ENSDARG00000036548


Danio rerio

Features
Gene ID: ENSDARG00000036548
  
Biological name :s1pr2
  
Synonyms : Q9I8K8 / s1pr2 / sphingosine-1-phosphate receptor 2
  
Possible biological names infered from orthology : O95136 / P52592
  
Species: Danio rerio
  
Chr. number: 3
Strand: -1
Band:
Gene start: 54616015
Gene end: 54669185
  
Corresponding Affymetrix probe sets: Dr.20936.1.A1_at (Zebrafish Array)   Dr.20936.1.S1_at (Zebrafish Array)   
  
Cross references: Ensembl peptide - ENSDARP00000053105
NCBI entrez gene - 170457     See in Manteia.
RefSeq - NM_001159970
RefSeq Peptide - NP_001153442
swissprot - Q9I8K8
ZFIN ID - ZDB-GENE-020123-2
Ensembl - ENSDARG00000036548
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 S1PR2ENSG00000267534Homo sapiens
 S1pr2ENSMUSG00000043895Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
s1pr1 / sphingosine-1-phosphate receptor 1 / O08530* / P21453*ENSDARG0000004269044
s1pr5a / sphingosine-1-phosphate receptor 5aENSDARG0000004052644
s1pr3a / sphingosine-1-phosphate receptor 3a / S1PR3* / Q9Z0U9* / Q99500* / sphingosine-1-phosphate receptor 3*ENSDARG0000004247041
s1pr5b / sphingosine-1-phosphate receptor 5b / S1PR5* / Q9H228* / Q91X56* / sphingosine-1-phosphate receptor 5*ENSDARG0000005219238
s1pr4 / sphingosine-1-phosphate receptor 4 / O95977* / Q9Z0L1*ENSDARG0000007485135
lpar3 / lysophosphatidic acid receptor 3 / Q9UBY5*ENSDARG0000010181430
lpar2b / lysophosphatidic acid receptor 2b / LPAR2* / Q9HBW0* / lysophosphatidic acid receptor 2*ENSDARG0000004256129
lpar2a / lysophosphatidic acid receptor 2a / LPAR2* / Q9HBW0* / lysophosphatidic acid receptor 2*ENSDARG0000004233828
gpr6 / G protein-coupled receptor 6 / P46095*ENSDARG0000005240024
cnr1 / cannabinoid receptor 1 / P21554* / P47746* / Mus musculus cannabinoid receptor 1 (brain) (Cnr1), transcript variant 2, mRNA.*ENSDARG0000000902024
gpr12 / G protein-coupled receptor 12 / P35412* / P47775*ENSDARG0000006293422
lpar1 / lysophosphatidic acid receptor 1 / P61793* / Q92633*ENSDARG0000009984022
gpr185b / G protein-coupled receptor 185 bENSDARG0000003656021
gpr186 / G protein-coupled receptor 186ENSDARG0000009486021
gpr185a / G protein-coupled receptor 185 aENSDARG0000006040020
cnr2 / cannabinoid receptor 2 / P34972* / P47936*ENSDARG0000003997019


Protein motifs (from Interpro)
Interpro ID Name
 IPR000276  G protein-coupled receptor, rhodopsin-like
 IPR000987  EDG-1 sphingosine 1-phosphate receptor
 IPR004061  Sphingosine 1-phosphate receptor
 IPR004063  EDG-5 sphingosine 1-phosphate receptor
 IPR017452  GPCR, rhodopsin-like, 7TM


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001944 vasculature development IGI
 biological_processGO:0003007 heart morphogenesis IMP
 biological_processGO:0003143 embryonic heart tube morphogenesis IMP
 biological_processGO:0003315 heart rudiment formation IMP
 biological_processGO:0003318 cell migration to the midline involved in heart development IMP
 biological_processGO:0003319 cardioblast migration to the midline involved in heart rudiment formation IMP
 biological_processGO:0003376 sphingosine-1-phosphate signaling pathway IMP
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007186 G-protein coupled receptor signaling pathway IEA
 biological_processGO:0007492 endoderm development IMP
 biological_processGO:0007507 heart development IMP
 biological_processGO:0008078 mesodermal cell migration IGI
 biological_processGO:0030336 negative regulation of cell migration IMP
 biological_processGO:0035050 embryonic heart tube development IMP
 biological_processGO:0035676 anterior lateral line neuromast hair cell development IMP
 biological_processGO:0035677 posterior lateral line neuromast hair cell development IMP
 biological_processGO:0042074 cell migration involved in gastrulation IMP
 biological_processGO:0048703 embryonic viscerocranium morphogenesis IGI
 biological_processGO:0048840 otolith development IMP
 biological_processGO:0048901 anterior lateral line neuromast development IMP
 biological_processGO:0060026 convergent extension IMP
 biological_processGO:0060027 convergent extension involved in gastrulation IDA
 biological_processGO:0060872 semicircular canal development IMP
 biological_processGO:0060973 cell migration involved in heart development IMP
 biological_processGO:0061035 regulation of cartilage development IMP
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0004871 obsolete signal transducer activity IEA
 molecular_functionGO:0004930 G-protein coupled receptor activity IEA
 molecular_functionGO:0038036 sphingosine-1-phosphate receptor activity IEA


Pathways (from Reactome)
Pathway description
G alpha (i) signalling events
Lysosphingolipid and LPA receptors


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000017 endoderm endoderm antero-medial region decreased object quality , abnormal
endoderm anterior region increased width , abnormal
endoderm anterior region perforate , abnormal
endoderm convergent extension process quality , abnormal
endoderm anterior region apoptotic , abnormal
endoderm apoptotic process increased occurrence , abnormal
Show

 ZFA:0000028 heart primordium heart primordium mislocalised laterally , abnormal
Show

 ZFA:0000054 pericardium pericardium edematous , abnormal
pericardium swollen , abnormal
Show

 ZFA:0000060 prechordal plate prechordal plate flat , abnormal
prechordal plate increased length , abnormal
prechordal plate increased width , abnormal
Show

 ZFA:0000107 eye eye decreased size , abnormal
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 ZFA:0000114 heart heart malformed , abnormal
heart split bilaterally , abnormal
heart bifurcated , abnormal
heart cleft , abnormal
heart quality , abnormal
heart edematous , abnormal
heart duplicated , abnormal
heart fused with heart , abnormal
heart shape , abnormal
heart increased amount , abnormal
Show

 ZFA:0000115 heart rudiment heart rudiment bifurcated , abnormal
heart rudiment split , abnormal
heart rudiment malformed , abnormal
heart rudiment increased amount , abnormal
Show

 ZFA:0000117 hypoblast hypoblast mesodermal cell spatial pattern , abnormal
Show

 ZFA:0000123 liver liver bilateral , abnormal
Show

 ZFA:0000131 neural keel neural keel increased length , abnormal
Show

 ZFA:0000360 heart tube heart tube increased amount , abnormal
heart tube mislocalised laterally , abnormal
heart tube split bilaterally , abnormal
heart tube bifurcated , abnormal
heart tube duplicated , abnormal
Show

 ZFA:0000428 saccule saccule decreased size , abnormal
Show

 ZFA:0000431 semicircular canal semicircular canal morphology , abnormal
semicircular canal broken into two pieces , abnormal
Show

 ZFA:0000471 atrium atrium duplicated , abnormal
Show

 ZFA:0000700 utricle utricle increased size , abnormal
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 ZFA:0000940 posterior lateral line neuromast posterior lateral line neuromast decreased size , abnormal
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 ZFA:0000944 posterior lateral line posterior lateral line has fewer parts of type posterior lateral line neuromast , abnormal
Show

 ZFA:0001058 caudal fin caudal fin endoderm blistered , abnormal
caudal fin blistered , abnormal
Show

 ZFA:0001094 whole organism whole organism lethal (sensu genetics) , abnormal
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 ZFA:0001104 pharyngeal endoderm pharyngeal endoderm disorganized , abnormal
pharyngeal endoderm mislocalised posteriorly , abnormal
pharyngeal endoderm mislocalised laterally , abnormal
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 ZFA:0001117 post-vent region post-vent region epithelium blistered , abnormal
Show

 ZFA:0001205 Meckel s cartilage Meckels cartilage hypoplastic , abnormal
Meckels cartilage malformed , abnormal
Meckels cartilage disorganized , abnormal
Meckels cartilage aplastic , abnormal
Show

 ZFA:0001216 splanchnocranium splanchnocranium bone mineralization disrupted , abnormal
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 ZFA:0001227 mandibular arch skeleton mandibular arch skeleton shape , abnormal
mandibular arch skeleton size , abnormal
mandibular arch skeleton mislocalised , abnormal
mandibular arch skeleton hypoplastic , abnormal
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 ZFA:0001273 ventral mandibular arch ventral mandibular arch morphology , abnormal
ventral mandibular arch anterior-posterior axis decreased length , abnormal
ventral mandibular arch disorganized , abnormal
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 ZFA:0001285 intersegmental vessel intersegmental vessel morphology , abnormal
intersegmental vessel shortened , abnormal
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 ZFA:0001320 endocardium endocardium unfused from endocardium , abnormal
endocardium mislocalised , abnormal
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 ZFA:0001321 neurocranial trabecula neurocranial trabecula hypoplastic , abnormal
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 ZFA:0001379 pharyngeal ectoderm pharyngeal ectoderm disorganized , abnormal
pharyngeal ectoderm increased area , abnormal
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 ZFA:0001399 palatoquadrate cartilage palatoquadrate cartilage aplastic , abnormal
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 ZFA:0001405 ethmoid cartilage ethmoid cartilage hypoplastic , abnormal
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 ZFA:0001439 anatomical system anatomical system quality , abnormal
Show

 ZFA:0001470 anterior lateral line anterior lateral line neuromast hair cell decreased amount , abnormal
Show

 ZFA:0001612 pharyngeal arch 1 pharyngeal arch 1 morphology , abnormal
pharyngeal arch 1 decreased length , abnormal
Show

 ZFA:0001617 otolith otolith increased size , abnormal
otolith malformed , abnormal
Show

 ZFA:0005463 oral ectoderm oral ectoderm hypoplastic , abnormal
oral ectoderm disorganized , abnormal
oral ectoderm mislocalised anteriorly , abnormal
Show

 ZFA:0005490 myocardial precursor myocardial precursor mislocalised laterally , abnormal
Show

 ZFA:0005597 median fin median fin blistered , abnormal
Show

 ZFA:0009183 epidermal cell epidermal cell aggregated , abnormal
epidermal cell cell aggregation decreased amount , abnormal
Show

 ZFA:0009367 neuromast hair cell neuromast hair cell apoptotic , abnormal
Show

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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