ENSMUSG00000028820


Mus musculus

Features
Gene ID: ENSMUSG00000028820
  
Biological name :Sfpq
  
Synonyms : Q8VIJ6 / Sfpq / Splicing factor, proline- and glutamine-rich
  
Possible biological names infered from orthology : P23246
  
Species: Mus musculus
  
Chr. number: 4
Strand: 1
Band: D2.2
Gene start: 127021324
Gene end: 127037013
  
Corresponding Affymetrix probe sets: 10508217 (MoGene1.0st)   1423795_at (Mouse Genome 430 2.0 Array)   1423796_at (Mouse Genome 430 2.0 Array)   1436898_at (Mouse Genome 430 2.0 Array)   1438458_a_at (Mouse Genome 430 2.0 Array)   1438459_x_at (Mouse Genome 430 2.0 Array)   1439058_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000030623
NCBI entrez gene - 71514     See in Manteia.
MGI - MGI:1918764
RefSeq - NM_023603
RefSeq - XM_006503406
RefSeq Peptide - NP_076092
swissprot - Q8VIJ6
Ensembl - ENSMUSG00000028820
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 sfpqENSDARG00000011564Danio rerio
 SFPQENSGALG00000002514Gallus gallus
 SFPQENSG00000116560Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Pspc1 / Q8R326 / Paraspeckle component 1 / Q8WXF1*ENSMUSG0000002193841
Nono / Q99K48 / non-POU-domain-containing, octamer binding protein / Q15233* / non-POU domain containing octamer binding*ENSMUSG0000003131138


Protein motifs (from Interpro)
Interpro ID Name
 IPR000504  RNA recognition motif domain
 IPR012975  NOPS
 IPR034525  PSF, RNA recognition motif 1
 IPR034526  PSF, NOPS domain
 IPR035979  RNA-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IEA
 biological_processGO:0000380 alternative mRNA splicing, via spliceosome IEA
 biological_processGO:0000724 double-strand break repair via homologous recombination IEA
 biological_processGO:0002218 activation of innate immune response IEA
 biological_processGO:0002376 immune system process IEA
 biological_processGO:0006281 DNA repair IEA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006397 mRNA processing IEA
 biological_processGO:0006974 cellular response to DNA damage stimulus IMP
 biological_processGO:0008380 RNA splicing IEA
 biological_processGO:0042752 regulation of circadian rhythm IMP
 biological_processGO:0042754 negative regulation of circadian rhythm IMP
 biological_processGO:0045087 innate immune response IEA
 biological_processGO:0045876 positive regulation of sister chromatid cohesion IMP
 biological_processGO:0045892 negative regulation of transcription, DNA-templated IMP
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IEA
 biological_processGO:0048511 rhythmic process IEA
 biological_processGO:0051276 chromosome organization IMP
 biological_processGO:0051726 regulation of cell cycle IMP
 biological_processGO:0070932 histone H3 deacetylation IMP
 biological_processGO:1902177 positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway IEA
 cellular_componentGO:0000785 chromatin IEA
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0016363 nuclear matrix ISO
 cellular_componentGO:0016607 nuclear speck IEA
 cellular_componentGO:0031012 extracellular matrix ISO
 cellular_componentGO:0042382 paraspeckles IEA
 cellular_componentGO:0090575 RNA polymerase II transcription factor complex IDA
 molecular_functionGO:0000976 transcription regulatory region sequence-specific DNA binding IDA
 molecular_functionGO:0000980 RNA polymerase II distal enhancer sequence-specific DNA binding IDA
 molecular_functionGO:0001047 core promoter binding IDA
 molecular_functionGO:0003676 nucleic acid binding IEA
 molecular_functionGO:0003677 DNA binding ISO
 molecular_functionGO:0003682 chromatin binding IDA
 molecular_functionGO:0003723 RNA binding IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0042803 protein homodimerization activity IEA
 molecular_functionGO:0042826 histone deacetylase binding IEA
 molecular_functionGO:0044212 transcription regulatory region DNA binding IEA


Pathways (from Reactome)
Pathway description
PTK6 Regulates Proteins Involved in RNA Processing


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0011400 complete lethality "all individuals of a given genotype in a population die before the end of the normal lifespan but time(s) of death are unspecified" [MGI:llw2]
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Allelic Composition: Mex3cGt(DD0642)Wtsi/Mex3cGt(DD0642)Wtsi
Genetic Background: FVB.129P2(B6)-Mex3cGt(DD0642)Wtsi

 MP:0020476 abnormal circardian behavior entrainment "anomaly in the synchronization of a circadian behavior to environmental time cues such as light" [GO:0009649]
Show

Allelic Composition: Mex3cGt(DD0642)Wtsi/Mex3cGt(DD0642)Wtsi
Genetic Background: FVB.129P2(B6)-Mex3cGt(DD0642)Wtsi

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000038751 Ptk6 / Q64434 / PTK6 protein tyrosine kinase 6 / Q13882* / protein tyrosine kinase 6*  / reaction






 

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