ENSG00000116560


Homo sapiens

Features
Gene ID: ENSG00000116560
  
Biological name :SFPQ
  
Synonyms : P23246 / SFPQ / splicing factor proline and glutamine rich
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 1
Strand: -1
Band: p34.3
Gene start: 35176378
Gene end: 35193148
  
Corresponding Affymetrix probe sets: 201585_s_at (Human Genome U133 Plus 2.0 Array)   201586_s_at (Human Genome U133 Plus 2.0 Array)   214016_s_at (Human Genome U133 Plus 2.0 Array)   221768_at (Human Genome U133 Plus 2.0 Array)   226898_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000349748
Ensembl peptide - ENSP00000424440
Ensembl peptide - ENSP00000425071
NCBI entrez gene - 6421     See in Manteia.
OMIM - 605199
RefSeq - XM_017002054
RefSeq - XM_005271113
RefSeq - XM_005271115
RefSeq - XM_011541950
RefSeq - XM_017002053
RefSeq - NM_005066
RefSeq - XM_005271112
RefSeq Peptide - NP_005057
swissprot - H0Y9U2
swissprot - H0Y9K7
swissprot - P23246
Ensembl - ENSG00000116560
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 sfpqENSDARG00000011564Danio rerio
 SFPQENSGALG00000002514Gallus gallus
 SfpqENSMUSG00000028820Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
PSPC1 / Q8WXF1 / paraspeckle component 1ENSG0000012139040
NONO / Q15233 / non-POU domain containing octamer bindingENSG0000014714038


Protein motifs (from Interpro)
Interpro ID Name
 IPR000504  RNA recognition motif domain
 IPR012975  NOPS
 IPR034525  PSF, RNA recognition motif 1
 IPR034526  PSF, NOPS domain
 IPR035979  RNA-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IGI
 biological_processGO:0000380 alternative mRNA splicing, via spliceosome IMP
 biological_processGO:0000724 double-strand break repair via homologous recombination IMP
 biological_processGO:0002218 activation of innate immune response IDA
 biological_processGO:0002376 immune system process IEA
 biological_processGO:0006281 DNA repair IEA
 biological_processGO:0006310 DNA recombination IEA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006397 mRNA processing TAS
 biological_processGO:0006974 cellular response to DNA damage stimulus IEA
 biological_processGO:0008380 RNA splicing TAS
 biological_processGO:0042752 regulation of circadian rhythm IEA
 biological_processGO:0042754 negative regulation of circadian rhythm IEA
 biological_processGO:0045087 innate immune response IEA
 biological_processGO:0045876 positive regulation of sister chromatid cohesion IEA
 biological_processGO:0045892 negative regulation of transcription, DNA-templated IEA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IMP
 biological_processGO:0048511 rhythmic process IEA
 biological_processGO:0051276 chromosome organization IEA
 biological_processGO:0051726 regulation of cell cycle IEA
 biological_processGO:0070932 histone H3 deacetylation IEA
 biological_processGO:1902177 positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway IDA
 cellular_componentGO:0000785 chromatin IDA
 cellular_componentGO:0005634 nucleus IDA
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0016363 nuclear matrix IDA
 cellular_componentGO:0016607 nuclear speck IEA
 cellular_componentGO:0042382 paraspeckles IEA
 cellular_componentGO:0090575 RNA polymerase II transcription factor complex IEA
 molecular_functionGO:0000976 transcription regulatory region sequence-specific DNA binding IEA
 molecular_functionGO:0000980 RNA polymerase II distal enhancer sequence-specific DNA binding IEA
 molecular_functionGO:0001047 core promoter binding IEA
 molecular_functionGO:0003676 nucleic acid binding IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003682 chromatin binding IEA
 molecular_functionGO:0003723 RNA binding IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0042803 protein homodimerization activity IPI
 molecular_functionGO:0042826 histone deacetylase binding IPI
 molecular_functionGO:0044212 transcription regulatory region DNA binding IDA


Pathways (from Reactome)
Pathway description
PTK6 Regulates Proteins Involved in RNA Processing


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000101213 PTK6 / Q13882 / protein tyrosine kinase 6  / reaction






 

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