Manteia

ENSMUSG00000016458

Mus musculus

Features

Gene ID:	ENSMUSG00000016458

Biological name :	Wt1

Synonyms :	Wilms tumor 1 homolog / Wt1

Possible biological names infered from orthology :	P19544 / Wilms tumor 1

Species:	Mus musculus

Chr. number:	2
Strand:	1
Band:	E2
Gene start:	105126529
Gene end:	105173616

Corresponding Affymetrix probe sets:	10474295 (MoGene1.0st) 1425995_s_at (Mouse Genome 430 2.0 Array)

Cross references:	Ensembl peptide - ENSMUSP00000106728 Ensembl peptide - ENSMUSP00000150563 Ensembl peptide - ENSMUSP00000123592 Ensembl peptide - ENSMUSP00000120702 Ensembl peptide - ENSMUSP00000120054 Ensembl peptide - ENSMUSP00000117891 Ensembl peptide - ENSMUSP00000106727 NCBI entrez gene - 22431 See in Manteia. MGI - MGI:98968 RefSeq - NM_144783 RefSeq Peptide - NP_659032 swissprot - A2A400 swissprot - A0A1L1SU00 swissprot - A2A405 swissprot - F6Y2T6 swissprot - F6VXG5 swissprot - A2A404 swissprot - A2A401 Ensembl - ENSMUSG00000016458

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed

Ortholog prediction (from Ensembl)

Ortholog name	ID	Species
wt1a	ENSDARG00000031420	Danio rerio
wt1b	ENSDARG00000007990	Danio rerio
WT1	ENSGALG00000012115	Gallus gallus
WT1	ENSG00000184937	Homo sapiens

Paralog prediction (from Ensembl)

Paralog name	ID	Similarity(%)
Egr2 / P08152 / E3 SUMO-protein ligase EGR2 / P11161* / early growth response 2*	ENSMUSG00000037868	22
Egr1 / P08046 / Early growth response protein 1 / P18146* / early growth response 1*	ENSMUSG00000038418	21
Egr4 / Q9WUF2 / Early growth response protein 4 / Q05215* / early growth response 4*	ENSMUSG00000071341	19
Egr3 / P43300 / Mus musculus early growth response 3 (Egr3), transcript variant 3, mRNA. / Q06889* / early growth response 3*	ENSMUSG00000033730	18

Protein motifs (from Interpro)

Interpro ID	Name
IPR000976	Wilm"s tumour protein, N-terminal
IPR013087	Zinc finger C2H2-type
IPR017987	Wilm"s tumour protein
IPR036236	Zinc finger C2H2 superfamily

Gene Ontology (GO)

Type	GO ID	Term	Ev.Code
biological_process	GO:0006355	regulation of transcription, DNA-templated	IEA
cellular_component	GO:0005634	nucleus	IEA
cellular_component	GO:0005654	nucleoplasm	IEA
cellular_component	GO:0005829	cytosol	IEA
molecular_function	GO:0003676	nucleic acid binding	IEA

Pathways (from Reactome)

Pathway description

No match

Phenotype (from MGI, Zfin or HPO)

ID	Phenotype	Definition	Genetic BG
MP:0000267	abnormal cardiac development	"aberrant formation or incomplete differentiation of the heart" [MGI:cls, J:53370]	Show Allelic Composition: Lasp1^tm1Chew/Lasp1^tm1Chew Genetic Background: B6.129X1-Lasp1^tm1Chew
MP:0000277	abnormal heart shape	"malformation of the form or the patterning of the heart" [J:18048]	Show Allelic Composition: Lasp1^tm1Chew/Lasp1^tm1Chew Genetic Background: B6.129X1-Lasp1^tm1Chew
MP:0000297	abnormal endocardial cushion morphology	"malformation of the mounds of embryonic connective tissue that bulge into the embryonic atrioventricular canal; these mounds eventually fuse to form the valves between the right and left atrioventricular orifices" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Zfpm2^tm1Sho/Zfpm2^tm2Sho,Nkx2-5^tm1(cre)Rjs/Nkx2-5⁺ Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd
MP:0000520	absent kidney	"missing paired organs that excrete urine" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:49471]	Show Allelic Composition: Pax2^1Neu/Pax2⁺ Genetic Background: involves: 102 * C57BL/6
MP:0000522	cysts in kidney cortex	"abnormal membranous sacs appearing in the renal lobules, tubules and glomeruli" [J:50844]	Show Allelic Composition: Mtbp^tm1Glo/Mtbp⁺,Trp53^tm1Tyj/Trp53⁺ Genetic Background: involves: 129S2/SvPas * 129S7/SvEvBrd * C57BL/6J Allelic Composition: Wt1^tm1Mlh/Wt1⁺ Genetic Background: 129P2/OlaHsd-Wt1^tm1Mlh Allelic Composition: Wt1^tm1Mlh/Wt1⁺ Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * MF1
MP:0000527	abnormal kidney development	"anomalous differentiation of the paired organs responsible for urine secretion" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Fcgr1^tm1Jsv/Fcgr1^tm1Jsv,Fcgr2b^tm1Ttk/Fcgr2b^tm1Ttk,Fcgr3^tm1Jsv/Fcgr3^tm1Jsv Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * BALB/c * C57BL/6 Allelic Composition: Wt1^tm1Mlh/Wt1^tm1Mlh Genetic Background: involves: 129P2/OlaHsd * C57BL/6 Allelic Composition: Pax2^1Neu/Pax2⁺,Wt1^tm1Jae/Wt1⁺ Genetic Background: involves: 102 * 129S4/SvJae * C57BL/6
MP:0000528	delayed kidney development	"late onset of the induction and/or differentiation of the kidney" [J:18048]	Show Allelic Composition: App^tm2.1Tcs/App^tm2.1Tcs,Cast^tm1Tcs/Cast^tm1Tcs Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0000530	abnormal kidney vasculature	"malformation or malfunctioning of the blood vessel network of the organ of excretion" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:tc]	Show Allelic Composition: Prox1^tm2Gco/Prox1⁺,Tg(Tek-cre)1Ywa/0 Genetic Background: involves: 129S1/Sv * C57BL/6 * NMRI * SJL
MP:0000596	abnormal liver development	"anomalous differentiation of the liver" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Lasp1^tm1Chew/Lasp1^tm1Chew Genetic Background: B6.129X1-Lasp1^tm1Chew
MP:0000600	liver hypoplasia	"reduced size of liver due to decreased cell number " [J:57631]	Show Allelic Composition: Lasp1^tm1Chew/Lasp1^tm1Chew Genetic Background: B6.129X1-Lasp1^tm1Chew
MP:0000690	absent spleen	"missing organ that functions to filter blood and to store red corpuscles and platelets" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:55583]	Show Allelic Composition: Eng^tm1Mle/Eng^tm1Mle Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0001145	abnormal male reproductive anatomy	"anomalous structure of the organs associated with producing offspring in the gender that produces spermatozoa" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Wt1^tm2.1Vih/Wt1⁺ Genetic Background: involves: 129S7/SvEvBrd * C57BL/6
MP:0001146	abnormal testis morphology	"anomalous structure of the male reproductive glands" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Wt1^tm2.1Vih/Wt1⁺ Genetic Background: involves: 129S7/SvEvBrd * C57BL/6
MP:0001147	small testis	"reduced size of the male reproductive glands" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:58959]	Show Allelic Composition: Prox1^tm2Gco/Prox1⁺,Tg(Tek-cre)1Ywa/0 Genetic Background: involves: 129S1/Sv * C57BL/6 * NMRI * SJL Allelic Composition: Plekha5^{Tg(AMH-cre)1Flor}/0,Wt1^tm1Jae/Wt1^tm2Vih Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6 * SJL
MP:0001176	abnormal lung development	"malformation or arrest of differentiation of the organs of respiration" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:54931]	Show Allelic Composition: Fcgr1^tm1Jsv/Fcgr1^tm1Jsv,Fcgr2b^tm1Ttk/Fcgr2b^tm1Ttk,Fcgr3^tm1Jsv/Fcgr3^tm1Jsv Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * BALB/c * C57BL/6
MP:0001178	pulmonary hypoplasia	"reduced size of the respiratory organ due to incomplete development of all or part of the organ " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Pathology , 2nd edition:ISBN 0-397-51047-0]	Show Allelic Composition: Eng^tm1Mle/Eng^tm1Mle Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0001544	abnormal cardiovascular system physiology	"anomalous function of the blood, blood vessels, and/or the heart" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Gjb6^tm1Kwi/Gjb6^tm1Kwi Genetic Background: involves: 129P2/OlaHsd
MP:0001633	poor circulation	"insufficient movement of blood throughout the body" [MGI:cls, J:45302]	Show Allelic Composition: Tg(GATA5-cre)1Krc/0,Wt1^tm1.1Ndha/Wt1^tm1Nhsn Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas
MP:0001698	reduced embryo size	"smaller proportions of embryo compared to littermates" [J:61790]	Show Allelic Composition: Wt1^tm1Mlh/Wt1^tm1Mlh Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0001785	edema	"an accumulation of an excessive amount of watery fluid in cells or intercellular tissues" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:54065]	Show Allelic Composition: Fcgr1^tm1Jsv/Fcgr1^tm1Jsv,Fcgr2b^tm1Ttk/Fcgr2b^tm1Ttk,Fcgr3^tm1Jsv/Fcgr3^tm1Jsv Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * BALB/c * C57BL/6 Allelic Composition: Tg(GATA5-cre)1Krc/0,Wt1^tm1.1Ndha/Wt1^tm1Nhsn Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas
MP:0001919	abnormal reproductive system physiology	"anomaly in the function of the organs associated with producing offspring " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Prox1^tm2Gco/Prox1⁺,Tg(Tek-cre)1Ywa/0 Genetic Background: involves: 129S1/Sv * C57BL/6 * NMRI * SJL
MP:0001925	male infertility	"inability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]	Show Allelic Composition: Prox1^tm2Gco/Prox1⁺,Tg(Tek-cre)1Ywa/0 Genetic Background: involves: 129S1/Sv * C57BL/6 * NMRI * SJL Allelic Composition: Plekha5^{Tg(AMH-cre)1Flor}/0,Wt1^tm1Jae/Wt1^tm2Vih Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6 * SJL
MP:0002080	prenatal lethality	"death anytime between fertilization and E18.5" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Psmb9^tm1Stl/Psmb9^tm1Stl,Trp53^tm1Brd/Trp53^tm1Brd Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0002083	premature death	"death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Psmb9^tm1Stl/Psmb9^tm1Stl,Trp53^tm1Brd/Trp53^tm1Brd Genetic Background: involves: 129P2/OlaHsd * C57BL/6 Allelic Composition: Wt1^tm1.1Lahe/Wt1⁺ Genetic Background: involves: 129S2/SvPas * C57BL/6 * FVB/NCrl * SJL
MP:0002085	abnormal embryonic tissue morphology	"structural abnormality or development of any embryonic tissue resulting in morphological abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Fcgr1^tm1Jsv/Fcgr1^tm1Jsv,Fcgr2b^tm1Ttk/Fcgr2b^tm1Ttk,Fcgr3^tm1Jsv/Fcgr3^tm1Jsv Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * BALB/c * C57BL/6
MP:0002169	no phenotype detected	"normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Maf^Ofl/Maf^Ofl Genetic Background: either: 102/ElH or C3H/HeH Allelic Composition: Wt1^tm1.1Jak/Wt1^tm1.1Jak Genetic Background: involves: 129S4/SvJae Allelic Composition: Wt1^tm2.1Vih/Wt1⁺ Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 Allelic Composition: Wt1^tm1Nhsn/Wt1⁺ Genetic Background: involves: 129S2/SvPas * C57BL/6
MP:0002188	small heart	"reduced size of the heart relative to average" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:67044]	Show Allelic Composition: Fcgr1^tm1Jsv/Fcgr1^tm1Jsv,Fcgr2b^tm1Ttk/Fcgr2b^tm1Ttk,Fcgr3^tm1Jsv/Fcgr3^tm1Jsv Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * BALB/c * C57BL/6
MP:0002209	germ cell depletion	"reduced numbers of any of the reproductive (generative) cells of a multicellular organism, whether they are undifferentiated or fully differentiated" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Ccnd1^tm1Dsn/Ccnd1^tm1Dsn Genetic Background: involves: 129P2/OlaHsd * C57BL/6J Allelic Composition: Wt1^tm1Asc/Wt1^tm1Asc Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J
MP:0002212	abnormal secondary sex determination	"gonadal development may or may not be normal, and the phenotype of the animal outside the gonad does not match chromosomal sex or is ambiguous" [llw2:Linda Washburn , Mouse Genome Informatics Curator]	Show Allelic Composition: Apc^Min/Apc⁺,Ccnd1^tm1Dsn/Ccnd1^tm1Dsn Genetic Background: involves: C57BL/6J Allelic Composition: Plekha5^{Tg(AMH-cre)1Flor}/0,Wt1^tm1Jae/Wt1^tm2Vih Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6 * SJL
MP:0002214	streak gonad	"impairment of genital ridge development; aplasia of gonadal tissue which is sometimes replaced with functionless tissue" [llw2:Linda Washburn , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]	Show Allelic Composition: Apc^Min/Apc⁺,Ccnd1^tm1Dsn/Ccnd1^tm1Dsn Genetic Background: involves: C57BL/6J
MP:0002216	abnormal seminiferous tubule morphology	"malformation of the tubules in the testes where spermatogenesis occurs" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Plekha5^{Tg(AMH-cre)1Flor}/0,Wt1^tm1Jae/Wt1^tm2Vih Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6 * SJL
MP:0002705	dilated renal tubules	"enlarged lumens of the loops of Henle and/or collecting ducts of the kidney" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Prox1^tm2Gco/Prox1⁺,Tg(Tek-cre)1Ywa/0 Genetic Background: involves: 129S1/Sv * C57BL/6 * NMRI * SJL
MP:0002743	glomerulonephritis	"glomerular disease characterized by diffuse inflammatory reaction that is not the acute response to infection of the kidneys" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]	Show Allelic Composition: Mtbp^tm1Glo/Mtbp⁺,Trp53^tm1Tyj/Trp53⁺ Genetic Background: involves: 129S2/SvPas * 129S7/SvEvBrd * C57BL/6J Allelic Composition: Wt1^tm1Mlh/Wt1⁺ Genetic Background: 129P2/OlaHsd-Wt1^tm1Mlh Allelic Composition: Wt1^tm1Mlh/Wt1⁺ Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * MF1
MP:0002786	abnormal Leydig cell morphology	"malformation or absence of the interstitial cells of the seminiferous tubules that secrete testosterone" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]	Show Allelic Composition: Plekha5^{Tg(AMH-cre)1Flor}/0,Wt1^tm1Jae/Wt1^tm2Vih Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6 * SJL
MP:0002871	albuminuria	"presence of excess albumin in the urine" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]	Show Allelic Composition: Wt1^tm1.1Ceng/Wt1^tm1.1Ceng,Tg(tetO-cre)LC1Bjd/0,Tg(NPHS2-rtTA2M2)1Jbk/0 Genetic Background:* involves: BALB/c * C57BL/6 * FVB/N
MP:0002962	increased protein excretion	"greater than the normal amount of serum proteins voided by the kidneys" [RGD:Rat Genome Database submission]	Show Allelic Composition: Psmb9^tm1Stl/Psmb9^tm1Stl,Trp53^tm1Brd/Trp53^tm1Brd Genetic Background: involves: 129P2/OlaHsd * C57BL/6 Allelic Composition: Wt1^tm1Mlh/Wt1⁺ Genetic Background: involves: 129P2/OlaHsd * C57BL/6 Allelic Composition: Wt1^tm1Mlh/Wt1⁺ Genetic Background: 129P2/OlaHsd-Wt1^tm1Mlh Allelic Composition: Wt1^tm1Mlh/Wt1⁺ Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * MF1 Allelic Composition: Wt1^tm1.1Lahe/Wt1⁺ Genetic Background: involves: 129S2/SvPas * C57BL/6 * FVB/NCrl * SJL
MP:0002989	small kidney	"reduced physical bulk one or both of the organs responsible for urine secretion" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Ccnd1^tm1Dsn/Ccnd1^tm1Dsn Genetic Background: involves: 129P2/OlaHsd * C57BL/6J Allelic Composition: Wt1^tm1Asc/Wt1^tm1Asc Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J Allelic Composition: Wt1^tm2Asc/Wt1^tm2Asc Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J Allelic Composition: Pax2^1Neu/Pax2⁺,Wt1^tm1Jae/Wt1⁺ Genetic Background: involves: 102 * 129S4/SvJae * C57BL/6 Allelic Composition: Col1a1^{tm2(tetO-LIN28B)Gqda}/Col1a1^{tm3(tetO-Mirlet7g/Mir21)Gqda},Gt(ROSA)26Sor^{tm1(rtTA,EGFP)Nagy}/Gt(ROSA)26Sor⁺,Wt1^{tm2(cre/ERT2)Wtp}/Wt1⁺ Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6
MP:0002995	primary sex reversal	"gonad type is not consistent with chromosomal sex" [llw2:Linda Washburn , Mouse Genome Informatics Curator]	Show Allelic Composition: Ccnd1^tm1Dsn/Ccnd1^tm1Dsn Genetic Background: involves: 129P2/OlaHsd * C57BL/6J Allelic Composition: Wt1^tm1Asc/Wt1^tm1Asc Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J
MP:0003057	abnormal epicardium morphology	"anomalous structure of the visceral layer of the pericardium that surrounds and attaches to all the surfaces of the heart" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8, ava:Anna V. Anagnostopoulos, Mouse Genome Informatics Curator]	Show Allelic Composition: Ache^tm1.1Pata/Ache^tm1.1Pata Genetic Background: involves: 129X1/SvJ
MP:0003215	renal interstitial fibrosis	"formation of fibrous tissue within the interstices of the kidney as a result of repair or a reactive process" [RGD:Rat Genome Database submission]	Show Allelic Composition: Wt1^tm2Hst/Wt1⁺ Genetic Background: chimera involves: 129P2/OlaHsd * C57BL/6JLac * CBA/CaLac
MP:0003578	absent ovary	"absence of the female reproductive gland containing the germ cells" [ncbi:Matthew Mailman, NCBI request]	Show Allelic Composition: Wt1^tm1Mlh/Wt1^tm1Mlh Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0003606	kidney failure	"cessation of renal function" [ncbi:Matthew Mailman, NCBI request]	Show Allelic Composition: Wt1^tm2Hst/Wt1⁺ Genetic Background: chimera involves: 129P2/OlaHsd * C57BL/6JLac * CBA/CaLac
MP:0003626	kidney medulla hypoplasia		Show Allelic Composition: Pax2^1Neu/Pax2⁺,Wt1^tm1Jae/Wt1⁺ Genetic Background: involves: 102 * 129S4/SvJae * C57BL/6
MP:0003675	kidney cysts	"abnormal membranous sacs in any portion of the pair of organs responsible for urine secretion" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]	Show Allelic Composition: Wt1^tm2Hst/Wt1⁺ Genetic Background: chimera involves: 129P2/OlaHsd * C57BL/6JLac * CBA/CaLac Allelic Composition: Col1a1^{tm2(tetO-LIN28B)Gqda}/Col1a1⁺,Gt(ROSA)26Sor^{tm1(rtTA,EGFP)Nagy}/Gt(ROSA)26Sor⁺,Wt1^{tm2(cre/ERT2)Wtp}/Wt1⁺ Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6
MP:0003920	abnormal right ventricle morphology	"structural anomaly of the right lower chamber of the heart " [smb:Susan M Bello, Mouse Genome Informatics Curator]	Show Allelic Composition: Tg(GATA5-cre)1Krc/0,Wt1^tm1.1Ndha/Wt1^tm1Nhsn Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas
MP:0003924	herniated diaphragm	"protrusion of abdominal contents into the thoracic cavity through the diaphragm" [smb:Susan M Bello, Mouse Genome Informatics Curator]	Show Allelic Composition: Fcgr1^tm1Jsv/Fcgr1^tm1Jsv,Fcgr2b^tm1Ttk/Fcgr2b^tm1Ttk,Fcgr3^tm1Jsv/Fcgr3^tm1Jsv Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * BALB/c * C57BL/6 Allelic Composition: Wt1^tm1Jae/Wt1^tm1Jae Genetic Background: involves: 129S4/SvJae * C57BL/6 * MF1 Allelic Composition: Wt1^tm1.1Ndha/Wt1^tm1.1Ndha,Tg(Gata4G2-cre)#Roja/0 Genetic Background:* involves: 129P2/OlaHsd
MP:0004057	thin myocardial compact layer	"reduced thickness of the outer, dense layer of the myocardium " [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]	Show Allelic Composition: Wt1^{tm1(EGFP/cre)Wtp}/Wt1⁺,Zfpm2^tm1Sho/Zfpm2^tm2Sho Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129S7/SvEvBrd
MP:0004109	abnormal Sertoli cell development	"anomalous differentiation of cells that support germ cell differentiation in males" [llw2:Linda Washburn , Mouse Genome Informatics Curator]	Show Allelic Composition: Plekha5^{Tg(AMH-cre)1Flor}/0,Wt1^tm1Jae/Wt1^tm2Vih Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6 * SJL
MP:0004195	abnormal calyx morphology	"any structural anomaly of any of the branches of the renal pelvis that surround each renal papilla and collect urine" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]	Show Allelic Composition: Pax2^1Neu/Pax2⁺,Wt1^tm1Jae/Wt1⁺ Genetic Background: involves: 102 * 129S4/SvJae * C57BL/6
MP:0004505	decreased renal glomerulus number	"reduced number of the capillary loops of the kidney that normally function as a filtration unit" [MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]	Show Allelic Composition: Pax2^1Neu/Pax2⁺,Wt1^tm1Jae/Wt1⁺ Genetic Background: involves: 102 * 129S4/SvJae * C57BL/6
MP:0004754	abnormal kidney collecting duct	"any structural anomaly of the duct that drains fluid from the nephron and either allows bodily reabsorbtion of water or allows the fluid to drain to the bladder via the ureter; the collecting duct system also maintains acid-base homeostasis" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Pax2^1Neu/Pax2⁺,Wt1^tm1Jae/Wt1⁺ Genetic Background: involves: 102 * 129S4/SvJae * C57BL/6
MP:0005159	azoospermia	"absence of living spermatozoa " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Prox1^tm2Gco/Prox1⁺,Tg(Tek-cre)1Ywa/0 Genetic Background: involves: 129S1/Sv * C57BL/6 * NMRI * SJL
MP:0005244	hemopericardium	"bleeding into the pericardial space" [Pathology:ISBN 0-397-51047-0]	Show Allelic Composition: Fcgr1^tm1Jsv/Fcgr1^tm1Jsv,Fcgr2b^tm1Ttk/Fcgr2b^tm1Ttk,Fcgr3^tm1Jsv/Fcgr3^tm1Jsv Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * BALB/c * C57BL/6 Allelic Composition: Wt1^tm1Mlh/Wt1^tm1Mlh Genetic Background: involves: 129P2/OlaHsd * C57BL/6 Allelic Composition: Tg(GATA5-cre)1Krc/0,Wt1^tm1.1Ndha/Wt1^tm1Nhsn Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas
MP:0005264	glomerulosclerosis	"hyaline deposits or scarring within the renal glomeruli, often occurring with renal arteriosclerosis or diabetes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Psmb9^tm1Stl/Psmb9^tm1Stl,Trp53^tm1Brd/Trp53^tm1Brd Genetic Background: involves: 129P2/OlaHsd * C57BL/6 Allelic Composition: Wt1^tm2Hst/Wt1⁺ Genetic Background: chimera involves: 129P2/OlaHsd * C57BL/6JLac * CBA/CaLac Allelic Composition: Wt1^tm1Mlh/Wt1⁺ Genetic Background: involves: 129P2/OlaHsd * C57BL/6 Allelic Composition: Wt1^tm1Mlh/Wt1⁺ Genetic Background: 129P2/OlaHsd-Wt1^tm1Mlh Allelic Composition: Wt1^tm1Mlh/Wt1⁺ Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * MF1 Allelic Composition: Wt1^tm1.1Lahe/Wt1⁺ Genetic Background: involves: 129S2/SvPas * C57BL/6 * FVB/NCrl * SJL Allelic Composition: Wt1^tm1.1Ceng/Wt1^tm1.1Ceng,Tg(tetO-cre)LC1Bjd/0,Tg(NPHS2-rtTA2M2)1Jbk/0 Genetic Background:* involves: BALB/c * C57BL/6 * FVB/N
MP:0005313	absent adrenal gland	"missing endocrine glands that are normally located above the kidney and responsible for hormone and epinepherine secretion" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:56651]	Show Allelic Composition: Eng^tm1Mle/Eng^tm1Mle Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0005325	abnormal glomerulus	"anomalous structure of the capillary loops of the kidney that normally function as a filtration unit" [J:57971, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Ccnd1^tm1Dsn/Ccnd1^tm1Dsn Genetic Background: involves: 129P2/OlaHsd * C57BL/6J Allelic Composition: Wt1^tm1Asc/Wt1^tm1Asc Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J Allelic Composition: Wt1^tm2Asc/Wt1^tm2Asc Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J Allelic Composition: Wt1^tm1.1Lahe/Wt1⁺ Genetic Background: involves: 129S2/SvPas * C57BL/6 * FVB/NCrl * SJL
MP:0005326	abnormal podocytes	"anomalous structure of the foot processes of the epithelial cells of the glomerulus" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, J:57971]	Show Allelic Composition: Wt1^tm1.1Lahe/Wt1⁺ Genetic Background: involves: 129S2/SvPas * C57BL/6 * FVB/NCrl * SJL
MP:0005327	abnormal mesangial cell	"anomalous structure of the phagocytic cell in the capillary tuft of the renal glomerulus, interposed between endothelial cells and the basement membrane in the central or stalk region of the tuft" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:57971]	Show Allelic Composition: Wt1^tm2Hst/Wt1⁺ Genetic Background: chimera involves: 129P2/OlaHsd * C57BL/6JLac * CBA/CaLac Allelic Composition: Wt1^tm1Mlh/Wt1⁺ Genetic Background: involves: 129P2/OlaHsd * C57BL/6 Allelic Composition: Wt1^tm1Mlh/Wt1⁺ Genetic Background: 129P2/OlaHsd-Wt1^tm1Mlh Allelic Composition: Wt1^tm1Mlh/Wt1⁺ Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * MF1 Allelic Composition: Wt1^tm1.1Lahe/Wt1⁺ Genetic Background: involves: 129S2/SvPas * C57BL/6 * FVB/NCrl * SJL
MP:0005644	agonadal	"denoting the absence of gonads" [llw2:Linda Washburn , Mouse Genome Informatics Curator]	Show Allelic Composition: Wt1^tm1Mlh/Wt1^tm1Mlh Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0006301	abnormal mesenchyme morphology	"abnormality in the loosely packed, unspecialized cells that derive mostly from the mesoderm and contribute to connective tissue, bone, cartilage and circulatory and lymphatic systems." [J:120305, mnk:Michelle Knowlton_MGI Curator]	Show Allelic Composition: Wt1^tm1.1Ndha/Wt1^tm1.1Ndha,Tg(Gata4G2-cre)#Roja/0 Genetic Background:* involves: 129P2/OlaHsd Allelic Composition: Wt1^tm1Jae/Wt1^tm1Jae Genetic Background: involves: 129S4/SvJae
MP:0006415	absent testes	"absence of the male reproductive glands containing the germ cells" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]	Show Allelic Composition: Wt1^tm1Mlh/Wt1^tm1Mlh Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0008138	absent podocyte foot process	"absence of the footlike extension of podocytes that interdigitate with one another to form the walls of the glomerular capillaries" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]	Show Allelic Composition: Wt1^tm2Hst/Wt1⁺ Genetic Background: chimera involves: 129P2/OlaHsd * C57BL/6JLac * CBA/CaLac
MP:0008140	podocyte foot process effacement	"thinning of the footlike extension of podocytes that interdigitate with one another to form the walls of the glomerular capillaries" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]	Show Allelic Composition: Psmb9^tm1Stl/Psmb9^tm1Stl,Trp53^tm1Brd/Trp53^tm1Brd Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0009322	increased splenocyte apoptosis	"increase in the number of spleen cells undergoing programmed cell death" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]	Show Allelic Composition: Wt1^tm1Jae/Wt1^tm1Jae Genetic Background: involves: 129S4/SvJae * C57BL/6 * MF1
MP:0009323	abnormal spleen development	"aberrant formation or incomplete differentiation of the organ that filters blood and stores red corpuscles and platelets" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]	Show Allelic Composition: Wt1^tm1Jae/Wt1^tm1Jae Genetic Background: involves: 129S4/SvJae * C57BL/6 * MF1
MP:0010118	abnormal intermediate mesoderm	"any anomaly of the band of mesoderm located between the segmented paraxial mesoderm and the lateral plate mesoderm, that develops into the nephrogenic cord" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]	Show Allelic Composition: Wt1^tm1.1Ndha/Wt1^tm1.1Ndha,Tg(Gata4G2-cre)#Roja/0 Genetic Background:* involves: 129P2/OlaHsd
MP:0010294	increased kidney tumor incidence	"greater than the expected number of tumors originating in the kidney in a given population in a given time period" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Col1a1^{tm2(tetO-LIN28B)Gqda}/Col1a1⁺,Gt(ROSA)26Sor^{tm1(rtTA,EGFP)Nagy}/Gt(ROSA)26Sor⁺,Wt1^{tm2(cre/ERT2)Wtp}/Wt1⁺ Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6
MP:0010500	myocardium hypoplasia	"underdevelopment or reduced size, usually due to a reduced number of cells, of the heart myocardium" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Wt1^tm1Mlh/Wt1^tm1Mlh Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0010551	abnormal coronary vessel morphology	"any structural anomaly of any of the arteries or veins that supply blood to the heart or return blood from the heart muscles to the circulation" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Wt1^tm1.1Ndha/Wt1^tm1.1Ndha,Tg(Gata4G2-cre)#Roja/0 Genetic Background:* involves: 129P2/OlaHsd Allelic Composition: Wt1^tm1.1Ndha/Wt1^tm1.1Ndha,Tg(Tek-cre/ERT2)1Arnd/0 Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2
MP:0010556	thin ventricle myocardium compact layer	"reduced thickness of the ventricular portion of the outer, dense layer of the myocardium" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Wt1^tm1.1Ndha/Wt1^tm1.1Ndha,Tg(Gata4G2-cre)#Roja/0 Genetic Background:* involves: 129P2/OlaHsd
MP:0010819	primary atelectasis	"nonexpansion of the lungs after birth, seen in stillborn organisms and in live born animals that do not establish respiration" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]	Show Allelic Composition: Wt1^tm1Jae/Wt1^tm1Jae Genetic Background: involves: 129S4/SvJae * C57BL/6 * MF1 Allelic Composition: Wt1^tm1Jae/Wt1^tm1Jae Genetic Background: involves: 129S4/SvJae * C3H * C57BL/6
MP:0010985	abnormal kidney mesenchyme morphology	"any structural anomaly of the embryonic connective tissue made up of loosely aggregated mesenchymal cells, supported by interlaminar jelly, in the developing kidney" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Col1a1^{tm2(tetO-LIN28B)Gqda}/Col1a1⁺,Gt(ROSA)26Sor^{tm1(rtTA,EGFP)Nagy}/Gt(ROSA)26Sor⁺,Wt1^{tm2(cre/ERT2)Wtp}/Wt1⁺ Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6
MP:0011086	partial postnatal lethality	"the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]	Show Allelic Composition: Pax2^1Neu/Pax2⁺,Wt1^tm1Jae/Wt1⁺ Genetic Background: involves: 102 * 129S4/SvJae * C57BL/6
MP:0011087	complete neonatal lethality	"death of all organisms of a given genotype in a population within the neonatal period after birth (Mus: P0)" [MGI:csmith]	Show Allelic Composition: Wt1^tm1Jae/Wt1^tm1Jae Genetic Background: involves: 129S4/SvJae * C57BL/6 * MF1 Allelic Composition: Wt1^tm1Jae/Wt1^tm1Jae Genetic Background: involves: 129S4/SvJae * C3H * C57BL/6 Allelic Composition: Wt1^tm1Asc/Wt1⁺ Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 Allelic Composition: Wt1^tm1Asc/Wt1^tm1Asc Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J Allelic Composition: Wt1^tm2Asc/Wt1^tm2Asc Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J
MP:0011089	complete perinatal lethality	"death of all organisms of a given genotype in a population within the perinatal period (Mus: E18.5 through postnatal day 1)" [MGI:csmith]	Show Allelic Composition: Wt1^tm1Jae/Wt1^tm1Jae Genetic Background: involves: 129S4/SvJae * C57BL/6 * MF1 Allelic Composition: Wt1^tm1Nhsn/Wt1^tm1Nhsn Genetic Background: involves: 129S2/SvPas * C57BL/6 Allelic Composition: Wt1^{tm1(EGFP/cre)Wtp}/Wt1⁺,Zfpm2^tm1Sho/Zfpm2^tm2Sho Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129S7/SvEvBrd
MP:0011092	complete embryonic lethality	"death of all organisms of a given genotype in a population within the embryonic period prior to organogenesis (Mus: prior to E14)" [MGI:csmith]	Show Allelic Composition: Xpc^tm1Brd/Xpc^tm1Brd Genetic Background: involves: 129S7/SvEvBrd * C57BL
MP:0011099	complete lethality throughout fetal growth and development	"death of all organisms of a given genotype in a population between the completion of organogenesis and birth (Mus: E14 to approximately E18.5)" [MGI:csmith]	Show Allelic Composition: Fcgr1^tm1Jsv/Fcgr1^tm1Jsv,Fcgr2b^tm1Ttk/Fcgr2b^tm1Ttk,Fcgr3^tm1Jsv/Fcgr3^tm1Jsv Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * BALB/c * C57BL/6 Allelic Composition: Wt1^tm2.1Vih/Wt1^tm2.1Vih Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 Allelic Composition: Wt1^tm1Mlh/Wt1^tm1Mlh Genetic Background: involves: 129P2/OlaHsd * C57BL/6 Allelic Composition: Tg(GATA5-cre)1Krc/0,Wt1^tm1.1Ndha/Wt1^tm1Nhsn Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas
MP:0011101	partial prenatal lethality	"the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith]	Show Allelic Composition: Wt1^tm1Jae/Wt1^tm1Jae Genetic Background: involves: 129S4/SvJae * C57BL/6 * MF1
MP:0011108	partial embryonic lethality during organogenesis	"the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]	Show Allelic Composition: Wt1^tm1Mlh/Wt1^tm1Mlh Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0011109	partial lethality throughout fetal growth and development	"the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between the completion of organogenesis and birth (Mus: E14 to approximately E18.5)" [MGI:csmith]	Show Allelic Composition: Pax2^1Neu/Pax2⁺,Wt1^tm1Jae/Wt1⁺ Genetic Background: involves: 102 * 129S4/SvJae * C57BL/6 Allelic Composition: Wt1^tm1.1Ndha/Wt1^tm1.1Ndha,Tg(Gata4G2-cre)#Roja/0 Genetic Background:* involves: 129P2/OlaHsd
MP:0011290	decreased nephron number	"reduction in the total number of filtering units of the kidney" [MGI:anna]	Show Allelic Composition: Pax2^1Neu/Pax2⁺,Wt1^tm1Jae/Wt1⁺ Genetic Background: involves: 102 * 129S4/SvJae * C57BL/6
MP:0011301	juxtaglomerular cell hyperplasia	"increased number of the specialized smooth muscle cells that synthesize, store, and secrete renin and are found in the wall of each afferent arteriole of a kidney glomerulus near its point of entry adjacent to a macula densa" [MGI:anna]	Show Allelic Composition: Wt1^tm1Mlh/Wt1⁺ Genetic Background: involves: 129P2/OlaHsd * C57BL/6 Allelic Composition: Wt1^tm1Mlh/Wt1⁺ Genetic Background: 129P2/OlaHsd-Wt1^tm1Mlh Allelic Composition: Wt1^tm1Mlh/Wt1⁺ Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * MF1
MP:0011316	abnormal kidney interlobular artery morphology	"any structural anomaly of the branches of the arcuate arteries of the kidney that radiate outward throught the renal columns and supply the glomeruli" [ISBN:0-683-40008-8]	Show Allelic Composition: Wt1^tm2Hst/Wt1⁺ Genetic Background: chimera involves: 129P2/OlaHsd * C57BL/6JLac * CBA/CaLac
MP:0011320	abnormal glomerular capillary morphology	"any structural anomaly of the small branching blood vessels in the kidney glomerulus that receives blood from the kidney afferent arterioles; these capillaries are under high pressure for filtering within the glomerulus" [MGI:csmith]	Show Allelic Composition: Wt1^tm2Hst/Wt1⁺ Genetic Background: chimera involves: 129P2/OlaHsd * C57BL/6JLac * CBA/CaLac
MP:0011353	expanded mesangial matrix	"increase in the amount of mesangial matrix present in the basement membrane surrounding the glomerular capillaries that also contain the intraglomerular mesangial cells" [MGI:csmith]	Show Allelic Composition: Wt1^tm2Hst/Wt1⁺ Genetic Background: chimera involves: 129P2/OlaHsd * C57BL/6JLac * CBA/CaLac Allelic Composition: Wt1^tm1Mlh/Wt1⁺ Genetic Background: involves: 129P2/OlaHsd * C57BL/6 Allelic Composition: Wt1^tm1Mlh/Wt1⁺ Genetic Background: 129P2/OlaHsd-Wt1^tm1Mlh Allelic Composition: Wt1^tm1Mlh/Wt1⁺ Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * MF1 Allelic Composition: Wt1^tm1.1Lahe/Wt1⁺ Genetic Background: involves: 129S2/SvPas * C57BL/6 * FVB/NCrl * SJL
MP:0011366	absent metanephros	"absence of the primordium of the permanent kidney, which develops later than and caudal to the mesonephros, from the mesonephric duct and nephrogenic cord" [MGI:anna]	Show Allelic Composition: Wt1^tm1Mlh/Wt1^tm1Mlh Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0011368	increased kidney apoptosis	"increase in the number of cells of the kidney undergoing programmed cell death" [MGI:anna]	Show Allelic Composition: Pax2^1Neu/Pax2⁺,Wt1^tm1Jae/Wt1⁺ Genetic Background: involves: 102 * 129S4/SvJae * C57BL/6
MP:0011386	increased metanephric mesenchyme apoptosis	"increase in the number of cells of the metanephric mesenchyme (MM) undergoing programmed cell death; usually due to failure of MM cells to interact with the ureteric bud (UB) tips after UB invasion" [MGI:anna]	Show Allelic Composition: Fcgr1^tm1Jsv/Fcgr1^tm1Jsv,Fcgr2b^tm1Ttk/Fcgr2b^tm1Ttk,Fcgr3^tm1Jsv/Fcgr3^tm1Jsv Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * BALB/c * C57BL/6
MP:0011402	renal cast	"any of the various casts formed from gelled protein precipitated in the distal convoluted tubules and collecting ducts of nephrons and molded to the tubular or duct lumen which dislodge and pass into the urine; types named for their constituent material include acellular casts (e.g. granular, hyaline, waxy, or fatty casts) and cellular casts (e.g. red or white blood cell casts)" [MGI:anna]	Show Allelic Composition: Wt1^tm1Mlh/Wt1⁺ Genetic Background: involves: 129P2/OlaHsd * C57BL/6 Allelic Composition: Wt1^tm1Mlh/Wt1⁺ Genetic Background: 129P2/OlaHsd-Wt1^tm1Mlh Allelic Composition: Wt1^tm1Mlh/Wt1⁺ Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * MF1
MP:0011409	increased renal glomerulus basement membrane thickness	"increased width of the layer of extracellular matrix that lies between the endothelium of the glomerular capillaries and the podocytes of the inner or visceral layer of the Bowman capsule" [MGI:anna]	Show Allelic Composition: Wt1^tm1.1Lahe/Wt1⁺ Genetic Background: involves: 129S2/SvPas * C57BL/6 * FVB/NCrl * SJL
MP:0011411	abnormal gonadal ridge morphology	"any structural anomaly of the elevation of thickened mesothelium and underlying mesenchyme found on the ventromedial border of the embryonic mesonephros in which the primordial germ cells become embedded, establishing it as the primordium of the testis or ovary" [MGI:anna]	Show Allelic Composition: Fcgr1^tm1Jsv/Fcgr1^tm1Jsv,Fcgr2b^tm1Ttk/Fcgr2b^tm1Ttk,Fcgr3^tm1Jsv/Fcgr3^tm1Jsv Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * BALB/c * C57BL/6
MP:0011427	mesangial cell hyperplasia	"increased number of the phagocytic cells in the capillary tuft of the renal glomerulus, interposed between endothelial cells and the basement membrane in the central or stalk region of the tuft" [MGI:anna]	Show Allelic Composition: Wt1^tm2Hst/Wt1⁺ Genetic Background: chimera involves: 129P2/OlaHsd * C57BL/6JLac * CBA/CaLac Allelic Composition: Wt1^tm1Mlh/Wt1⁺ Genetic Background: involves: 129P2/OlaHsd * C57BL/6 Allelic Composition: Wt1^tm1Mlh/Wt1⁺ Genetic Background: 129P2/OlaHsd-Wt1^tm1Mlh Allelic Composition: Wt1^tm1Mlh/Wt1⁺ Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * MF1
MP:0011430	mesangiolysis	"an injurious glomerular process that affects primarily the mesangium, starting with loosening and detachment of its matrix and progressing to dissolution/attenuation with degeneration of mesangial cells; mesangial cells may show only edema and vacuolization, or may undergo severe degeneration and necrosis" [MGI:anna]	Show Allelic Composition: Wt1^tm1.1Lahe/Wt1⁺ Genetic Background: involves: 129S2/SvPas * C57BL/6 * FVB/NCrl * SJL
MP:0011498	abnormal glomerular capsule parietal layer morphology	"any structural anomaly of the outer layer of the glomerular capsule composed of a single layer of simple squamous epithelium" [MGI:anna]	Show Allelic Composition: Wt1^tm1.1Lahe/Wt1⁺ Genetic Background: involves: 129S2/SvPas * C57BL/6 * FVB/NCrl * SJL
MP:0011500	decreased glomerular capsule space	"reduced volume of the luminal region between the glomerular capsule visceral and parietal layers, into which filtrate enters after passing through the filtration barrier from the glomerular capillaries" [MGI:csmith]	Show Allelic Composition: Wt1^tm2Hst/Wt1⁺ Genetic Background: chimera involves: 129P2/OlaHsd * C57BL/6JLac * CBA/CaLac
MP:0011506	glomerular crescent	"formation of a crescent-shaped (semi-lunar) glomerular lesion corresponding to extracapillary proliferation of Bowman s capsular epithelium and acquiring a fibroblast-like spindled morphology, possibly stimulated by release of fibrinogen from a ruptured glomerular basement membrane; epithelial crescents occur in aggressive forms of glomerulonephritis, may be accompanied by collagen and fibrin deposition and/or monocyte and macrophage proliferation, may protrude into Bowman s space, and ultimately compress and destroy the glomerular tuft" [MGI:anna]	Show Allelic Composition: Wt1^tm2Hst/Wt1⁺ Genetic Background: chimera involves: 129P2/OlaHsd * C57BL/6JLac * CBA/CaLac
MP:0011868	podocyte microvillus transformation	"aberrant formation of numerous slender cellular projections resembling microvilli or vesicle-like structures along the apical surface of podocytes, suggestive of podocyte injury" [MGI:anna]	Show Allelic Composition: Wt1^tm2Hst/Wt1⁺ Genetic Background: chimera involves: 129P2/OlaHsd * C57BL/6JLac * CBA/CaLac
MP:0011871	podocyte hypertrophy	"increase in the bulk size of the modified epithelial cell of the visceral layer of the Bowman capsule in the renal corpuscle, due to cell enlargement" [MGI:anna]	Show Allelic Composition: Wt1^tm2Hst/Wt1⁺ Genetic Background: chimera involves: 129P2/OlaHsd * C57BL/6JLac * CBA/CaLac Allelic Composition: Wt1^tm1Mlh/Wt1⁺ Genetic Background: involves: 129P2/OlaHsd * C57BL/6 Allelic Composition: Wt1^tm1Mlh/Wt1⁺ Genetic Background: 129P2/OlaHsd-Wt1^tm1Mlh Allelic Composition: Wt1^tm1Mlh/Wt1⁺ Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * MF1 Allelic Composition: Wt1^tm1.1Lahe/Wt1⁺ Genetic Background: involves: 129S2/SvPas * C57BL/6 * FVB/NCrl * SJL
MP:0012251	abnormal diaphragm development	"malformation or incomplete differentiation of the thin musculomembranous barrier separating the abdominal and thoracic cavities and functioning in respiration" [MGI:anna]	Show Allelic Composition: Wt1^tm1Jae/Wt1^tm1Jae Genetic Background: involves: 129S4/SvJae * C57BL/6 * MF1 Allelic Composition: Wt1^tm1Mlh/Wt1^tm1Mlh Genetic Background: involves: 129P2/OlaHsd * C57BL/6 Allelic Composition: Wt1^tm1.1Ndha/Wt1^tm1.1Ndha,Tg(Gata4G2-cre)#Roja/0 Genetic Background:* involves: 129P2/OlaHsd
MP:0012496	abnormal pleuropericardial membrane morphology	"any structural anomaly of the membrane formed by the paired folds that grow out from the lateral part of the body wall; the folds fuse and meet with the dorsal and ventral mesentery of the foregut, separating the pleural cavities from the pericardial cavity" [MGI:csmith, UBERON:0006278]	Show Allelic Composition: Ins2^Akita/Ins2^Akita,Itga1^tm1Gdnr/Itga1^tm1Gdnr Genetic Background: C.Cg-Ins2^Akita Itga1^tm1Gdnr
MP:0012515	abnormal heart apex morphology	"any structural anomaly of the lowest superficial part of the heart, normally directed downward, forward, and to the left, and overlapped by the left lung and pleura; the heart apex is formed by the inferolateral part of the left ventricle and responsible for regulating ventricle contraction" [MGI:anna]	Show Allelic Composition: Fcgr1^tm1Jsv/Fcgr1^tm1Jsv,Fcgr2b^tm1Ttk/Fcgr2b^tm1Ttk,Fcgr3^tm1Jsv/Fcgr3^tm1Jsv Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * BALB/c * C57BL/6 Allelic Composition: Wt1^tm1Mlh/Wt1^tm1Mlh Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0012684	abnormal pleural cavity morphology	"any structural anomaly of the potential space between the two pleurae (visceral and parietal) of the lungs; the pleural cavity, with its associated pleurae, aids optimal functioning of the lungs during breathing; it normally contains a thin film of serous fluid which lubricates the opposed pleural membranes so that they can glide smoothly against one another during ventilation" [MGI:anna]	Show Allelic Composition: Wt1^tm1.1Ndha/Wt1^tm1.1Ndha,Tg(Gata4G2-cre)#Roja/0 Genetic Background:* involves: 129P2/OlaHsd
MP:0013310	abnormal adrenal gland development	"aberrant formation or incomplete differentiation of the pair of endocrine glands located above the kidney that are responsible for steroid hormone secretion from the cortex and neurotransmitter (such as epinephrine and norepinephrine) secretion from the medulla" [MGI:anna]	Show Allelic Composition: Wt1^tm1Mlh/Wt1^tm1Mlh Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Interacting proteins (from Reactome)

Interactor ID

Name

Interaction type

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