ENSDARG00000036338


Danio rerio

Features
Gene ID: ENSDARG00000036338
  
Biological name :vps11
  
Synonyms : vacuolar protein sorting 11 / vps11
  
Possible biological names infered from orthology : Q91W86 / Q9H270 / VPS11, CORVET/HOPS core subunit
  
Species: Danio rerio
  
Chr. number: 10
Strand: -1
Band:
Gene start: 29751029
Gene end: 29768556
  
Corresponding Affymetrix probe sets:
  
Cross references: Ensembl peptide - ENSDARP00000052786
NCBI entrez gene - 565852     See in Manteia.
RefSeq - NM_001037708
RefSeq Peptide - NP_001032797
swissprot - F1QVG9
ZFIN ID - ZDB-GENE-050731-5
Ensembl - ENSDARG00000036338
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 VPS11ENSGALG00000029536Gallus gallus
 VPS11ENSG00000160695Homo sapiens
 Vps11ENSMUSG00000032127Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR000547  Clathrin, heavy chain/VPS, 7-fold repeat
 IPR001841  Zinc finger, RING-type
 IPR011990  Tetratricopeptide-like helical domain superfamily
 IPR013083  Zinc finger, RING/FYVE/PHD-type
 IPR015943  WD40/YVTN repeat-like-containing domain superfamily
 IPR016024  Armadillo-type fold
 IPR016528  Vacuolar protein sorting-associated protein 11
 IPR017986  WD40-repeat-containing domain
 IPR024763  Vacuolar protein sorting protein 11, C-terminal


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001889 liver development IMP
 biological_processGO:0003406 retinal pigment epithelium development IMP
 biological_processGO:0003407 neural retina development IMP
 biological_processGO:0006886 intracellular protein transport IEA
 biological_processGO:0006904 vesicle docking involved in exocytosis IBA
 biological_processGO:0007032 endosome organization IBA
 biological_processGO:0007040 lysosome organization IBA
 biological_processGO:0010507 negative regulation of autophagy IMP
 biological_processGO:0016192 vesicle-mediated transport IEA
 biological_processGO:0030318 melanocyte differentiation IMP
 biological_processGO:0035542 regulation of SNARE complex assembly IBA
 biological_processGO:0048794 swim bladder development IMP
 biological_processGO:0060036 notochord cell vacuolation IMP
 biological_processGO:1902362 melanocyte apoptotic process IMP
 cellular_componentGO:0005768 endosome IBA
 cellular_componentGO:0030897 HOPS complex IBA
 molecular_functionGO:0030674 protein binding, bridging IBA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000029 hindbrain hindbrain oligodendrocyte decreased distribution , abnormal
hindbrain apoptotic , abnormal
Show

 ZFA:0000046 retinal neural layer retinal neural layer chromatin condensed , abnormal
retinal neural layer detached from retinal pigmented epithelium , abnormal
Show

 ZFA:0000054 pericardium pericardium edematous , abnormal
Show

 ZFA:0000076 swim bladder swim bladder absent , abnormal
Show

 ZFA:0000107 eye eye decreased pigmentation , abnormal
Show

 ZFA:0000123 liver liver hyperplastic , abnormal
Show

 ZFA:0000128 midbrain midbrain cell death increased occurrence , abnormal
Show

 ZFA:0000135 notochord notochord vacuole disorganized , abnormal
notochord vacuole broken , abnormal
Show

 ZFA:0000144 retinal pigmented epithelium retinal pigmented epithelium morphology , abnormal
retinal pigmented epithelium decreased pigmentation , abnormal
retinal pigmented epithelium chromatin condensed , abnormal
retinal pigmented epithelium vacuolated , abnormal
retinal pigmented epithelium melanocyte immature , abnormal
Show

 ZFA:0001114 head head melanocyte decreased pigmentation , abnormal
head iridophore decreased amount , abnormal
Show

 ZFA:0001463 melanophore stripe melanophore stripe melanosome morphology , abnormal
Show

 ZFA:0001466 photoreceptor outer segment layer photoreceptor outer segment layer retinal rod cell collapsed , abnormal
photoreceptor outer segment layer collapsed , abnormal
photoreceptor outer segment layer photoreceptor outer segment membrane displaced to photoreceptor outer segment layer vacuolar lumen, abnormal
photoreceptor outer segment layer retinal rod cell vacuolated , abnormal
Show

 ZFA:0005220 larval melanophore stripe larval melanophore stripe melanocyte decreased pigmentation , abnormal
larval melanophore stripe decreased pigmentation , abnormal
Show

 ZFA:0005221 dorsal larval melanophore stripe dorsal larval melanophore stripe vacuole increased amount , abnormal
dorsal larval melanophore stripe melanosome decreased amount , abnormal
Show

 ZFA:0009091 melanocyte melanocyte decreased amount , abnormal
melanocyte melanosome aggregated , abnormal
melanocyte broken , abnormal
melanocyte morphology , abnormal
Show

 ZFA:0009199 iridophore iridophore decreased amount , abnormal
Show

 ZFA:0009275 retinal rod cell retinal rod cell nucleus mislocalised , abnormal
Show

 ZFA:0009280 Muller cell Muller cell hypertrophic , abnormal
Show

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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