ENSDARG00000020610


Danio rerio

Features
Gene ID: ENSDARG00000020610
  
Biological name :tnnt2a
  
Synonyms : tnnt2a / troponin T type 2a (cardiac)
  
Possible biological names infered from orthology :
  
Species: Danio rerio
  
Chr. number: 23
Strand: -1
Band:
Gene start: 5653224
Gene end: 5685172
  
Corresponding Affymetrix probe sets: Dr.14260.1.S1_a_at (Zebrafish Array)   
  
Cross references: Ensembl peptide - ENSDARP00000124292
Ensembl peptide - ENSDARP00000124963
Ensembl peptide - ENSDARP00000067350
Ensembl peptide - ENSDARP00000093541
NCBI entrez gene - 58071     See in Manteia.
swissprot - E7EYC9
swissprot - F1R0K6
swissprot - F8W403
swissprot - F8W5V4
ZFIN ID - ZDB-GENE-000626-1
Ensembl - ENSDARG00000020610
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
No match


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
tnnt2b / troponin T type 2b (cardiac)ENSDARG0000010069457
tnnt2e / troponin T2e, cardiacENSDARG0000004582254
tnnt2c / troponin T2c, cardiacENSDARG0000003224253
tnnt1 / troponin T type 1 (skeletal, slow) / P13805* / O88346* / troponin T1, skeletal, slow* / troponin T1, slow skeletal type*ENSDARG0000003795452
tnnt3b / troponin T type 3b (skeletal, fast) / TNNT3* / P45378* / troponin T3, skeletal, fast* / troponin T3, fast skeletal type*ENSDARG0000006845750
tnnt2d / troponin T2d, cardiacENSDARG0000000298849
tnnt3a / troponin T type 3a (skeletal, fast) / TNNT3* / P45378* / troponin T3, skeletal, fast* / troponin T3, fast skeletal type*ENSDARG0000003027045


Protein motifs (from Interpro)
Interpro ID Name
 IPR001978  Troponin
 IPR027707  Troponin T


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001568 blood vessel development IMP
 biological_processGO:0001569 branching involved in blood vessel morphogenesis IMP
 biological_processGO:0001944 vasculature development IMP
 biological_processGO:0006809 nitric oxide biosynthetic process IMP
 biological_processGO:0006937 regulation of muscle contraction IEA
 biological_processGO:0006941 striated muscle contraction IMP
 biological_processGO:0007507 heart development IMP
 biological_processGO:0008015 blood circulation IMP
 biological_processGO:0008016 regulation of heart contraction IMP
 biological_processGO:0010749 regulation of nitric oxide mediated signal transduction IDA
 biological_processGO:0021591 ventricular system development IMP
 biological_processGO:0045214 sarcomere organization IMP
 biological_processGO:0048793 pronephros development IMP
 biological_processGO:0048845 venous blood vessel morphogenesis IMP
 biological_processGO:0055010 ventricular cardiac muscle tissue morphogenesis IMP
 biological_processGO:0060047 heart contraction IMP
 biological_processGO:0060218 hematopoietic stem cell differentiation IMP
 biological_processGO:0060840 artery development IMP
 biological_processGO:0097535 lymphoid lineage cell migration into thymus IMP
 cellular_componentGO:0005861 troponin complex IMP


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000007 blood blood accumulation blood vasculature , abnormal
blood accumulation trunk , abnormal
blood increased accumulation caudal vein , abnormal
blood flow rate , abnormal
Show

 ZFA:0000008 brain brain quality , abnormal
brain decreased size , abnormal
Show

 ZFA:0000009 cardiac ventricle cardiac ventricle decreased size , abnormal
cardiac ventricle decreased functionality , abnormal
cardiac ventricle decreased diameter , abnormal
cardiac ventricle trabecular layer absent , abnormal
Show

 ZFA:0000014 dorsal aorta dorsal aorta unlumenized , abnormal
dorsal aorta structure , abnormal
dorsal aorta vascular associated smooth muscle cell amount , ameliorated
dorsal aorta anatomical region absent , abnormal
dorsal aorta vascular associated smooth muscle cell absent , abnormal
dorsal aorta vascular associated smooth muscle cell decreased amount , abnormal
Show

 ZFA:0000037 anatomical structure anatomical structure decreased amount , abnormal
anatomical structure increased amount , abnormal
Show

 ZFA:0000054 pericardium pericardium edematous , abnormal
Show

 ZFA:0000099 brain vasculature brain vasculature hemorrhagic , abnormal
Show

 ZFA:0000110 fourth ventricle fourth ventricle decreased diameter , abnormal
Show

 ZFA:0000114 heart heart quality , abnormal
heart non-contractile , abnormal
heart morphology , abnormal
heart non-functional , abnormal
heart absent , abnormal
heart decreased amount , abnormal
heart amount , ameliorated
heart increased amount , abnormal
heart Notch signaling pathway decreased process quality , abnormal
Show

 ZFA:0000123 liver liver decreased size , abnormal
Show

 ZFA:0000170 basibranchial basibranchial condensed , abnormal
Show

 ZFA:0000173 bulbus arteriosus bulbus arteriosus absent , abnormal
Show

 ZFA:0000186 common cardinal vein common cardinal vein blood vessel endothelial cell decreased amount , abnormal
Show

 ZFA:0000423 anterior cardinal vein anterior cardinal vein unlumenized , abnormal
Show

 ZFA:0000445 optic tectum optic tectum microglial cell migration process quality , abnormal
optic tectum decreased width , abnormal
optic tectum microglial cell decreased amount , abnormal
Show

 ZFA:0000471 atrium atrium dilated , abnormal
atrium increased size , abnormal
Show

 ZFA:0000477 posterior cardinal vein posterior cardinal vein unlumenized , abnormal
Show

 ZFA:0001051 caudal division of the internal carotid artery caudal division of the internal carotid artery blood vessel endothelial cell migration process quality , abnormal
Show

 ZFA:0001078 thymus thymus decreased size , abnormal
thymus hematopoietic multipotent progenitor cell decreased amount , abnormal
Show

 ZFA:0001094 whole organism whole organism lethal (sensu genetics) , abnormal
whole organism decreased amount , abnormal
whole organism viability , abnormal
Show

 ZFA:0001115 trunk trunk hematopoietic multipotent progenitor cell decreased amount , abnormal
trunk anterior side increased accumulation nucleate erythrocyte , abnormal
Show

 ZFA:0001261 ventricular system ventricular system decreased size , abnormal
Show

 ZFA:0001267 cranial vasculature cranial vasculature unlumenized , abnormal
Show

 ZFA:0001272 palatoquadrate arch palatoquadrate arch decreased length , abnormal
Show

 ZFA:0001285 intersegmental vessel intersegmental vessel structure , abnormal
intersegmental vessel unlumenized , abnormal
intersegmental vessel blood vessel lumenization process quality , abnormal
intersegmental vessel structure, cavities , abnormal
Show

 ZFA:0001286 caudal vein plexus caudal vein plexus sprouting angiogenesis increased occurrence , abnormal
caudal vein plexus angiogenic sprout increased amount , abnormal
caudal vein plexus decreased size , abnormal
Show

 ZFA:0001315 atrioventricular canal atrioventricular canal decreased amount , abnormal
atrioventricular canal amount , ameliorated
Show

 ZFA:0001320 endocardium endocardium hypotrophic , abnormal
Show

 ZFA:0001345 interrenal gland interrenal gland animal organ morphogenesis process quality , abnormal
interrenal gland position , abnormal
interrenal gland epithelial to mesenchymal transition decreased occurrence , abnormal
Show

 ZFA:0001346 interrenal primordium interrenal primordium position , abnormal
Show

 ZFA:0001374 atrial myocardium atrial myocardium cardiac muscle cell increased amount , abnormal
Show

 ZFA:0001400 ceratohyal cartilage ceratohyal cartilage orientation ceratohyal cartilage , abnormal
Show

 ZFA:0001439 anatomical system anatomical system quality , abnormal
Show

 ZFA:0001496 simple columnar epithelium simple columnar epithelium displaced , abnormal
Show

 ZFA:0001497 simple cuboidal epithelium simple cuboidal epithelium displaced , abnormal
Show

 ZFA:0001516 ceratobranchial cartilage ceratobranchial cartilage orientation ceratobranchial cartilage , abnormal
Show

 ZFA:0001557 pronephric glomerulus pronephric glomerulus unfused from pronephric glomerulus , abnormal
pronephric glomerulus right side unfused from pronephric glomerulus left side, abnormal
pronephric glomerulus separated from pronephric glomerulus , abnormal
Show

 ZFA:0001639 vascular endothelium vascular endothelium increased size , abnormal
vascular endothelium mislocalised , abnormal
Show

 ZFA:0005002 basilar artery basilar artery decreased diameter , abnormal
Show

 ZFA:0005005 aortic arch 1 aortic arch 1 blood vessel endothelial cell migration process quality , abnormal
aortic arch 1 cell migration involved in heart development decreased occurrence , abnormal
Show

 ZFA:0005020 central artery central artery physical object quality , abnormal
central artery decreased diameter , abnormal
Show

 ZFA:0005023 hematopoietic system hematopoietic system decreased functionality , abnormal
Show

 ZFA:0005024 trunk vasculature trunk vasculature morphology , abnormal
trunk vasculature decreased amount , abnormal
trunk vasculature blood vessel lumenization decreased process quality , abnormal
Show

 ZFA:0005028 ventral wall of dorsal aorta ventral wall of dorsal aorta hematopoietic stem cell decreased amount , abnormal
ventral wall of dorsal aorta has fewer parts of type hematopoietic stem cell , abnormal
Show

 ZFA:0005035 subintestinal vein subintestinal vein morphology , abnormal
subintestinal vein blood vessel morphogenesis disrupted , abnormal
Show

 ZFA:0005037 post-vent vasculature post-vent vasculature morphology , abnormal
Show

 ZFA:0005059 trabecular layer trabecular layer aplastic , abnormal
trabecular layer absent , abnormal
Show

 ZFA:0005061 ventricular myocardium ventricular myocardium sarcomere disorganized , abnormal
ventricular myocardium cardiac muscle cell increased amount , abnormal
Show

 ZFA:0005063 cardiac conduction system cardiac conduction system mislocalised , abnormal
Show

 ZFA:0005064 atrioventricular valve atrioventricular valve absent , abnormal
Show

 ZFA:0005069 sinoatrial node sinoatrial node increased distribution , abnormal
sinoatrial node increased area , abnormal
Show

 ZFA:0005081 internal carotid artery internal carotid artery blood vessel endothelial cell migration process quality , abnormal
Show

 ZFA:0005091 hepatic sinusoid hepatic sinusoid aplastic , abnormal
Show

 ZFA:0005309 pronephric glomerular capillary pronephric glomerular capillary increased size , abnormal
Show

 ZFA:0005314 blood vessel blood vessel collapsed , abnormal
Show

 ZFA:0005802 interrenal angiogenic sprout interrenal angiogenic sprout mislocalised laterally , abnormal
Show

 ZFA:0009014 hematopoietic stem cell hematopoietic stem cell decreased amount , abnormal
Show

 ZFA:0009065 endothelial cell endothelial cell apoptotic process increased occurrence , abnormal
Show

 ZFA:0009099 chromaffin cell chromaffin cell mislocalised , abnormal
Show

 ZFA:0009316 cardiac muscle cell cardiac muscle cell cell projection transient , abnormal
cardiac muscle cell electric potential , abnormal
cardiac muscle cell sarcomere disorganized , abnormal
cardiac muscle cell increased amount , abnormal
cardiac muscle cell decreased area , abnormal
cardiac muscle cell increased volume , abnormal
cardiac muscle cell decreased volume , abnormal
cardiac muscle cell absent , abnormal
cardiac muscle cell Notch signaling pathway decreased process quality , abnormal
cardiac muscle cell mislocalised , abnormal
cardiac muscle cell basal side absent , abnormal
Show

 ZFA:0009354 hematopoietic multipotent progenitor cell hematopoietic multipotent progenitor cell decreased amount , abnormal
Show

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
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