ENSMUSG00000020515


Mus musculus

Features
Gene ID: ENSMUSG00000020515
  
Biological name :Cnot8
  
Synonyms : Cnot8 / Mus musculus CCR4-NOT transcription complex, subunit 8 (Cnot8), transcript variant 2, mRNA. / Q9D8X5
  
Possible biological names infered from orthology : CCR4-NOT transcription complex subunit 8 / Q9UFF9
  
Species: Mus musculus
  
Chr. number: 11
Strand: 1
Band: B1.3
Gene start: 58104153
Gene end: 58118594
  
Corresponding Affymetrix probe sets: 10376314 (MoGene1.0st)   1421135_a_at (Mouse Genome 430 2.0 Array)   1451102_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000020822
Ensembl peptide - ENSMUSP00000104471
Ensembl peptide - ENSMUSP00000116116
NCBI entrez gene - 69125     See in Manteia.
MGI - MGI:1916375
RefSeq - XM_006534106
RefSeq - NM_001356477
RefSeq - NM_026949
RefSeq - XM_006534102
RefSeq - XM_006534103
RefSeq - XM_006534104
RefSeq - XM_006534105
RefSeq Peptide - NP_001343406
RefSeq Peptide - NP_081225
swissprot - Q9D8X5
swissprot - A2AFQ7
Ensembl - ENSMUSG00000020515
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 cnot8ENSDARG00000020043Danio rerio
 CNOT8ENSGALG00000003950Gallus gallus
 CNOT8ENSG00000155508Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Cnot7 / Q60809 / CCR4-NOT transcription complex subunit 7 / Q9UIV1*ENSMUSG0000003160174


Protein motifs (from Interpro)
Interpro ID Name
 IPR006941  Ribonuclease CAF1
 IPR012337  Ribonuclease H-like superfamily
 IPR027212  CCR4-NOT transcription complex subunit 8
 IPR036397  Ribonuclease H superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006417 regulation of translation IEA
 biological_processGO:0008284 positive regulation of cell proliferation IEA
 biological_processGO:0017148 negative regulation of translation IBA
 biological_processGO:0031047 gene silencing by RNA IEA
 biological_processGO:0043928 exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay IEA
 biological_processGO:0061014 positive regulation of mRNA catabolic process IEA
 biological_processGO:0090305 nucleic acid phosphodiester bond hydrolysis IEA
 biological_processGO:0090503 RNA phosphodiester bond hydrolysis, exonucleolytic IEA
 cellular_componentGO:0000932 P-body IBA
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0030014 CCR4-NOT complex IEA
 cellular_componentGO:0030015 CCR4-NOT core complex IBA
 molecular_functionGO:0000175 3"-5"-exoribonuclease activity IEA
 molecular_functionGO:0003676 nucleic acid binding IEA
 molecular_functionGO:0003723 RNA binding IEA
 molecular_functionGO:0004518 nuclease activity IEA
 molecular_functionGO:0004527 exonuclease activity IEA
 molecular_functionGO:0004535 poly(A)-specific ribonuclease activity IBA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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