ENSMUSG00000031311


Mus musculus

Features
Gene ID: ENSMUSG00000031311
  
Biological name :Nono
  
Synonyms : Nono / non-POU-domain-containing, octamer binding protein / Q99K48
  
Possible biological names infered from orthology : non-POU domain containing octamer binding / Q15233
  
Species: Mus musculus
  
Chr. number: X
Strand: 1
Band: D
Gene start: 101429318
Gene end: 101448591
  
Corresponding Affymetrix probe sets: 10601164 (MoGene1.0st)   1415820_x_at (Mouse Genome 430 2.0 Array)   1431239_at (Mouse Genome 430 2.0 Array)   1447160_at (Mouse Genome 430 2.0 Array)   1448103_s_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000033673
Ensembl peptide - ENSMUSP00000122890
NCBI entrez gene - 53610     See in Manteia.
MGI - MGI:1855692
RefSeq - NM_001252518
RefSeq - NM_023144
RefSeq Peptide - NP_001239447
RefSeq Peptide - NP_075633
swissprot - Q99K48
swissprot - Q4FK11
swissprot - B1AXT0
Ensembl - ENSMUSG00000031311
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 nonoENSDARG00000020482Danio rerio
 NONOENSGALG00000005507Gallus gallus
 NONOENSG00000147140Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Pspc1 / Q8R326 / Paraspeckle component 1 / Q8WXF1*ENSMUSG0000002193860
Sfpq / Q8VIJ6 / Splicing factor, proline- and glutamine-rich / P23246*ENSMUSG0000002882056


Protein motifs (from Interpro)
Interpro ID Name
 IPR000504  RNA recognition motif domain
 IPR012975  NOPS
 IPR034552  p54nrb, RNA recognition motif 1
 IPR035979  RNA-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000398 mRNA splicing, via spliceosome IBA
 biological_processGO:0002218 activation of innate immune response IEA
 biological_processGO:0002376 immune system process IEA
 biological_processGO:0006281 DNA repair IEA
 biological_processGO:0006310 DNA recombination IEA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006397 mRNA processing IEA
 biological_processGO:0006974 cellular response to DNA damage stimulus IEA
 biological_processGO:0007623 circadian rhythm IEA
 biological_processGO:0008380 RNA splicing IEA
 biological_processGO:0042752 regulation of circadian rhythm IMP
 biological_processGO:0045087 innate immune response IEA
 biological_processGO:0045892 negative regulation of transcription, DNA-templated IDA
 biological_processGO:0048511 rhythmic process IEA
 biological_processGO:1903377 negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway ISO
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005730 nucleolus IEA
 cellular_componentGO:0016363 nuclear matrix IEA
 cellular_componentGO:0016607 nuclear speck IEA
 cellular_componentGO:0042382 paraspeckles ISO
 cellular_componentGO:0090575 RNA polymerase II transcription factor complex IDA
 molecular_functionGO:0000980 RNA polymerase II distal enhancer sequence-specific DNA binding IDA
 molecular_functionGO:0001047 core promoter binding IDA
 molecular_functionGO:0003676 nucleic acid binding IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003682 chromatin binding IDA
 molecular_functionGO:0003723 RNA binding IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0042802 identical protein binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000609 abnormal liver physiology "aberrant function of this bile-secreting exocrine gland, which is important for detoxification; for fat, carbohydrate, and protein metabolism; and for glycogen storage " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Mex3cGt(DD0642)Wtsi/Mex3cGt(DD0642)Wtsi
Genetic Background: FVB.129P2(B6)-Mex3cGt(DD0642)Wtsi

 MP:0001695 abnormal gastrulation "anomalous development and invagination of the embryonic germ layers" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Sharpincpdm-Dem/Sharpincpdm-Dem
Genetic Background: CBy.OcB3-Sharpincpdm-Dem

Allelic Composition: NonoGt(P030B07)Wrst/Y
Genetic Background: chimera involves: 129P2/OlaHsd

 MP:0001792 impaired wound healing "reduced ability or inability to self-repair and close wounds" [J:65302, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Mex3cGt(DD0642)Wtsi/Mex3cGt(DD0642)Wtsi
Genetic Background: FVB.129P2(B6)-Mex3cGt(DD0642)Wtsi

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Il13tm3.1Anjm/Il13+,Il1rl1tm1Anjm/Il1rl1tm1Anjm
Genetic Background: involves: 129P2/OlaHsd * BALB/c

 MP:0003077 abnormal cell cycle "failure to progress or abnormal progression through the stages of of the cell cycle" [smb:Susan M. Bello, Mouse Genome Informatics Curator, J:91266]
Show

Allelic Composition: Mex3cGt(DD0642)Wtsi/Mex3cGt(DD0642)Wtsi
Genetic Background: FVB.129P2(B6)-Mex3cGt(DD0642)Wtsi

 MP:0008009 delayed cellular replicative senescence "slower progression of the process in which a cell progresses from its inception to the end of its lifespan, which occurs as the cell continues cycles of growth and division" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Mex3cGt(DD0642)Wtsi/Mex3cGt(DD0642)Wtsi
Genetic Background: FVB.129P2(B6)-Mex3cGt(DD0642)Wtsi

 MP:0011703 increased fibroblast proliferation "greater the expansion rate of a fibroblast cell population by cell division" [MGI:csmith]
Show

Allelic Composition: Mex3cGt(DD0642)Wtsi/Mex3cGt(DD0642)Wtsi
Genetic Background: FVB.129P2(B6)-Mex3cGt(DD0642)Wtsi

 MP:0020470 shortened circadian behavior period "decrease in the cycle length of a behavior expressed when exposed to constant conditions without temporal cues" [MGI:smb]
Show

Allelic Composition: Mex3cGt(DD0642)Wtsi/Mex3cGt(DD0642)Wtsi
Genetic Background: FVB.129P2(B6)-Mex3cGt(DD0642)Wtsi

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
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