ENSDARG00000015918


Danio rerio

Features
Gene ID: ENSDARG00000015918
  
Biological name :dlat
  
Synonyms : dihydrolipoamide S-acetyltransferase (E2 component of pyruvate dehydrogenase complex) / dlat
  
Possible biological names infered from orthology : dihydrolipoamide S-acetyltransferase / Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial / P10515 / Q8BMF4
  
Species: Danio rerio
  
Chr. number: 21
Strand: -1
Band:
Gene start: 23019372
Gene end: 23035120
  
Corresponding Affymetrix probe sets: Dr.2810.1.S1_at (Zebrafish Array)   Dr.2810.2.A1_at (Zebrafish Array)   
  
Cross references: Ensembl peptide - ENSDARP00000023098
swissprot - B3DIV6
ZFIN ID - ZDB-GENE-030131-2921
Ensembl - ENSDARG00000015918
  
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 DLATENSGALG00000007904Gallus gallus
 DLATENSG00000150768Homo sapiens
 DlatENSMUSG00000000168Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
pdhx / pyruvate dehydrogenase complex, component X / O00330* / Q8BKZ9* / Pyruvate dehydrogenase protein X component, mitochondrial *ENSDARG0000005175628


Protein motifs (from Interpro)
Interpro ID Name
 IPR000089  Biotin/lipoyl attachment
 IPR001078  2-oxoacid dehydrogenase acyltransferase, catalytic domain
 IPR003016  2-oxo acid dehydrogenase, lipoyl-binding site
 IPR004167  Peripheral subunit-binding domain
 IPR006257  Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex
 IPR011053  Single hybrid motif


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006086 acetyl-CoA biosynthetic process from pyruvate IMP
 biological_processGO:0006090 pyruvate metabolic process IMP
 biological_processGO:0008152 metabolic process IEA
 biological_processGO:0009583 detection of light stimulus IMP
 biological_processGO:0050908 detection of light stimulus involved in visual perception IMP
 biological_processGO:0055114 oxidation-reduction process IEA
 cellular_componentGO:0005759 mitochondrial matrix IEA
 cellular_componentGO:0045254 pyruvate dehydrogenase complex IEA
 molecular_functionGO:0004738 pyruvate dehydrogenase activity IMP
 molecular_functionGO:0004742 dihydrolipoyllysine-residue acetyltransferase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0016746 transferase activity, transferring acyl groups IEA


Pathways (from Reactome)
Pathway description
Regulation of pyruvate dehydrogenase (PDH) complex
Glyoxylate metabolism and glycine degradation
Signaling by Retinoic Acid
Pyruvate metabolism


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000107 eye eye quality , abnormal
Show

 ZFA:0000282 sensory system sensory system quality , abnormal
Show

 ZFA:0001094 whole organism whole organism pyruvate amount , ameliorated
whole organism pyruvate increased amount , abnormal
whole organism lactate amount , ameliorated
whole organism lactate increased amount , abnormal
whole organism dead , abnormal
whole organism decreased life span , abnormal
whole organism life span , ameliorated
whole organism lethargic , abnormal
whole organism behavioural activity , ameliorated
Show

 ZFA:0009090 pigment cell pigment cell quality , abnormal
Show

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000021346 pdhb / pyruvate dehydrogenase E1 beta subunit / P11177* / Q9D051* / Pyruvate dehydrogenase E1 component subunit beta, mitochondrial *  / complex
 ENSDARG00000008785 dldh / dihydrolipoamide dehydrogenase / DLD* / O08749* / P09622* / Dihydrolipoyl dehydrogenase, mitochondrial *  / complex
 ENSDARG00000020876 pdk2a / pyruvate dehydrogenase kinase, isozyme 2a / PDK2* / Q9JK42* / Q15119* / pyruvate dehydrogenase kinase 2* / [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial *  / reaction
 ENSDARG00000105187 gcshb / glycine cleavage system protein H (aminomethyl carrier), b / GCSH* / P23434* / Q91WK5* / AC092718.3* / AC092718.8* / glycine cleavage system protein H* / Glycine cleavage system H p...  / reaction
 ENSDARG00000015918 dlat / dihydrolipoamide S-acetyltransferase (E2 component of pyruvate dehydrogenase complex) / P10515* / Q8BMF4* / dihydrolipoamide S-acetyltransferase* / Dihydrolipoyllysine-residue acetyl...  / complex
 ENSDARG00000013128 pdk1 / pyruvate dehydrogenase kinase, isozyme 1 / Q15118* / Q8BFP9* / pyruvate dehydrogenase kinase 1* / [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial *  / reaction
 ENSDARG00000054848 pdk4 / pyruvate dehydrogenase kinase, isozyme 4 / O70571* / Q16654* / pyruvate dehydrogenase kinase 4* / pyruvate dehydrogenase kinase, isoenzyme 4*  / reaction
 ENSDARG00000051756 pdhx / pyruvate dehydrogenase complex, component X / O00330* / Q8BKZ9* / Pyruvate dehydrogenase protein X component, mitochondrial *  / complex
 ENSDARG00000099791 pdk3b / pyruvate dehydrogenase kinase, isozyme 3b / PDK3* / Q922H2* / Q15120* / pyruvate dehydrogenase kinase 3* / pyruvate dehydrogenase kinase, isoenzyme 3*  / reaction






 

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