ENSDARG00000015472


Danio rerio

Features
Gene ID: ENSDARG00000015472
  
Biological name :gpc4
  
Synonyms : glypican 4 / gpc4
  
Possible biological names infered from orthology : O75487 / P51655
  
Species: Danio rerio
  
Chr. number: 14
Strand: -1
Band:
Gene start: 31090151
Gene end: 31151148
  
Corresponding Affymetrix probe sets: Dr.25758.1.S1_at (Zebrafish Array)   Dr.2793.1.A1_at (Zebrafish Array)   
  
Cross references: Ensembl peptide - ENSDARP00000007058
swissprot - F1QKN6
ZFIN ID - ZDB-GENE-011119-1
Ensembl - ENSDARG00000015472
  
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 GPC4ENSGALG00000006080Gallus gallus
 GPC4ENSG00000076716Homo sapiens
 Gpc4ENSMUSG00000031119Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
gpc6a / glypican 6a / GPC6* / Q9Y625* / glypican 6*ENSDARG0000010315650
gpc6b / glypican 6b / GPC6* / Q9Y625* / glypican 6*ENSDARG0000010421948
gpc1b / glypican 1b / GPC1* / P35052* / glypican 1*ENSDARG0000009058539
gpc1a / glypican 1a / GPC1* / P35052* / Q9QZF2* / glypican 1*ENSDARG0000001934138
gpc2 / glypican 2 / Q8N158*ENSDARG0000010421723
gpc5b / glypican 5bENSDARG0000002458823
gpc5a / glypican 5a / GPC5* / P78333* / glypican 5*ENSDARG0000010364723
gpc3 / glypican 3 / P51654* / Q8CFZ4*ENSDARG0000003219920
CU467828.1ENSDARG0000007408218


Protein motifs (from Interpro)
Interpro ID Name
 IPR001863  Glypican
 IPR031180  Glypican-4


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001702 gastrulation with mouth forming second IMP
 biological_processGO:0003379 establishment of cell polarity involved in gastrulation cell migration IMP
 biological_processGO:0008104 protein localization IGI
 biological_processGO:0009826 unidimensional cell growth IMP
 biological_processGO:0009966 regulation of signal transduction IEA
 biological_processGO:0014812 muscle cell migration IMP
 biological_processGO:0030166 proteoglycan biosynthetic process IMP
 biological_processGO:0030198 extracellular matrix organization IMP
 biological_processGO:0030334 regulation of cell migration IGI
 biological_processGO:0030903 notochord development IMP
 biological_processGO:0036342 post-anal tail morphogenesis IMP
 biological_processGO:0042074 cell migration involved in gastrulation IGI
 biological_processGO:0051216 cartilage development IMP
 biological_processGO:0055001 muscle cell development IMP
 biological_processGO:0055002 striated muscle cell development IMP
 biological_processGO:0060026 convergent extension IMP
 biological_processGO:0060027 convergent extension involved in gastrulation IMP
 biological_processGO:0060028 convergent extension involved in axis elongation IMP
 biological_processGO:0060030 dorsal convergence IMP
 biological_processGO:0060536 cartilage morphogenesis IMP
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0031225 anchored component of membrane IEA
 cellular_componentGO:0046658 anchored component of plasma membrane IEA
 molecular_functionGO:0005515 protein binding IPI


Pathways (from Reactome)
Pathway description
A tetrasaccharide linker sequence is required for GAG synthesis
HS-GAG biosynthesis
HS-GAG degradation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000001 Kupffer s vesicle Kupffers vesicle ciliated cell oriented towards Kupffers vesicle anterior region, abnormal
Show

 ZFA:0000003 adaxial cell adaxial cell shape , abnormal
Show

 ZFA:0000017 endoderm endoderm mislocalised , abnormal
Show

 ZFA:0000022 floor plate floor plate ciliated cell oriented towards floor plate anterior region, abnormal
Show

 ZFA:0000060 prechordal plate prechordal plate elongated , abnormal
Show

 ZFA:0000092 axis axis decreased length , abnormal
axis increased width , abnormal
axis shortened , abnormal
Show

 ZFA:0000095 pharyngeal arch 3-7 skeleton pharyngeal arch 3-7 skeleton quality , abnormal
Show

 ZFA:0000106 extension extension decreased length , abnormal
extension aplastic , abnormal
Show

 ZFA:0000107 eye eye morphology , abnormal
eye mislocalised medially , abnormal
Show

 ZFA:0000109 forebrain forebrain increased width , abnormal
Show

 ZFA:0000131 neural keel neural keel decreased length , abnormal
Show

 ZFA:0000135 notochord notochord decreased length , abnormal
notochord increased width , abnormal
notochord cell disorganized , abnormal
notochord undulate , abnormal
notochord quality , abnormal
Show

 ZFA:0000150 pronephric duct pronephric duct ciliated cell oriented towards pronephric duct anterior region, abnormal
Show

 ZFA:0000155 somite somite quality , abnormal
somite decreased length , abnormal
somite increased width , abnormal
somite increased amount , abnormal
somite U-shaped , abnormal
Show

 ZFA:0000270 maxilla maxilla absent , abnormal
Show

 ZFA:0000369 intermandibularis intermandibularis disorganized , abnormal
Show

 ZFA:0000422 retroarticular retroarticular malformed , abnormal
retroarticular shortened , abnormal
retroarticular absent , abnormal
Show

 ZFA:0000621 quadrate quadrate absent , abnormal
Show

 ZFA:0000671 horizontal myoseptum horizontal myoseptum decreased amount , abnormal
Show

 ZFA:0000692 symplectic symplectic decreased length , abnormal
symplectic decreased volume , abnormal
Show

 ZFA:0001056 myotome myotome decreased length , abnormal
Show

 ZFA:0001064 rhombomere rhombomere increased width , abnormal
Show

 ZFA:0001069 ventral fin fold ventral fin fold cell dislocated proctodeum , abnormal
Show

 ZFA:0001086 muscle pioneer muscle pioneer decreased amount , abnormal
muscle pioneer increased amount , abnormal
Show

 ZFA:0001094 whole organism whole organism shape , abnormal
whole organism decreased length , abnormal
whole organism morphology , abnormal
whole organism medial-lateral axis increased length , abnormal
whole organism anterior-posterior axis dwarf-like , abnormal
whole organism has extra parts of type post-vent region , abnormal
whole organism anterior-posterior axis decreased length , abnormal
Show

 ZFA:0001114 head head decreased size , abnormal
Show

 ZFA:0001115 trunk trunk decreased length , abnormal
Show

 ZFA:0001117 post-vent region post-vent region quality , abnormal
post-vent region decreased length , abnormal
post-vent region deformed , abnormal
post-vent region notochord folded , abnormal
post-vent region malformed , abnormal
post-vent region truncated , abnormal
Show

 ZFA:0001157 posterior lateral line primordium posterior lateral line primordium increased amount , abnormal
posterior lateral line primordium decreased amount , abnormal
posterior lateral line primordium morphology , abnormal
posterior lateral line primordium circular , abnormal
posterior lateral line primordium increased thickness , abnormal
posterior lateral line primordium mislocalised , abnormal
posterior lateral line primordium mislocalised dorsally , abnormal
posterior lateral line primordium mislocalised anteriorly , abnormal
Show

 ZFA:0001205 Meckel s cartilage Meckels cartilage structure , abnormal
Meckels cartilage chondrocyte disorganized , abnormal
Meckels cartilage shape , abnormal
Meckels cartilage condensed , abnormal
Meckels cartilage deformed , abnormal
Meckels cartilage perpendicular to whole organism anterior-posterior axis, abnormal
Meckels cartilage chondrocyte circular , abnormal
Meckels cartilage shortened , abnormal
Meckels cartilage cartilage morphogenesis process quality , abnormal
Meckels cartilage chondrocyte morphology , abnormal
Meckels cartilage chondrocyte positional polarity , abnormal
Show

 ZFA:0001227 mandibular arch skeleton mandibular arch skeleton chondrocyte morphology , abnormal
mandibular arch skeleton chondrocyte position , abnormal
Show

 ZFA:0001239 ceratobranchial 5 bone ceratobranchial 5 bone absent , abnormal
Show

 ZFA:0001390 pancreatic bud pancreatic bud split medially , abnormal
Show

 ZFA:0001400 ceratohyal cartilage ceratohyal cartilage structure , abnormal
ceratohyal cartilage chondrocyte disorganized , abnormal
ceratohyal cartilage decreased length , abnormal
ceratohyal cartilage decreased volume , abnormal
ceratohyal cartilage condensed , abnormal
ceratohyal cartilage deformed , abnormal
ceratohyal cartilage perpendicular to whole organism anterior-posterior axis, abnormal
ceratohyal cartilage chondrocyte circular , abnormal
ceratohyal cartilage chondrocyte decreased size , abnormal
Show

 ZFA:0001458 cranial cartilage cranial cartilage deformed , abnormal
cranial cartilage extracellular matrix composition , abnormal
Show

 ZFA:0001460 pharyngeal arch cartilage pharyngeal arch cartilage deformed , abnormal
Show

 ZFA:0001511 interhyal cartilage interhyal cartilage chondrocyte decreased amount , abnormal
Show

 ZFA:0001591 endochondral bone endochondral bone absent , abnormal
Show

 ZFA:0001652 head muscle head muscle decreased length , abnormal
Show

 ZFA:0001670 notochord posterior region notochord posterior region cell separated from notochord posterior region cell, abnormal
notochord posterior region folded , abnormal
Show

 ZFA:0005484 quadrate-anguloarticular joint quadrate-anguloarticular joint morphology , abnormal
Show

 ZFA:0005509 palate palate decreased length , abnormal
palate increased width , abnormal
palate chondrocyte irregular spatial pattern , abnormal
Show

 ZFA:0007016 anterior neural plate anterior neural plate increased width , abnormal
Show

 ZFA:0009000 cell cell extracellular matrix increased size , abnormal
cell extracellular matrix organization quality , abnormal
Show

 ZFA:0009065 endothelial cell endothelial cell mislocalised , abnormal
Show

 ZFA:0009084 chondrocyte chondrocyte microtubule organizing center disorganized , abnormal
Show

 ZFA:0009116 slow muscle cell slow muscle cell decreased length , abnormal
slow muscle cell disorganized , abnormal
Show

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   


© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr