ENSDARG00000021346


Danio rerio

Features
Gene ID: ENSDARG00000021346
  
Biological name :pdhb
  
Synonyms : pdhb / pyruvate dehydrogenase E1 beta subunit
  
Possible biological names infered from orthology : P11177 / Pyruvate dehydrogenase E1 component subunit beta, mitochondrial / Q9D051
  
Species: Danio rerio
  
Chr. number: 22
Strand: 1
Band:
Gene start: 10201826
Gene end: 10212502
  
Corresponding Affymetrix probe sets: Dr.3570.1.S1_at (Zebrafish Array)   NM_213154_at (Zebrafish Genome Array with custom cdf files)   
  
Cross references: Ensembl peptide - ENSDARP00000002122
Ensembl peptide - ENSDARP00000115411
NCBI entrez gene - 406428     See in Manteia.
RefSeq - NM_213154
RefSeq Peptide - NP_998319
swissprot - Q1LVS0
swissprot - Q7T368
ZFIN ID - ZDB-GENE-040426-2173
Ensembl - ENSDARG00000021346
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 PDHBENSGALG00000029576Gallus gallus
 PDHBENSG00000168291Homo sapiens
 PdhbENSMUSG00000021748Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
bckdhb / branched chain keto acid dehydrogenase E1, beta polypeptide / P21953* / Q6P3A8* / branched chain keto acid dehydrogenase E1 subunit beta* / 2-oxoisovalerate dehydrogenase subunit b...ENSDARG0000001467628


Protein motifs (from Interpro)
Interpro ID Name
 IPR005475  Transketolase-like, pyrimidine-binding domain
 IPR009014  Transketolase C-terminal/Pyruvate-ferredoxin oxidoreductase domain II
 IPR027110  Pyruvate dehydrogenase E1 component subunit beta
 IPR029061  Thiamin diphosphate-binding fold
 IPR033248  Transketolase, C-terminal domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0008152 metabolic process IEA
 biological_processGO:0043473 pigmentation IMP
 biological_processGO:0055114 oxidation-reduction process IEA
 molecular_functionGO:0003824 catalytic activity IEA
 molecular_functionGO:0004738 pyruvate dehydrogenase activity IMP


Pathways (from Reactome)
Pathway description
Regulation of pyruvate dehydrogenase (PDH) complex
Glyoxylate metabolism and glycine degradation
Signaling by Retinoic Acid
Pyruvate metabolism


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000046 retinal neural layer retinal neural layer cholinergic neuron decreased amount , abnormal
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 ZFA:0000119 retinal inner nuclear layer retinal inner nuclear layer perforate , abnormal
Show

 ZFA:0001094 whole organism whole organism decreased behavioural activity , abnormal
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 ZFA:0001464 retinal outer nuclear layer retinal outer nuclear layer perforate , abnormal
Show

 ZFA:0009090 pigment cell pigment cell quality , abnormal
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 ZFA:0009091 melanocyte melanocyte increased area , abnormal
melanocyte melanosome spatial pattern , abnormal
melanocyte area , abnormal
Show

 ZFA:0009255 amacrine cell amacrine cell decreased amount , abnormal
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Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000105187 gcshb / glycine cleavage system protein H (aminomethyl carrier), b / GCSH* / P23434* / Q91WK5* / AC092718.3* / AC092718.8* / glycine cleavage system protein H* / Glycine cleavage system H p...  / reaction
 ENSDARG00000021346 pdhb / pyruvate dehydrogenase E1 beta subunit / P11177* / Q9D051* / Pyruvate dehydrogenase E1 component subunit beta, mitochondrial *  / complex
 ENSDARG00000015918 dlat / dihydrolipoamide S-acetyltransferase (E2 component of pyruvate dehydrogenase complex) / P10515* / Q8BMF4* / dihydrolipoamide S-acetyltransferase* / Dihydrolipoyllysine-residue acetyl...  / complex
 ENSDARG00000008785 dldh / dihydrolipoamide dehydrogenase / DLD* / O08749* / P09622* / Dihydrolipoyl dehydrogenase, mitochondrial *  / complex
 ENSDARG00000020876 pdk2a / pyruvate dehydrogenase kinase, isozyme 2a / PDK2* / Q9JK42* / Q15119* / pyruvate dehydrogenase kinase 2* / [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial *  / reaction
 ENSDARG00000013128 pdk1 / pyruvate dehydrogenase kinase, isozyme 1 / Q15118* / Q8BFP9* / pyruvate dehydrogenase kinase 1* / [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial *  / reaction
 ENSDARG00000054848 pdk4 / pyruvate dehydrogenase kinase, isozyme 4 / O70571* / Q16654* / pyruvate dehydrogenase kinase 4* / pyruvate dehydrogenase kinase, isoenzyme 4*  / reaction
 ENSDARG00000051756 pdhx / pyruvate dehydrogenase complex, component X / O00330* / Q8BKZ9* / Pyruvate dehydrogenase protein X component, mitochondrial *  / complex
 ENSDARG00000099791 pdk3b / pyruvate dehydrogenase kinase, isozyme 3b / PDK3* / Q922H2* / Q15120* / pyruvate dehydrogenase kinase 3* / pyruvate dehydrogenase kinase, isoenzyme 3*  / reaction






 

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