ENSG00000198121


Homo sapiens

Features
Gene ID: ENSG00000198121
  
Biological name :LPAR1
  
Synonyms : LPAR1 / lysophosphatidic acid receptor 1 / Q92633
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 9
Strand: -1
Band: q31.3
Gene start: 110873263
Gene end: 111038458
  
Corresponding Affymetrix probe sets: 204036_at (Human Genome U133 Plus 2.0 Array)   204037_at (Human Genome U133 Plus 2.0 Array)   204038_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000351755
Ensembl peptide - ENSP00000363553
Ensembl peptide - ENSP00000401810
Ensembl peptide - ENSP00000445697
Ensembl peptide - ENSP00000363552
NCBI entrez gene - 1902     See in Manteia.
OMIM - 602282
RefSeq - NM_001351403
RefSeq - NM_001351402
RefSeq - NM_001351420
RefSeq - NM_001401
RefSeq - NM_057159
RefSeq - XM_005251781
RefSeq - XM_005251782
RefSeq - XM_017014383
RefSeq - XM_017014384
RefSeq - XM_017014385
RefSeq - XM_017014386
RefSeq - XM_017014387
RefSeq - XM_017014388
RefSeq - XM_017014389
RefSeq - XM_017014390
RefSeq - XM_017014391
RefSeq - XM_017014392
RefSeq - XM_017014393
RefSeq - XM_017014394
RefSeq - XM_017014395
RefSeq - XM_017014396
RefSeq - XM_017014397
RefSeq - XM_017014398
RefSeq - XM_017014399
RefSeq - XM_017014400
RefSeq - XM_017014401
RefSeq - XM_017014402
RefSeq - XM_017014403
RefSeq - XM_017014404
RefSeq - XM_017014405
RefSeq - XM_017014406
RefSeq - XM_017014407
RefSeq - NM_001351404
RefSeq - NM_001351405
RefSeq - NM_001351406
RefSeq - NM_001351417
RefSeq - NM_001351419
RefSeq Peptide - NP_001338346
RefSeq Peptide - NP_001338347
RefSeq Peptide - NP_001338348
RefSeq Peptide - NP_001338349
RefSeq Peptide - NP_001392
RefSeq Peptide - NP_476500
RefSeq Peptide - NP_001338342
RefSeq Peptide - NP_001338343
RefSeq Peptide - NP_001338344
RefSeq Peptide - NP_001338345
RefSeq Peptide - NP_001338326
RefSeq Peptide - NP_001338327
RefSeq Peptide - NP_001338328
RefSeq Peptide - NP_001338329
RefSeq Peptide - NP_001338330
RefSeq Peptide - NP_001338331
RefSeq Peptide - NP_001338332
RefSeq Peptide - NP_001338333
RefSeq Peptide - NP_001338334
RefSeq Peptide - NP_001338335
RefSeq Peptide - NP_001338336
RefSeq Peptide - NP_001338337
RefSeq Peptide - NP_001338338
RefSeq Peptide - NP_001338339
RefSeq Peptide - NP_001338340
RefSeq Peptide - NP_001338341
swissprot - Q5VZX0
swissprot - Q6GPG7
swissprot - Q92633
swissprot - B1AP63
Ensembl - ENSG00000198121
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 lpar1ENSDARG00000099840Danio rerio
 LPAR1ENSGALG00000015729Gallus gallus
 Lpar1ENSMUSG00000038668Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
LPAR2 / Q9HBW0 / lysophosphatidic acid receptor 2ENSG0000006454750
LPAR3 / Q9UBY5 / lysophosphatidic acid receptor 3ENSG0000017151746
S1PR1 / P21453 / sphingosine-1-phosphate receptor 1ENSG0000017098934
S1PR3 / Q99500 / sphingosine-1-phosphate receptor 3ENSG0000021369433
S1PR4 / O95977 / sphingosine-1-phosphate receptor 4ENSG0000012591031
S1PR5 / Q9H228 / sphingosine-1-phosphate receptor 5ENSG0000018073929
S1PR2 / O95136 / sphingosine-1-phosphate receptor 2ENSG0000026753429
CNR1 / P21554 / cannabinoid receptor 1ENSG0000011843224
GPR3 / P46089 / G protein-coupled receptor 3ENSG0000018177322
GPR12 / P47775 / G protein-coupled receptor 12ENSG0000013297522
GPR6 / P46095 / G protein-coupled receptor 6ENSG0000014636021
CNR2 / P34972 / cannabinoid receptor 2ENSG0000018882221


Protein motifs (from Interpro)
Interpro ID Name
 IPR000276  G protein-coupled receptor, rhodopsin-like
 IPR002277  Lysophosphatidic acid receptor EDG-2
 IPR004065  Lysophosphatidic acid receptor
 IPR017452  GPCR, rhodopsin-like, 7TM


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000187 activation of MAPK activity IEA
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007186 G-protein coupled receptor signaling pathway IEA
 biological_processGO:0007193 adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway ISS
 biological_processGO:0007202 activation of phospholipase C activity IDA
 biological_processGO:0007204 positive regulation of cytosolic calcium ion concentration TAS
 biological_processGO:0007420 brain development IEA
 biological_processGO:0008360 regulation of cell shape ISS
 biological_processGO:0010942 positive regulation of cell death IEA
 biological_processGO:0010977 negative regulation of neuron projection development ISS
 biological_processGO:0014003 oligodendrocyte development IEA
 biological_processGO:0021549 cerebellum development IEA
 biological_processGO:0021554 optic nerve development IEA
 biological_processGO:0022008 neurogenesis IEA
 biological_processGO:0022038 corpus callosum development IEA
 biological_processGO:0032060 bleb assembly IEA
 biological_processGO:0035025 positive regulation of Rho protein signal transduction ISS
 biological_processGO:0042552 myelination IEA
 biological_processGO:0043065 positive regulation of apoptotic process IEA
 biological_processGO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling IEP
 biological_processGO:0043410 positive regulation of MAPK cascade ISS
 biological_processGO:0043951 negative regulation of cAMP-mediated signaling IEA
 biological_processGO:0051482 positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway IMP
 biological_processGO:0051496 positive regulation of stress fiber assembly ISS
 biological_processGO:0060326 cell chemotaxis IMP
 biological_processGO:0060999 positive regulation of dendritic spine development IEA
 biological_processGO:0071453 cellular response to oxygen levels IEA
 biological_processGO:0071673 positive regulation of smooth muscle cell chemotaxis IEA
 biological_processGO:1904566 cellular response to 1-oleoyl-sn-glycerol 3-phosphate IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005768 endosome IEA
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0005887 integral component of plasma membrane TAS
 cellular_componentGO:0009986 cell surface IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0030139 endocytic vesicle IDA
 cellular_componentGO:0043005 neuron projection IEA
 cellular_componentGO:0043025 neuronal cell body IEA
 cellular_componentGO:0043197 dendritic spine IEA
 cellular_componentGO:0043198 dendritic shaft IEA
 molecular_functionGO:0001965 G-protein alpha-subunit binding IEA
 molecular_functionGO:0004871 obsolete signal transducer activity IEA
 molecular_functionGO:0004930 G-protein coupled receptor activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005543 phospholipid binding IEA
 molecular_functionGO:0008289 lipid binding IEA
 molecular_functionGO:0030165 PDZ domain binding IEA
 molecular_functionGO:0035727 lysophosphatidic acid binding IDA
 molecular_functionGO:0070915 lysophosphatidic acid receptor activity IEA


Pathways (from Reactome)
Pathway description
G alpha (q) signalling events
G alpha (i) signalling events
Lysosphingolipid and LPA receptors


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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