ENSDARG00000037421


Danio rerio

Features
Gene ID: ENSDARG00000037421
  
Biological name :egr1
  
Synonyms : early growth response 1 / egr1 / P26632
  
Possible biological names infered from orthology : Early growth response protein 1 / P08046 / P18146
  
Species: Danio rerio
  
Chr. number: 14
Strand: -1
Band:
Gene start: 21332522
Gene end: 21336385
  
Corresponding Affymetrix probe sets: Dr.10183.1.S1_s_at (Zebrafish Array)   Dr.10183.1.S2_at (Zebrafish Array)   
  
Cross references: Ensembl peptide - ENSDARP00000054459
swissprot - B3DKJ7
swissprot - P26632
ZFIN ID - ZDB-GENE-980526-320
Ensembl - ENSDARG00000037421
  
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 EGR1ENSGALG00000007669Gallus gallus
 EGR1ENSG00000120738Homo sapiens
 Egr1ENSMUSG00000038418Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
egr2b / early growth response 2b / EGR2* / P11161* / P08152* / early growth response 2* / E3 SUMO-protein ligase EGR2 *ENSDARG0000004282634
egr3 / early growth response 3 / P43300* / Q06889* / Mus musculus early growth response 3 (Egr3), transcript variant 3, mRNA.*ENSDARG0000008915631
egr2a / early growth response 2a / EGR2* / P11161* / P08152* / early growth response 2* / E3 SUMO-protein ligase EGR2 *ENSDARG0000004409828
wt1b / wilms tumor 1b / WT1* / P19544* / Wilms tumor 1* / Wilms tumor 1 homolog*ENSDARG0000000799020
egr4 / early growth response 4 / Q05215* / Q9WUF2* / Early growth response protein 4 *ENSDARG0000007779920
wt1a / wilms tumor 1a / WT1* / P19544* / Wilms tumor 1* / Wilms tumor 1 homolog*ENSDARG0000003142019


Protein motifs (from Interpro)
Interpro ID Name
 IPR013083  Zinc finger, RING/FYVE/PHD-type
 IPR013087  Zinc finger C2H2-type
 IPR021839  Early growth response protein 1, C-terminal
 IPR021849  Early growth response protein


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0043010 camera-type eye development IMP
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II ISS
 biological_processGO:0048703 embryonic viscerocranium morphogenesis IMP
 biological_processGO:0060059 embryonic retina morphogenesis in camera-type eye IMP
 cellular_componentGO:0005634 nucleus ISS
 cellular_componentGO:0005737 cytoplasm ISS
 molecular_functionGO:0003676 nucleic acid binding IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0008270 zinc ion binding ISS
 molecular_functionGO:0010385 double-stranded methylated DNA binding ISS
 molecular_functionGO:0043565 sequence-specific DNA binding ISS
 molecular_functionGO:0044729 hemi-methylated DNA-binding ISS
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:1990841 promoter-specific chromatin binding ISS


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000046 retinal neural layer retinal neural layer decreased size , abnormal
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 ZFA:0000107 eye eye decreased size , abnormal
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 ZFA:0000119 retinal inner nuclear layer retinal inner nuclear layer has fewer parts of type retinal inner nuclear layer horizontal cell, abnormal
retinal inner nuclear layer physical object quality , abnormal
retinal inner nuclear layer poorly differentiated , abnormal
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 ZFA:0001115 trunk trunk decreased length , abnormal
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 ZFA:0001205 Meckel s cartilage Meckels cartilage hypoplastic , abnormal
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 ZFA:0001329 retinal inner plexiform layer retinal inner plexiform layer decreased thickness , abnormal
retinal inner plexiform layer malformed , abnormal
retinal inner plexiform layer has fewer parts of type retinal ganglion cell dendrite, abnormal
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 ZFA:0001330 retinal outer plexiform layer retinal outer plexiform layer decreased thickness , abnormal
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 ZFA:0001399 palatoquadrate cartilage palatoquadrate cartilage hypoplastic , abnormal
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 ZFA:0001400 ceratohyal cartilage ceratohyal cartilage malformed , abnormal
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 ZFA:0001422 hyosymplectic cartilage hyosymplectic cartilage malformed , abnormal
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 ZFA:0001464 retinal outer nuclear layer retinal outer nuclear layer poorly differentiated , abnormal
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 ZFA:0001516 ceratobranchial cartilage ceratobranchial cartilage hypoplastic , abnormal
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 ZFA:0001613 pharyngeal arch 3-7 pharyngeal arch 3-7 aplastic , abnormal
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 ZFA:0009255 amacrine cell amacrine cell poorly differentiated , abnormal
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 ZFA:0009262 retinal cone cell retinal cone cell undifferentiated , abnormal
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 ZFA:0009275 retinal rod cell retinal rod cell undifferentiated , abnormal
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 ZFA:0009280 Muller cell Muller cell poorly differentiated , abnormal
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 ZFA:0009310 retinal ganglion cell retinal ganglion cell dendrite morphogenesis decreased occurrence , abnormal
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 ZFA:0009318 retinal bipolar neuron retinal bipolar neuron poorly differentiated , abnormal
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Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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