ENSMUSG00000033730


Mus musculus

Features
Gene ID: ENSMUSG00000033730
  
Biological name :Egr3
  
Synonyms : Egr3 / Mus musculus early growth response 3 (Egr3), transcript variant 3, mRNA. / P43300
  
Possible biological names infered from orthology : early growth response 3 / Q06889
  
Species: Mus musculus
  
Chr. number: 14
Strand: 1
Band: D2
Gene start: 70077203
Gene end: 70082614
  
Corresponding Affymetrix probe sets: 10416251 (MoGene1.0st)   1421486_at (Mouse Genome 430 2.0 Array)   1436329_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000037042
Ensembl peptide - ENSMUSP00000153491
NCBI entrez gene - 13655     See in Manteia.
MGI - MGI:1306780
RefSeq - XM_006518519
RefSeq - NM_001289925
RefSeq - NM_001289927
RefSeq - NM_018781
RefSeq Peptide - NP_001276856
RefSeq Peptide - NP_061251
RefSeq Peptide - NP_001276854
swissprot - P43300
swissprot - Q3ZB14
Ensembl - ENSMUSG00000033730
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 egr3ENSDARG00000089156Danio rerio
 EGR3ENSG00000179388Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Egr2 / P08152 / E3 SUMO-protein ligase EGR2 / P11161* / early growth response 2*ENSMUSG0000003786851
Egr1 / P08046 / Early growth response protein 1 / P18146* / early growth response 1*ENSMUSG0000003841845
Egr4 / Q9WUF2 / Early growth response protein 4 / Q05215* / early growth response 4*ENSMUSG0000007134131
Wt1 / Wilms tumor 1 homolog / P19544* / Wilms tumor 1*ENSMUSG0000001645824


Protein motifs (from Interpro)
Interpro ID Name
 IPR013083  Zinc finger, RING/FYVE/PHD-type
 IPR013087  Zinc finger C2H2-type
 IPR021849  Early growth response protein
 IPR036236  Zinc finger C2H2 superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001938 positive regulation of endothelial cell proliferation IEA
 biological_processGO:0002042 cell migration involved in sprouting angiogenesis IEA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006366 transcription by RNA polymerase II IEA
 biological_processGO:0007274 neuromuscular synaptic transmission IMP
 biological_processGO:0007422 peripheral nervous system development IMP
 biological_processGO:0033089 positive regulation of T cell differentiation in thymus IMP
 biological_processGO:0035767 endothelial cell chemotaxis IEA
 biological_processGO:0035924 cellular response to vascular endothelial growth factor stimulus IEA
 biological_processGO:0043066 negative regulation of apoptotic process IEA
 biological_processGO:0044344 cellular response to fibroblast growth factor stimulus IEA
 biological_processGO:0045586 regulation of gamma-delta T cell differentiation IDA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IDA
 cellular_componentGO:0005634 nucleus IEA
 molecular_functionGO:0001228 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding IC
 molecular_functionGO:0003676 nucleic acid binding IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0043565 sequence-specific DNA binding IDA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000161 scoliosis "lateral and rotational curvature of the spine" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:53770, J:66943]
Show

Allelic Composition: Cd74tm3Liz/Cd74tm3Liz
Genetic Background: involves: 129S/SvEv * C57BL/6

 MP:0000745 tremors "repetitive, cyclical movements of the body or a body part; usually involuntary, but can also manifest in response to an attempt at movement" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Cd74tm3Liz/Cd74tm3Liz
Genetic Background: involves: 129S/SvEv * C57BL/6

 MP:0000937 abnormal motor neuron morphology "malformation or absence of cells that innervate an effector (muscle or glandular) tissue; responsible for transmission of motor impulses" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:60159]
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Allelic Composition: Egr3tm1Jmi/Egr3tm1Jmi,Gfra1tm3Jmi/Gfra1+,Tg(Hlxb9-GFP)1Tmj/0
Genetic Background: involves: 129X1/SvJ * C57BL/6 * SJL

 MP:0000938 motor neuron degeneration "retrogressive impairment of function or destruction of the cells that innervate an effector (muscle or glandular) tissue" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Egr3tm1Jmi/Egr3tm1Jmi,Gfra1tm3Jmi/Gfra1+,Tg(Hlxb9-GFP)1Tmj/0
Genetic Background: involves: 129X1/SvJ * C57BL/6 * SJL

 MP:0000939 reduced motor neuron number "fewer than normal numbers of cells that innervate an effector (muscle or glandular) tissue" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:60159]
Show

Allelic Composition: Cd74tm3Liz/Cd74tm3Liz
Genetic Background: involves: 129S/SvEv * C57BL/6

Allelic Composition: Gdnftm1.1Neas/Gdnftm1.1Neas,Egr3tm1(cre)Mod/Egr3tm1(cre)Mod
Genetic Background: involves: 129S1/Sv * C57BL/6 * C57BL/6J * SJL

Allelic Composition: Gdnftm1Bbd/Gdnftm1.1Neas,Egr3tm1(cre)Mod/Egr3+
Genetic Background: involves: 129S1/Sv * C57BL/6 * C57BL/6J * SJL

Allelic Composition: Egr3tm1Jmi/Egr3tm1Jmi,Gfra1tm3Jmi/Gfra1+,Tg(Hlxb9-GFP)1Tmj/0
Genetic Background: involves: 129X1/SvJ * C57BL/6 * SJL

Allelic Composition: Egr3tm1Jmi/Egr3tm1Jmi,Gfra1tm3Jmi/Gfra1+
Genetic Background: involves: 129X1/SvJ

 MP:0000959 abnormal somatic sensory system morphology 
Show

Allelic Composition: Cd74tm3Liz/Cd74tm3Liz
Genetic Background: involves: 129S/SvEv * C57BL/6

 MP:0000961 abnormal dorsal root ganglia morphology "malformed group of nerve cell bodies of each segmental nerve projecting from the spinal cord " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:60159]
Show

Allelic Composition: Cd74tm3Liz/Cd74tm3Liz
Genetic Background: involves: 129S/SvEv * C57BL/6

 MP:0001025 abnormal sympathetic neuron morphology "malformation or anomalous development of any of the neurons of the part of the autonomic nervous system that innervates smooth muscle, cardiac muscle and glands and mediates the body s response to stressful situations" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Cbx4tm1.1Gxu/Cbx4tm1.2Gxu,Tg(Foxn1-cre)1Tbo/0
Genetic Background: involves: 129S2/SvPas * C57BL/6J

Allelic Composition: Egr3tm1Jmi/Egr3tm1Jmi,Gt(ROSA)26Sortm1(CAG-taulacZ)Bene/Gt(ROSA)26Sor+,Tg(Dbh-cre)KH212Gsat/0
Genetic Background: involves: C57BL/6 * FVB/NTac

 MP:0001038 abnormal cholinergic neuron morphology "malformation or absence of the neurons that utilize acetylcholine as a neurotransmitter " [Principles of Neural Science, 3rd edition:ISBN 0-8385-8034-3]
Show

Allelic Composition: Cd74tm3Liz/Cd74tm3Liz
Genetic Background: involves: 129S/SvEv * C57BL/6

Allelic Composition: Gdnftm1.1Neas/Gdnftm1.1Neas,Egr3tm1(cre)Mod/Egr3tm1(cre)Mod
Genetic Background: involves: 129S1/Sv * C57BL/6 * C57BL/6J * SJL

Allelic Composition: Gdnftm1Bbd/Gdnftm1.1Neas,Egr3tm1(cre)Mod/Egr3+
Genetic Background: involves: 129S1/Sv * C57BL/6 * C57BL/6J * SJL

Allelic Composition: Egr3tm1Jmi/Egr3tm1Jmi,Gfra1tm3Jmi/Gfra1+,Tg(Hlxb9-GFP)1Tmj/0
Genetic Background: involves: 129X1/SvJ * C57BL/6 * SJL

Allelic Composition: Egr3tm1Jmi/Egr3tm1Jmi,Gfra1tm3Jmi/Gfra1+
Genetic Background: involves: 129X1/SvJ

 MP:0001344 blepharoptosis "ptosis, drooping eyelids " [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:24414]
Show

Allelic Composition: Cd74tm3Liz/Cd74tm3Liz
Genetic Background: involves: 129S/SvEv * C57BL/6

Allelic Composition: Egr3tm1Jmi/Egr3tm2.1Wgt,Tg(DBH-cre,-taulacZ)1Wgt/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * SJL

 MP:0001393 ataxia "inability to coordinate voluntary muscular movements" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:67231]
Show

Allelic Composition: Cd74tm3Liz/Cd74tm3Liz
Genetic Background: involves: 129S/SvEv * C57BL/6

Allelic Composition: Egr3tm1(cre)Mod/Egr3tm1(cre)Mod,Ntf3tm2Jae/Ntf3tm2Jae
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0001406 abnormal gait "unusual or distinctive way of walking" [J:65038]
Show

Allelic Composition: Cd74tm3Liz/Cd74tm3Liz
Genetic Background: involves: 129S/SvEv * C57BL/6

Allelic Composition: Egr3tm1(cre)Mod/Egr3tm1(cre)Mod,Ntf3tm2Jae/Ntf3tm2Jae
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0001504 abnormal posture "atypical position of the limbs or carriage of the body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:18984]
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Allelic Composition: Erbb2tm1Haus/Erbb2tm1Klee,Myf5tm3(cre)Sor/Myf5+
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0002272 abnormal nervous system electrophysiology "anomaly in the function of the nervous system as it relates to electrical phenomena" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Egr3tm1(cre)Mod/Egr3tm1(cre)Mod,Ntf3tm2Jae/Ntf3tm2Jae
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0002912 abnormal excitatory postsynaptic potential "defect in the potential detected in postsynaptic cells when an excitatory impulse arrives at the synapse causing depolarization" [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
Show

Allelic Composition: Cd74tm3Liz/Cd74tm3Liz
Genetic Background: involves: 129S/SvEv * C57BL/6

 MP:0003633 abnormal nervous system physiology 
Show

Allelic Composition: Cd74tm3Liz/Cd74tm3Liz
Genetic Background: involves: 129S/SvEv * C57BL/6

 MP:0004069 abnormal muscle spindle morphology "anomalous structure of the sensory organs in muscle that are involved in the stretch reflex" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
Show

Allelic Composition: Cd74tm3Liz/Cd74tm3Liz
Genetic Background: involves: 129S/SvEv * C57BL/6

 MP:0004263 abnormal limb posture "atypical position of the limbs compared to the normal carriage of the body" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cd74tm3Liz/Cd74tm3Liz
Genetic Background: involves: 129S/SvEv * C57BL/6

 MP:0004297 abnormal proprioceptive neuron morphology "any structural anomaly in the sensory neurons of the dorsal root ganglia that sense body position and send information about how much the muscle is stretched to the spinal cord" [MGI:hdene "Howard Dene, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cd74tm3Liz/Cd74tm3Liz
Genetic Background: involves: 129S/SvEv * C57BL/6

 MP:0005423 abnormal somatic nervous system physiology "anomalous function of any of the cranial and spinal nerves or their ganglia or the peripheral sensory receptors" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Cd74tm3Liz/Cd74tm3Liz
Genetic Background: involves: 129S/SvEv * C57BL/6

 MP:0008468 absent muscle spindles "absence of the sensory organs in muscle that are involved in the stretch reflex" [ISBN:0838580343 "Kandel ER, et al. Principles of Neural Science, 3rd edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cd74tm3Liz/Cd74tm3Liz
Genetic Background: involves: 129S/SvEv * C57BL/6

 MP:0008838 decreased transforming growth factor level "reduced concentration of a paracrine growth factor that has a potential role in embryonic development, cellular differentiation, hormone secretion, and immune function" [MESH:D12.644.276.374.687]
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Allelic Composition: Kmt2atm1Sjk/Kmt2atm1Sjk
Genetic Background: involves: 129S2/SvPas * CD-1

 MP:0009284 abnormal sympathetic neuron innervation "defective or incomplete supply of nerve fibers to sympathetic termini" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Egr3tm1Jmi/Egr3tm2.1Wgt,Tg(DBH-cre,-taulacZ)1Wgt/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * SJL

 MP:0009561 superior cervical ganglion degeneration "retrogressive pathological change or loss of the largest group of paravertebral ganglia of the sympathetic trunk which normally lies at the base of the skull and innervates the head and neck" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Egr3tm1Jmi/Egr3tm2.1Wgt,Tg(DBH-cre,-taulacZ)1Wgt/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * SJL

 MP:0011086 partial postnatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Cd74tm3Liz/Cd74tm3Liz
Genetic Background: involves: 129S/SvEv * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
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