Manteia

ENSMUSG00000038418

Mus musculus

Features

Gene ID:	ENSMUSG00000038418

Biological name :	Egr1

Synonyms :	Early growth response protein 1 / Egr1 / P08046

Possible biological names infered from orthology :	early growth response 1 / P18146

Species:	Mus musculus

Chr. number:	18
Strand:	1
Band:	B1
Gene start:	34859823
Gene end:	34864984

Corresponding Affymetrix probe sets:	10454782 (MoGene1.0st) 1417065_at (Mouse Genome 430 2.0 Array)

Cross references:	Ensembl peptide - ENSMUSP00000069616 Ensembl peptide - ENSMUSP00000126931 NCBI entrez gene - 13653 See in Manteia. MGI - MGI:95295 RefSeq - NM_007913 RefSeq Peptide - NP_031939 swissprot - P08046 swissprot - Q544D6 Ensembl - ENSMUSG00000038418

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed

Ortholog prediction (from Ensembl)

Ortholog name	ID	Species
egr1	ENSDARG00000037421	Danio rerio
EGR1	ENSGALG00000007669	Gallus gallus
EGR1	ENSG00000120738	Homo sapiens

Paralog prediction (from Ensembl)

Paralog name	ID	Similarity(%)
Egr2 / P08152 / E3 SUMO-protein ligase EGR2 / P11161* / early growth response 2*	ENSMUSG00000037868	34
Egr3 / P43300 / Mus musculus early growth response 3 (Egr3), transcript variant 3, mRNA. / Q06889* / early growth response 3*	ENSMUSG00000033730	33
Egr4 / Q9WUF2 / Early growth response protein 4 / Q05215* / early growth response 4*	ENSMUSG00000071341	23
Wt1 / Wilms tumor 1 homolog / P19544* / Wilms tumor 1*	ENSMUSG00000016458	20

Protein motifs (from Interpro)

Interpro ID	Name
IPR013083	Zinc finger, RING/FYVE/PHD-type
IPR013087	Zinc finger C2H2-type
IPR021839	Early growth response protein 1, C-terminal
IPR021849	Early growth response protein
IPR036236	Zinc finger C2H2 superfamily

Gene Ontology (GO)

Type	GO ID	Term	Ev.Code
biological_process	GO:0000122	negative regulation of transcription by RNA polymerase II	IDA
biological_process	GO:0001666	response to hypoxia	IMP
biological_process	GO:0002931	response to ischemia	IMP
biological_process	GO:0006351	transcription, DNA-templated	IEA
biological_process	GO:0006355	regulation of transcription, DNA-templated	IMP
biological_process	GO:0006366	transcription by RNA polymerase II	ISO
biological_process	GO:0009749	response to glucose	IDA
biological_process	GO:0010628	positive regulation of gene expression	ISO
biological_process	GO:0030217	T cell differentiation	IMP
biological_process	GO:0030509	BMP signaling pathway	IDA
biological_process	GO:0032868	response to insulin	IDA
biological_process	GO:0033233	regulation of protein sumoylation	ISO
biological_process	GO:0035914	skeletal muscle cell differentiation	IMP
biological_process	GO:0042981	regulation of apoptotic process	IMP
biological_process	GO:0044849	estrous cycle	IMP
biological_process	GO:0045080	positive regulation of chemokine biosynthetic process	IMP
biological_process	GO:0045893	positive regulation of transcription, DNA-templated	IDA
biological_process	GO:0045944	positive regulation of transcription by RNA polymerase II	IMP
biological_process	GO:0046886	positive regulation of hormone biosynthetic process	IMP
biological_process	GO:0050725	positive regulation of interleukin-1 beta biosynthetic process	IMP
biological_process	GO:0061418	regulation of transcription from RNA polymerase II promoter in response to hypoxia	IDA
biological_process	GO:0070498	interleukin-1-mediated signaling pathway	ISO
biological_process	GO:0071310	cellular response to organic substance	IDA
biological_process	GO:0071480	cellular response to gamma radiation	IMP
biological_process	GO:0071504	cellular response to heparin	ISS
biological_process	GO:0071506	cellular response to mycophenolic acid	ISS
biological_process	GO:0072110	glomerular mesangial cell proliferation	ISS
biological_process	GO:0072303	positive regulation of glomerular metanephric mesangial cell proliferation	ISS
biological_process	GO:0090090	negative regulation of canonical Wnt signaling pathway	IMP
biological_process	GO:0098759	cellular response to interleukin-8	ISO
biological_process	GO:1901216	positive regulation of neuron death	IEA
biological_process	GO:1902949	positive regulation of tau-protein kinase activity	IEA
biological_process	GO:2000182	regulation of progesterone biosynthetic process	IMP
cellular_component	GO:0005634	nucleus	ISO
cellular_component	GO:0005654	nucleoplasm	ISO
cellular_component	GO:0005737	cytoplasm	ISS
molecular_function	GO:0000976	transcription regulatory region sequence-specific DNA binding	ISO
molecular_function	GO:0000977	RNA polymerase II regulatory region sequence-specific DNA binding	IDA
molecular_function	GO:0000982	transcription factor activity, RNA polymerase II proximal promoter sequence-specific DNA binding	IDA
molecular_function	GO:0001077	transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding	IMP
molecular_function	GO:0003676	nucleic acid binding	IEA
molecular_function	GO:0003677	DNA binding	ISO
molecular_function	GO:0003700	DNA-binding transcription factor activity	ISO
molecular_function	GO:0008270	zinc ion binding	ISS
molecular_function	GO:0010385	double-stranded methylated DNA binding	ISO
molecular_function	GO:0035035	histone acetyltransferase binding	ISO
molecular_function	GO:0043565	sequence-specific DNA binding	ISS
molecular_function	GO:0044212	transcription regulatory region DNA binding	IDA
molecular_function	GO:0044729	hemi-methylated DNA-binding	ISO
molecular_function	GO:0046872	metal ion binding	IEA
molecular_function	GO:1990841	promoter-specific chromatin binding	ISS

Pathways (from Reactome)

Pathway description

No match

Phenotype (from MGI, Zfin or HPO)

ID	Phenotype	Definition	Genetic BG
MP:0000063	reduced bone density	"decreased mineral content of bone; indicator of bone strength" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:57315]	Show Allelic Composition: Prnp^tm2Edin/Prnp^tm2Edin Genetic Background: B6.129P2-Prnp^tm2Edin
MP:0000130	abnormal cancellous bone morphology	"structural anomaly of bone that has a latticelike or spongy structure" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Prnp^tm2Edin/Prnp^tm2Edin Genetic Background: B6.129P2-Prnp^tm2Edin
MP:0000217	abnormal white blood cell count	"anomalies in the number of leukocytes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Egr1^tm1Jmi/Egr1^tm1Jmi Genetic Background: involves: 129 * C57BL/6
MP:0000245	abnormal erythropoiesis	"atypical process of red blood cell formation" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, tc:Teresa Chu , Mouse Genome Informatics Curator]	Show Allelic Composition: Egr1^tm1Jmi/Egr1^tm1Jmi Genetic Background: involves: 129 * C57BL/6
MP:0000321	increased bone marrow cell number	"increased number of cells that make up the core cavitites of bones when compared to the norm" [tc:Teresa Chu , Mouse Genome Informatics Curator]	Show Allelic Composition: Egr1^tm1Jmi/Egr1^tm1Jmi Genetic Background: involves: 129 * C57BL/6
MP:0000609	abnormal liver physiology	"aberrant function of this bile-secreting exocrine gland, which is important for detoxification; for fat, carbohydrate, and protein metabolism; and for glycogen storage " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Prnp^tm2Edin/Prnp^tm2Edin Genetic Background: B6.129P2-Prnp^tm2Edin Allelic Composition: Egr1^tm1Jmi/Egr1^tm1Jmi Genetic Background: involves: 129 * C57BL/6
MP:0000955	abnormal spinal cord morphology	"malformation or disorganization of the cylindrical tissue of the vertebral canal that extends from the medulla oblongata to the conus medullaris" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Cecr2^{tm2b(EUCOMM)Hmgu}/Cecr2⁺ Genetic Background: C57BL/6N-Cecr2^{tm2b(EUCOMM)Hmgu}/Tcp
MP:0001126	abnormal ovary morphology	"malformed female reproductive gland containing the germ cells" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:35782]	Show Allelic Composition: Zic3^Bn/Zic3^Bn Genetic Background: BNT/LeJ
MP:0001132	absent mature ovarian follicles	"failure of ovarian follicle differentiation" [J:35782]	Show Allelic Composition: Egr1^tm1Pch/Egr1^tm1Pch Genetic Background: involves: 129S2/SvPas * C57BL/6J
MP:0001134	absent corpora lutea	"missing yellow endocrine body formed in the ovary after follicle rupture" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:35782]	Show Allelic Composition: Zic3^Bn/Zic3^Bn Genetic Background: BNT/LeJ Allelic Composition: Egr1^tm1Pch/Egr1^tm1Pch Genetic Background: involves: 129S2/SvPas * C57BL/6J
MP:0001153	small seminiferous tubules	"reduced diameter of the tubules in the testes where spermatogenesis occurs" [J:50844]	Show Allelic Composition: Egr1^tm1Pch/Egr1^tm1Pch Genetic Background: involves: 129S2/SvPas * C57BL/6J
MP:0001157	small seminal gland	"reduced size, compared to the norm, of one of the two folded, sac shaped, glands that is a diverticulum of the ductus deferens " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Egr1^tm1Pch/Egr1^tm1Pch Genetic Background: involves: 129S2/SvPas * C57BL/6J
MP:0001245	thick dermal layer	"increased depth of the dermis" [J:65033]	Show Allelic Composition: Egr1^tm1Jmi/Egr1^tm1Jmi Genetic Background: involves: 129 * C57BL/6
MP:0001258	decreased body length	"decreased crown to tail distance compared to controls" [cwg:Carroll W. Goldsmith, Mouse Genome Informatics Curator]	Show Allelic Composition: Cecr2^{tm2b(EUCOMM)Hmgu}/Cecr2⁺ Genetic Background: C57BL/6N-Cecr2^{tm2b(EUCOMM)Hmgu}/Tcp
MP:0001262	decreased body weight	"lower than normal average weight " [J:61295]	Show Allelic Composition: Zic3^Bn/Zic3^Bn Genetic Background: BNT/LeJ
MP:0001265	reduced body size	"smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]	Show Allelic Composition: Zic3^Bn/Zic3^Bn Genetic Background: BNT/LeJ
MP:0001312	abnormal cornea morphology	"malformation or absence of the transparent anterior portion of the fibrous coat of the eye that serves as the chief refractory structure " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]	Show Allelic Composition: Prnp^tm2Edin/Prnp^tm2Edin Genetic Background: B6.129P2-Prnp^tm2Edin
MP:0001573	abnormal circulating alanine transaminase level	"aberrent concentration in the blood of this enzyme, whcih transfers amino groups from l-alanine to 2-ketoglutarate, or the reverse (from l-glutamate to pyruvate); serum concentration is increased in viral hepatitis and myocardial infarction" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Prnp^tm2Edin/Prnp^tm2Edin Genetic Background: B6.129P2-Prnp^tm2Edin Allelic Composition: Egr1^tm1Jmi/Egr1^tm1Jmi Genetic Background: involves: 129 * C57BL/6
MP:0001577	anemia	"less than normal levels of red blood cells, hemoglobin or volume of packed red blood cells " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:53370]	Show Allelic Composition: Egr1^tm1Jmi/Egr1^tm1Jmi Genetic Background: involves: 129 * C57BL/6
MP:0001697	abnormal embryo size	"anomalous proportions of embryo compared to littermates" [cwg:Carroll W. Goldsmith, Mouse Genome Informatics Curator]	Show Allelic Composition: Cecr2^{tm2b(EUCOMM)Hmgu}/Cecr2⁺ Genetic Background: C57BL/6N-Cecr2^{tm2b(EUCOMM)Hmgu}/Tcp
MP:0001732	postnatal growth retardation	"slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Egr1^tm1Pch/Egr1^tm1Pch Genetic Background: involves: 129S2/SvPas * C57BL/6J Allelic Composition: Egr1^tm1Jmi/Egr1^tm1Jmi Genetic Background: involves: 129 * C57BL/6
MP:0001746	abnormal pituitary secretion	"altered ability of the pituitary to release its products" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Egr1^tm1Pch/Egr1^tm1Pch Genetic Background: involves: 129S2/SvPas * C57BL/6J
MP:0001764	abnormal homeostasis	"anomaly in the state of equilibrium in the body with respect to various functions and to chemical composition of the fluids and tissues" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Prnp^tm2Edin/Prnp^tm2Edin Genetic Background: B6.129P2-Prnp^tm2Edin
MP:0001860	liver inflammation	"local accumulation of fluid, plasma proteins, and leukocytes in the liver" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]	Show Allelic Composition: Prnp^tm2Edin/Prnp^tm2Edin Genetic Background: B6.129P2-Prnp^tm2Edin
MP:0001861	lung inflammation	"local accumulation of fluid, plasma proteins, and leukocytes in the lung" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]	Show Allelic Composition: Apoe^tm1Unc/Apoe^tm1Unc,Egr1^tm1Jmi/Egr1^tm1Jmi Genetic Background: involves: 129 * C57BL/6
MP:0001876	decreased inflammatory response	"less than expected response to injury, infection, or insult" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Egr1^tm1Jmi/Egr1^tm1Jmi Genetic Background: involves: 129 * C57BL/6
MP:0001919	abnormal reproductive system physiology	"anomaly in the function of the organs associated with producing offspring " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Zic3^Bn/Zic3^Bn Genetic Background: BNT/LeJ
MP:0001925	male infertility	"inability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]	Show Allelic Composition: Egr1^tm1Pch/Egr1^tm1Pch Genetic Background: involves: 129S2/SvPas * C57BL/6J Allelic Composition: Egr1^{tm1b(NCOM)Mfgc}/Egr1^{tm1b(NCOM)Mfgc} Genetic Background: C57BL/6N-Egr1^{tm1b(NCOM)Mfgc}/Tcp
MP:0001926	female infertility	"inability of female to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:34193]	Show Allelic Composition: Zic3^Bn/Zic3^Bn Genetic Background: BNT/LeJ Allelic Composition: Egr1^tm1Pch/Egr1^tm1Pch Genetic Background: involves: 129S2/SvPas * C57BL/6J Allelic Composition: Egr1^tm1The/Egr1^tm1The Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 Allelic Composition: Egr1^{tm1b(NCOM)Mfgc}/Egr1^{tm1b(NCOM)Mfgc} Genetic Background: C57BL/6N-Egr1^{tm1b(NCOM)Mfgc}/Tcp
MP:0001928	abnormal ovulation	"aberration in the release of an ovum from a rupturing Graafin follicle, normally regulated by a surge in lutenizing hormone" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Zic3^Bn/Zic3^Bn Genetic Background: BNT/LeJ Allelic Composition: Egr1^tm1Pch/Egr1^tm1Pch Genetic Background: involves: 129S2/SvPas * C57BL/6J
MP:0002024	T cell derived lymphoma	"group of heterogeneous lymphoid tumors representing malignant transformations of T-lymphocytes" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Egr1^tm1Jmi/Egr1^tm1Jmi Genetic Background: involves: 129 * C57BL/6
MP:0002051	skin papilloma	"a circumscribed, benign epithelial tumor projecting from the surrounding surface" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Egr1^tm1Jmi/Egr1^tm1Jmi Genetic Background: involves: 129 * C57BL/6
MP:0002052	decreased tumor incidence	"less than the expected number of abnormal growths in a specific population" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Apoe^tm1Unc/Apoe^tm1Unc,Egr1^tm1Jmi/Egr1^tm1Jmi Genetic Background: involves: 129 * C57BL/6
MP:0002083	premature death	"death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Apoe^tm1Unc/Apoe^tm1Unc,Egr1^tm1Jmi/Egr1^tm1Jmi Genetic Background: involves: 129 * C57BL/6
MP:0002090	abnormal vision	"inability or decreased ability to see " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Egr1^tm1Jmi/Egr1^tm1Jmi Genetic Background: involves: 129 * C57BL/6
MP:0002092	abnormal eye morphology	"abnormal development of the eye tissues resulting in morphological abnormality or abnormal structure of the visual system" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Prnp^tm2Edin/Prnp^tm2Edin Genetic Background: B6.129P2-Prnp^tm2Edin
MP:0002270	abnormal alveoli morphology	"any structural anomaly of the outpouching of the respiratory system where gas exchange occurs" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Apoe^tm1Unc/Apoe^tm1Unc,Egr1^tm1Jmi/Egr1^tm1Jmi Genetic Background: involves: 129 * C57BL/6
MP:0002566	abnormal sexual interaction	"altered initiation, failure of initiation or incomplete mating behavior" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Zic3^Bn/Zic3^Bn Genetic Background: BNT/LeJ
MP:0002637	small uterus	"reduced size of the female muscular organ of gestation" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Egr1^tm1Pch/Egr1^tm1Pch Genetic Background: involves: 129S2/SvPas * C57BL/6J
MP:0002687	oligozoospermia	"reduced concentration of spermatozoa " [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:57312]	Show Allelic Composition: Egr1^tm1Pch/Egr1^tm1Pch Genetic Background: involves: 129S2/SvPas * C57BL/6J
MP:0002697	abnormal eye size	"anomalous bulk of the organ of vision" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Egr1^tm1Jmi/Egr1^tm1Jmi Genetic Background: involves: 129 * C57BL/6
MP:0002764	short tibia	" reduced length of the medial and larger bone of the lower leg" [J:12736, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]	Show Allelic Composition: Cecr2^{tm2b(EUCOMM)Hmgu}/Cecr2⁺ Genetic Background: C57BL/6N-Cecr2^{tm2b(EUCOMM)Hmgu}/Tcp
MP:0002774	small prostate	"reduced size of the gland in males that secretes part of the seminiferous fluid" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]	Show Allelic Composition: Egr1^tm1Pch/Egr1^tm1Pch Genetic Background: involves: 129S2/SvPas * C57BL/6J
MP:0002780	decreased circulating testosterone level	"less than the normal blood concentration of this most potent androgen" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Egr1^tm1Pch/Egr1^tm1Pch Genetic Background: involves: 129S2/SvPas * C57BL/6J
MP:0002801	abnormal long-term recognition memory	"defects in long-term memory for objects that is consolidated over hours and days after training." [CFG:Center for Functional Genomics , Northwestern University]	Show Allelic Composition: Stat3^tm1Flv/Stat3^tm1Flv,Tg(Tek-cre)1Xyfu/0 Genetic Background: involves: C57BL/6
MP:0002908	delayed wound healing	"longer time requirement for the ability to self-repair and close wounds than normal" [J:63037]	Show Allelic Composition: Egr1^tm1Jmi/Egr1^tm1Jmi Genetic Background: involves: 129 * C57BL/6
MP:0003141	cardiac fibrosis	"formation of fibrous tissue within the heart often resulting from inflammation or injury " [smb:Susan M Bello, Mouse Genome Informatics Curator]	Show Allelic Composition: Zic3^Bn/Zic3^Bn Genetic Background: BNT/LeJ
MP:0003179	decreased platelet count	"fewer than the normal numbers of the non-nucleated cells found in the blood and involved in blood coagulation " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, hdene:Howard Dene , Mouse Genome Informatics Curator, J:93052]	Show Allelic Composition: Egr1^tm1Jmi/Egr1^tm1Jmi Genetic Background: involves: 129 * C57BL/6
MP:0003232	abnormal forebrain development	"anomaly in the formation or patterning of the anterior primitive cerebral vesicle; most rostral of three primary vesicles of the embryonic neural tube" [J:93081, smb:Susan M Bello, Mouse Genome Informatics Curator]	Show Allelic Composition: Cecr2^{tm2b(EUCOMM)Hmgu}/Cecr2⁺ Genetic Background: C57BL/6N-Cecr2^{tm2b(EUCOMM)Hmgu}/Tcp Allelic Composition: Egr1^{tm1b(NCOM)Mfgc}/Egr1^{tm1b(NCOM)Mfgc} Genetic Background: C57BL/6N-Egr1^{tm1b(NCOM)Mfgc}/Tcp
MP:0003426	pulmonary interstitial fibrosis	"formation of fibrous tissue within the interstices of the lung as a result of repair or a reactive process" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, J:63134]	Show Allelic Composition: Egr1^tm1Jmi/Egr1^tm1Jmi Genetic Background: involves: 129 * C57BL/6
MP:0003642	absent seminal gland	"absence of the two folded, sac shaped, glands that is a diverticulum of the ductus deferens " [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]	Show Allelic Composition: Egr1^{tm1b(NCOM)Mfgc}/Egr1^{tm1b(NCOM)Mfgc} Genetic Background: C57BL/6N-Egr1^{tm1b(NCOM)Mfgc}/Tcp
MP:0003691	abnormal microglial cell function	"anomalous activity of the small neuroglial cells, possibly of mesodermal origin, which may become phagocytic, in areas of neural damage or inflammation" [hdene:Howard Dene , Mouse Genome Informatics Curator]	Show Allelic Composition: Egr1^tm1Jmi/Egr1^tm1Jmi Genetic Background: involves: 129 * C57BL/6
MP:0003720	abnormal neural tube closure	"abnormal invagination and fusion of the neuroepithelial layer in early development" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator, J:99099]	Show Allelic Composition: Cecr2^{tm2b(EUCOMM)Hmgu}/Cecr2⁺ Genetic Background: C57BL/6N-Cecr2^{tm2b(EUCOMM)Hmgu}/Tcp Allelic Composition: Egr1^{tm1b(NCOM)Mfgc}/Egr1^{tm1b(NCOM)Mfgc} Genetic Background: C57BL/6N-Egr1^{tm1b(NCOM)Mfgc}/Tcp
MP:0003864	abnormal midbrain development	"anomaly in the formation of or the patterning of the part of the brainstem developing from the middle of the three primary cerebral vesicles of the embryo" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]	Show Allelic Composition: Cecr2^{tm2b(EUCOMM)Hmgu}/Cecr2⁺ Genetic Background: C57BL/6N-Cecr2^{tm2b(EUCOMM)Hmgu}/Tcp Allelic Composition: Egr1^{tm1b(NCOM)Mfgc}/Egr1^{tm1b(NCOM)Mfgc} Genetic Background: C57BL/6N-Egr1^{tm1b(NCOM)Mfgc}/Tcp
MP:0004046	abnormal mitosis	"anomaly in the process of cell division including both division of the nucleus (karyokinesis) and the cytoplasm (cytokinesis) " [smb:Susan M Bello, Mouse Genome Informatics Curator]	Show Allelic Composition: Egr1^tm1Jmi/Egr1^tm1Jmi Genetic Background: involves: 129 * C57BL/6
MP:0004499	increased incidence of chemically-induced tumors	"higher than normal frequency of tumor incidence induced by one or more chemical carcinogens or mutagens" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]	Show Allelic Composition: Egr1^tm1Jmi/Egr1^tm1Jmi Genetic Background: involves: 129 * C57BL/6
MP:0004759	decreased mitotic index	"decreased number of cells in G2/M phase" [Bertram_Weiss:Bayer_Schering_Pharma_AG]	Show Allelic Composition: Egr1^tm1Jmi/Egr1^tm1Jmi Genetic Background: involves: 129 * C57BL/6
MP:0004808	abnormal hematopoietic stem cell morphology	"any structural anomaly of the multipotent, self-renewing stem cells found in the bone marrow and the fetal liver; these give rise to all the types of both the myeloid and lymphoid cell lineages" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Egr1^tm1Jmi/Egr1^tm1Jmi Genetic Background: involves: 129 * C57BL/6
MP:0004848	abnormal liver size	"anomaly in the average size of the liver " [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Egr1^tm1Jmi/Egr1^tm1Jmi Genetic Background: involves: 129 * C57BL/6
MP:0004852	decreased testis weight	"reduced average weight of the male reproductive glands" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Egr1^tm1Pch/Egr1^tm1Pch Genetic Background: involves: 129S2/SvPas * C57BL/6J
MP:0004883	abnormal blood vessel healing	"anomaly in the repair process of blood vessels after injury" [MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]	Show Allelic Composition: Zic3^Bn/Zic3^Bn Genetic Background: BNT/LeJ
MP:0004896	abnormal endometrium morphology	"any structural anomaly of the glandular mucous membrane lining of the uterine cavity that is hormonally responsive during the estrous/menstrual cycle and during pregnancy" [MESH:A05.360.319.679.490, MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]	Show Allelic Composition: Egr1^tm1Pch/Egr1^tm1Pch Genetic Background: involves: 129S2/SvPas * C57BL/6J
MP:0004905	decreased uterus weight	"reduction in the weight of the female organ of gestation" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Zic3^Bn/Zic3^Bn Genetic Background: BNT/LeJ
MP:0004952	increased spleen weight	"greater than average weight of the organ that functions to filter blood and to store red corpuscles and platelets" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Egr1^tm1Jmi/Egr1^tm1Jmi Genetic Background: involves: 129 * C57BL/6
MP:0004984	increased osteoclast cell number	"greater than average number of the bone resorpting cells that remove bone tissue by degrading the mineralized matrix" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Prnp^tm2Edin/Prnp^tm2Edin Genetic Background: B6.129P2-Prnp^tm2Edin
MP:0005013	increased lymphocyte number	"greater than normal white blood cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Egr1^tm1Jmi/Egr1^tm1Jmi Genetic Background: involves: 129 * C57BL/6
MP:0005065	abnormal neutrophil morphology	"structural anomaly of the granular leukocytes that have a three- to five-lobed nucleus and a cytoplasm that contains inconspicuous granules stainable by neutral dyes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Egr1^tm1Jmi/Egr1^tm1Jmi Genetic Background: involves: 129 * C57BL/6
MP:0005132	decreased luteinizing hormone level	"lower than normal concentration of LH " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Zic3^Bn/Zic3^Bn Genetic Background: BNT/LeJ
MP:0005136	decreased growth hormone level	"less than the expected concentration of the hormone that promotes body growth, fat mobilization, and inhibition of glucose utilization" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Egr1^tm1Pch/Egr1^tm1Pch Genetic Background: involves: 129S2/SvPas * C57BL/6J
MP:0005164	abnormal response to injury	"anomaly in the body s reaction to trauma, especially that by physical means" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Egr1^tm1Jmi/Egr1^tm1Jmi Genetic Background: involves: 129 * C57BL/6
MP:0005184	abnormal circulating progesterone level	"aberration in the blood concentration of this antiestrogenic steroid" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Zic3^Bn/Zic3^Bn Genetic Background: BNT/LeJ
MP:0005340	altered susceptibility to atherosclerosis	"a change in the likelihood that an organism will develop thickening and loss of elasticity of arterial walls, involving lipid deposition and thickening of intimal layers within arteries" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Apoe^tm1Unc/Apoe^tm1Unc,Egr1^tm1Jmi/Egr1^tm1Jmi Genetic Background: involves: 129 * C57BL/6
MP:0005517	decreased liver regeneration	"less than the normal ability of liver to regenerate healthy tissue following partial hepatectomy" [RGD:Rat Genome Database submission, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Egr1^tm1Jmi/Egr1^tm1Jmi Genetic Background: involves: 129 * C57BL/6
MP:0005536	Leydig cell hypoplasia	"reduced numbers of the interstitial cells of the seminiferous tubules that secrete testosterone" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]	Show Allelic Composition: Egr1^tm1Pch/Egr1^tm1Pch Genetic Background: involves: 129S2/SvPas * C57BL/6J
MP:0005602	decreased angiogenesis	"reduced process of blood vessel formation and the subsequent remodeling process; does not refer to the initial establishment of the vascular network" [RGD:Rat Genome Database submission]	Show Allelic Composition: Apoe^tm1Unc/Apoe^tm1Unc,Egr1^tm1Jmi/Egr1^tm1Jmi Genetic Background: involves: 129 * C57BL/6
MP:0005656	decreased aggression	"when compared to controls, subjects exhibit less than the normal level of domineering, assaultive posture and/or hostile physical action" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, cwg:Carroll-Ann W. Goldsmith, Mouse Genome Informatics curator]	Show Allelic Composition: Egr1^tm1Pch/Egr1^tm1Pch Genetic Background: involves: 129S2/SvPas * C57BL/6J
MP:0006050	pulmonary fibrosis	"formation of fibrous tissue within the lung often resulting from inflammation or injury " [RGD:Rat Genome Database submission, smb:Susan M Bello, Mouse Genome Informatics Curator]	Show Allelic Composition: Egr1^tm1Jmi/Egr1^tm1Jmi Genetic Background: involves: 129 * C57BL/6 Allelic Composition: Egr1^tm1Jmi/Egr1^tm1Jmi,Tg(Scgb1a1-rtTA,-tTS,tetO-TGFB1)1Eli/? Genetic Background:* involves: 129 * C57BL/6
MP:0006058	decreased cerebral infarction size	"decreased size of necrotic area of the cerebrum resulting from a sudden insufficiency of arterial or venous blood supply " [RGD:Rat Genome Database submission, smb:Susan M Bello, Mouse Genome Informatics Curator]	Show Allelic Composition: Egr1^tm1Jmi/Egr1^tm1Jmi Genetic Background: involves: 129 * C57BL/6
MP:0006108	abnormal hindbrain development	"anomaly in the formation or pattering of the caudal region of the brain" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:93573]	Show Allelic Composition: Cecr2^{tm2b(EUCOMM)Hmgu}/Cecr2⁺ Genetic Background: C57BL/6N-Cecr2^{tm2b(EUCOMM)Hmgu}/Tcp Allelic Composition: Egr1^{tm1b(NCOM)Mfgc}/Egr1^{tm1b(NCOM)Mfgc} Genetic Background: C57BL/6N-Egr1^{tm1b(NCOM)Mfgc}/Tcp
MP:0008246	abnormal leukocyte morphology	"any structural anomaly of nucleated cells of the myeloid or lymphoid lineages, found in blood or other tissue" [CL:0000738, MESH:A11.118.637]	Show Allelic Composition: Egr1^tm1Jmi/Egr1^tm1Jmi Genetic Background: involves: 129 * C57BL/6
MP:0008259	abnormal optic disc morphology	"any structural anomaly of the area in the retina where all of the axons of the ganglion cells exit the retina to form the optic nerve" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]	Show Allelic Composition: Egr1^{tm1b(NCOM)Mfgc}/Egr1^{tm1b(NCOM)Mfgc} Genetic Background: C57BL/6N-Egr1^{tm1b(NCOM)Mfgc}/Tcp
MP:0008329	decreased somatotroph cell number	"reduced number of an acidophilic cell of the anterior pituitary that produces growth hormone, somatotropin" [CL:0000295, MESH:A06.407.747.608.937]	Show Allelic Composition: Egr1^tm1Pch/Egr1^tm1Pch Genetic Background: involves: 129S2/SvPas * C57BL/6J
MP:0008365	adenohypophysis hypoplasia	"underdevelopment or reduced size, usually due to a reduced cell number, of the anterior lobe of the pituitary gland" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Egr1^tm1Pch/Egr1^tm1Pch Genetic Background: involves: 129S2/SvPas * C57BL/6J
MP:0008552	abnormal circulating tumor necrosis factor level	"anomaly in the amount in the blood of a serum glycoprotein produced by activated macrophages and NK cells and involved in initiating local inflammatory responses, particularly by its action on the endothelium of local blood vessels; its actions result in increased vascular permeability and induction of expression of adhesion molecules on the endothelium" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MESH:D12.644.276.374.500.800]	Show Allelic Composition: Prnp^tm2Edin/Prnp^tm2Edin Genetic Background: B6.129P2-Prnp^tm2Edin
MP:0008752	abnormal tumor necrosis factor level	"deviation from the normal levels of a serum glycoprotein produced by activated macrophages and NK cells and involved in initiating local inflammatory responses, particularly by its action on the endothelium of local blood vessels; its actions result in increased vascular permeability and induction of expression of adhesion molecules on the endothelium" [MESH:D12.644.276.374.500.800]	Show Allelic Composition: Egr1^tm1Jmi/Egr1^tm1Jmi Genetic Background: involves: 129 * C57BL/6
MP:0008872	abnormal response to xenobiotics	"any anomaly in the physiological or morphological changes induced by a foreign compound, such as changes in blood pressure, changes in hormone or protein levels or hypertrophy or hypotrophy of an organ" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]	Show Allelic Composition: Egr1^tm1Jmi/Egr1^tm1Jmi Genetic Background: involves: 129 * C57BL/6
MP:0009009	absent estrous cycle	"failure of female animals to enter or progress through their sexual cycle" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]	Show Allelic Composition: Zic3^Bn/Zic3^Bn Genetic Background: BNT/LeJ
MP:0009355	increased liver triglyceride level	"higher than normal concentration of triacylglycerols in the liver" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]	Show Allelic Composition: Egr1^tm1Jmi/Egr1^tm1Jmi Genetic Background: involves: 129 * C57BL/6
MP:0009828	delayed tumor appearance	"later onset of tumor occurence than expected, but with expected incidence" [MGI:mberry "Melissa Berry, Genetics Resources Curator"]	Show Allelic Composition: Apoe^tm1Unc/Apoe^tm1Unc,Egr1^tm1Jmi/Egr1^tm1Jmi Genetic Background: involves: 129 * C57BL/6
MP:0009829	enlarged eye anterior chamber	"increased size of the space in the eye, filled with aqueous humor, and bounded anteriorly by the cornea and a small portion of the sclera and posteriorly by a small portion of the ciliary body, the iris, and part of the crystalline lens" [MESH:A09.371.060.067, MGI:mberry "Melissa Berry, Genetics Resources Curator"]	Show Allelic Composition: Egr1^tm1Jmi/Egr1^tm1Jmi Genetic Background: involves: 129 * C57BL/6
MP:0010308	decreased tumor latency	"earlier onset of tumor occurrence than expected" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Egr1^tm1Jmi/Egr1^tm1Jmi Genetic Background: involves: 129 * C57BL/6
MP:0011110	partial preweaning lethality	"the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]	Show Allelic Composition: Egr1^{tm1b(NCOM)Mfgc}/Egr1^{tm1b(NCOM)Mfgc} Genetic Background: C57BL/6N-Egr1^{tm1b(NCOM)Mfgc}/Tcp
MP:0012432	decreased prostate gland tumor incidence	"less than the expected number of neoplams in the prostate gland occurring in a specific population in a given time period" [MGI:csmith]	Show Allelic Composition: Apoe^tm1Unc/Apoe^tm1Unc,Egr1^tm1Jmi/Egr1^tm1Jmi Genetic Background: involves: 129 * C57BL/6
MP:0013293	embryonic lethality prior to tooth bud stage	"death prior to the appearance of tooth buds (Mus: E12-E12.5)" [MGI:smb]	Show Allelic Composition: Egr1^{tm1b(NCOM)Mfgc}/Egr1^{tm1b(NCOM)Mfgc} Genetic Background: C57BL/6N-Egr1^{tm1b(NCOM)Mfgc}/Tcp
MP:0013599	Leydig cell atrophy	"acquired diminution of the interstitial cells that are found adjacent to the seminiferous tubules in the testicle and produce testosterone in the presence of luteinizing hormone (LH), associated with wasting as from death and reabsorbtion of cells, diminished cellular proliferation, decreased cellular volume, pressure, ischemia, malnutrition, reduced function or malfunction, or hormonal changes" [MGI:Anna]	Show Allelic Composition: Zic3^Bn/Zic3^Bn Genetic Background: BNT/LeJ

Interacting proteins (from Reactome)

Interactor ID

Name

Interaction type

No match

1 s.

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