ENSG00000211934


Homo sapiens

Features
Gene ID: ENSG00000211934
  
Biological name :IGHV1-2
  
Synonyms : IGHV1-2 / immunoglobulin heavy variable 1-2 / P23083
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 14
Strand: -1
Band: q32.33
Gene start: 105986582
Gene end: 105987083
  
Corresponding Affymetrix probe sets:
  
Cross references: Ensembl peptide - ENSP00000375003
swissprot - P23083
Ensembl - ENSG00000211934
  
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ighv1-2ENSDARG00000096350Danio rerio
 ighv2-1ENSDARG00000096406Danio rerio
 ighv2-2ENSDARG00000096424Danio rerio
 ighv2-3ENSDARG00000096376Danio rerio
 Ighv1-11ENSMUSG00000102888Mus musculus
 Ighv1-12ENSMUSG00000095416Mus musculus
 Ighv1-19ENSMUSG00000096410Mus musculus
 Ighv1-22ENSMUSG00000094561Mus musculus
 Ighv1-26ENSMUSG00000094546Mus musculus
 Ighv1-34ENSMUSG00000093955Mus musculus
 Ighv1-4ENSMUSG00000095442Mus musculus
 Ighv1-42ENSMUSG00000094652Mus musculus
 Ighv1-5ENSMUSG00000096499Mus musculus
 Ighv1-50ENSMUSG00000094198Mus musculus
 Ighv1-52ENSMUSG00000095204Mus musculus
 Ighv1-53ENSMUSG00000093894Mus musculus
 Ighv1-54ENSMUSG00000094787Mus musculus
 Ighv1-55ENSMUSG00000095589Mus musculus
 Ighv1-56ENSMUSG00000094862Mus musculus
 Ighv1-62-1ENSMUSG00000102313Mus musculus
 Ighv1-63ENSMUSG00000096672Mus musculus
 Ighv1-64ENSMUSG00000094088Mus musculus
 Ighv1-66ENSMUSG00000095519Mus musculus
 Ighv1-69ENSMUSG00000094502Mus musculus
 Ighv1-7ENSMUSG00000095200Mus musculus
 Ighv1-72ENSMUSG00000096074Mus musculus
 Ighv1-74ENSMUSG00000094124Mus musculus
 Ighv1-75ENSMUSG00000096020Mus musculus
 Ighv1-76ENSMUSG00000093896Mus musculus
 Ighv1-77ENSMUSG00000096452Mus musculus
 Ighv1-84ENSMUSG00000094940Mus musculus
 Ighv1-85ENSMUSG00000096150Mus musculus
 Ighv1-9ENSMUSG00000094694Mus musculus
 P01749ENSMUSG00000094087Mus musculus
 P01754ENSMUSG00000096767Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
IGHV1OR15-1 / immunoglobulin heavy variable 1/OR15-1 (non-functional)ENSG0000027050591
AC135068.8ENSG0000028117991
IGHV1-3 / A0A0C4DH29 / immunoglobulin heavy variable 1-3ENSG0000021193588
IGHV1-18 / A0A0C4DH31 / immunoglobulin heavy variable 1-18ENSG0000021194586
P01743 / IGHV1-46 / immunoglobulin heavy variable 1-46ENSG0000021196285
IGHV1-45 / A0A0A0MS14 / immunoglobulin heavy variable 1-45ENSG0000021196181
IGHV1-24 / A0A0C4DH33 / immunoglobulin heavy variable 1-24ENSG0000021195080
P01742 / IGHV1-69 / immunoglobulin heavy variable 1-69ENSG0000021197379
IGHV1-69D / A0A0B4J2H0 / immunoglobulin heavy variable 1-69DENSG0000028041179
IGHV1-58 / A0A0C4DH39 / immunoglobulin heavy variable 1-58ENSG0000021196878
IGHV1OR21-1 / immunoglobulin heavy variable 1/OR21-1 (non-functional)ENSG0000027728277
A0A0G2JMI3 / IGHV1-69-2 / immunoglobulin heavy variable 1-69-2ENSG0000028199077
IGHV7-4-1 / A0A0J9YVY3 / immunoglobulin heavy variable 7-4-1ENSG0000028212277
IGHV1OR15-9 / immunoglobulin heavy variable 1/OR15-9 (non-functional)ENSG0000018840376
IGHV7-81 / immunoglobulin heavy variable 7-81 (non-functional)ENSG0000021197970
IGHV5-51 / A0A0C4DH38 / immunoglobulin heavy variable 5-51ENSG0000021196658
A0A0J9YXX1 / IGHV5-10-1 / immunoglobulin heavy variable 5-10-1ENSG0000028265158


Protein motifs (from Interpro)
Interpro ID Name
No match


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002250 adaptive immune response IEA
 biological_processGO:0002376 immune system process IEA
 biological_processGO:0006508 proteolysis IEA
 biological_processGO:0006898 receptor-mediated endocytosis TAS
 biological_processGO:0006955 immune response NAS
 biological_processGO:0006956 complement activation TAS
 biological_processGO:0006958 complement activation, classical pathway TAS
 biological_processGO:0030449 regulation of complement activation TAS
 biological_processGO:0038095 Fc-epsilon receptor signaling pathway TAS
 biological_processGO:0038096 Fc-gamma receptor signaling pathway involved in phagocytosis TAS
 biological_processGO:0050776 regulation of immune response TAS
 biological_processGO:0050900 leukocyte migration TAS
 cellular_componentGO:0005576 extracellular region TAS
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0016020 membrane IEA
 molecular_functionGO:0003823 antigen binding NAS
 molecular_functionGO:0004252 serine-type endopeptidase activity TAS


Pathways (from Reactome)
Pathway description
Initial triggering of complement
Classical antibody-mediated complement activation
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
Cell surface interactions at the vascular wall
FCGR activation
Regulation of actin dynamics for phagocytic cup formation
Role of phospholipids in phagocytosis
Scavenging of heme from plasma
Fc epsilon receptor (FCERI) signaling
Role of LAT2/NTAL/LAB on calcium mobilization
FCERI mediated MAPK activation
FCERI mediated Ca+2 mobilization
FCERI mediated NF-kB activation
CD22 mediated BCR regulation
Regulation of Complement cascade
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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