ENSDARG00000031420


Danio rerio

Features
Gene ID: ENSDARG00000031420
  
Biological name :wt1a
  
Synonyms : wilms tumor 1a / wt1a
  
Possible biological names infered from orthology : P19544 / Wilms tumor 1 / Wilms tumor 1 homolog / WT1
  
Species: Danio rerio
  
Chr. number: 25
Strand: -1
Band:
Gene start: 15178225
Gene end: 15214161
  
Corresponding Affymetrix probe sets: Dr.8214.1.S1_at (Zebrafish Array)   Dr.8214.2.A1_at (Zebrafish Array)   Dr.8214.2.S1_a_at (Zebrafish Array)   NM_131046_at (Zebrafish Genome Array with custom cdf files)   
  
Cross references: Ensembl peptide - ENSDARP00000029174
NCBI entrez gene - 30245     See in Manteia.
RefSeq - NM_131046
RefSeq Peptide - NP_571121
swissprot - Q9PUT7
ZFIN ID - ZDB-GENE-980526-558
Ensembl - ENSDARG00000031420
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 WT1ENSGALG00000012115Gallus gallus
 WT1ENSG00000184937Homo sapiens
 Wt1ENSMUSG00000016458Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
wt1b / wilms tumor 1b / WT1* / P19544* / Wilms tumor 1* / Wilms tumor 1 homolog*ENSDARG0000000799072
egr2b / early growth response 2b / EGR2* / P11161* / P08152* / early growth response 2* / E3 SUMO-protein ligase EGR2 *ENSDARG0000004282626
egr1 / P26632 / early growth response 1 / P08046* / P18146* / Early growth response protein 1 *ENSDARG0000003742123
egr2a / early growth response 2a / EGR2* / P11161* / P08152* / early growth response 2* / E3 SUMO-protein ligase EGR2 *ENSDARG0000004409823
egr3 / early growth response 3 / P43300* / Q06889* / Mus musculus early growth response 3 (Egr3), transcript variant 3, mRNA.*ENSDARG0000008915622
egr4 / early growth response 4 / Q05215* / Q9WUF2* / Early growth response protein 4 *ENSDARG0000007779919


Protein motifs (from Interpro)
Interpro ID Name
 IPR000976  Wilm"s tumour protein, N-terminal
 IPR013087  Zinc finger C2H2-type
 IPR017987  Wilm"s tumour protein


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0008285 negative regulation of cell proliferation IBA
 biological_processGO:0030325 adrenal gland development IMP
 biological_processGO:0032835 glomerulus development IMP
 biological_processGO:0039021 pronephric glomerulus development IMP
 biological_processGO:0039022 pronephric duct development IGI
 biological_processGO:0048793 pronephros development IMP
 biological_processGO:0061032 visceral serous pericardium development IMP
 biological_processGO:0072112 glomerular visceral epithelial cell differentiation IMP
 biological_processGO:0072149 glomerular visceral epithelial cell fate commitment IGI
 cellular_componentGO:0005634 nucleus IEA
 molecular_functionGO:0003676 nucleic acid binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000054 pericardium pericardium edematous , abnormal
Show

 ZFA:0000084 yolk yolk edematous , abnormal
Show

 ZFA:0000088 YSL YSL edematous , abnormal
Show

 ZFA:0000150 pronephric duct pronephric duct malformed , abnormal
Show

 ZFA:0000151 pronephros pronephros lacks all parts of type pronephric podocyte , abnormal
pronephros morphology , abnormal
pronephros decreased size , abnormal
Show

 ZFA:0000155 somite somite spatial pattern , abnormal
somite mislocalised , abnormal
Show

 ZFA:0001070 presumptive pronephric mesoderm presumptive pronephric mesoderm malformed , abnormal
Show

 ZFA:0001094 whole organism whole organism increased curvature , abnormal
whole organism lethal (sensu genetics) , abnormal
whole organism edematous , abnormal
Show

 ZFA:0001206 intermediate mesoderm intermediate mesoderm absent , abnormal
Show

 ZFA:0001346 interrenal primordium interrenal primordium increased size , abnormal
interrenal primordium absent , abnormal
interrenal primordium decreased size , abnormal
Show

 ZFA:0001438 coelom coelom edematous , abnormal
Show

 ZFA:0001557 pronephric glomerulus pronephric glomerulus aplastic , abnormal
pronephric glomerulus unfused from pronephric glomerulus , abnormal
pronephric glomerulus cystic , abnormal
pronephric glomerulus poorly differentiated , abnormal
Show

 ZFA:0001558 pronephric tubule pronephric tubule aplastic , abnormal
pronephric tubule absent , abnormal
Show

 ZFA:0001673 pronephric podocyte pronephric podocyte decreased amount , abnormal
pronephric podocyte absent , abnormal
Show

 ZFA:0005808 proepicardial cluster proepicardial cluster decreased amount , abnormal
proepicardial cluster absent , abnormal
Show

 ZFA:0009285 podocyte podocyte podocyte foot morphology , abnormal
podocyte podocyte foot flattened , abnormal
Show

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

1 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr