ENSDARG00000033999


Danio rerio

Features
Gene ID: ENSDARG00000033999
  
Biological name :cyp26a1
  
Synonyms : cyp26a1 / cytochrome P450, family 26, subfamily A, polypeptide 1
  
Possible biological names infered from orthology : cytochrome P450 family 26 subfamily A member 1 / O43174
  
Species: Danio rerio
  
Chr. number: 12
Strand: -1
Band:
Gene start: 8954761
Gene end: 8958353
  
Corresponding Affymetrix probe sets: Dr.5757.1.S1_at (Zebrafish Array)   NM_131146_at (Zebrafish Genome Array with custom cdf files)   
  
Cross references: Ensembl peptide - ENSDARP00000041727
Ensembl peptide - ENSDARP00000126883
NCBI entrez gene - 30381     See in Manteia.
RefSeq - NM_131146
RefSeq Peptide - NP_571221
swissprot - Q7SXV4
swissprot - R4GEH0
ZFIN ID - ZDB-GENE-990415-44
Ensembl - ENSDARG00000033999
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 CYP26A1ENSGALG00000033695Gallus gallus
 O43174ENSG00000095596Homo sapiens
 Cyp26a1ENSMUSG00000024987Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
cyp26c1 / cytochrome P450, family 26, subfamily C, polypeptide 1 / Q6V0L0* / cytochrome P450 family 26 subfamily C member 1*ENSDARG0000005602942
cyp26b1 / cytochrome P450, family 26, subfamily b, polypeptide 1 / Q811W2* / Q9NR63* / Cytochrome P450 26B1 * / cytochrome P450 family 26 subfamily B member 1*ENSDARG0000007712141
cyp51 / Q1JPY5 / cytochrome P450, family 51 / Q8K0C4* / Q16850* / CYP51A1* / Lanosterol 14-alpha demethylase * / cytochrome P450 family 51 subfamily A member 1*ENSDARG0000004264120


Protein motifs (from Interpro)
Interpro ID Name
 IPR001128  Cytochrome P450
 IPR002401  Cytochrome P450, E-class, group I
 IPR017972  Cytochrome P450, conserved site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0055114 oxidation-reduction process IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0004497 monooxygenase activity IEA
 molecular_functionGO:0005506 iron ion binding IEA
 molecular_functionGO:0016491 oxidoreductase activity IEA
 molecular_functionGO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen IEA
 molecular_functionGO:0020037 heme binding IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Vitamins
RA biosynthesis pathway


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000009 cardiac ventricle cardiac ventricle has fewer parts of type cardiac muscle cell , abnormal
cardiac ventricle decreased size , abnormal
cardiac ventricle has number of cardiac muscle cell , ameliorated
cardiac ventricle cardiac ventricle morphogenesis process quality , ameliorated
cardiac ventricle cardiac ventricle morphogenesis decreased process quality , abnormal
cardiac ventricle cell migration involved in heart formation decreased process quality , abnormal
cardiac ventricle establishment of cell polarity decreased process quality , abnormal
cardiac ventricle cardiac muscle cell circular , abnormal
Show

 ZFA:0000029 hindbrain hindbrain edematous , abnormal
hindbrain has fewer parts of type T interneuron , abnormal
hindbrain wholly posterioralized , abnormal
hindbrain morphology , abnormal
Show

 ZFA:0000042 midbrain hindbrain boundary midbrain hindbrain boundary absent , abnormal
Show

 ZFA:0000084 yolk yolk increased accumulation blood , abnormal
Show

 ZFA:0000107 eye eye decreased size , abnormal
Show

 ZFA:0000114 heart heart edematous , abnormal
heart has fewer parts of type cardiac muscle cell , abnormal
heart increased amount , abnormal
heart decreased amount , abnormal
Show

 ZFA:0000140 pancreas pancreas increased length , abnormal
pancreas mislocalised anteriorly , abnormal
Show

 ZFA:0000141 pectoral fin bud pectoral fin bud decreased size , abnormal
Show

 ZFA:0000151 pronephros pronephros wholly anterioralized , abnormal
Show

 ZFA:0000155 somite somite spatial pattern , abnormal
Show

 ZFA:0000173 bulbus arteriosus bulbus arteriosus outflow tract morphogenesis process quality , ameliorated
bulbus arteriosus outflow tract morphogenesis decreased process quality , abnormal
Show

 ZFA:0000297 vagal lobe vagal lobe distended , abnormal
Show

 ZFA:0000471 atrium atrium has fewer parts of type cardiac muscle cell , abnormal
Show

 ZFA:0001032 rhombomere 4 rhombomere 4 increased size , abnormal
Show

 ZFA:0001058 caudal fin caudal fin shortened , abnormal
Show

 ZFA:0001094 whole organism whole organism increased curvature , abnormal
whole organism decreased amount , abnormal
whole organism increased amount , abnormal
Show

 ZFA:0001104 pharyngeal endoderm pharyngeal endoderm condensed , abnormal
Show

 ZFA:0001117 post-vent region post-vent region structure , abnormal
Show

 ZFA:0001161 pectoral fin pectoral fin morphology , abnormal
Show

 ZFA:0001267 cranial vasculature cranial vasculature has fewer parts of type endothelial cell , abnormal
Show

 ZFA:0001320 endocardium endocardium has fewer parts of type endothelial cell , abnormal
Show

 ZFA:0001620 pronephric proximal convoluted tubule pronephric proximal convoluted tubule increased distribution , abnormal
Show

 ZFA:0001621 pronephric proximal straight tubule pronephric proximal straight tubule increased distribution , abnormal
Show

 ZFA:0001622 pronephric distal early tubule pronephric distal early tubule mislocalised , abnormal
Show

 ZFA:0001624 pronephric distal late tubule pronephric distal late tubule decreased distribution , abnormal
Show

 ZFA:0005004 aortic arch aortic arch has extra parts of type blood vessel endothelial cell , abnormal
Show

 ZFA:0005007 aortic arch 3 aortic arch 3 has extra parts of type blood vessel endothelial cell , abnormal
Show

 ZFA:0005008 aortic arch 4 aortic arch 4 has extra parts of type blood vessel endothelial cell , abnormal
Show

 ZFA:0005061 ventricular myocardium ventricular myocardium cardiac muscle cell mislocalised , abnormal
ventricular myocardium cell-cell junction spatial pattern , abnormal
ventricular myocardium bicellular tight junction spatial pattern , abnormal
ventricular myocardium increased distance ventricular endocardium , abnormal
Show

 ZFA:0009316 cardiac muscle cell cardiac muscle cell external to heart , abnormal
cardiac muscle cell mislocalised , abnormal
Show

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000045926 crabp1a / cellular retinoic acid binding protein 1a / CRABP1* / P29762* / P62965* / cellular retinoic acid binding protein 1*  / reaction
 ENSDARG00000035904 crabp1b / cellular retinoic acid binding protein 1b / CRABP1* / P29762* / P62965* / cellular retinoic acid binding protein 1*  / reaction






 

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