ENSMUSG00000031601


Mus musculus

Features
Gene ID: ENSMUSG00000031601
  
Biological name :Cnot7
  
Synonyms : CCR4-NOT transcription complex subunit 7 / Cnot7 / Q60809
  
Possible biological names infered from orthology : Q9UIV1
  
Species: Mus musculus
  
Chr. number: 8
Strand: -1
Band: A4
Gene start: 40492540
Gene end: 40515847
  
Corresponding Affymetrix probe sets: 10578287 (MoGene1.0st)   1423641_s_at (Mouse Genome 430 2.0 Array)   1430519_a_at (Mouse Genome 430 2.0 Array)   1460665_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000034012
Ensembl peptide - ENSMUSP00000117304
Ensembl peptide - ENSMUSP00000119319
Ensembl peptide - ENSMUSP00000122933
NCBI entrez gene - 18983     See in Manteia.
MGI - MGI:1298230
RefSeq - XM_011242183
RefSeq - NM_001271542
RefSeq - NM_001271543
RefSeq - NM_011135
RefSeq - XM_006509306
RefSeq - XM_006509307
RefSeq - XM_011242180
RefSeq Peptide - NP_001258471
RefSeq Peptide - NP_001258472
RefSeq Peptide - NP_035265
swissprot - Q543X5
swissprot - Q60809
swissprot - Q3TLK9
Ensembl - ENSMUSG00000031601
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 cnot7ENSDARG00000032116Danio rerio
 CNOT7ENSGALG00000013649Gallus gallus
 CNOT7ENSG00000198791Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Cnot8 / Q9D8X5 / Mus musculus CCR4-NOT transcription complex, subunit 8 (Cnot8), transcript variant 2, mRNA. / Q9UFF9* / CCR4-NOT transcription complex subunit 8*ENSMUSG0000002051576


Protein motifs (from Interpro)
Interpro ID Name
 IPR006941  Ribonuclease CAF1
 IPR012337  Ribonuclease H-like superfamily
 IPR036397  Ribonuclease H superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II ISO
 biological_processGO:0000289 nuclear-transcribed mRNA poly(A) tail shortening IMP
 biological_processGO:0000290 deadenylation-dependent decapping of nuclear-transcribed mRNA IMP
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006417 regulation of translation IEA
 biological_processGO:0008284 positive regulation of cell proliferation ISS
 biological_processGO:0008285 negative regulation of cell proliferation ISS
 biological_processGO:0010629 negative regulation of gene expression ISO
 biological_processGO:0017148 negative regulation of translation IBA
 biological_processGO:0031047 gene silencing by RNA IMP
 biological_processGO:0033962 cytoplasmic mRNA processing body assembly IGI
 biological_processGO:0042509 regulation of tyrosine phosphorylation of STAT protein ISO
 biological_processGO:0043928 exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay ISO
 biological_processGO:0045070 positive regulation of viral genome replication ISO
 biological_processGO:0045892 negative regulation of transcription, DNA-templated ISO
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IDA
 biological_processGO:0051607 defense response to virus ISO
 biological_processGO:0060213 positive regulation of nuclear-transcribed mRNA poly(A) tail shortening ISO
 biological_processGO:0060339 negative regulation of type I interferon-mediated signaling pathway ISO
 biological_processGO:0061014 positive regulation of mRNA catabolic process ISO
 biological_processGO:0090305 nucleic acid phosphodiester bond hydrolysis IEA
 biological_processGO:0090503 RNA phosphodiester bond hydrolysis, exonucleolytic IEA
 biological_processGO:1900153 positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay ISS
 cellular_componentGO:0000932 P-body IEA
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0016604 nuclear body ISO
 cellular_componentGO:0016607 nuclear speck ISO
 cellular_componentGO:0030014 CCR4-NOT complex ISO
 cellular_componentGO:0030015 CCR4-NOT core complex IBA
 cellular_componentGO:0075341 host cell PML body ISO
 molecular_functionGO:0000175 3"-5"-exoribonuclease activity ISO
 molecular_functionGO:0001191 transcriptional repressor activity, RNA polymerase II transcription factor binding ISO
 molecular_functionGO:0003676 nucleic acid binding IEA
 molecular_functionGO:0003723 RNA binding IEA
 molecular_functionGO:0004518 nuclease activity IEA
 molecular_functionGO:0004527 exonuclease activity IEA
 molecular_functionGO:0004532 exoribonuclease activity ISS
 molecular_functionGO:0004535 poly(A)-specific ribonuclease activity ISO
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008134 transcription factor binding ISO
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001146 abnormal testis morphology "anomalous structure of the male reproductive glands" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Shhtm1Amc/Shhtm1Amc,Tg(SFTPC-rtTA)5Jaw/0,Tg(tetO-Shh)1Jaw/0
Genetic Background: involves: FVB/N

 MP:0001147 small testis "reduced size of the male reproductive glands" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:58959]
Show

Allelic Composition: Npc1m1N/Npc1m1N,Npc2tm1Plob/Npc2tm1Plob
Genetic Background: involves: 129S1/Sv * BALB/c * C57BL/6

 MP:0001152 Leydig cell hyperplasia "increased number of interstitial cells of the seminiferous tubules that secrete testosterone" [J:45065]
Show

Allelic Composition: Shhtm1Amc/Shhtm1Amc,Tg(SFTPC-rtTA)5Jaw/0,Tg(tetO-Shh)1Jaw/0
Genetic Background: involves: FVB/N

 MP:0001153 small seminiferous tubules "reduced diameter of the tubules in the testes where spermatogenesis occurs" [J:50844]
Show

Allelic Composition: Cnot7tm1Jpr/Cnot7tm1Jpr
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0001154 seminiferous tubule degeneration "a retrogressive impairment of function or destruction of the tubules in the testes where spermatogenesis occurs" [J:50844]
Show

Allelic Composition: Npc1m1N/Npc1m1N,Npc2tm1Plob/Npc2tm1Plob
Genetic Background: involves: 129S1/Sv * BALB/c * C57BL/6

Allelic Composition: Cnot7tm1Jpr/Cnot7tm1Jpr
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0001925 male infertility "inability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]
Show

Allelic Composition: Npc1m1N/Npc1m1N,Npc2tm1Plob/Npc2tm1Plob
Genetic Background: involves: 129S1/Sv * BALB/c * C57BL/6

Allelic Composition: Cnot7tm1Jpr/Cnot7tm1Jpr
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0001929 abnormal gametogenesis "defective formation or differentiation of germ cells" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:42324]
Show

Allelic Composition: Shhtm1Amc/Shhtm1Amc,Tg(SFTPC-rtTA)5Jaw/0,Tg(tetO-Shh)1Jaw/0
Genetic Background: involves: FVB/N

 MP:0002675 asthenozoospermia "loss or reduction of the mobility of the spermatozoa, frequently associated with infertility" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Npc1m1N/Npc1m1N,Npc2tm1Plob/Npc2tm1Plob
Genetic Background: involves: 129S1/Sv * BALB/c * C57BL/6

 MP:0002687 oligozoospermia "reduced concentration of spermatozoa " [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:57312]
Show

Allelic Composition: Npc1m1N/Npc1m1N,Npc2tm1Plob/Npc2tm1Plob
Genetic Background: involves: 129S1/Sv * BALB/c * C57BL/6

Allelic Composition: Cnot7tm1Jpr/Cnot7tm1Jpr
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0002784 abnormal Sertoli cell morphology "malformation of the cells of the seminiferous tubules that create the blood-testes barrier and enable spermatogenesis" [J:65900, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Npc1m1N/Npc1m1N,Npc2tm1Plob/Npc2tm1Plob
Genetic Background: involves: 129S1/Sv * BALB/c * C57BL/6

 MP:0004852 decreased testis weight "reduced average weight of the male reproductive glands" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cnot7tm1Jpr/Cnot7tm1Jpr
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0004901 decreased male germ cell number "reduced numbers of male germ cells whether they are undifferentiated or fully differentiated" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cnot7tm1Jpr/Cnot7tm1Jpr
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0005250 Sertoli cell hypoplasia "decreased number of cells of the seminiferous tubules that create the blood-testes barrier and enable spermatogenesis" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:70212]
Show

Allelic Composition: Cnot7tm1Jpr/Cnot7tm1Jpr
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0005578 teratozoospermia "presence of malformed spermatozoa in the semen; malformations include the physical bending of the sperm to produce kinks or bends" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, ava:Anna V. Anagnostopoulos , Mouse Genome Informatics Curator]
Show

Allelic Composition: Npc1m1N/Npc1m1N,Npc2tm1Plob/Npc2tm1Plob
Genetic Background: involves: 129S1/Sv * BALB/c * C57BL/6

 MP:0006362 abnormal male germ cell morphology "any structural anomaly of male germ cells whether they are undifferentiated or fully differentiated" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cnot7tm1Jpr/Cnot7tm1Jpr
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0006380 abnormal spermatid morphology "anomaly in the number or structure of the male germ cells that without further cell division give rise to mature spermatozoa" [ISBN:0-8036-0655-99 "Taber s Cyclopedic Medical Dictionary, 19th edition", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Npc1m1N/Npc1m1N,Npc2tm1Plob/Npc2tm1Plob
Genetic Background: involves: 129S1/Sv * BALB/c * C57BL/6

 MP:0008280 male germ cell apoptosis "presence of male germs cells that undergo programmed cell death" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Npc1m1N/Npc1m1N,Npc2tm1Plob/Npc2tm1Plob
Genetic Background: involves: 129S1/Sv * BALB/c * C57BL/6

 MP:0008892 abnormal sperm flagellum "any strucutral anomaly of the whiplike posterior filiform portion of the spermatozoon that provides sperm motility" [MESH:A05.360.490.890.840]
Show

Allelic Composition: Npc1m1N/Npc1m1N,Npc2tm1Plob/Npc2tm1Plob
Genetic Background: involves: 129S1/Sv * BALB/c * C57BL/6

 MP:0009230 abnormal sperm head morphology "any structural abnormality of the head segment of the sperm cell which contains the nucleus with densely coiled chromatin fibers, and is surrounded anteriorly by the acrosome which contains enzymes used for penetrating the female egg" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Npc1m1N/Npc1m1N,Npc2tm1Plob/Npc2tm1Plob
Genetic Background: involves: 129S1/Sv * BALB/c * C57BL/6

 MP:0009832 abnormal sperm mitochondrial sheath morphology "any structural anomaly or impairment of the tightly packed helical sheath of ATP-producing mitochondria restricted to the midpiece of the sperm flagellum" [PMID:14581499]
Show

Allelic Composition: Npc1m1N/Npc1m1N,Npc2tm1Plob/Npc2tm1Plob
Genetic Background: involves: 129S1/Sv * BALB/c * C57BL/6

 MP:0020550 multinucleated giant male germ cells "presence of large cells containing multiple nuclei formed abnormal opening of the cytoplasmic bridges that are part of normal germ cell division" [PMID:16272280, url:https://ntp.niehs.nih.gov/nnl/male_reproductive/testis/setubmgcel/index.htm]
Show

Allelic Composition: Npc1m1N/Npc1m1N,Npc2tm1Plob/Npc2tm1Plob
Genetic Background: involves: 129S1/Sv * BALB/c * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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