ENSDARG00000035924


Danio rerio

Features
Gene ID: ENSDARG00000035924
  
Biological name :dync1li2
  
Synonyms : dync1li2 / dynein, cytoplasmic 1, light intermediate chain 2
  
Possible biological names infered from orthology : Cytoplasmic dynein 1 light intermediate chain 2 / O43237 / Q6PDL0
  
Species: Danio rerio
  
Chr. number: 7
Strand: -1
Band:
Gene start: 44674956
Gene end: 44704910
  
Corresponding Affymetrix probe sets: Dr.3237.1.A1_at (Zebrafish Array)   
  
Cross references: Ensembl peptide - ENSDARP00000031864
NCBI entrez gene - 573266     See in Manteia.
RefSeq - XM_005166450
RefSeq Peptide - NP_001017669
swissprot - F1RB89
ZFIN ID - ZDB-GENE-050417-156
Ensembl - ENSDARG00000035924
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ENSGALG00000022206Gallus gallus
 DYNC1LI2ENSGALG00000005241Gallus gallus
 O43237ENSG00000135720Homo sapiens
 Q6PDL0ENSMUSG00000035770Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
dync1li1 / dynein, cytoplasmic 1, light intermediate chain 1 / Q8R1Q8* / Q9Y6G9* / Cytoplasmic dynein 1 light intermediate chain 1 *ENSDARG0000009831761


Protein motifs (from Interpro)
Interpro ID Name
 IPR008467  Dynein 1 light intermediate chain
 IPR022780  Dynein family light intermediate chain
 IPR027417  P-loop containing nucleoside triphosphate hydrolase


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007018 microtubule-based movement IEA
 biological_processGO:0009794 regulation of mitotic cell cycle, embryonic IMP
 biological_processGO:0060236 regulation of mitotic spindle organization IMP
 biological_processGO:0090235 regulation of metaphase plate congression IMP
 cellular_componentGO:0005813 centrosome IBA
 cellular_componentGO:0005868 cytoplasmic dynein complex IEA
 molecular_functionGO:0003777 microtubule motor activity IEA
 molecular_functionGO:0045504 dynein heavy chain binding IBA


Pathways (from Reactome)
Pathway description
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
Separation of Sister Chromatids
Resolution of Sister Chromatid Cohesion
RHO GTPases Activate Formins


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000077 tail bud tail bud malformed , abnormal
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 ZFA:0000093 blastomere blastomere increased size , abnormal
blastomere deformed , abnormal
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 ZFA:0001094 whole organism whole organism decreased amount , abnormal
whole organism elongated , abnormal
whole organism oblong , abnormal
whole organism deformed , abnormal
whole organism nucleus decreased amount , abnormal
Show

 ZFA:0001175 blastodisc blastodisc furrowed , abnormal
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 ZFA:0009000 cell cell mitotic spindle elongated , abnormal
cell mitotic spindle pole structure , abnormal
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Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000041363 dctn3 / dynactin 3 (p22) / O75935* / Q9Z0Y1* / dynactin subunit 3*  / complex
 ENSDARG00000060948 dync1i1 / dynein, cytoplasmic 1, intermediate chain 1 / O14576* / O88485* / Cytoplasmic dynein 1 intermediate chain 1 *  / complex
 ENSDARG00000019743 dctn1a / dynactin 1a / DCTN1* / Q14203* / dynactin subunit 1*  / complex
 ENSDARG00000100252 capzb / capping protein (actin filament) muscle Z-line, beta / P47756* / capping actin protein of muscle Z-line beta subunit*  / complex
 ENSDARG00000056753 dctn1b / dynactin 1b / DCTN1* / O08788* / Q14203* / dynactin subunit 1* / Mus musculus dynactin 1 (Dctn1), transcript variant 4, mRNA.*  / complex
 ENSDARG00000098317 dync1li1 / dynein, cytoplasmic 1, light intermediate chain 1 / Q8R1Q8* / Q9Y6G9* / Cytoplasmic dynein 1 light intermediate chain 1 *  / complex
 ENSDARG00000035924 dync1li2 / dynein, cytoplasmic 1, light intermediate chain 2 / O43237* / Q6PDL0* / Cytoplasmic dynein 1 light intermediate chain 2 *  / complex
 ENSDARG00000056090 capza1b / capping protein (actin filament) muscle Z-line, alpha 1b / P52907* / CAPZA1* / 4933400A11Rik* / RIKEN cDNA 4933400A11 gene* / capping actin protein of muscle Z-line alpha subunit 1*  / complex
 ENSDARG00000058454 dynll1 / dynein, light chain, LC8-type 1 / P63168* / P63167* / BC048507* / cDNA sequence BC048507* / Dynein light chain 1, cytoplasmic *  / complex
 ENSDARG00000069790 dynll2a / dynein, light chain, LC8-type 2a / Q9D0M5* / DYNLL2* / Q96FJ2* / dynein light chain LC8-type 2* / Dynein light chain 2, cytoplasmic *  / complex






 

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