ENSGALG00000007904


Gallus gallus

Features
Gene ID: ENSGALG00000007904
  
Biological name :DLAT
  
Synonyms : dihydrolipoamide S-acetyltransferase / DLAT
  
Possible biological names infered from orthology : Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial / P10515 / Q8BMF4
  
Species: Gallus gallus
  
Chr. number: 24
Strand: -1
Band:
Gene start: 6158727
Gene end: 6165163
  
Corresponding Affymetrix probe sets: Gga.8300.1.S1_at (Chicken Array)   Gga.8300.3.S1_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000012815
NCBI entrez gene - 419796     See in Manteia.
RefSeq - XM_417933
swissprot - E1C6N5
Ensembl - ENSGALG00000007904
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 dlatENSDARG00000015918Danio rerio
 DLATENSG00000150768Homo sapiens
 DlatENSMUSG00000000168Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
PDHX / pyruvate dehydrogenase protein X component, mitochondrial / O00330* / Q8BKZ9* / pyruvate dehydrogenase complex component X*ENSGALG0000003375328


Protein motifs (from Interpro)
Interpro ID Name
 IPR000089  Biotin/lipoyl attachment
 IPR001078  2-oxoacid dehydrogenase acyltransferase, catalytic domain
 IPR003016  2-oxo acid dehydrogenase, lipoyl-binding site
 IPR004167  Peripheral subunit-binding domain
 IPR006257  Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex
 IPR011053  Single hybrid motif
 IPR023213  Chloramphenicol acetyltransferase-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006086 acetyl-CoA biosynthetic process from pyruvate IEA
 biological_processGO:0006090 pyruvate metabolic process IEA
 biological_processGO:0008152 metabolic process IEA
 cellular_componentGO:0005739 mitochondrion IEA
 cellular_componentGO:0005759 mitochondrial matrix IEA
 cellular_componentGO:0043209 myelin sheath IEA
 cellular_componentGO:0045254 pyruvate dehydrogenase complex IEA
 molecular_functionGO:0004742 dihydrolipoyllysine-residue acetyltransferase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0016746 transferase activity, transferring acyl groups IEA
 molecular_functionGO:0034604 pyruvate dehydrogenase (NAD+) activity IEA
 molecular_functionGO:0042802 identical protein binding IEA


Pathways (from Reactome)
Pathway description
Regulation of pyruvate dehydrogenase (PDH) complex
Glyoxylate metabolism and glycine degradation
Signaling by Retinoic Acid
Pyruvate metabolism


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSGALG00000016430 PDHA1 / PDHA2* / P35486* / P35487* / P08559* / P29803* / pyruvate dehydrogenase E1 alpha 1* / pyruvate dehydrogenase E1 alpha 1 subunit* / pyruvate dehydrogenase E1 alpha 2 subunit* / Pyruv...  / complex
 ENSGALG00000007904 DLAT / dihydrolipoamide S-acetyltransferase / P10515* / Q8BMF4* / Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial *  / complex
 ENSGALG00000029576 PDHB / pyruvate dehydrogenase E1 component subunit beta, mitochondrial / P11177* / Q9D051* / pyruvate dehydrogenase E1 beta subunit*  / complex
 ENSGALG00000007931 DLD / dihydrolipoamide dehydrogenase / O08749* / P09622* / Dihydrolipoyl dehydrogenase, mitochondrial *  / complex
 ENSGALG00000009700 PDK4 / pyruvate dehydrogenase kinase 4 / O70571* / Q16654* / pyruvate dehydrogenase kinase, isoenzyme 4*  / reaction
 ENSGALG00000016323 PDK3 / pyruvate dehydrogenase kinase 3 / Q15120* / Q922H2* / pyruvate dehydrogenase kinase, isoenzyme 3*  / reaction
 ENSGALG00000013235 PDK1 / pyruvate dehydrogenase kinase 1 / Q15118* / Q8BFP9* / [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial *  / reaction






 

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