ENSG00000213694


Homo sapiens

Features
Gene ID: ENSG00000213694
  
Biological name :S1PR3
  
Synonyms : Q99500 / S1PR3 / sphingosine-1-phosphate receptor 3
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 9
Strand: 1
Band: q22.1
Gene start: 88991447
Gene end: 89005010
  
Corresponding Affymetrix probe sets: 228176_at (Human Genome U133 Plus 2.0 Array)   231741_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000365006
Ensembl peptide - ENSP00000350878
NCBI entrez gene - 1903     See in Manteia.
OMIM - 601965
RefSeq - NM_005226
RefSeq Peptide - NP_005217
swissprot - Q99500
Ensembl - ENSG00000213694
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 s1pr3aENSDARG00000042470Danio rerio
 S1pr3ENSMUSG00000067586Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
S1PR1 / P21453 / sphingosine-1-phosphate receptor 1ENSG0000017098951
S1PR5 / Q9H228 / sphingosine-1-phosphate receptor 5ENSG0000018073944
S1PR2 / O95136 / sphingosine-1-phosphate receptor 2ENSG0000026753441
S1PR4 / O95977 / sphingosine-1-phosphate receptor 4ENSG0000012591038
LPAR1 / Q92633 / lysophosphatidic acid receptor 1ENSG0000019812132
LPAR2 / Q9HBW0 / lysophosphatidic acid receptor 2ENSG0000006454730
LPAR3 / Q9UBY5 / lysophosphatidic acid receptor 3ENSG0000017151728
CNR1 / P21554 / cannabinoid receptor 1ENSG0000011843224
GPR6 / P46095 / G protein-coupled receptor 6ENSG0000014636023
GPR3 / P46089 / G protein-coupled receptor 3ENSG0000018177322
GPR12 / P47775 / G protein-coupled receptor 12ENSG0000013297522
CNR2 / P34972 / cannabinoid receptor 2ENSG0000018882221


Protein motifs (from Interpro)
Interpro ID Name
 IPR000276  G protein-coupled receptor, rhodopsin-like
 IPR004061  Sphingosine 1-phosphate receptor
 IPR004062  EDG-3 sphingosine 1-phosphate receptor
 IPR017452  GPCR, rhodopsin-like, 7TM


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001816 cytokine production IEA
 biological_processGO:0003376 sphingosine-1-phosphate signaling pathway IEA
 biological_processGO:0006954 inflammatory response IEA
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007186 G-protein coupled receptor signaling pathway TAS
 biological_processGO:0007193 adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway IEA
 biological_processGO:0007204 positive regulation of cytosolic calcium ion concentration TAS
 biological_processGO:0007219 Notch signaling pathway IEA
 biological_processGO:0008284 positive regulation of cell proliferation TAS
 biological_processGO:0009653 anatomical structure morphogenesis TAS
 biological_processGO:0032651 regulation of interleukin-1 beta production IEA
 biological_processGO:1903141 negative regulation of establishment of endothelial barrier IMP
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0005887 integral component of plasma membrane TAS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0004871 obsolete signal transducer activity IEA
 molecular_functionGO:0004930 G-protein coupled receptor activity TAS
 molecular_functionGO:0005178 integrin binding IPI
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008289 lipid binding TAS
 molecular_functionGO:0038036 sphingosine-1-phosphate receptor activity IEA


Pathways (from Reactome)
Pathway description
G alpha (i) signalling events
Lysosphingolipid and LPA receptors


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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