ENSMUSG00000063434


Mus musculus

Features
Gene ID: ENSMUSG00000063434
  
Biological name :Sorcs3
  
Synonyms : Q8VI51 / Sorcs3 / VPS10 domain-containing receptor SorCS3
  
Possible biological names infered from orthology : Q9UPU3 / sortilin related VPS10 domain containing receptor 3
  
Species: Mus musculus
  
Chr. number: 19
Strand: 1
Band: D1
Gene start: 48206025
Gene end: 48805505
  
Corresponding Affymetrix probe sets: 10463875 (MoGene1.0st)   1425110_at (Mouse Genome 430 2.0 Array)   1425111_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000077919
NCBI entrez gene - 66673     See in Manteia.
MGI - MGI:1913923
RefSeq - NM_025696
RefSeq Peptide - NP_079972
swissprot - Q1HL22
swissprot - Q8VI51
Ensembl - ENSMUSG00000063434
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 SORCS3ENSDARG00000103535Danio rerio
 sorcs3bENSDARG00000077349Danio rerio
 SORCS3ENSGALG00000008434Gallus gallus
 Q9UPU3ENSG00000156395Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Sorcs1 / sortilin related VPS10 domain containing receptor 1 / Q8WY21*ENSMUSG0000004353161
Q9EPR5 / Sorcs2 / sortilin-related VPS10 domain containing receptor 2 / Q96PQ0*ENSMUSG0000002909340
Sorl1 / O88307 / Sortilin-related receptor / Q92673* / sortilin related receptor 1*ENSMUSG0000004931321
Sort1 / Q6PHU5 / Sortilin / Q99523* / sortilin 1*ENSMUSG0000006874716


Protein motifs (from Interpro)
Interpro ID Name
 IPR000601  PKD domain
 IPR006581  VPS10
 IPR013783  Immunoglobulin-like fold
 IPR015943  WD40/YVTN repeat-like-containing domain superfamily
 IPR031777  Sortilin, C-terminal
 IPR031778  Sortilin, N-terminal
 IPR035986  PKD domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007612 learning IMP
 biological_processGO:0007613 memory IMP
 biological_processGO:1900452 regulation of long term synaptic depression IMP
 cellular_componentGO:0014069 postsynaptic density IDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0005515 protein binding IPI


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001899 absent long term depression "lack of the normal, persistent activity-dependent decrease in synaptic efficacy between neurons, often following slow, weak stimulation of CA1 neurons" [Principles of Neural Science:ISBN 0-8385-8034-3, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Dclre1cm1Brck/Dclre1cm1Brck
Genetic Background: involves: C57BL/6

 MP:0008428 abnormal spatial working memory "anomaly in the ability to spontaneously process spatial location information in order to naviagate or perform other behavior using such locational cues, without previous encounters or training at that location" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Dclre1cm1Brck/Dclre1cm1Brck
Genetic Background: involves: C57BL/6

 MP:0012307 impaired spatial learning "impaired ability to ascertain or acquire spatial location information in order to improve navigation or other behavior using such location cues" [MGI:csmith]
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Allelic Composition: Dclre1cm1Brck/Dclre1cm1Brck
Genetic Background: involves: C57BL/6

 MP:0012312 impaired avoidance learning behavior "impaired ability to associate a previously neutral stimulus with an unpleasant or punishing stimuli so that the animal learns to avoid the previously neutral stimulus" [http://orcid.org/0000-0001-5208-3432]
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Allelic Composition: Dclre1cm1Brck/Dclre1cm1Brck
Genetic Background: involves: C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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