ENSMUSG00000102888


Mus musculus
activationIghv1-11complementcellreceptorregulationfcerimediatedphagocytosisbclassicalpathwayresponsesignalingplasmaimmunoglobulinantigenbindingrolemobilizationbcrrecognitionengulfmentdefensebacteriuminnateimmuneexternalsidemembranecomplex

Features
Gene ID: ENSMUSG00000102888
  
Biological name :Ighv1-11
  
Synonyms : Ighv1-11
  
Possible biological names infered from orthology : A0A0A0MS14 / A0A0C4DH29 / A0A0C4DH31 / A0A0C4DH39 / AC135068.8 / IGHV1-18 / IGHV1-2 / IGHV1-3 / IGHV1-45 / IGHV1-58 / IGHV1OR15-1 / immunoglobulin heavy variable 1-18 / immunoglobulin heavy variable 1-2 / immunoglobulin heavy variable 1-3 / immunoglobulin heavy variable 1-45 / immunoglobulin heavy variable 1-58 / immunoglobulin heavy variable 1/OR15-1 (non-functional) / P23083
  
Species: Mus musculus
  
Chr. number: 12
Strand: -1
Band: F2
Gene start: 114612243
Gene end: 114612675
  
Corresponding Affymetrix probe sets:
  
Cross references: Ensembl peptide - ENSMUSP00000141570
MGI - MGI:5009835
swissprot - A0A0A6YWI9
Ensembl - ENSMUSG00000102888
  
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ighv1-2ENSDARG00000096350Danio rerio
 ighv2-1ENSDARG00000096406Danio rerio
 ighv2-2ENSDARG00000096424Danio rerio
 ighv2-3ENSDARG00000096376Danio rerio
 AC135068.8ENSG00000281179Homo sapiens
 IGHV1-18ENSG00000211945Homo sapiens
 IGHV1-3ENSG00000211935Homo sapiens
 IGHV1-45ENSG00000211961Homo sapiens
 IGHV1-58ENSG00000211968Homo sapiens
 IGHV1OR15-1ENSG00000270505Homo sapiens
 P23083ENSG00000211934Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Ighv1-64 / P23083* / IGHV1-3* / IGHV1-2* / IGHV1-58* / IGHV1-18* / IGHV1-45* / A0A0C4DH39* / A0A0C4DH29* / A0A0A0MS14* / A0A0C4DH31* / AC135068.8* / IGHV1OR15-1* / immunoglobulin heavy vari...ENSMUSG0000009408873
Ighv1-50 / P23083* / IGHV1-3* / IGHV1-2* / IGHV1-45* / IGHV1-18* / IGHV1-58* / A0A0A0MS14* / AC135068.8* / A0A0C4DH31* / A0A0C4DH29* / A0A0C4DH39* / IGHV1OR15-1* / immunoglobulin heavy vari...ENSMUSG0000009419873
Ighv1-53 / P23083* / IGHV1-3* / IGHV1-2* / IGHV1-45* / IGHV1-18* / IGHV1-58* / A0A0A0MS14* / AC135068.8* / A0A0C4DH31* / A0A0C4DH29* / A0A0C4DH39* / IGHV1OR15-1* / immunoglobulin heavy vari...ENSMUSG0000009389472
P01749 / Ighv1-61 / Ig heavy chain V region 3 / P23083* / IGHV1-3* / IGHV1-2* / IGHV1-58* / IGHV1-18* / IGHV1-45* / A0A0C4DH29* / A0A0A0MS14* / A0A0C4DH39* / A0A0C4DH31* / AC135068.8* / IG...ENSMUSG0000009408772
Ighv1-55 / P23083* / IGHV1-3* / IGHV1-2* / IGHV1-45* / IGHV1-18* / IGHV1-58* / A0A0A0MS14* / AC135068.8* / A0A0C4DH31* / A0A0C4DH29* / A0A0C4DH39* / IGHV1OR15-1* / immunoglobulin heavy vari...ENSMUSG0000009558972
Ighv1-74 / P23083* / IGHV1-3* / IGHV1-2* / IGHV1-58* / IGHV1-18* / IGHV1-45* / A0A0C4DH39* / A0A0C4DH29* / A0A0A0MS14* / A0A0C4DH31* / AC135068.8* / IGHV1OR15-1* / immunoglobulin heavy vari...ENSMUSG0000009412471
Ighv1-69 / P23083* / IGHV1-3* / IGHV1-2* / IGHV1-58* / IGHV1-18* / IGHV1-45* / A0A0C4DH39* / A0A0C4DH29* / A0A0A0MS14* / A0A0C4DH31* / AC135068.8* / IGHV1OR15-1* / immunoglobulin heavy vari...ENSMUSG0000009450271
Ighv1-84 / P23083* / IGHV1-3* / IGHV1-2* / IGHV1-58* / IGHV1-18* / IGHV1-45* / A0A0C4DH39* / A0A0C4DH29* / A0A0A0MS14* / A0A0C4DH31* / AC135068.8* / IGHV1OR15-1* / immunoglobulin heavy vari...ENSMUSG0000009494070
Ighv1-52 / P23083* / IGHV1-3* / IGHV1-2* / IGHV1-45* / IGHV1-18* / IGHV1-58* / A0A0A0MS14* / AC135068.8* / A0A0C4DH31* / A0A0C4DH29* / A0A0C4DH39* / IGHV1OR15-1* / immunoglobulin heavy vari...ENSMUSG0000009520470
Ighv1-72 / P23083* / IGHV1-3* / IGHV1-2* / IGHV1-58* / IGHV1-18* / IGHV1-45* / A0A0C4DH39* / A0A0C4DH29* / A0A0A0MS14* / A0A0C4DH31* / AC135068.8* / IGHV1OR15-1* / immunoglobulin heavy vari...ENSMUSG0000009607470
Ighv1-85 / P23083* / IGHV1-3* / IGHV1-2* / IGHV1-58* / IGHV1-18* / IGHV1-45* / A0A0C4DH39* / A0A0C4DH29* / A0A0A0MS14* / A0A0C4DH31* / AC135068.8* / IGHV1OR15-1* / immunoglobulin heavy vari...ENSMUSG0000009615069
Ighv1-76 / P23083* / IGHV1-3* / IGHV1-2* / IGHV1-58* / IGHV1-18* / IGHV1-45* / A0A0C4DH39* / A0A0C4DH29* / A0A0A0MS14* / A0A0C4DH31* / AC135068.8* / IGHV1OR15-1* / immunoglobulin heavy vari...ENSMUSG0000009389668
Ighv1-7 / P23083* / IGHV1-3* / IGHV1-2* / IGHV1-58* / IGHV1-18* / IGHV1-45* / A0A0C4DH39* / A0A0C4DH29* / A0A0A0MS14* / A0A0C4DH31* / AC135068.8* / IGHV1OR15-1* / immunoglobulin heavy varia...ENSMUSG0000009520068
Ighv1-12 / P23083* / IGHV1-3* / IGHV1-2* / IGHV1-45* / IGHV1-18* / IGHV1-58* / A0A0C4DH39* / A0A0C4DH31* / A0A0A0MS14* / A0A0C4DH29* / AC135068.8* / IGHV1OR15-1* / immunoglobulin heavy vari...ENSMUSG0000009541668
Ighv1-4 / P23083* / IGHV1-3* / IGHV1-2* / IGHV1-45* / IGHV1-18* / IGHV1-58* / A0A0C4DH39* / A0A0C4DH31* / A0A0A0MS14* / A0A0C4DH29* / AC135068.8* / IGHV1OR15-1* / immunoglobulin heavy varia...ENSMUSG0000009544268
Ighv1-75 / P23083* / IGHV1-3* / IGHV1-2* / IGHV1-58* / IGHV1-18* / IGHV1-45* / A0A0C4DH39* / A0A0C4DH29* / A0A0A0MS14* / A0A0C4DH31* / AC135068.8* / IGHV1OR15-1* / immunoglobulin heavy vari...ENSMUSG0000009602068
P01754 / Ighv1-62-3 / Ig heavy chain V region 1-62-3 / P23083* / IGHV1-3* / IGHV1-2* / IGHV1-58* / IGHV1-18* / IGHV1-45* / A0A0C4DH29* / A0A0A0MS14* / A0A0C4DH39* / A0A0C4DH31* / AC135068....ENSMUSG0000009676768
Ighv1-26 / immunoglobulin heavy variable 1-26 / P23083* / IGHV1-2* / IGHV1-3* / IGHV1-45* / IGHV1-18* / IGHV1-58* / AC135068.8* / A0A0A0MS14* / A0A0C4DH29* / A0A0C4DH31* / A0A0C4DH39* / IGH...ENSMUSG0000009454667
Ighv1-66 / P23083* / IGHV1-3* / IGHV1-2* / IGHV1-58* / IGHV1-18* / IGHV1-45* / A0A0C4DH39* / A0A0C4DH29* / A0A0A0MS14* / A0A0C4DH31* / AC135068.8* / IGHV1OR15-1* / immunoglobulin heavy vari...ENSMUSG0000009551967
Ighv1-19 / P23083* / IGHV1-3* / IGHV1-2* / IGHV1-45* / IGHV1-18* / IGHV1-58* / A0A0C4DH39* / A0A0C4DH31* / A0A0A0MS14* / A0A0C4DH29* / AC135068.8* / IGHV1OR15-1* / immunoglobulin heavy vari...ENSMUSG0000009641067


Protein motifs (from Interpro)
Interpro ID Name
No match


Gene Ontology (GO)
cell recognitionestablishment of localizationcellular component organizationnitrogen compound metabolic processimmune responseprimary metabolic processorganic substance metabolic processimmune effector processresponse to stressresponse to external stimulusresponse to biotic stimuluscell communicationcellular response to stimuluscell activationcell recognitionestablishment of localizationcellular component organizationnitrogen compound metabolic processimmune responseprimary metabolic processorganic substance metabolic processimmune effector processresponse to stressresponse to external stimulusresponse to biotic stimuluscell communicationcellular response to stimuluscell activationcell recognitionestablishment of localizationcellular component organizationnitrogen compound metabolic processimmune responseprimary metabolic processorganic substance metabolic processimmune effector processresponse to stressresponse to external stimulusresponse to biotic stimuluscell communicationcellular response to stimuluscell activationcell recognitionestablishment of localizationcellular component organizationnitrogen compound metabolic processimmune responseprimary metabolic processorganic substance metabolic processimmune effector processresponse to stressresponse to external stimulusresponse to biotic stimuluscell communicationcellular response to stimuluscell activationcell recognitionestablishment of localizationcellular component organizationnitrogen compound metabolic processimmune responseprimary metabolic processorganic substance metabolic processimmune effector processresponse to stressresponse to external stimulusresponse to biotic stimuluscell communicationcellular response to stimuluscell activationcell recognitionestablishment of localizationcellular component organizationnitrogen compound metabolic processimmune responseprimary metabolic processorganic substance metabolic processimmune effector processresponse to stressresponse to external stimulusresponse to biotic stimuluscell communicationcellular response to stimuluscell activationcell recognitionestablishment of localizationcellular component organizationnitrogen compound metabolic processimmune responseprimary metabolic processorganic substance metabolic processimmune effector processresponse to stressresponse to external stimulusresponse to biotic stimuluscell communicationcellular response to stimuluscell activationcell recognitionestablishment of localizationcellular component organizationnitrogen compound metabolic processimmune responseprimary metabolic processorganic substance metabolic processimmune effector processresponse to stressresponse to external stimulusresponse to biotic stimuluscell communicationcellular response to stimuluscell activationcell recognitionestablishment of localizationcellular component organizationnitrogen compound metabolic processimmune responseprimary metabolic processorganic substance metabolic processimmune effector processresponse to stressresponse to external stimulusresponse to biotic stimuluscell communicationcellular response to stimuluscell activationcell recognitionestablishment of localizationcellular component organizationnitrogen compound metabolic processimmune responseprimary metabolic processorganic substance metabolic processimmune effector processresponse to stressresponse to external stimulusresponse to biotic stimuluscell communicationcellular response to stimuluscell activationcell recogcell recognitionestablishmestablishment of localizationcellular ccellular component organizationnitrogen cnitrogen compound metabolic processimmune resimmune responseprimary meprimary metabolic processorganic suorganic substance metabolic processimmune effimmune effector processresponse tresponse to stressresponse tresponse to external stimulusresponse tresponse to biotic stimuluscell commucell communicationcellular rcellular response to stimuluscell activcell activation
antigen bindingprotein bindingantigen bindingprotein bindingantigen bindingprotein bindingantigen bindingprotein bindingantigen bindingprotein bindingantigen bindingprotein bindingantigen bindingprotein bindingantigen bindingprotein bindingantigen bindingprotein bindingantigen bindingprotein bindingantigen bindingantigen bindingprotein bindingprotein binding
cellmembraneprotein-containing complexextracellular regioncellmembraneprotein-containing complexextracellular regioncellmembraneprotein-containing complexextracellular regioncellmembraneprotein-containing complexextracellular regioncellmembraneprotein-containing complexextracellular regioncellmembraneprotein-containing complexextracellular regioncellmembraneprotein-containing complexextracellular regioncellmembraneprotein-containing complexextracellular regioncellmembraneprotein-containing complexextracellular regioncellmembraneprotein-containing complexextracellular regioncellcellmembranemembraneprotein-containing complexprotein-containing complexextracellular regionextracellular region
TypeGO IDTermEv.Code
 biological_processGO:0006910 phagocytosis, recognition IBA
 biological_processGO:0006911 phagocytosis, engulfment IBA
 biological_processGO:0006958 complement activation, classical pathway IBA
 biological_processGO:0042742 defense response to bacterium IBA
 biological_processGO:0045087 innate immune response IBA
 biological_processGO:0050853 B cell receptor signaling pathway IBA
 biological_processGO:0050871 positive regulation of B cell activation IBA
 cellular_componentGO:0009897 external side of plasma membrane IBA
 cellular_componentGO:0042571 immunoglobulin complex, circulating IBA
 cellular_componentGO:0072562 blood microparticle IBA
 molecular_functionGO:0003823 antigen binding IBA
 molecular_functionGO:0034987 immunoglobulin receptor binding IBA


Pathways (from Reactome)
Pathway description
Initial triggering of complement
Classical antibody-mediated complement activation
Cell surface interactions at the vascular wall
FCGR activation
Regulation of actin dynamics for phagocytic cup formation
Role of phospholipids in phagocytosis
Scavenging of heme from plasma
Fc epsilon receptor (FCERI) signaling
Role of LAT2/NTAL/LAB on calcium mobilization
FCERI mediated MAPK activation
FCERI mediated Ca+2 mobilization
FCERI mediated NF-kB activation
CD22 mediated BCR regulation
Regulation of Complement cascade
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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