ENSG00000155508


Homo sapiens

Features
Gene ID: ENSG00000155508
  
Biological name :CNOT8
  
Synonyms : CCR4-NOT transcription complex subunit 8 / CNOT8 / Q9UFF9
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 5
Strand: 1
Band: q33.2
Gene start: 154857553
Gene end: 154876793
  
Corresponding Affymetrix probe sets: 202162_s_at (Human Genome U133 Plus 2.0 Array)   202163_s_at (Human Genome U133 Plus 2.0 Array)   202164_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000428842
Ensembl peptide - ENSP00000428600
Ensembl peptide - ENSP00000429108
Ensembl peptide - ENSP00000431034
Ensembl peptide - ENSP00000430833
Ensembl peptide - ENSP00000430493
Ensembl peptide - ENSP00000430215
Ensembl peptide - ENSP00000429882
Ensembl peptide - ENSP00000429810
Ensembl peptide - ENSP00000429576
Ensembl peptide - ENSP00000429394
Ensembl peptide - ENSP00000429310
Ensembl peptide - ENSP00000285896
Ensembl peptide - ENSP00000384747
Ensembl peptide - ENSP00000428090
Ensembl peptide - ENSP00000428305
Ensembl peptide - ENSP00000428359
Ensembl peptide - ENSP00000428550
Ensembl peptide - ENSP00000428565
Ensembl peptide - ENSP00000428576
NCBI entrez gene - 9337     See in Manteia.
OMIM - 603731
RefSeq - XM_017010058
RefSeq - NM_001301075
RefSeq - NM_001301077
RefSeq - NM_001301080
RefSeq - NM_001301082
RefSeq - NM_001301083
RefSeq - NM_001301086
RefSeq - NM_004779
RefSeq - XM_005268527
RefSeq - XM_011537706
RefSeq - XM_011537708
RefSeq - XM_017010048
RefSeq - XM_017010049
RefSeq - XM_017010050
RefSeq - XM_017010051
RefSeq - XM_017010052
RefSeq - XM_017010053
RefSeq - XM_017010054
RefSeq - XM_017010055
RefSeq - XM_017010056
RefSeq - XM_017010057
RefSeq - NM_001301073
RefSeq - NM_001301074
RefSeq Peptide - NP_001288003
RefSeq Peptide - NP_001288004
RefSeq Peptide - NP_001288006
RefSeq Peptide - NP_001288009
RefSeq Peptide - NP_001288011
RefSeq Peptide - NP_001288012
RefSeq Peptide - NP_001288015
RefSeq Peptide - NP_004770
RefSeq Peptide - NP_001288002
swissprot - E5RJC5
swissprot - Q9UFF9
swissprot - B7Z9U0
swissprot - E5RIU0
swissprot - E5RIL2
swissprot - E5RHP3
swissprot - E5RHL9
swissprot - E5RHG0
swissprot - E5RHD6
swissprot - E5RGE4
swissprot - E5RFJ4
Ensembl - ENSG00000155508
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 cnot8ENSDARG00000020043Danio rerio
 CNOT8ENSGALG00000003950Gallus gallus
 Cnot8ENSMUSG00000020515Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
CNOT7 / Q9UIV1 / CCR4-NOT transcription complex subunit 7ENSG0000019879174


Protein motifs (from Interpro)
Interpro ID Name
 IPR006941  Ribonuclease CAF1
 IPR012337  Ribonuclease H-like superfamily
 IPR027212  CCR4-NOT transcription complex subunit 8
 IPR036397  Ribonuclease H superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000289 nuclear-transcribed mRNA poly(A) tail shortening TAS
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated NAS
 biological_processGO:0006417 regulation of translation IEA
 biological_processGO:0006977 DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest TAS
 biological_processGO:0008284 positive regulation of cell proliferation IMP
 biological_processGO:0008285 negative regulation of cell proliferation TAS
 biological_processGO:0031047 gene silencing by RNA IEA
 biological_processGO:0035195 gene silencing by miRNA TAS
 biological_processGO:0043928 exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay IDA
 biological_processGO:0061014 positive regulation of mRNA catabolic process IMP
 biological_processGO:0090305 nucleic acid phosphodiester bond hydrolysis IEA
 biological_processGO:0090503 RNA phosphodiester bond hydrolysis, exonucleolytic IEA
 cellular_componentGO:0000932 P-body IBA
 cellular_componentGO:0005622 intracellular IDA
 cellular_componentGO:0005634 nucleus TAS
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0030014 CCR4-NOT complex IDA
 cellular_componentGO:0030015 CCR4-NOT core complex IBA
 molecular_functionGO:0000175 3"-5"-exoribonuclease activity IDA
 molecular_functionGO:0003676 nucleic acid binding IEA
 molecular_functionGO:0003700 DNA-binding transcription factor activity TAS
 molecular_functionGO:0003723 RNA binding IEA
 molecular_functionGO:0004518 nuclease activity IEA
 molecular_functionGO:0004527 exonuclease activity IEA
 molecular_functionGO:0004535 poly(A)-specific ribonuclease activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Deadenylation of mRNA
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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