ENSG00000198791


Homo sapiens

Features
Gene ID: ENSG00000198791
  
Biological name :CNOT7
  
Synonyms : CCR4-NOT transcription complex subunit 7 / CNOT7 / Q9UIV1
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 8
Strand: -1
Band: p22
Gene start: 17224964
Gene end: 17246878
  
Corresponding Affymetrix probe sets: 1552344_s_at (Human Genome U133 Plus 2.0 Array)   218250_s_at (Human Genome U133 Plus 2.0 Array)   225053_at (Human Genome U133 Plus 2.0 Array)   233019_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000429093
Ensembl peptide - ENSP00000429079
Ensembl peptide - ENSP00000429632
Ensembl peptide - ENSP00000487113
Ensembl peptide - ENSP00000430263
Ensembl peptide - ENSP00000430160
Ensembl peptide - ENSP00000355279
Ensembl peptide - ENSP00000428147
Ensembl peptide - ENSP00000428783
NCBI entrez gene - 29883     See in Manteia.
OMIM - 604913
RefSeq - NM_013354
RefSeq - NM_001322087
RefSeq - NM_001322088
RefSeq - NM_001322089
RefSeq - NM_001322090
RefSeq - NM_001322091
RefSeq - NM_001322092
RefSeq - NM_001322093
RefSeq - NM_001322094
RefSeq - NM_001322095
RefSeq - NM_001322096
RefSeq - NM_001322097
RefSeq - NM_001322098
RefSeq - NM_001322099
RefSeq - NM_001322100
RefSeq - NM_054026
RefSeq - XM_005273481
RefSeq Peptide - NP_001309029
RefSeq Peptide - NP_037486
RefSeq Peptide - NP_473367
RefSeq Peptide - NP_001309022
RefSeq Peptide - NP_001309023
RefSeq Peptide - NP_001309024
RefSeq Peptide - NP_001309025
RefSeq Peptide - NP_001309026
RefSeq Peptide - NP_001309027
RefSeq Peptide - NP_001309028
RefSeq Peptide - NP_001309016
RefSeq Peptide - NP_001309017
RefSeq Peptide - NP_001309018
RefSeq Peptide - NP_001309019
RefSeq Peptide - NP_001309020
RefSeq Peptide - NP_001309021
swissprot - E5RGA8
swissprot - Q9UIV1
swissprot - H0YAV9
swissprot - H0YBT3
swissprot - E5RJE0
swissprot - E5RHV9
swissprot - E5RGH2
Ensembl - ENSG00000198791
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 cnot7ENSDARG00000032116Danio rerio
 CNOT7ENSGALG00000013649Gallus gallus
 Cnot7ENSMUSG00000031601Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
CNOT8 / Q9UFF9 / CCR4-NOT transcription complex subunit 8ENSG0000015550875


Protein motifs (from Interpro)
Interpro ID Name
 IPR006941  Ribonuclease CAF1
 IPR012337  Ribonuclease H-like superfamily
 IPR036397  Ribonuclease H superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IMP
 biological_processGO:0000289 nuclear-transcribed mRNA poly(A) tail shortening TAS
 biological_processGO:0000290 deadenylation-dependent decapping of nuclear-transcribed mRNA IEA
 biological_processGO:0005975 carbohydrate metabolic process TAS
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006417 regulation of translation IEA
 biological_processGO:0006977 DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest TAS
 biological_processGO:0007165 signal transduction TAS
 biological_processGO:0008284 positive regulation of cell proliferation IMP
 biological_processGO:0008285 negative regulation of cell proliferation IDA
 biological_processGO:0010629 negative regulation of gene expression IMP
 biological_processGO:0031047 gene silencing by RNA ISS
 biological_processGO:0033962 cytoplasmic mRNA processing body assembly IEA
 biological_processGO:0035195 gene silencing by miRNA TAS
 biological_processGO:0042509 regulation of tyrosine phosphorylation of STAT protein IMP
 biological_processGO:0043928 exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay IDA
 biological_processGO:0045070 positive regulation of viral genome replication IMP
 biological_processGO:0045892 negative regulation of transcription, DNA-templated IMP
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IEA
 biological_processGO:0051607 defense response to virus IMP
 biological_processGO:0060213 positive regulation of nuclear-transcribed mRNA poly(A) tail shortening IMP
 biological_processGO:0060339 negative regulation of type I interferon-mediated signaling pathway IMP
 biological_processGO:0061014 positive regulation of mRNA catabolic process IMP
 biological_processGO:0090305 nucleic acid phosphodiester bond hydrolysis IEA
 biological_processGO:0090503 RNA phosphodiester bond hydrolysis, exonucleolytic IEA
 biological_processGO:1900153 positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay IMP
 cellular_componentGO:0000932 P-body IBA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005737 cytoplasm IMP
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0016020 membrane HDA
 cellular_componentGO:0016604 nuclear body IDA
 cellular_componentGO:0016607 nuclear speck IMP
 cellular_componentGO:0030014 CCR4-NOT complex NAS
 cellular_componentGO:0030015 CCR4-NOT core complex IBA
 cellular_componentGO:0075341 host cell PML body IMP
 molecular_functionGO:0000175 3"-5"-exoribonuclease activity IDA
 molecular_functionGO:0001191 transcriptional repressor activity, RNA polymerase II transcription factor binding IMP
 molecular_functionGO:0003676 nucleic acid binding IEA
 molecular_functionGO:0003700 DNA-binding transcription factor activity TAS
 molecular_functionGO:0003723 RNA binding IEA
 molecular_functionGO:0004518 nuclease activity IEA
 molecular_functionGO:0004527 exonuclease activity IEA
 molecular_functionGO:0004532 exoribonuclease activity IDA
 molecular_functionGO:0004535 poly(A)-specific ribonuclease activity IEA
 molecular_functionGO:0004871 obsolete signal transducer activity TAS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008134 transcription factor binding IPI
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Deadenylation of mRNA
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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