ENSG00000125910


Homo sapiens

Features
Gene ID: ENSG00000125910
  
Biological name :S1PR4
  
Synonyms : O95977 / S1PR4 / sphingosine-1-phosphate receptor 4
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 19
Strand: 1
Band: p13.3
Gene start: 3172346
Gene end: 3180332
  
Corresponding Affymetrix probe sets: 206437_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000246115
NCBI entrez gene - 8698     See in Manteia.
OMIM - 603751
RefSeq - NM_003775
RefSeq Peptide - NP_003766
swissprot - O95977
Ensembl - ENSG00000125910
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 s1pr4ENSDARG00000074851Danio rerio
 S1PR4ENSGALG00000013371Gallus gallus
 S1pr4ENSMUSG00000044199Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
S1PR5 / Q9H228 / sphingosine-1-phosphate receptor 5ENSG0000018073939
S1PR3 / Q99500 / sphingosine-1-phosphate receptor 3ENSG0000021369438
S1PR1 / P21453 / sphingosine-1-phosphate receptor 1ENSG0000017098936
S1PR2 / O95136 / sphingosine-1-phosphate receptor 2ENSG0000026753432
LPAR2 / Q9HBW0 / lysophosphatidic acid receptor 2ENSG0000006454730
LPAR1 / Q92633 / lysophosphatidic acid receptor 1ENSG0000019812129
LPAR3 / Q9UBY5 / lysophosphatidic acid receptor 3ENSG0000017151726
CNR1 / P21554 / cannabinoid receptor 1ENSG0000011843223
CNR2 / P34972 / cannabinoid receptor 2ENSG0000018882222
GPR3 / P46089 / G protein-coupled receptor 3ENSG0000018177321
GPR6 / P46095 / G protein-coupled receptor 6ENSG0000014636021
GPR12 / P47775 / G protein-coupled receptor 12ENSG0000013297520


Protein motifs (from Interpro)
Interpro ID Name
 IPR000276  G protein-coupled receptor, rhodopsin-like
 IPR004061  Sphingosine 1-phosphate receptor
 IPR004064  EDG-6 sphingosine 1-phosphate receptor
 IPR017452  GPCR, rhodopsin-like, 7TM


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0003376 sphingosine-1-phosphate signaling pathway IEA
 biological_processGO:0006955 immune response TAS
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007186 G-protein coupled receptor signaling pathway TAS
 biological_processGO:0007189 adenylate cyclase-activating G-protein coupled receptor signaling pathway IEA
 biological_processGO:0007202 activation of phospholipase C activity TAS
 biological_processGO:0007204 positive regulation of cytosolic calcium ion concentration TAS
 cellular_componentGO:0005739 mitochondrion IDA
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0005887 integral component of plasma membrane TAS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0004871 obsolete signal transducer activity IEA
 molecular_functionGO:0004930 G-protein coupled receptor activity TAS
 molecular_functionGO:0008289 lipid binding TAS
 molecular_functionGO:0038036 sphingosine-1-phosphate receptor activity IEA


Pathways (from Reactome)
Pathway description
G alpha (i) signalling events
Lysosphingolipid and LPA receptors


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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