ENSMUSG00000037868


Mus musculus

Features
Gene ID: ENSMUSG00000037868
  
Biological name :Egr2
  
Synonyms : E3 SUMO-protein ligase EGR2 / Egr2 / P08152
  
Possible biological names infered from orthology : early growth response 2 / P11161
  
Species: Mus musculus
  
Chr. number: 10
Strand: 1
Band: B5.1
Gene start: 67535475
Gene end: 67542188
  
Corresponding Affymetrix probe sets: 10363735 (MoGene1.0st)   1427682_a_at (Mouse Genome 430 2.0 Array)   1427683_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000101078
Ensembl peptide - ENSMUSP00000115709
Ensembl peptide - ENSMUSP00000118941
Ensembl peptide - ENSMUSP00000116799
Ensembl peptide - ENSMUSP00000116621
Ensembl peptide - ENSMUSP00000116502
Ensembl peptide - ENSMUSP00000041053
NCBI entrez gene - 13654     See in Manteia.
MGI - MGI:95296
RefSeq - XM_006513208
RefSeq - XM_006513210
RefSeq - XM_006513211
RefSeq - XM_006513212
RefSeq - XM_006513213
RefSeq - XM_011243367
RefSeq - XM_011243368
RefSeq - NM_010118
RefSeq - XM_006513209
RefSeq Peptide - NP_034248
RefSeq Peptide - NP_001334387
swissprot - Q3U207
swissprot - D3Z4G7
swissprot - D3Z3K7
swissprot - D3YYY2
swissprot - D3YXS2
swissprot - P08152
swissprot - D3Z4X9
Ensembl - ENSMUSG00000037868
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 egr2aENSDARG00000044098Danio rerio
 egr2bENSDARG00000042826Danio rerio
 EGR2ENSGALG00000040971Gallus gallus
 EGR2ENSG00000122877Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Egr3 / P43300 / Mus musculus early growth response 3 (Egr3), transcript variant 3, mRNA. / Q06889* / early growth response 3*ENSMUSG0000003373042
Egr1 / P08046 / Early growth response protein 1 / P18146* / early growth response 1*ENSMUSG0000003841839
Egr4 / Q9WUF2 / Early growth response protein 4 / Q05215* / early growth response 4*ENSMUSG0000007134129
Wt1 / Wilms tumor 1 homolog / P19544* / Wilms tumor 1*ENSMUSG0000001645824


Protein motifs (from Interpro)
Interpro ID Name
 IPR013083  Zinc finger, RING/FYVE/PHD-type
 IPR013087  Zinc finger C2H2-type
 IPR021849  Early growth response protein
 IPR036236  Zinc finger C2H2 superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006366 transcription by RNA polymerase II IDA
 biological_processGO:0006611 protein export from nucleus IDA
 biological_processGO:0007611 learning or memory IEA
 biological_processGO:0007622 rhythmic behavior IMP
 biological_processGO:0008045 motor neuron axon guidance IGI
 biological_processGO:0014037 Schwann cell differentiation IMP
 biological_processGO:0016925 protein sumoylation IEA
 biological_processGO:0021569 rhombomere 3 development IGI
 biological_processGO:0021612 facial nerve structural organization IGI
 biological_processGO:0021660 rhombomere 3 formation IMP
 biological_processGO:0021666 rhombomere 5 formation IMP
 biological_processGO:0030278 regulation of ossification IMP
 biological_processGO:0032868 response to insulin IEA
 biological_processGO:0035284 brain segmentation IMP
 biological_processGO:0035914 skeletal muscle cell differentiation IMP
 biological_processGO:0042552 myelination IMP
 biological_processGO:0045444 fat cell differentiation IMP
 biological_processGO:0045893 positive regulation of transcription, DNA-templated IDA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II ISO
 biological_processGO:0048168 regulation of neuronal synaptic plasticity IEA
 biological_processGO:0071310 cellular response to organic substance IDA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005737 cytoplasm IDA
 cellular_componentGO:0043231 intracellular membrane-bounded organelle ISO
 molecular_functionGO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding ISO
 molecular_functionGO:0001077 transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding ISO
 molecular_functionGO:0001102 RNA polymerase II activating transcription factor binding IPI
 molecular_functionGO:0003676 nucleic acid binding IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003682 chromatin binding IDA
 molecular_functionGO:0003700 DNA-binding transcription factor activity ISO
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0031625 ubiquitin protein ligase binding ISO
 molecular_functionGO:0044212 transcription regulatory region DNA binding IDA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0071837 HMG box domain binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000458 abnormal mandible morphology "malformation of the lower bony framework of the mouth where the inferior teeth are held" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Cenpbtm2Khac/Cenpbtm2Khac
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0000585 kinked tail "a sharp bend or zig-zag in the tail" [J:61295]
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Allelic Composition: Erbb2tm1Cbm/Erbb2tm2.1Cbm
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0000745 tremors "repetitive, cyclical movements of the body or a body part; usually involuntary, but can also manifest in response to an attempt at movement" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Cenpbtm2Khac/Cenpbtm2Khac
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

Allelic Composition: Egr2tm1Jmi/Egr2tm1Jmi
Genetic Background: Not Specified

Allelic Composition: Egr2tm4Pch/Egr2tm4Pch
Genetic Background: involves: BALB/c * C57BL/6

Allelic Composition: Egr2tm2Jmi/Egr2tm2Jmi
Genetic Background: B6.Cg-Egr2tm2Jmi

 MP:0000746 weakness "state of being infirm or less strong than littermates" [J:45400]
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Allelic Composition: Egr2tm2Jmi/Egr2tm2Jmi
Genetic Background: B6.Cg-Egr2tm2Jmi

 MP:0000753 paralysis "loss of power of voluntary movement in a muscle through injury or disease of its nerve supply" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Egr2tm4Pch/Egr2tm4Pch
Genetic Background: involves: BALB/c * C57BL/6

 MP:0000755 hindlimb paralysis "loss of power of voluntary movement in the muscles of the hindlimb through injury or disease of it or its nerve supply" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Egr2tm2Jmi/Egr2tm2Jmi
Genetic Background: B6.Cg-Egr2tm2Jmi

 MP:0000848 abnormal pons "malformed band of nerve fibers in the brain connecting the medulla oblongata and the mesencephalon; this region conveys information about movement from the cerebral hemisphere to the cerebellum" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:1776, Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
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Allelic Composition: Mapk8tm1Jcbr/Mapk8tm1Jcbr,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * SJL

Allelic Composition: Cacna1dtm1Hgn/Cacna1dtm1Hgn,Egr2tm2(cre)Pch/Egr2+
Genetic Background: involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ

Allelic Composition: Crygntm1a(EUCOMM)Wtsi/Crygntm1a(EUCOMM)Wtsi,Egr2tm2(cre)Pch/Egr2+
Genetic Background: involves: 129S2/SvPas * C57BL/6N

 MP:0000920 abnormal myelination "atypical or altered myelination in axon sheaths" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Erbb2tm1Cbm/Erbb2tm2.1Cbm
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Egr2tm1Jmi/Egr2tm1Jmi
Genetic Background: Not Specified

Allelic Composition: Egr2tm4Pch/Egr2tm4Pch
Genetic Background: involves: BALB/c * C57BL/6

Allelic Composition: Egr2tm2Jmi/Egr2tm2Jmi
Genetic Background: B6.Cg-Egr2tm2Jmi

Allelic Composition: Egr2tm2(cre)Pch/Egr2+,Ptpn11tm1.1Wbm/Ptpn11tm1.1Wbm
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6 * SJL

Allelic Composition: Egr2tm2(cre)Pch/Egr2+,Gt(ROSA)26Sortm7(Pik3ca*,EGFP)Rsky/?
Genetic Background: involves: 129S2/SvPas * C57BL/6

Allelic Composition: Egr2tm2(cre)Pch/Egr2+,Gt(ROSA)26Sortm7(Pik3ca*,EGFP)Rsky/?,Ptpn11tm1.1Wbm/Ptpn11tm1.1Wbm
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6

 MP:0000921 demyelination "loss of the myelin sheath without loss of axons or fiber tracts" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Egr2tm2(cre)Pch/?,Mnat1tm2Tpm/Mnat1tm2.1Tpm
Genetic Background: involves: 129S2/SvPas

Allelic Composition: Egr2tm2(cre)Pch/Egr2+,Erbb2tm2Cbm/Erbb2tm2Cbm
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6

 MP:0000933 abnormal rhombomere morphology "malformation of the transverse segments in the hindbrain region of the developing neural tube" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:1776]
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Allelic Composition: Cenpbtm2Khac/Cenpbtm2Khac
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0000937 abnormal motor neuron morphology "malformation or absence of cells that innervate an effector (muscle or glandular) tissue; responsible for transmission of motor impulses" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:60159]
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Allelic Composition: Gbatm2Rlp/Gbatm2Rlp
Genetic Background: involves: 129S4/SvJae

 MP:0000939 reduced motor neuron number "fewer than normal numbers of cells that innervate an effector (muscle or glandular) tissue" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:60159]
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Allelic Composition: Egr2tm2(cre)Pch/Egr2+,Ptpn11tm1.1Wbm/Ptpn11tm1.1Wbm
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6 * SJL

 MP:0000955 abnormal spinal cord morphology "malformation or disorganization of the cylindrical tissue of the vertebral canal that extends from the medulla oblongata to the conus medullaris" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Gbatm2Rlp/Gbatm2Rlp
Genetic Background: involves: 129S4/SvJae

 MP:0001053 abnormal neuromuscular synapse "malformed or absent membrane to membrane contact of a motor axon and a muscle myofiber resulting in aberrant transmission of nerve impulses" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:60159, J:47439]
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Allelic Composition: Egr2tm2Jmi/Egr2tm2Jmi
Genetic Background: B6.Cg-Egr2tm2Jmi

 MP:0001056 abnormal cranial nerve morphology "any anomaly, deformity, or malformation of any of the twelve nerves that emerge from the cranium as opposed to the spinal nerves" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:45302]
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Allelic Composition: Cenpbtm2Khac/Cenpbtm2Khac
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

Allelic Composition: Egr2tm1Pch/Egr2tm1Pch
Genetic Background: involves: 129S2/SvPas * C57BL/6 * DBA/2

 MP:0001065 abnormal trigeminal nerve morphology "malformed chief sensory nerve of the face and motor nerve of the muscles of mastication; has three major divisions: ophthalmic, maxillary and mandibular " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, Principles of Neural Science:ISBN 0-8385-8034-3, J:33038]
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Allelic Composition: Egr2tm1Pch/Egr2tm1Pch
Genetic Background: involves: 129S2/SvPas * C57BL/6 * DBA/2

 MP:0001070 abnormal abducens nerve morphology "any anomaly, deformity, or malformation of the 6th cranial nerve, which originates in the abducens nucleus of the pons and sends motor fibers to the lateral rectus muscles of the eye" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Egr2tm1Pch/Egr2tm1Pch
Genetic Background: involves: 129S2/SvPas * C57BL/6 * DBA/2

 MP:0001071 abnormal facial nerve morphology "malformed or misprojection of motor axons from the pons to the face" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:29973]
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Allelic Composition: Egr2tm1Pch/Egr2tm1Pch
Genetic Background: involves: 129S2/SvPas * C57BL/6 * DBA/2

 MP:0001073 abnormal glossopharyngeal nerve morphology "malformed or misprojection of sensory and autonomic axons to the parotid gland, carotid body, posterior third of the tongue" [Principles of Neural Science:ISBN 0-8385-8034-3, J:33038]
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Allelic Composition: Egr2tm1Pch/Egr2tm1Pch
Genetic Background: involves: 129S2/SvPas * C57BL/6 * DBA/2

 MP:0001074 abnormal vagus nerve morphology "malformed or misprojection of autonomic, sensory and motor axons of the tenth cranial nerve to the pharynx, larynx, trachea, lungs, heart and GI tract" [Principles of Neural Science:ISBN 0-8385-8034-3, J:33038]
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Allelic Composition: Egr2tm1Pch/Egr2tm1Pch
Genetic Background: involves: 129S2/SvPas * C57BL/6 * DBA/2

 MP:0001081 abnormal cranial ganglia morphology "any anomaly, deformity, or malformation of the groups of nerve cell bodies associated with the twelve cranial nerves" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:45302]
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Allelic Composition: Cenpbtm2Khac/Cenpbtm2Khac
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

Allelic Composition: Egr2tm1Pch/Egr2tm1Pch
Genetic Background: involves: 129S2/SvPas * C57BL/6 * DBA/2

 MP:0001082 abnormal geniculate ganglion morphology "malformed group of sensory neuron cell bodies associated with the facial nerve (seventh cranial nerve)" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:45302]
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Allelic Composition: Egr2tm4Pch/Egr2tm4Pch
Genetic Background: involves: BALB/c * C57BL/6

 MP:0001092 abnormal trigeminal ganglion morphology "malformed group of sensory neuron cell bodies associated with the trigeminal nerve (fifth cranial nerve)" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:33038]
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Allelic Composition: Cenpbtm2Khac/Cenpbtm2Khac
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

Allelic Composition: Egr2tm4Pch/Egr2tm4Pch
Genetic Background: involves: BALB/c * C57BL/6

 MP:0001096 abnormal glossopharyngeal ganglion morphology "malformed group of neuron cell bodies associated with the ninth cranial nerve" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Egr2tm4Pch/Egr2tm4Pch
Genetic Background: involves: BALB/c * C57BL/6

 MP:0001100 abnormal vagus ganglion morphology "malformed group of sensory neuron cell bodies associated with the vagus nerve" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Egr2tm4Pch/Egr2tm4Pch
Genetic Background: involves: BALB/c * C57BL/6

 MP:0001106 abnormal Schwann cell "malformed or absent cells which form the insulating myelin sheaths of peripheral axons" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Egr2tm1Pch/Egr2tm1Pch
Genetic Background: involves: 129S2/SvPas * C57BL/6 * DBA/2

Allelic Composition: Egr2tm1Jmi/Egr2tm1Jmi
Genetic Background: Not Specified

Allelic Composition: Egr2tm2Jmi/Egr2tm2Jmi
Genetic Background: B6.Cg-Egr2tm2Jmi

 MP:0001107 reduced Schwann cell number "fewer than normal cells that sheath the axons of the peripheral nervous system" [J:29971]
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Allelic Composition: Erbb2tm1Cbm/Erbb2tm2.1Cbm
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001156 abnormal spermatogenesis "incomplete maturation or aberrant formation of the male gametes" [J:58959]
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Allelic Composition: Lrp8tm1Her/Lrp8tm1Her,Vldlrtm1Her/Vldlrtm1Her
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
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Allelic Composition: Cenpbtm2Khac/Cenpbtm2Khac
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0001263 weight loss "progressive reduction of body weight below normal average for age" [J:45400]
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Allelic Composition: Cenpbtm2Khac/Cenpbtm2Khac
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

Allelic Composition: Egr2tm2Jmi/Egr2tm2Jmi
Genetic Background: B6.Cg-Egr2tm2Jmi

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
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Allelic Composition: Cenpbtm2Khac/Cenpbtm2Khac
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

Allelic Composition: Egr2tm1Jmi/Egr2tm1Jmi
Genetic Background: Not Specified

Allelic Composition: Egr2tm4Pch/Egr2tm4Pch
Genetic Background: involves: BALB/c * C57BL/6

 MP:0001290 delayed eyelid opening "late average time for the first postnatal eye opening" [J:17792]
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Allelic Composition: Cenpbtm2Khac/Cenpbtm2Khac
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0001402 hypoactivity "reduced movement from one place to another" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:64289]
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Allelic Composition: Cenpbtm2Khac/Cenpbtm2Khac
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0001405 impaired coordination "reduced ability to execute integrated movements of muscle" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Egr2tm1Jmi/Egr2tm1Jmi
Genetic Background: Not Specified

 MP:0001406 abnormal gait "unusual or distinctive way of walking" [J:65038]
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Allelic Composition: Erbb2tm1Cbm/Erbb2tm2.1Cbm
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Egr2tm2(cre)Pch/?,Mnat1tm2Tpm/Mnat1tm2.1Tpm
Genetic Background: involves: 129S2/SvPas

Allelic Composition: Egr2tm2Jmi/Egr2tm2Jmi
Genetic Background: B6.Cg-Egr2tm2Jmi

 MP:0001524 impaired limb coordination "reduced ability to organize limb movements to execute complex maneuvers, such as walking" [J:64962, MGI:CLS, J:17123]
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Allelic Composition: Egr2tm4Pch/Egr2tm4Pch
Genetic Background: involves: BALB/c * C57BL/6

 MP:0001544 abnormal cardiovascular system physiology "anomalous function of the blood, blood vessels, and/or the heart" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Destm1.1Ccrs/Des+
Genetic Background: involves: 129 * C57BL/6J

 MP:0001732 postnatal growth retardation "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Cenpbtm2Khac/Cenpbtm2Khac
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0001954 respiratory distress "physical difficulty or inability to breathe" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:54931]
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Allelic Composition: Egr2tm2Jmi/Egr2tm2Jmi
Genetic Background: B6.Cg-Egr2tm2Jmi

 MP:0001961 abnormal reflex "anomalies in an involuntary response to a peripheral stimulus" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Cd28tm1Mak/Cd28tm1Mak,Tnfsf14tm1Kpf/Tnfsf14tm1Kpf
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6

 MP:0002066 abnormal motor capabilities/coordination/movement "altered ability to coordinate voluntary movement or repetitive, compulsive movements" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Cenpbtm2Khac/Cenpbtm2Khac
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Erbb2tm1Cbm/Erbb2tm2.1Cbm
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002113 abnormal skeleton development "anomalous differentiation or remodeling of bone tissue resulting in morphological abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Cenpbtm2Khac/Cenpbtm2Khac
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0002151 abnormal neural tube morphology/development "anomalous structure of or development of the embryonic neural tube resulting in structural anomaly" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Cenpbtm2Khac/Cenpbtm2Khac
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Egr2tm2(cre)Pch/?,Gt(ROSA)26Sortm5(CAG-EGFP,-lacZ)Dym/?,Tg(Fev-flpe)1Dym/?
Genetic Background: involves: 129S2/SvPas

 MP:0002184 abnormal innervation "the malformation, misprojection or malfunction of the connection of nerve fibers with a target" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Cd28tm1Mak/Cd28tm1Mak,Tnfsf14tm1Kpf/Tnfsf14tm1Kpf
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6

 MP:0002199 abnormal brain commissure morphology "absent or defective structure in a bundle of nerve fibers connecting the two brain hemispheres" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Cd28tm1Mak/Cd28tm1Mak,Tnfsf14tm1Kpf/Tnfsf14tm1Kpf
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6

 MP:0002327 abnormal respiratory function "anomaly in any measure of the processes involved in respiration" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Phox2btm4Jbr/Phox2b+,Tg(Pou3f4-cre)32Cren/0
Genetic Background: involves: 129S2/SvPas * C57BL/6 * CD-1 * DBA/2

 MP:0002625 left ventricle hypertrophy "increased size of the left ventricle" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Destm1.1Ccrs/Des+
Genetic Background: involves: 129 * C57BL/6J

 MP:0002651 abnormal sciatic nerve "malformation, absence or misprojection of the nerve which originates in the lumbar and sacral spinal cord (L4 to S3) and supplies motor and sensory innervation to the lower extremity" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Erbb2tm1Cbm/Erbb2tm2.1Cbm
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Egr2tm1Pch/Egr2tm1Pch
Genetic Background: involves: 129S2/SvPas * C57BL/6 * DBA/2

Allelic Composition: Egr2tm1Jmi/Egr2tm1Jmi
Genetic Background: Not Specified

Allelic Composition: Egr2tm2Jmi/Egr2tm2Jmi
Genetic Background: B6.Cg-Egr2tm2Jmi

Allelic Composition: Egr2tm2(cre)Pch/Egr2+,Gt(ROSA)26Sortm8(Map2k1*,EGFP)Rsky/?
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0002747 abnormal aortic valve morphology "malformation of the valve between the left ventricle and the ascending aorta" [J:82728, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Destm1.1Ccrs/Des+
Genetic Background: involves: 129 * C57BL/6J

 MP:0002752 abnormal somatic nervous system morphology "malformation or absence of any of the cranial and spinal nerves or their ganglia or the peripheral sensory receptors" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Egr2tm1Pch/Egr2tm1Pch
Genetic Background: involves: 129S2/SvPas * C57BL/6 * DBA/2

 MP:0002764 short tibia " reduced length of the medial and larger bone of the lower leg" [J:12736, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Egr2tm1Pch/Egr2tm1Pch
Genetic Background: involves: 129S2/SvPas * C57BL/6 * DBA/2

 MP:0002855 abnormal cochlear ganglion morphology "malformation, malfunction or absence of the group of nerve cell bodies that conveys auditory sensation from the organ of Corti to the hindbrain and resides on the cochlear part of the vestibulocochlear nerve (eighth cranial nerve)" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Cenpbtm2Khac/Cenpbtm2Khac
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

Allelic Composition: Egr2tm4Pch/Egr2tm4Pch
Genetic Background: involves: BALB/c * C57BL/6

 MP:0002896 abnormal bone mineralization "defect in the process by which minerals are deposited into bone" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Egr2tm1Pch/Egr2tm1Pch
Genetic Background: involves: 129S2/SvPas * C57BL/6 * DBA/2

 MP:0003029 alkalemia "decreased concentration of H-ion in the blood or a rise in pH" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, RGD:Rat Genome Database submission]
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Allelic Composition: Egr2tm2(cre)Pch/Egr2+,Phox2btm4Jbr/Phox2b+
Genetic Background: involves: 129S2/SvPas * C57BL/6 * DBA/2

 MP:0003055 abnormal epiphyseal plate morphology "malformed or absent cartilagenous center of ossification on the long bones permitting growth of the bone in both directions during development" [MeSH:National Library of Medicine - Medical Subject Headings, 2003]
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Allelic Composition: Egr2tm1Pch/Egr2tm1Pch
Genetic Background: involves: 129S2/SvPas * C57BL/6 * DBA/2

 MP:0003109 short femur "reduced length of the long bone of the thigh" [ava:Anna V. Anagnostopoulos, Mouse Genome Informatics Curator, Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Egr2tm1Pch/Egr2tm1Pch
Genetic Background: involves: 129S2/SvPas * C57BL/6 * DBA/2

 MP:0003313 abnormal locomotor activation "altered ability or desire of an animal to initiate locomotor activity" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Erbb2tm1Cbm/Erbb2tm2.1Cbm
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0003409 decreased width of hypertrophic chondrocyte zone "decreased width of cartilage cell matrix layer " [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Egr2tm1Pch/Egr2tm1Pch
Genetic Background: involves: 129S2/SvPas * C57BL/6 * DBA/2

 MP:0003723 abnormal long bone morphology "malformation of any of the several elongated bones of the extremities " [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
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Allelic Composition: Egr2tm1Pch/Egr2tm1Pch
Genetic Background: involves: 129S2/SvPas * C57BL/6 * DBA/2

 MP:0003795 abnormal bone structure 
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Allelic Composition: Egr2tm1Pch/Egr2tm1Pch
Genetic Background: involves: 129S2/SvPas * C57BL/6 * DBA/2

 MP:0003871 abnormal myelin sheath morphology "malformation of the insulating envelope that surrounds nerve fibers or axons" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Erbb2tm1Cbm/Erbb2tm2.1Cbm
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Egr2tm2(cre)Pch/Egr2+,Gt(ROSA)26Sortm8(Map2k1*,EGFP)Rsky/?
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0003921 abnormal left ventricle morphology "structural anomaly of the left lower chamber of the heart " [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Destm1.1Ccrs/Des+
Genetic Background: involves: 129 * C57BL/6J

 MP:0003961 decreased lean body mass "less than average fat-free physical bulk or volume of the body including all its components except adipose tissue" [honda:Hiraoki Onda, Mouse GEnome Informatics Curator]
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Allelic Composition: Egr2tm2(cre)Pch/?,Mnat1tm2Tpm/Mnat1tm2.1Tpm
Genetic Background: involves: 129S2/SvPas

 MP:0003993 abnormal ventral spinal root morphology "any anomaly, deformity, or malformation of the anterior bundle of nerves emerging from the spinal cord to join with the posterior/dorsal nerve bundle at each spinal cord segment to form one of the 31 paired peripheral nerves" [brs:Beverly Richards-Smith, Mouse Genome Informatics Curator]
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Allelic Composition: Egr2tm2(cre)Pch/Egr2+,Erbb2tm1Cbm/Erbb2tm2Cbm
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6

 MP:0003994 abnormal dorsal spinal root morphology "any anomaly, deformity, or malformation of the posterior bundle of nerves emerging from the spinal cord to join with the anterior/ventral nerve bundle at each spinal cord segment to form one of the 31 paired peripheral nerves" [brs:Beverly Richards-Smith, Mouse Genome Informatics Curator]
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Allelic Composition: Erbb2tm1Cbm/Erbb2tm2.1Cbm
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0004074 abnormal Schwann cell precursors "malformation or absence of the progenitors of cells that sheath the axons of the peripheral nervous system" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
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Allelic Composition: Egr2tm2(cre)Pch/?,Mnat1tm2Tpm/Mnat1tm2.1Tpm
Genetic Background: involves: 129S2/SvPas

 MP:0004355 short radius "reduced length of the short bone of the lateral forearm" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Egr2tm1Pch/Egr2tm1Pch
Genetic Background: involves: 129S2/SvPas * C57BL/6 * DBA/2

 MP:0004568 fusion of glossopharyngeal and vagus nerve "union of the ninth and tenth cranial nerves into a single structure" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Cenpbtm2Khac/Cenpbtm2Khac
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

Allelic Composition: Egr2tm2Jmi/Egr2tm2Jmi
Genetic Background: B6.Cg-Egr2tm2Jmi

Allelic Composition: Egr2tm2Jmi/Egr2+
Genetic Background: B6.Cg-Egr2tm2Jmi

 MP:0004686 decreased length of long bones "reduced end-to-end length of the several elongated bones of the extremities" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Egr2tm1Pch/Egr2tm1Pch
Genetic Background: involves: 129S2/SvPas * C57BL/6 * DBA/2

 MP:0004736 abnormal distortion product otoacoustic emission "any abnormality in the sound produced by the cochlea in response to stimulation with 2 simultaneous tones of different frequencies; this measurement is particularly useful in assessing the functional state of OHCs" [eMedicine:http://www.emedicine.com/ent/topic372.htm, MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Cacna1dtm1Hgn/Cacna1dtm1Hgn,Egr2tm2(cre)Pch/Egr2+
Genetic Background: involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ

 MP:0004738 abnormal brainstem auditory evoked potential "anomaly in the electrical activity generated in response to short tone bursts; may be used to evaluate sensorineural hearing function" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Cd28tm1Mak/Cd28tm1Mak,Tnfsf14tm1Kpf/Tnfsf14tm1Kpf
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6

Allelic Composition: Crygntm1a(EUCOMM)Wtsi/Crygntm1a(EUCOMM)Wtsi,Egr2tm2(cre)Pch/Egr2+
Genetic Background: involves: 129S2/SvPas * C57BL/6N

 MP:0004811 abnormal neuron physiology "anomalous function of the cells of the nervous system that receive, conduct, and transmit impulses" [MESH:National Library of Medicine_Medical Subject Headings]
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Allelic Composition: Phox2btm4Jbr/Phox2b+,Tg(Pgk1-cre)1Lni/0
Genetic Background: involves: 129S2/SvPas * BALB/c * C57BL/6

 MP:0005150 cachexia "general weight loss and wasting occurring in the course of chronic disease" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Erbb2tm1Cbm/Erbb2tm2.1Cbm
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0005403 abnormal nerve conduction "anomaly in the act of transmitting electricity along a single nerve" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Egr2tm2(cre)Pch/Egr2+,Gt(ROSA)26Sortm8(Map2k1*,EGFP)Rsky/?
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0005573 increased breathing frequency "greater than the normal number of breaths in a given period of time" [RGD:Rat Genome Database submission]
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Allelic Composition: Egr2tm4Pch/Egr2tm4Pch
Genetic Background: involves: BALB/c * C57BL/6

 MP:0005576 decreased pulmonary ventilation "less than the normal total volume of gas per minute inspired or expired " [RGD:Rat Genome Database submission]
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Allelic Composition: Egr2tm2(cre)Pch/Egr2+,Phox2btm4Jbr/Phox2b+
Genetic Background: involves: 129S2/SvPas * C57BL/6 * DBA/2

 MP:0006009 abnormal neuronal migration "defective or impaired movement of immature neurons from germinal zones to specific positions where they will reside as they mature" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Gbatm2Rlp/Gbatm2Rlp
Genetic Background: involves: 129S4/SvJae

 MP:0006047 aortic valve insufficiency "the aortic valve does not close tightly enough to prevent leakage. " [smb:Susan M Bello, Mouse Genome Informatics Curator, RGD:Rat Genome Database submission]
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Allelic Composition: Destm1.1Ccrs/Des+
Genetic Background: involves: 129 * C57BL/6J

 MP:0006108 abnormal hindbrain development "anomaly in the formation or pattering of the caudal region of the brain" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:93573]
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Allelic Composition: Egr2tm1Jmi/Egr2tm1Jmi
Genetic Background: Not Specified

 MP:0006276 abnormal autonomic nervous system physiology "anomaly in the function of the sensory and motor neurons that run between the central nervous system (especially the hypothalamus and medulla oblongata) and various internal organs (heart, lungs, endocrine and exocrine glands), responsible for controling involuntary bodily functions" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, smb:Susan M Bello, Mouse Genome Informatics Curator, Taber s Cyclopedic Medical Dictionary:19th edition: ISBN N 0-8036-0655-99]
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Allelic Composition: Egr2tm2(cre)Pch/Egr2+,Phox2btm4Jbr/Phox2b+
Genetic Background: involves: 129S2/SvPas * C57BL/6 * DBA/2

 MP:0008150 decreased diameter of long bones "reduced width of the cross-sectional distance that extends from one lateral edge of a long bone, through its center and to the opposite lateral edge" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Egr2tm1Pch/Egr2tm1Pch
Genetic Background: involves: 129S2/SvPas * C57BL/6 * DBA/2

 MP:0008152 decreased diameter of femur "reduced width of the cross-sectional distance that extends from one lateral edge of the femur, through its center and to the opposite lateral edge" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Egr2tm1Pch/Egr2tm1Pch
Genetic Background: involves: 129S2/SvPas * C57BL/6 * DBA/2

 MP:0008155 decreased diameter of radius "reduced width of the cross-sectional distance that extends from one lateral edge of the radius, through its center and to the opposite lateral edge" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Egr2tm1Pch/Egr2tm1Pch
Genetic Background: involves: 129S2/SvPas * C57BL/6 * DBA/2

 MP:0008156 decreased diameter of tibia "reduced width of the cross-sectional distance that extends from one lateral edge of the tibia, through its center and to the opposite lateral edge" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Egr2tm1Pch/Egr2tm1Pch
Genetic Background: involves: 129S2/SvPas * C57BL/6 * DBA/2

 MP:0008814 reduced nerve conduction velocity "decrease in the rate at which an eletrical impulse travels through a nerve" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Egr2tm2Jmi/Egr2tm2Jmi
Genetic Background: B6.Cg-Egr2tm2Jmi

Allelic Composition: Egr2tm2(cre)Pch/Egr2+,Ptpn11tm1.1Wbm/Ptpn11tm1.1Wbm
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6 * SJL

 MP:0008948 decreased neuron number "fewer than normal numbers of the cells of the nervous system that receive, conduct, and transmit impulses" [MESH:A08.663]
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Allelic Composition: Cacna1dtm1Hgn/Cacna1dtm1Hgn,Egr2tm2(cre)Pch/Egr2+
Genetic Background: involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ

Allelic Composition: Crygntm1a(EUCOMM)Wtsi/Crygntm1a(EUCOMM)Wtsi,Egr2tm2(cre)Pch/Egr2+
Genetic Background: involves: 129S2/SvPas * C57BL/6N

 MP:0009619 abnormal optokinetic reflex "any anomaly in the nystagmus or deviation of the eyes in response to stimulation of the visual system by movement; normally, this reflex functions to stabilize a moving image on the retina" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Cd28tm1Mak/Cd28tm1Mak,Tnfsf14tm1Kpf/Tnfsf14tm1Kpf
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6

 MP:0009937 abnormal neuron differentiation "abnormal growth or development of the cells of the nervous system that receive, conduct, and transmit impulses" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Phox2btm3Jbr/Phox2btm3Jbr,Egr2tm2(cre)Pch/Egr2+
Genetic Background: involves: 129S2/SvPas * C57BL/6 * DBA/2

 MP:0010050 hypermyelination "anomaly in the process by which myelin sheaths are formed and maintained around neurons resulting in increased myelin formation" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Egr2tm2(cre)Pch/Egr2+,Gt(ROSA)26Sortm8(Map2k1*,EGFP)Rsky/?
Genetic Background: involves: 129S2/SvPas * C57BL/6

Allelic Composition: Egr2tm2(cre)Pch/Egr2+,Gt(ROSA)26Sortm8(Map2k1*,EGFP)Rsky/?,Ptpn11tm1.1Wbm/Ptpn11tm1.1Wbm
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6

 MP:0010463 aorta stenosis "diffuse constriction or narrowing of the aorta" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Destm1.1Ccrs/Des+
Genetic Background: involves: 129 * C57BL/6J

 MP:0010591 enlarged aortic valve "an increase in the total area occupied by the aortic valve" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Destm1.1Ccrs/Des+
Genetic Background: involves: 129 * C57BL/6J

 MP:0010593 thick aortic valve cusps "an increase in the ratio of the aortic valve cusp thickness to the aortic wall thickness" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Destm1.1Ccrs/Des+
Genetic Background: involves: 129 * C57BL/6J

Allelic Composition: Egr2tm3Pch/Egr2tm3Pch,Tg(Tek-cre)1Ywa/0
Genetic Background: involves: 129S2/SvPas * C57BL/6 * SJL

 MP:0010595 abnormal aortic valve cusp morphology "any structural anomaly of the three fibrous triangular components and associated flap of the aortic valve" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Egr2tm3Pch/Egr2tm3Pch,Tg(Tek-cre)1Ywa/0
Genetic Background: involves: 129S2/SvPas * C57BL/6 * SJL

 MP:0010605 thick pulmonary valve cusps "an increase in the ratio of the pulmonary valve cusp thickness to the pulmonary artery wall thickness" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Destm1.1Ccrs/Des+
Genetic Background: involves: 129 * C57BL/6J

Allelic Composition: Egr2tm3Pch/Egr2tm3Pch,Tg(Tek-cre)1Ywa/0
Genetic Background: involves: 129S2/SvPas * C57BL/6 * SJL

 MP:0011042 abnormal horizontal vestibuloocular reflex "any anomaly in the nystagmus or deviation of the eyes in response to stimulation along the horizontal axis of the vestibular system" [MGI:smb]
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Allelic Composition: Cd28tm1Mak/Cd28tm1Mak,Tnfsf14tm1Kpf/Tnfsf14tm1Kpf
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6

 MP:0011083 complete lethality at weaning "premature death at weaning age of all organisms of a given genotype in a population, often due to the inability to make the transition to solid food" [MGI:csmith]
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Allelic Composition: Egr2tm4Pch/Egr2tm4Pch
Genetic Background: involves: BALB/c * C57BL/6

 MP:0011085 complete postnatal lethality "premature death anytime between the neonatal period and weaning age of all organisms of a given genotype in a population (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
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Allelic Composition: Cenpbtm2Khac/Cenpbtm2Khac
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

Allelic Composition: Egr2tm1Jmi/Egr2tm1Jmi
Genetic Background: Not Specified

Allelic Composition: Egr2tm2Jmi/Egr2tm2Jmi
Genetic Background: B6.Cg-Egr2tm2Jmi

Allelic Composition: Phox2btm3Jbr/Phox2btm3Jbr,Egr2tm2(cre)Pch/Egr2+
Genetic Background: involves: 129S2/SvPas * C57BL/6 * DBA/2

 MP:0011086 partial postnatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
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Allelic Composition: Egr2tm1Pch/Egr2tm1Pch
Genetic Background: involves: 129S2/SvPas * C57BL/6 * DBA/2

 MP:0011088 partial neonatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the neonatal period after birth (Mus: P0)" [MGI:csmith]
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Allelic Composition: Cenpbtm2Khac/Cenpbtm2Khac
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0011406 abnormal retrotrapezoid nucleus morphology "any structural anomaly in the loose collection of neurons that reside in the rostral medulla close to the medullary surface, ventral and immediately caudal of nVII, that are crucial for CO2 sensing in the brain" [MGI:smb, PMID:21900566]
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Allelic Composition: Egr2tm2(cre)Pch/Egr2+,Phox2btm4Jbr/Phox2b+
Genetic Background: involves: 129S2/SvPas * C57BL/6 * DBA/2

 MP:0011730 increased myelin sheath thickness "increase in the depth of the insulating envelope that surrounds nerve fibers or axons" [MGI:smb]
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Allelic Composition: Egr2tm2(cre)Pch/Egr2+,Gt(ROSA)26Sortm8(Map2k1*,EGFP)Rsky/?
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0011906 increased Schwann cell proliferation "increase in the expansion rate of a Schwann cell population by cell division" [MGI:csmith]
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Allelic Composition: Egr2tm1Jmi/Egr2tm1Jmi
Genetic Background: Not Specified

Allelic Composition: Egr2tm4Pch/Egr2tm4Pch
Genetic Background: involves: BALB/c * C57BL/6

 MP:0011966 abnormal auditory brainstem response waveform shape "any anomaly in the characteristic pattern of electrical activity recording of a series of vertex positive waves generated by neurons in the ascending auditory system, that can be recorded from scalp electrograms by using computer-averaged responses to short tone bursts" [MGI:csmith]
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Allelic Composition: Cacna1dtm1Hgn/Cacna1dtm1Hgn,Egr2tm2(cre)Pch/Egr2+
Genetic Background: involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ

 MP:0011994 increased nerve conduction velocity "increase in the rate at which an electrical impulse travels through a nerve" [MGI:csmith]
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Allelic Composition: Egr2tm2(cre)Pch/Egr2+,Gt(ROSA)26Sortm8(Map2k1*,EGFP)Rsky/?
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0012674 tomacula "focal myelin swellings due to redundant folding of myelin sheaths; often sausage-shaped and excessively folded" [MGI:smb]
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Allelic Composition: Egr2tm2(cre)Pch/Egr2+,Gt(ROSA)26Sortm8(Map2k1*,EGFP)Rsky/?
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0012793 decreased rhombomere 3 size "reduced size of the third transiently divided segment of the developing rhombencephalon; rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates; rhombomeres are numbered in caudal to rostral order" [MGI:anna]
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Allelic Composition: Egr2tm1Pch/Egr2tm1Pch
Genetic Background: involves: 129S2/SvPas * C57BL/6 * DBA/2

Allelic Composition: Egr2tm1Pch/Egr2tm3Pch
Genetic Background: involves: 129S2/SvPas * C57BL/6 * DBA/2

 MP:0012795 absent rhombomere 3 "absence of the third transiently divided segment of the developing rhombencephalon; rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates; rhombomeres are numbered in caudal to rostral order" [MGI:anna]
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Allelic Composition: Cenpbtm2Khac/Cenpbtm2Khac
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

Allelic Composition: Egr2tm1Pch/Egr2tm1Pch
Genetic Background: involves: 129S2/SvPas * C57BL/6 * DBA/2

Allelic Composition: Egr2tm1.1Jchn/Egr2+
Genetic Background: involves: 129S2/SvPas * C57BL/6 * DBA/2

 MP:0012801 decreased rhombomere 5 size "reduced size of the fifth transiently divided segment of the developing rhombencephalon; rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates; rhombomeres are numbered in caudal to rostral order" [MGI:anna]
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Allelic Composition: Egr2tm1Pch/Egr2tm1Pch
Genetic Background: involves: 129S2/SvPas * C57BL/6 * DBA/2

 MP:0012803 absent rhombomere 5 "absence of the fifth transiently divided segment of the developing rhombencephalon; rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates; rhombomeres are numbered in caudal to rostral order" [MGI:anna]
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Allelic Composition: Cenpbtm2Khac/Cenpbtm2Khac
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

Allelic Composition: Egr2tm1Pch/Egr2tm1Pch
Genetic Background: involves: 129S2/SvPas * C57BL/6 * DBA/2

Allelic Composition: Egr2tm1.1Jchn/Egr2+
Genetic Background: involves: 129S2/SvPas * C57BL/6 * DBA/2

 MP:0012805 decreased rhombomere 6 size "reduced size of the sixth transiently divided segment of the developing rhombencephalon; rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates; rhombomeres are numbered in caudal to rostral order" [MGI:anna]
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Allelic Composition: Egr2tm1Pch/Egr2tm1Pch
Genetic Background: involves: 129S2/SvPas * C57BL/6 * DBA/2

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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