ENSMUSG00000071341


Mus musculus

Features
Gene ID: ENSMUSG00000071341
  
Biological name :Egr4
  
Synonyms : Early growth response protein 4 / Egr4 / Q9WUF2
  
Possible biological names infered from orthology : early growth response 4 / Q05215
  
Species: Mus musculus
  
Chr. number: 6
Strand: -1
Band: C3
Gene start: 85511121
Gene end: 85513589
  
Corresponding Affymetrix probe sets: 10545859 (MoGene1.0st)   1449977_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000093433
NCBI entrez gene - 13656     See in Manteia.
MGI - MGI:99252
RefSeq - NM_020596
RefSeq Peptide - NP_065621
swissprot - Q3URA9
swissprot - Q9WUF2
Ensembl - ENSMUSG00000071341
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 egr4ENSDARG00000077799Danio rerio
 EGR4ENSGALG00000016086Gallus gallus
 EGR4ENSG00000135625Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Egr2 / P08152 / E3 SUMO-protein ligase EGR2 / P11161* / early growth response 2*ENSMUSG0000003786829
Egr1 / P08046 / Early growth response protein 1 / P18146* / early growth response 1*ENSMUSG0000003841826
Egr3 / P43300 / Mus musculus early growth response 3 (Egr3), transcript variant 3, mRNA. / Q06889* / early growth response 3*ENSMUSG0000003373025
Wt1 / Wilms tumor 1 homolog / P19544* / Wilms tumor 1*ENSMUSG0000001645821


Protein motifs (from Interpro)
Interpro ID Name
 IPR013087  Zinc finger C2H2-type
 IPR036236  Zinc finger C2H2 superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IEA
 cellular_componentGO:0005634 nucleus IEA
 molecular_functionGO:0003676 nucleic acid binding IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0043565 sequence-specific DNA binding IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001147 small testis "reduced size of the male reproductive glands" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:58959]
Show

Allelic Composition: Spi1tm1Ram/Spi1+
Genetic Background: involves: 129S2/SvPas

 MP:0001152 Leydig cell hyperplasia "increased number of interstitial cells of the seminiferous tubules that secrete testosterone" [J:45065]
Show

Allelic Composition: Spi1tm1Ram/Spi1+
Genetic Background: involves: 129S2/SvPas

 MP:0001156 abnormal spermatogenesis "incomplete maturation or aberrant formation of the male gametes" [J:58959]
Show

Allelic Composition: Spi1tm1Ram/Spi1+
Genetic Background: involves: 129S2/SvPas

 MP:0001925 male infertility "inability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]
Show

Allelic Composition: Spi1tm1Ram/Spi1+
Genetic Background: involves: 129S2/SvPas

 MP:0002216 abnormal seminiferous tubule morphology "malformation of the tubules in the testes where spermatogenesis occurs" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Spi1tm1Ram/Spi1+
Genetic Background: involves: 129S2/SvPas

 MP:0002687 oligozoospermia "reduced concentration of spermatozoa " [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:57312]
Show

Allelic Composition: Spi1tm1Ram/Spi1+
Genetic Background: involves: 129S2/SvPas

 MP:0004852 decreased testis weight "reduced average weight of the male reproductive glands" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Spi1tm1Ram/Spi1+
Genetic Background: involves: 129S2/SvPas

 MP:0004901 decreased male germ cell number "reduced numbers of male germ cells whether they are undifferentiated or fully differentiated" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Spi1tm1Ram/Spi1+
Genetic Background: involves: 129S2/SvPas

 MP:0005169 abnormal male meiosis "malfunction in the process of nuclear division that results in sperm with one half the normal chromosome number of the original cell" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Spi1tm1Ram/Spi1+
Genetic Background: involves: 129S2/SvPas

 MP:0005578 teratozoospermia "presence of malformed spermatozoa in the semen; malformations include the physical bending of the sperm to produce kinks or bends" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, ava:Anna V. Anagnostopoulos , Mouse Genome Informatics Curator]
Show

Allelic Composition: Spi1tm1Ram/Spi1+
Genetic Background: involves: 129S2/SvPas

 MP:0008280 male germ cell apoptosis "presence of male germs cells that undergo programmed cell death" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Spi1tm1Ram/Spi1+
Genetic Background: involves: 129S2/SvPas

 MP:0008892 abnormal sperm flagellum "any strucutral anomaly of the whiplike posterior filiform portion of the spermatozoon that provides sperm motility" [MESH:A05.360.490.890.840]
Show

Allelic Composition: Spi1tm1Ram/Spi1+
Genetic Background: involves: 129S2/SvPas

 MP:0008893 detached sperm flagellum "fragmentation of the whiplike posterior filiform portion of the spermatozoon that provides sperm motility from the sperm head" [MESH:A05.360.490.890.840, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Spi1tm1Ram/Spi1+
Genetic Background: involves: 129S2/SvPas

 MP:0009230 abnormal sperm head morphology "any structural abnormality of the head segment of the sperm cell which contains the nucleus with densely coiled chromatin fibers, and is surrounded anteriorly by the acrosome which contains enzymes used for penetrating the female egg" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Spi1tm1Ram/Spi1+
Genetic Background: involves: 129S2/SvPas

 MP:0009237 kinked sperm flagellum "a sharp bend or zigzag in the sperm tail" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Spi1tm1Ram/Spi1+
Genetic Background: involves: 129S2/SvPas

 MP:0009238 coiled sperm flagellum "abnormal twisting of the sperm flagellum into coils or spirals" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Spi1tm1Ram/Spi1+
Genetic Background: involves: 129S2/SvPas

 MP:0011750 abnormal seminiferous tubule epithelium morphology "any structural anomaly of the stratified epithelial lining of the seminiferous tubules, consisting of the developing spermatozoa and the supporting Sertoli cells, which are tall, columnar type cells that line the tubule" [MGI:csmith]
Show

Allelic Composition: Spi1tm1Ram/Spi1+
Genetic Background: involves: 129S2/SvPas

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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