ENSDARG00000020043


Danio rerio

Features
Gene ID: ENSDARG00000020043
  
Biological name :cnot8
  
Synonyms : CCR4-NOT transcription complex, subunit 8 / cnot8
  
Possible biological names infered from orthology : Mus musculus CCR4-NOT transcription complex, subunit 8 (Cnot8), transcript variant 2, mRNA. / Q9D8X5 / Q9UFF9
  
Species: Danio rerio
  
Chr. number: 21
Strand: -1
Band:
Gene start: 36442085
Gene end: 36453594
  
Corresponding Affymetrix probe sets: Dr.8928.1.S1_at (Zebrafish Array)   Dr.8928.2.S1_at (Zebrafish Array)   NM_213479_at (Zebrafish Genome Array with custom cdf files)   
  
Cross references: Ensembl peptide - ENSDARP00000147629
Ensembl peptide - ENSDARP00000016880
NCBI entrez gene - 406788     See in Manteia.
RefSeq - NM_213479
RefSeq - XM_005173877
RefSeq Peptide - NP_998644
swissprot - A8E5K6
ZFIN ID - ZDB-GENE-040426-2845
Ensembl - ENSDARG00000020043
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 CNOT8ENSGALG00000003950Gallus gallus
 CNOT8ENSG00000155508Homo sapiens
 Cnot8ENSMUSG00000020515Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
cnot7 / Q08BM8 / CCR4-NOT transcription complex, subunit 7 / Q60809* / Q9UIV1*ENSDARG0000003211679


Protein motifs (from Interpro)
Interpro ID Name
 IPR006941  Ribonuclease CAF1
 IPR012337  Ribonuclease H-like superfamily
 IPR027212  CCR4-NOT transcription complex subunit 8


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0017148 negative regulation of translation IBA
 biological_processGO:0043928 exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay IBA
 biological_processGO:0048666 neuron development IMP
 biological_processGO:0090503 RNA phosphodiester bond hydrolysis, exonucleolytic IEA
 cellular_componentGO:0000932 P-body IBA
 cellular_componentGO:0030015 CCR4-NOT core complex IBA
 molecular_functionGO:0003676 nucleic acid binding IEA
 molecular_functionGO:0004535 poly(A)-specific ribonuclease activity IBA


Pathways (from Reactome)
Pathway description
Deadenylation of mRNA
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000008 brain brain edematous , abnormal
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 ZFA:0000032 hypothalamus hypothalamus posterior side has extra parts of type dopaminergic neuron , abnormal
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 ZFA:0000035 lens lens shape , abnormal
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 ZFA:0000084 yolk yolk edematous , abnormal
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 ZFA:0000107 eye eye edematous , abnormal
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 ZFA:0000114 heart heart edematous , abnormal
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Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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