ENSG00000267534


Homo sapiens

Features
Gene ID: ENSG00000267534
  
Biological name :S1PR2
  
Synonyms : O95136 / S1PR2 / sphingosine-1-phosphate receptor 2
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 19
Strand: -1
Band: p13.2
Gene start: 10221433
Gene end: 10231331
  
Corresponding Affymetrix probe sets: 208537_at (Human Genome U133 Plus 2.0 Array)   227684_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000466933
Ensembl peptide - ENSP00000496438
NCBI entrez gene - 9294     See in Manteia.
OMIM - 605111
RefSeq - NM_004230
RefSeq Peptide - NP_004221
swissprot - A0A024R7B2
swissprot - O95136
Ensembl - ENSG00000267534
  
Related genetic diseases (OMIM): 610419 - Deafness, autosomal recessive 68, 610419
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 s1pr2ENSDARG00000036548Danio rerio
 S1pr2ENSMUSG00000043895Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
S1PR1 / P21453 / sphingosine-1-phosphate receptor 1ENSG0000017098947
S1PR5 / Q9H228 / sphingosine-1-phosphate receptor 5ENSG0000018073945
S1PR3 / Q99500 / sphingosine-1-phosphate receptor 3ENSG0000021369444
S1PR4 / O95977 / sphingosine-1-phosphate receptor 4ENSG0000012591035
LPAR2 / Q9HBW0 / lysophosphatidic acid receptor 2ENSG0000006454732
LPAR3 / Q9UBY5 / lysophosphatidic acid receptor 3ENSG0000017151730
LPAR1 / Q92633 / lysophosphatidic acid receptor 1ENSG0000019812129
GPR6 / P46095 / G protein-coupled receptor 6ENSG0000014636026
CNR1 / P21554 / cannabinoid receptor 1ENSG0000011843224
GPR3 / P46089 / G protein-coupled receptor 3ENSG0000018177324
GPR12 / P47775 / G protein-coupled receptor 12ENSG0000013297523
CNR2 / P34972 / cannabinoid receptor 2ENSG0000018882222


Protein motifs (from Interpro)
Interpro ID Name
 IPR000276  G protein-coupled receptor, rhodopsin-like
 IPR004061  Sphingosine 1-phosphate receptor
 IPR004063  EDG-5 sphingosine 1-phosphate receptor
 IPR017452  GPCR, rhodopsin-like, 7TM


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000187 activation of MAPK activity TAS
 biological_processGO:0003376 sphingosine-1-phosphate signaling pathway IEA
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007186 G-protein coupled receptor signaling pathway IEA
 biological_processGO:0008284 positive regulation of cell proliferation TAS
 biological_processGO:0010800 positive regulation of peptidyl-threonine phosphorylation IEA
 biological_processGO:0031532 actin cytoskeleton reorganization IMP
 biological_processGO:0046847 filopodium assembly IMP
 biological_processGO:0090394 negative regulation of excitatory postsynaptic potential IEA
 biological_processGO:1903142 positive regulation of establishment of endothelial barrier IMP
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0001664 G-protein coupled receptor binding IPI
 molecular_functionGO:0004871 obsolete signal transducer activity IEA
 molecular_functionGO:0004930 G-protein coupled receptor activity IEA
 molecular_functionGO:0005178 integrin binding IPI
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008289 lipid binding TAS
 molecular_functionGO:0038036 sphingosine-1-phosphate receptor activity IEA


Pathways (from Reactome)
Pathway description
G alpha (i) signalling events
Lysosphingolipid and LPA receptors


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 HP:0000007 Autosomal recessive inheritance "A mode of inheritance that is observed for traits related to a gene encoded on one of the autosomes (i.e., the human chromosomes 1-22) in which a trait manifests in homozygotes. In the context of medical genetics, autosomal recessive disorders manifest in homozygotes (with two copies of the mutant allele) or compound heterozygotes (whereby each copy of a gene has a distinct mutant allele)." [HPO:curators]
Show

 HP:0000407 Hearing loss, sensorineural "Hearing loss caused by damage or dysfunction of the auditory nerve (cranial nerve VIII)." [HPO:curators]
Show

 HP:0003593 Early onset 
Show

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr