ENSG00000120738


Homo sapiens

Features
Gene ID: ENSG00000120738
  
Biological name :EGR1
  
Synonyms : early growth response 1 / EGR1 / P18146
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 5
Strand: 1
Band: q31.2
Gene start: 138465490
Gene end: 138469315
  
Corresponding Affymetrix probe sets: 201693_s_at (Human Genome U133 Plus 2.0 Array)   201694_s_at (Human Genome U133 Plus 2.0 Array)   227404_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000239938
NCBI entrez gene - 1958     See in Manteia.
OMIM - 128990
RefSeq - NM_001964
RefSeq Peptide - NP_001955
swissprot - P18146
swissprot - Q546S1
Ensembl - ENSG00000120738
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 egr1ENSDARG00000037421Danio rerio
 EGR1ENSGALG00000007669Gallus gallus
 Egr1ENSMUSG00000038418Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
EGR2 / P11161 / early growth response 2ENSG0000012287734
EGR3 / Q06889 / early growth response 3ENSG0000017938833
EGR4 / Q05215 / early growth response 4ENSG0000013562523
WT1 / P19544 / Wilms tumor 1ENSG0000018493720


Protein motifs (from Interpro)
Interpro ID Name
 IPR013083  Zinc finger, RING/FYVE/PHD-type
 IPR013087  Zinc finger C2H2-type
 IPR021839  Early growth response protein 1, C-terminal
 IPR021849  Early growth response protein
 IPR036236  Zinc finger C2H2 superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IEA
 biological_processGO:0001666 response to hypoxia IEA
 biological_processGO:0002931 response to ischemia IEA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006366 transcription by RNA polymerase II IDA
 biological_processGO:0009749 response to glucose IEA
 biological_processGO:0010628 positive regulation of gene expression IMP
 biological_processGO:0030217 T cell differentiation IEA
 biological_processGO:0030509 BMP signaling pathway IEA
 biological_processGO:0032868 response to insulin IEA
 biological_processGO:0033233 regulation of protein sumoylation IDA
 biological_processGO:0035914 skeletal muscle cell differentiation IEA
 biological_processGO:0042981 regulation of apoptotic process IEA
 biological_processGO:0044849 estrous cycle IEA
 biological_processGO:0045080 positive regulation of chemokine biosynthetic process IEA
 biological_processGO:0045893 positive regulation of transcription, DNA-templated IEA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IEA
 biological_processGO:0046886 positive regulation of hormone biosynthetic process IEA
 biological_processGO:0050725 positive regulation of interleukin-1 beta biosynthetic process IEA
 biological_processGO:0060337 type I interferon signaling pathway TAS
 biological_processGO:0061418 regulation of transcription from RNA polymerase II promoter in response to hypoxia IEA
 biological_processGO:0070498 interleukin-1-mediated signaling pathway IMP
 biological_processGO:0071310 cellular response to organic substance IEA
 biological_processGO:0071480 cellular response to gamma radiation IEA
 biological_processGO:0071504 cellular response to heparin ISS
 biological_processGO:0071506 cellular response to mycophenolic acid ISS
 biological_processGO:0072110 glomerular mesangial cell proliferation ISS
 biological_processGO:0072303 positive regulation of glomerular metanephric mesangial cell proliferation ISS
 biological_processGO:0090090 negative regulation of canonical Wnt signaling pathway IEA
 biological_processGO:0098759 cellular response to interleukin-8 IDA
 biological_processGO:1901216 positive regulation of neuron death IEA
 biological_processGO:1902949 positive regulation of tau-protein kinase activity IEA
 biological_processGO:2000182 regulation of progesterone biosynthetic process IEA
 cellular_componentGO:0005634 nucleus ISS
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005737 cytoplasm ISS
 molecular_functionGO:0000976 transcription regulatory region sequence-specific DNA binding IDA
 molecular_functionGO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding IEA
 molecular_functionGO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding NAS
 molecular_functionGO:0000982 transcription factor activity, RNA polymerase II proximal promoter sequence-specific DNA binding IEA
 molecular_functionGO:0001077 transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding IEA
 molecular_functionGO:0003676 nucleic acid binding IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003700 DNA-binding transcription factor activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008270 zinc ion binding IDA
 molecular_functionGO:0010385 double-stranded methylated DNA binding IDA
 molecular_functionGO:0035035 histone acetyltransferase binding IPI
 molecular_functionGO:0043565 sequence-specific DNA binding IDA
 molecular_functionGO:0044212 transcription regulatory region DNA binding IEA
 molecular_functionGO:0044729 hemi-methylated DNA-binding IDA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:1990841 promoter-specific chromatin binding IDA


Pathways (from Reactome)
Pathway description
Regulation of PTEN gene transcription
Interferon alpha/beta signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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