ENSDARG00000011564


Danio rerio

Features
Gene ID: ENSDARG00000011564
  
Biological name :sfpq
  
Synonyms : sfpq / splicing factor proline/glutamine-rich
  
Possible biological names infered from orthology : P23246 / Q8VIJ6 / splicing factor proline and glutamine rich
  
Species: Danio rerio
  
Chr. number: 19
Strand: 1
Band:
Gene start: 40025928
Gene end: 40055391
  
Corresponding Affymetrix probe sets: Dr.369.1.A1_at (Zebrafish Array)   NM_213278_at (Zebrafish Genome Array with custom cdf files)   
  
Cross references: Ensembl peptide - ENSDARP00000126177
Ensembl peptide - ENSDARP00000126326
Ensembl peptide - ENSDARP00000020522
NCBI entrez gene - 406564     See in Manteia.
RefSeq - NM_213278
RefSeq Peptide - NP_998443
swissprot - I3ITQ3
swissprot - I3ITB4
swissprot - Q1L8R2
ZFIN ID - ZDB-GENE-040426-2452
Ensembl - ENSDARG00000011564
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 SFPQENSGALG00000002514Gallus gallus
 SFPQENSG00000116560Homo sapiens
 SfpqENSMUSG00000028820Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
pspc1 / Q1JPY8 / paraspeckle component 1 / Q8R326* / Q8WXF1*ENSDARG0000000662141
nono / non-POU domain containing, octamer-binding / Q15233* / Q99K48* / non-POU-domain-containing, octamer binding protein*ENSDARG0000002048239


Protein motifs (from Interpro)
Interpro ID Name
 IPR000504  RNA recognition motif domain
 IPR012975  NOPS
 IPR034525  PSF, RNA recognition motif 1
 IPR034526  PSF, NOPS domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000380 alternative mRNA splicing, via spliceosome IBA
 biological_processGO:0006355 regulation of transcription, DNA-templated IBA
 biological_processGO:0007420 brain development IMP
 biological_processGO:0021522 spinal cord motor neuron differentiation IMP
 biological_processGO:0021547 midbrain-hindbrain boundary initiation IMP
 biological_processGO:0021591 ventricular system development IMP
 biological_processGO:0021654 rhombomere boundary formation IMP
 biological_processGO:0021955 central nervous system neuron axonogenesis IMP
 biological_processGO:0048681 negative regulation of axon regeneration IMP
 biological_processGO:0048859 formation of anatomical boundary IMP
 cellular_componentGO:0005634 nucleus IDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0043005 neuron projection IDA
 molecular_functionGO:0000976 transcription regulatory region sequence-specific DNA binding IBA
 molecular_functionGO:0003676 nucleic acid binding IEA
 molecular_functionGO:0003723 RNA binding IEA


Pathways (from Reactome)
Pathway description
PTK6 Regulates Proteins Involved in RNA Processing


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000008 brain brain quality , abnormal
brain decreased size , abnormal
brain necrotic , abnormal
Show

 ZFA:0000029 hindbrain hindbrain axon decreased amount , abnormal
hindbrain increased distribution , abnormal
hindbrain lacks all parts of type rhombomere compartment boundary, abnormal
hindbrain neurogenesis increased process quality , abnormal
Show

 ZFA:0000032 hypothalamus hypothalamus absent , abnormal
Show

 ZFA:0000042 midbrain hindbrain boundary midbrain hindbrain boundary increased thickness , abnormal
midbrain hindbrain boundary decreased distribution , abnormal
Show

 ZFA:0000054 pericardium pericardium edematous , abnormal
Show

 ZFA:0000059 postoptic commissure postoptic commissure morphology , abnormal
postoptic commissure astrocyte mislocalised , abnormal
Show

 ZFA:0000084 yolk yolk shape , abnormal
yolk swollen , abnormal
Show

 ZFA:0000100 cerebellum cerebellum neuron spatial pattern , abnormal
Show

 ZFA:0000107 eye eye decreased size , abnormal
eye axon decreased amount , abnormal
Show

 ZFA:0000109 forebrain forebrain axon decreased amount , abnormal
forebrain commissural neuron axon guidance disrupted , abnormal
Show

 ZFA:0000110 fourth ventricle fourth ventricle decreased diameter , abnormal
fourth ventricle decreased size , abnormal
Show

 ZFA:0000114 heart heart quality , abnormal
heart morphology , abnormal
Show

 ZFA:0000128 midbrain midbrain axon decreased amount , abnormal
midbrain structure , abnormal
Show

 ZFA:0000152 retina retina has extra parts of type retinal ganglion cell , abnormal
Show

 ZFA:0000159 tectal ventricle tectal ventricle decreased size , abnormal
Show

 ZFA:0000161 third ventricle third ventricle decreased size , abnormal
Show

 ZFA:0000282 sensory system sensory system quality , abnormal
Show

 ZFA:0000320 caudal commissure caudal commissure absent , abnormal
Show

 ZFA:0000396 nervous system nervous system quality , abnormal
Show

 ZFA:0000435 cranial nerve II cranial nerve II regeneration increased process quality , abnormal
cranial nerve II commissural neuron axon guidance disrupted , abnormal
Show

 ZFA:0000445 optic tectum optic tectum necrotic , abnormal
Show

 ZFA:0000690 supraoptic commissure supraoptic commissure absent , abnormal
Show

 ZFA:0000696 telencephalic ventricle telencephalic ventricle decreased size , abnormal
Show

 ZFA:0001064 rhombomere rhombomere compartment boundary absent , abnormal
Show

 ZFA:0001094 whole organism whole organism viability , abnormal
whole organism necrotic , abnormal
whole organism edematous , abnormal
whole organism lethal (sensu genetics) , abnormal
whole organism movement behavioral quality , abnormal
whole organism decreased length , abnormal
whole organism bent , abnormal
whole organism immobile , abnormal
whole organism increased curvature , abnormal
whole organism dead , abnormal
whole organism mobility , ameliorated
Show

 ZFA:0001108 anterior commissure anterior commissure morphology , abnormal
anterior commissure decreased size , abnormal
anterior commissure astrocyte mislocalised , abnormal
Show

 ZFA:0001114 head head flat , abnormal
head pointed , abnormal
Show

 ZFA:0001115 trunk trunk decreased length , abnormal
trunk curved ventral , abnormal
trunk has fewer parts of type motor neuron axon, abnormal
trunk has fewer parts of type nerve glial cell (sensu Vertebrata), abnormal
Show

 ZFA:0001117 post-vent region post-vent region curved , abnormal
post-vent region kinked , abnormal
post-vent region immobile , abnormal
Show

 ZFA:0001259 forebrain ventricle forebrain ventricle decreased size , abnormal
Show

 ZFA:0001261 ventricular system ventricular system decreased size , abnormal
ventricular system collapsed , abnormal
Show

 ZFA:0001439 anatomical system anatomical system quality , abnormal
Show

 ZFA:0001692 hindbrain commissure hindbrain commissure axon disorganized , abnormal
hindbrain commissure axon decreased amount , abnormal
Show

 ZFA:0005730 cranial motor neuron cranial motor neuron axon decreased amount , abnormal
Show

 ZFA:0009052 motor neuron motor neuron axonogenesis disrupted , abnormal
motor neuron axon decreased amount , abnormal
Show

 ZFA:0009090 pigment cell pigment cell quality , abnormal
Show

 ZFA:0009310 retinal ganglion cell retinal ganglion cell axon regeneration increased process quality , abnormal
retinal ganglion cell axon extension involved in regeneration increased process quality , abnormal
retinal ganglion cell axon regeneration increased rate , abnormal
Show

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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