ENSGALG00000007931


Gallus gallus

Features
Gene ID: ENSGALG00000007931
  
Biological name :DLD
  
Synonyms : dihydrolipoamide dehydrogenase / DLD
  
Possible biological names infered from orthology : Dihydrolipoyl dehydrogenase, mitochondrial / O08749 / P09622
  
Species: Gallus gallus
  
Chr. number: 1
Strand: 1
Band:
Gene start: 14867128
Gene end: 14880879
  
Corresponding Affymetrix probe sets: Gga.4909.2.S1_s_at (Chicken Array)   Gga.4909.3.S1_a_at (Chicken Array)   Gga.4909.3.S1_s_at (Chicken Array)   GgaAffx.11655.1.S1_s_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000047071
Ensembl peptide - ENSGALP00000059833
Ensembl peptide - ENSGALP00000012869
NCBI entrez gene - 417699     See in Manteia.
RefSeq - NM_001030727
RefSeq - XM_015275709
RefSeq Peptide - NP_001025898
swissprot - A0A1L1RM48
swissprot - Q5ZM32
Ensembl - ENSGALG00000007931
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 dldhENSDARG00000008785Danio rerio
 DLDENSG00000091140Homo sapiens
 DldENSMUSG00000020664Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR004099  Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain
 IPR006258  Dihydrolipoamide dehydrogenase
 IPR012999  Pyridine nucleotide-disulphide oxidoreductase, class I, active site
 IPR016156  FAD/NAD-linked reductase, dimerisation domain superfamily
 IPR023753  FAD/NAD(P)-binding domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006120 mitochondrial electron transport, NADH to ubiquinone IEA
 biological_processGO:0006508 proteolysis IEA
 biological_processGO:0007369 gastrulation IEA
 biological_processGO:0022900 electron transport chain IEA
 biological_processGO:0042391 regulation of membrane potential IEA
 biological_processGO:0045454 cell redox homeostasis IEA
 biological_processGO:0048240 sperm capacitation IEA
 biological_processGO:0055114 oxidation-reduction process IEA
 biological_processGO:0106077 histone succinylation IEA
 cellular_componentGO:0005623 cell IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005739 mitochondrion IEA
 cellular_componentGO:0005929 cilium IEA
 cellular_componentGO:0043159 acrosomal matrix IEA
 cellular_componentGO:0043209 myelin sheath IEA
 cellular_componentGO:0045252 oxoglutarate dehydrogenase complex IEA
 cellular_componentGO:0045254 pyruvate dehydrogenase complex IEA
 molecular_functionGO:0004148 dihydrolipoyl dehydrogenase activity IEA
 molecular_functionGO:0009055 electron transfer activity IEA
 molecular_functionGO:0016491 oxidoreductase activity IEA
 molecular_functionGO:0016668 oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor IEA
 molecular_functionGO:0034604 pyruvate dehydrogenase (NAD+) activity IEA
 molecular_functionGO:0050660 flavin adenine dinucleotide binding IEA


Pathways (from Reactome)
Pathway description
Regulation of pyruvate dehydrogenase (PDH) complex
Glyoxylate metabolism and glycine degradation
Signaling by Retinoic Acid
Glycine degradation
Pyruvate metabolism
Branched-chain amino acid catabolism
Lysine catabolism
Citric acid cycle (TCA cycle)


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSGALG00000007904 DLAT / dihydrolipoamide S-acetyltransferase / P10515* / Q8BMF4* / Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial *  / complex
 ENSGALG00000007931 DLD / dihydrolipoamide dehydrogenase / O08749* / P09622* / Dihydrolipoyl dehydrogenase, mitochondrial *  / complex
 ENSGALG00000016430 PDHA1 / PDHA2* / P35486* / P35487* / P08559* / P29803* / pyruvate dehydrogenase E1 alpha 1* / pyruvate dehydrogenase E1 alpha 1 subunit* / pyruvate dehydrogenase E1 alpha 2 subunit* / Pyruv...  / complex
 ENSGALG00000009700 PDK4 / pyruvate dehydrogenase kinase 4 / O70571* / Q16654* / pyruvate dehydrogenase kinase, isoenzyme 4*  / reaction
 ENSGALG00000014155 OGDH / oxoglutarate dehydrogenase / Q02218* / Q60597* / 2-oxoglutarate dehydrogenase, mitochondrial *  / complex
 ENSGALG00000016323 PDK3 / pyruvate dehydrogenase kinase 3 / Q15120* / Q922H2* / pyruvate dehydrogenase kinase, isoenzyme 3*  / reaction
 ENSGALG00000013235 PDK1 / pyruvate dehydrogenase kinase 1 / Q15118* / Q8BFP9* / [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial *  / reaction
 ENSGALG00000011266 PPM1K / protein phosphatase, Mg2+/Mn2+ dependent 1K / Q8BXN7* / Q8N3J5* / protein phosphatase 1K (PP2C domain containing)*  / reaction
 ENSGALG00000029576 PDHB / pyruvate dehydrogenase E1 component subunit beta, mitochondrial / P11177* / Q9D051* / pyruvate dehydrogenase E1 beta subunit*  / complex






 

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