUSG000000408566


Protein motifs (from Interpro)
Interpro ID Name
 IPR000152  EGF-type aspartate/asparagine hydroxylation site
 IPR000372  Leucine-rich repeat N-terminal domain
 IPR000483  Cysteine-rich flanking region, C-terminal
 IPR000742  EGF-like domain
 IPR001611  Leucine-rich repeat
 IPR001791  Laminin G domain
 IPR001881  EGF-like calcium-binding domain
 IPR003591  Leucine-rich repeat, typical subtype
 IPR006207  Cystine knot, C-terminal
 IPR009030  Growth factor receptor cysteine-rich domain superfamily
 IPR013032  EGF-like, conserved site
 IPR013320  Concanavalin A-like lectin/glucanase domain superfamily
 IPR018097  EGF-like calcium-binding, conserved site
 IPR032675  Leucine-rich repeat domain superfamily


Gene Ontology (GO)
anatomical structure developmentresponse to external stimuluscellular component organizationresponse to chemicalmovement of cell or subcellular componentcellular developmental processorganic substance metabolic processcell growthresponse to endogenous stimuluscellular response to stimuluscell communicationdevelopmental growthcell deathmulticellular organism reproductionanatomical structure developmentresponse to external stimuluscellular component organizationresponse to chemicalmovement of cell or subcellular componentcellular developmental processorganic substance metabolic processcell growthresponse to endogenous stimuluscellular response to stimuluscell communicationdevelopmental growthcell deathmulticellular organism reproductionanatomical structure developmentresponse to external stimuluscellular component organizationresponse to chemicalmovement of cell or subcellular componentcellular developmental processorganic substance metabolic processcell growthresponse to endogenous stimuluscellular response to stimuluscell communicationdevelopmental growthcell deathmulticellular organism reproductionanatomical structure developmentresponse to external stimuluscellular component organizationresponse to chemicalmovement of cell or subcellular componentcellular developmental processorganic substance metabolic processcell growthresponse to endogenous stimuluscellular response to stimuluscell communicationdevelopmental growthcell deathmulticellular organism reproductionanatomical structure developmentresponse to external stimuluscellular component organizationresponse to chemicalmovement of cell or subcellular componentcellular developmental processorganic substance metabolic processcell growthresponse to endogenous stimuluscellular response to stimuluscell communicationdevelopmental growthcell deathmulticellular organism reproductionanatomical structure developmentresponse to external stimuluscellular component organizationresponse to chemicalmovement of cell or subcellular componentcellular developmental processorganic substance metabolic processcell growthresponse to endogenous stimuluscellular response to stimuluscell communicationdevelopmental growthcell deathmulticellular organism reproductionanatomical structure developmentresponse to external stimuluscellular component organizationresponse to chemicalmovement of cell or subcellular componentcellular developmental processorganic substance metabolic processcell growthresponse to endogenous stimuluscellular response to stimuluscell communicationdevelopmental growthcell deathmulticellular organism reproductionanatomical structure developmentresponse to external stimuluscellular component organizationresponse to chemicalmovement of cell or subcellular componentcellular developmental processorganic substance metabolic processcell growthresponse to endogenous stimuluscellular response to stimuluscell communicationdevelopmental growthcell deathmulticellular organism reproductionanatomical structure developmentresponse to external stimuluscellular component organizationresponse to chemicalmovement of cell or subcellular componentcellular developmental processorganic substance metabolic processcell growthresponse to endogenous stimuluscellular response to stimuluscell communicationdevelopmental growthcell deathmulticellular organism reproductionanatomical structure developmentresponse to external stimuluscellular component organizationresponse to chemicalmovement of cell or subcellular componentcellular developmental processorganic substance metabolic processcell growthresponse to endogenous stimuluscellular response to stimuluscell communicationdevelopmental growthcell deathmulticellular organism reproductionanatomicalanatomical structure developmentresponse tresponse to external stimuluscellular ccellular component organizationresponse tresponse to chemicalmovement omovement of cell or subcellular componentcellular dcellular developmental processorganic suorganic substance metabolic processcell growtcell growthresponse tresponse to endogenous stimuluscellular rcellular response to stimuluscell commucell communicationdevelopmendevelopmental growthcell deathcell deathmulticellumulticellular organism reproduction
protein bindingion bindingprotein bindingion bindingprotein bindingion bindingprotein bindingion bindingprotein bindingion bindingprotein bindingion bindingprotein bindingion bindingprotein bindingion bindingprotein bindingion bindingprotein bindingion bindingprotein bindingprotein bindingion bindingion binding
extracellular regioncellmembraneextracellular regioncellmembraneextracellular regioncellmembraneextracellular regioncellmembraneextracellular regioncellmembraneextracellular regioncellmembraneextracellular regioncellmembraneextracellular regioncellmembraneextracellular regioncellmembraneextracellular regioncellmembraneextracellular regionextracellular regioncellcellmembranemembrane
TypeGO IDTermEv.Code
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0007399 nervous system development IEA
 biological_processGO:0007411 axon guidance IEA
 biological_processGO:0008285 negative regulation of cell proliferation IGI
 biological_processGO:0009887 animal organ morphogenesis IMP
 biological_processGO:0010629 negative regulation of gene expression IGI
 biological_processGO:0030154 cell differentiation IEA
 biological_processGO:0030308 negative regulation of cell growth IEA
 biological_processGO:0032870 cellular response to hormone stimulus IEA
 biological_processGO:0035385 Roundabout signaling pathway IEA
 biological_processGO:0048846 axon extension involved in axon guidance IEA
 biological_processGO:0050919 negative chemotaxis IEA
 biological_processGO:0051414 response to cortisol IEA
 biological_processGO:0061364 apoptotic process involved in luteolysis IEA
 biological_processGO:0070100 negative regulation of chemokine-mediated signaling pathway IEA
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005615 extracellular space IEA
 cellular_componentGO:0005886 plasma membrane TAS
 molecular_functionGO:0005102 signaling receptor binding TAS
 molecular_functionGO:0005509 calcium ion binding IEA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0048495 Roundabout binding IEA


Pathways (from Reactome)
Pathway description
Signaling by ROBO receptors


Phenotype (from MGI, Zfin or HPO)
cardiovascular system phenotyperenal/urinary system phenotypegrowth/size phenotypemuscle phenotyperespiratory system phenotypemortality/agingnervous system phenotypecellular phenotypedigestive/alimentary phenotypeendocrine/exocrine gland phenotypeintegument phenotypeliver/biliary system phenotypeskeleton phenotypecardiovascular system phenotyperenal/urinary system phenotypegrowth/size phenotypemuscle phenotyperespiratory system phenotypemortality/agingnervous system phenotypecellular phenotypedigestive/alimentary phenotypeendocrine/exocrine gland phenotypeintegument phenotypeliver/biliary system phenotypeskeleton phenotypecardiovascular system phenotyperenal/urinary system phenotypegrowth/size phenotypemuscle phenotyperespiratory system phenotypemortality/agingnervous system phenotypecellular phenotypedigestive/alimentary phenotypeendocrine/exocrine gland phenotypeintegument phenotypeliver/biliary system phenotypeskeleton phenotypecardiovascular system phenotyperenal/urinary system phenotypegrowth/size phenotypemuscle phenotyperespiratory system phenotypemortality/agingnervous system phenotypecellular phenotypedigestive/alimentary phenotypeendocrine/exocrine gland phenotypeintegument phenotypeliver/biliary system phenotypeskeleton phenotypecardiovascular system phenotyperenal/urinary system phenotypegrowth/size phenotypemuscle phenotyperespiratory system phenotypemortality/agingnervous system phenotypecellular phenotypedigestive/alimentary phenotypeendocrine/exocrine gland phenotypeintegument phenotypeliver/biliary system phenotypeskeleton phenotypecardiovascular system phenotyperenal/urinary system phenotypegrowth/size phenotypemuscle phenotyperespiratory system phenotypemortality/agingnervous system phenotypecellular phenotypedigestive/alimentary phenotypeendocrine/exocrine gland phenotypeintegument phenotypeliver/biliary system phenotypeskeleton phenotypecardiovascular system phenotyperenal/urinary system phenotypegrowth/size phenotypemuscle phenotyperespiratory system phenotypemortality/agingnervous system phenotypecellular phenotypedigestive/alimentary phenotypeendocrine/exocrine gland phenotypeintegument phenotypeliver/biliary system phenotypeskeleton phenotypecardiovascular system phenotyperenal/urinary system phenotypegrowth/size phenotypemuscle phenotyperespiratory system phenotypemortality/agingnervous system phenotypecellular phenotypedigestive/alimentary phenotypeendocrine/exocrine gland phenotypeintegument phenotypeliver/biliary system phenotypeskeleton phenotypecardiovascular system phenotyperenal/urinary system phenotypegrowth/size phenotypemuscle phenotyperespiratory system phenotypemortality/agingnervous system phenotypecellular phenotypedigestive/alimentary phenotypeendocrine/exocrine gland phenotypeintegument phenotypeliver/biliary system phenotypeskeleton phenotypecardiovascular system phenotyperenal/urinary system phenotypegrowth/size phenotypemuscle phenotyperespiratory system phenotypemortality/agingnervous system phenotypecellular phenotypedigestive/alimentary phenotypeendocrine/exocrine gland phenotypeintegument phenotypeliver/biliary system phenotypeskeleton phenotypecardiovasccardiovascular system phenotyperenal/urinrenal/urinary system phenotypegrowth/sizgrowth/size phenotypemuscle phemuscle phenotyperespiratorrespiratory system phenotypemortality/mortality/agingnervous synervous system phenotypecellular pcellular phenotypedigestive/digestive/alimentary phenotypeendocrine/endocrine/exocrine gland phenotypeintegumentintegument phenotypeliver/bililiver/biliary system phenotypeskeleton pskeleton phenotype
IDPhenotypeDefinition Genetic BG
 MP:0000276 right ventricle hypertrophy "increased size of the right ventricle" [J:33629]
Show

Allelic Composition: Ptger4tm1Matb/Ptger4tm1Matb
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0000520 absent kidney "missing paired organs that excrete urine" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:49471]
Show

Allelic Composition: Ptger4tm1Matb/Ptger4tm1Matb
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0000757 herniated abdominal wall "protrusions through and/or into the abdominal wall often resulting in the extrusion of viscera" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:40203]
Show

Allelic Composition: Rapgef3tm1.1Chen/Rapgef3tm1.1Chen
Genetic Background: B6.129(Cg)-Rapgef3tm1.1Chen

 MP:0000761 thin diaphragm muscle "reduced thickness of the diaphragm muscle" [MGI:CLS, J:60159]
Show

Allelic Composition: Gsdma3Fgn/Gsdma3+
Genetic Background: involves: BALB/c * C3H/HeH

Allelic Composition: Slit3tm1.1Dor/Slit3tm1.1Dor
Genetic Background: involves: 129S1/Sv * C57BL/6J

 MP:0001177 atelectasis "collapse of the lung or any portion of the lung, or decreased or absent air in the lung, resulting in loss of lung volume " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:54931, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Gsdma3Fgn/Gsdma3+
Genetic Background: involves: BALB/c * C3H/HeH

Allelic Composition: Slit3tm1.1Dor/Slit3tm1.1Dor
Genetic Background: involves: 129S1/Sv * C57BL/6J

 MP:0001182 lung hemorrhage "bleeding in the respiratory organs" [J:66345]
Show

Allelic Composition: Gsdma3Fgn/Gsdma3+
Genetic Background: involves: BALB/c * C3H/HeH

Allelic Composition: Slit3tm1.1Dor/Slit3tm1.1Dor
Genetic Background: involves: 129S1/Sv * C57BL/6J

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
Show

Allelic Composition: Gsdma3Fgn/Gsdma3+
Genetic Background: involves: BALB/c * C3H/HeH

Allelic Composition: Slit3tm1.1Dor/Slit3tm1.1Dor
Genetic Background: involves: 129S1/Sv * C57BL/6J

 MP:0001614 abnormal vasculature "anomalies in the structure of development of the network of tubes that carries blood through the body" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Cadpstm1.1Tfr/Cadpstm1.2Tfr,Ptf1atm1.1(cre)Cvw/Ptf1a+
Genetic Background: B6.Cg-Ptf1atm1.1(cre)Cvw Cadpstm1.1Tfr Cadpstm1.2Tfr

 MP:0001954 respiratory distress "physical difficulty or inability to breathe" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:54931]
Show

Allelic Composition: Gsdma3Fgn/Gsdma3+
Genetic Background: involves: BALB/c * C3H/HeH

Allelic Composition: Slit3tm1.1Dor/Slit3tm1.1Dor
Genetic Background: involves: 129S1/Sv * C57BL/6J

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Gsdma3Fgn/Gsdma3+
Genetic Background: involves: BALB/c * C3H/HeH

Allelic Composition: Slit3tm1.1Dor/Slit3tm1.1Dor
Genetic Background: involves: 129S1/Sv * C57BL/6J

 MP:0002135 abnormal kidney morphology "abnormal development of the kidney resulting in structural abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Ptger4tm1Matb/Ptger4tm1Matb
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0002189 abnormal myocardial trabeculae morphology "malformation of the supporting bundles of muscular fibers lining the walls of the heart" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Rapgef3tm1.1Chen/Rapgef3tm1.1Chen
Genetic Background: B6.129(Cg)-Rapgef3tm1.1Chen

 MP:0002279 abnormal diaphragm morphology "structural defect in the thin musculomebraneous barrier that separates the abdominal and thoracic cavities; these muscles often used for breathing control" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Slit3tm1.1Dor/Slit3tm1.1Dor
Genetic Background: involves: 129S1/Sv * C57BL/6J

 MP:0002961 abnormal axon guidance "defect in the signaling mechanisms that allow precise navigation and connections of axonal growth cones to effector tissues " [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
Show

Allelic Composition: Slit1tm1.1Matl/Slit1tm1.1Matl,Slit2tm1Matl/Slit2tm1Matl,Slit3tm1.1Dor/Slit3tm1.1Dor
Genetic Background: involves: 129S1/Sv * 129S2/SvPas

Allelic Composition: Slit1tm1.1Matl/Slit1tm1.1Matl,Slit2tm1Matl/Slit2tm1Matl,Slit3tm1.1Dor/Slit3+
Genetic Background: involves: 129S1/Sv * 129S2/SvPas

 MP:0003270 intestinal obstruction "any impediment, blockage, or reversal of the normal flow of the intestinal contents toward the anus " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, ncbi:Matthew Mailman, NCBI request]
Show

Allelic Composition: Gsdma3Fgn/Gsdma3+
Genetic Background: involves: BALB/c * C3H/HeH

Allelic Composition: Slit3tm1.1Dor/Slit3tm1.1Dor
Genetic Background: involves: 129S1/Sv * C57BL/6J

 MP:0003446 renal hypoplasia "decreased cell number in the kidney leading to reduced size" [llw2:Linda Washburn , Mouse Genome Informatics Curator]
Show

Allelic Composition: Ptger4tm1Matb/Ptger4tm1Matb
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

Allelic Composition: Slit3b2b2362.1Clo/Slit3b2b2362.1Clo
Genetic Background: C57BL/6J-Slit3b2b2362.1Clo

 MP:0003924 herniated diaphragm "protrusion of abdominal contents into the thoracic cavity through the diaphragm" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Gsdma3Fgn/Gsdma3+
Genetic Background: involves: BALB/c * C3H/HeH

Allelic Composition: Slit3tm1.1Dor/Slit3tm1.1Dor
Genetic Background: involves: 129S1/Sv * C57BL/6J

Allelic Composition: Slit3Gt(OST106158)Lex/Slit3Gt(OST106158)Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6

Allelic Composition: Ndst1tm1Je/Ndst1tm1Je,Slit3tm1.1Dor/Slit3+,Tg(Tek-cre)1Ywa/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

Allelic Composition: Ndst1tm1Je/Ndst1tm1Je,Slit3tm1.1Dor/Slit3tm1.1Dor,Tg(Tek-cre)1Ywa/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

 MP:0005155 herniated intestine "protrusion of any portion of the intestine from its normal anatomical position" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Gsdma3Fgn/Gsdma3+
Genetic Background: involves: BALB/c * C3H/HeH

Allelic Composition: Slit3tm1.1Dor/Slit3tm1.1Dor
Genetic Background: involves: 129S1/Sv * C57BL/6J

 MP:0009503 abnormal mammary gland duct morphology "any structural anomaly of the canals that lead from the lobes of the mammary gland to the tip of the nipple and are responsible for carrying milk toward the nipple in a lactating female" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Slit1tm1.1Matl/Slit1+,Slit2tm1Matl/Slit2tm1Matl
Genetic Background: involves: 129S2/SvPas

 MP:0009678 abnormal spinal cord lateral column morphology "any structural anomaly of the region of white matter of the spinal cord that is located between the dorsal and ventral spinal roots" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Slit1tm1.1Matl/Slit1tm1.1Matl,Slit2tm1Matl/Slit2tm1Matl,Slit3tm1.1Dor/Slit3tm1.1Dor
Genetic Background: involves: 129S1/Sv * 129S2/SvPas

Allelic Composition: Slit1tm1.1Matl/Slit1tm1.1Matl,Slit2tm1Matl/Slit2tm1Matl,Slit3tm1.1Dor/Slit3+
Genetic Background: involves: 129S1/Sv * 129S2/SvPas

 MP:0009695 abnormal spinal cord ventral commissure morphology "any structural anomaly of the band of nerve fibers which cross the midline of the spinal cord ventral to the central canal and posterior grey commissure" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Slit1tm1.1Matl/Slit1tm1.1Matl,Slit2tm1Matl/Slit2tm1Matl,Slit3tm1.1Dor/Slit3+
Genetic Background: involves: 129S1/Sv * 129S2/SvPas

 MP:0010018 lung vascular congestion "obstruction of the normal flux of blood within the blood vessel network of the lung" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Gsdma3Fgn/Gsdma3+
Genetic Background: involves: BALB/c * C3H/HeH

 MP:0010173 increased mammary gland epithelium proliferation "increase in the expansion rate of the cells of the mammary gland epithelium by cell division" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Slit2tm1Matl/Slit2tm1Matl,Slit3tm1.1Dor/Slit3tm1.1Dor
Genetic Background: involves: 129S1/Sv * 129S2/SvPas

 MP:0010402 ventricular septal defect "abnormal communications between the two lower chambers of the heart, including such defects in the perimembranous, inlet, outlet (infundibular), central muscular, marginal muscular, or apical muscular regions" [MESH:C14.240.400.560.540]
Show

Allelic Composition: Slit3b2b2362.1Clo/Slit3b2b2362.1Clo
Genetic Background: C57BL/6J-Slit3b2b2362.1Clo

 MP:0010912 herniated liver "protrusion of any portion of the liver from its normal anatomical position" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Gsdma3Fgn/Gsdma3+
Genetic Background: involves: BALB/c * C3H/HeH

Allelic Composition: Slit3tm1.1Dor/Slit3tm1.1Dor
Genetic Background: involves: 129S1/Sv * C57BL/6J

 MP:0011660 ectopia cordis "congenital condition in which the heart is exposed and/or protruding from the thorax due to abnormal development of the sternum, pericardium and/or the abdominal wall" [ISBN:0-683-40008-8]
Show

Allelic Composition: Slit3b2b2362.1Clo/Slit3b2b2362.1Clo
Genetic Background: C57BL/6J-Slit3b2b2362.1Clo

 MP:0011667 double outlet right ventricle with atrioventricular septal defect "a form of DORV in which there is also a complete atrioventricular canal" [MGI:csmith]
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Allelic Composition: Slit3b2b2362.1Clo/Slit3b2b2362.1Clo
Genetic Background: C57BL/6J-Slit3b2b2362.1Clo

 MP:0011668 double outlet right ventricle, Taussig bing type "a form of DORV in which blood from the left ventricle passes through a ventricular septal defect to the pulmonary artery, and blood from the right ventricle is directed to the aorta" [MGI:csmith]
Show

Allelic Composition: Slit3b2b2362.1Clo/Slit3b2b2362.1Clo
Genetic Background: C57BL/6J-Slit3b2b2362.1Clo

 MP:0011682 renal glomerulus cysts "abnormal membranous sacs in any portion of the renal glomerulus" [MGI:csmith]
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Allelic Composition: Slit3b2b2362.1Clo/Slit3b2b2362.1Clo
Genetic Background: C57BL/6J-Slit3b2b2362.1Clo

 MP:0012061 abnormal central tendon morphology "any structural anomaly of the three-lobed cloverleaf-shaped aponeurosis situated at the center of the diaphragm; the central tendon is fused with the fibrous pericardium that provides attachment for the muscle fibers" [MGI:csmith]
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Allelic Composition: Gsdma3Fgn/Gsdma3+
Genetic Background: involves: BALB/c * C3H/HeH

Allelic Composition: Slit3tm1.1Dor/Slit3tm1.1Dor
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0012251 abnormal diaphragm development "malformation or incomplete differentiation of the thin musculomembranous barrier separating the abdominal and thoracic cavities and functioning in respiration" [MGI:anna]
Show

Allelic Composition: Gsdma3Fgn/Gsdma3+
Genetic Background: involves: BALB/c * C3H/HeH

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000056427 Slit3 / Q9WVB4 / Slit homolog 3 protein / O75094* / slit guidance ligand 3*  / reaction






 

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