ENSMUSG00000038668


Mus musculus

Features
Gene ID: ENSMUSG00000038668
  
Biological name :Lpar1
  
Synonyms : Lpar1 / Lysophosphatidic acid receptor 1 / P61793
  
Possible biological names infered from orthology : Q92633
  
Species: Mus musculus
  
Chr. number: 4
Strand: -1
Band: B3
Gene start: 58435255
Gene end: 58553898
  
Corresponding Affymetrix probe sets: 10513256 (MoGene1.0st)   1417143_at (Mouse Genome 430 2.0 Array)   1426110_a_at (Mouse Genome 430 2.0 Array)   1448606_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000116856
Ensembl peptide - ENSMUSP00000103201
Ensembl peptide - ENSMUSP00000121440
Ensembl peptide - ENSMUSP00000123694
Ensembl peptide - ENSMUSP00000052581
Ensembl peptide - ENSMUSP00000103196
Ensembl peptide - ENSMUSP00000103197
Ensembl peptide - ENSMUSP00000103200
NCBI entrez gene - 14745     See in Manteia.
MGI - MGI:108429
RefSeq - XM_011249935
RefSeq - NM_172989
RefSeq - XM_011249928
RefSeq - XM_011249929
RefSeq - XM_011249930
RefSeq - XM_011249931
RefSeq - XM_011249932
RefSeq - XM_011249933
RefSeq - XM_011249934
RefSeq - NM_001290486
RefSeq - NM_010336
RefSeq Peptide - NP_001277415
RefSeq Peptide - NP_034466
RefSeq Peptide - NP_766577
swissprot - Q544V2
swissprot - A2AMJ1
swissprot - A2AMI9
swissprot - A2AMJ0
swissprot - P61793
Ensembl - ENSMUSG00000038668
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 lpar1ENSDARG00000099840Danio rerio
 LPAR1ENSGALG00000015729Gallus gallus
 LPAR1ENSG00000198121Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Lpar2 / lysophosphatidic acid receptor 2 / Q9HBW0*ENSMUSG0000003186150
Lpar3 / Q9EQ31 / Lysophosphatidic acid receptor 3 / Q9UBY5*ENSMUSG0000003683247
S1pr1 / O08530 / Sphingosine 1-phosphate receptor 1 / P21453*ENSMUSG0000004509234
S1pr3 / Q9Z0U9 / Sphingosine 1-phosphate receptor 3 / Q99500*ENSMUSG0000006758633
S1pr5 / Q91X56 / Sphingosine 1-phosphate receptor 5 / Q9H228*ENSMUSG0000004508730
S1pr4 / Q9Z0L1 / Sphingosine 1-phosphate receptor 4 / O95977*ENSMUSG0000004419929
S1pr2 / P52592 / Sphingosine 1-phosphate receptor 2 / O95136*ENSMUSG0000004389528
Cnr1 / P47746 / Mus musculus cannabinoid receptor 1 (brain) (Cnr1), transcript variant 2, mRNA. / P21554* / cannabinoid receptor 1*ENSMUSG0000004428825
Gpr12 / P35412 / G-protein coupled receptor 12 / P47775*ENSMUSG0000004146821
Cnr2 / P47936 / Cannabinoid receptor 2 / P34972*ENSMUSG0000006258521
Gpr3 / P35413 / G-protein coupled receptor 3 / P46089*ENSMUSG0000004964921
Gpr6 / Q6YNI2 / G-protein coupled receptor 6 / P46095*ENSMUSG0000004692221


Protein motifs (from Interpro)
Interpro ID Name
 IPR000276  G protein-coupled receptor, rhodopsin-like
 IPR002277  Lysophosphatidic acid receptor EDG-2
 IPR004065  Lysophosphatidic acid receptor
 IPR017452  GPCR, rhodopsin-like, 7TM


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000187 activation of MAPK activity IDA
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007186 G-protein coupled receptor signaling pathway IEA
 biological_processGO:0007193 adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway IDA
 biological_processGO:0007202 activation of phospholipase C activity IDA
 biological_processGO:0007420 brain development IEA
 biological_processGO:0008360 regulation of cell shape IMP
 biological_processGO:0010942 positive regulation of cell death IEA
 biological_processGO:0010977 negative regulation of neuron projection development IMP
 biological_processGO:0014003 oligodendrocyte development IEA
 biological_processGO:0021549 cerebellum development IEA
 biological_processGO:0021554 optic nerve development IEA
 biological_processGO:0022008 neurogenesis IEA
 biological_processGO:0022038 corpus callosum development IEA
 biological_processGO:0032060 bleb assembly IGI
 biological_processGO:0035025 positive regulation of Rho protein signal transduction IMP
 biological_processGO:0042552 myelination IEA
 biological_processGO:0043065 positive regulation of apoptotic process IEA
 biological_processGO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling IEA
 biological_processGO:0043410 positive regulation of MAPK cascade IDA
 biological_processGO:0043951 negative regulation of cAMP-mediated signaling IEA
 biological_processGO:0051482 positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway ISO
 biological_processGO:0051496 positive regulation of stress fiber assembly IDA
 biological_processGO:0060326 cell chemotaxis ISO
 biological_processGO:0060999 positive regulation of dendritic spine development IEA
 biological_processGO:0071453 cellular response to oxygen levels IEA
 biological_processGO:0071673 positive regulation of smooth muscle cell chemotaxis IEA
 biological_processGO:1904566 cellular response to 1-oleoyl-sn-glycerol 3-phosphate IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005768 endosome IEA
 cellular_componentGO:0005886 plasma membrane ISO
 cellular_componentGO:0005887 integral component of plasma membrane IDA
 cellular_componentGO:0009986 cell surface ISS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0030139 endocytic vesicle ISO
 cellular_componentGO:0043005 neuron projection IEA
 cellular_componentGO:0043025 neuronal cell body IEA
 cellular_componentGO:0043197 dendritic spine IEA
 cellular_componentGO:0043198 dendritic shaft IEA
 molecular_functionGO:0001965 G-protein alpha-subunit binding IEA
 molecular_functionGO:0004871 obsolete signal transducer activity IEA
 molecular_functionGO:0004930 G-protein coupled receptor activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005543 phospholipid binding IEA
 molecular_functionGO:0030165 PDZ domain binding IPI
 molecular_functionGO:0035727 lysophosphatidic acid binding ISO
 molecular_functionGO:0070915 lysophosphatidic acid receptor activity IEA


Pathways (from Reactome)
Pathway description
G alpha (q) signalling events
G alpha (i) signalling events
Lysosphingolipid and LPA receptors


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000063 reduced bone density "decreased mineral content of bone; indicator of bone strength" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:57315]
Show

Allelic Composition: Loxhd1mpc231H/Loxhd1mpc231H
Genetic Background: involves: BALB/c * C3H/HeH * C57BL/6J

 MP:0000428 abnormal craniofacial morphology "anomalous structure or development of the face and/or cranium" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: au/a
Genetic Background: (C3H/HeH x 101/H)F1

 MP:0000445 short snout "reduced length of the anterior facial part of the muzzle" [J:53370]
Show

Allelic Composition: Foxc1tm1Blh/Foxc1tm1Blh,Foxc2tm1Blh/Foxc2tm1Blh
Genetic Background: involves: 129S6/SvEvTac * Black Swiss

Allelic Composition: Lpar1tm1Mcox/Lpar1tm1Mcox
Genetic Background: B6.129P2-Lpar1tm1Mcox

 MP:0000914 exencephaly "neurocranial defects resulting in exposure or extrusion of the brain" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:49840]
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Allelic Composition: Foxc1tm1Blh/Foxc1tm1Blh,Foxc2tm1Blh/Foxc2tm1Blh
Genetic Background: involves: 129S6/SvEvTac * Black Swiss

 MP:0001106 abnormal Schwann cell "malformed or absent cells which form the insulating myelin sheaths of peripheral axons" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Foxc1tm1Blh/Foxc1tm1Blh,Foxc2tm1Blh/Foxc2tm1Blh
Genetic Background: involves: 129S6/SvEvTac * Black Swiss

 MP:0001107 reduced Schwann cell number "fewer than normal cells that sheath the axons of the peripheral nervous system" [J:29971]
Show

Allelic Composition: Foxc1tm1Blh/Foxc1tm1Blh,Foxc2tm1Blh/Foxc2tm1Blh
Genetic Background: involves: 129S6/SvEvTac * Black Swiss

 MP:0001255 decreased body height "decreased shoulder to floor distance compared to controls" [dlb:Donna Burkart, Mouse Genome Informatics Curator]
Show

Allelic Composition: au/a
Genetic Background: (C3H/HeH x 101/H)F1

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
Show

Allelic Composition: Loxhd1mpc231H/Loxhd1mpc231H
Genetic Background: involves: BALB/c * C3H/HeH * C57BL/6J

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
Show

Allelic Composition: Foxc1tm1Blh/Foxc1tm1Blh,Foxc2tm1Blh/Foxc2tm1Blh
Genetic Background: involves: 129S6/SvEvTac * Black Swiss

 MP:0001300 ocular hypertelorism "increased distance between the eyes " [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Foxc1tm1Blh/Foxc1tm1Blh,Foxc2tm1Blh/Foxc2tm1Blh
Genetic Background: involves: 129S6/SvEvTac * Black Swiss

Allelic Composition: Lpar1tm1Mcox/Lpar1tm1Mcox
Genetic Background: B6.129P2-Lpar1tm1Mcox

 MP:0001402 hypoactivity "reduced movement from one place to another" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:64289]
Show

Allelic Composition: au/a
Genetic Background: (C3H/HeH x 101/H)F1

 MP:0001436 abnormal suckling behavior "reduced ability or inability to exert suction by the mouth, or atypical suckling pattern" [J:16461]
Show

Allelic Composition: Foxc1tm1Blh/Foxc1tm1Blh,Foxc2tm1Blh/Foxc2tm1Blh
Genetic Background: involves: 129S6/SvEvTac * Black Swiss

 MP:0001732 postnatal growth retardation "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Foxc1tm1Blh/Foxc1tm1Blh,Foxc2tm1Blh/Foxc2tm1Blh
Genetic Background: involves: 129S6/SvEvTac * Black Swiss

 MP:0001906 increased dopamine level "greater than the normal concentration of this catecholamine neurotransmitter, dervied from tyrosine and the precursor to norepinephrine and epinephrine" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Lpar1tm1Mcox/Lpar1tm1Mcox
Genetic Background: B6.129P2-Lpar1tm1Mcox

 MP:0001914 hemorrhage "loss of blood from the vascular compartment to the exterior or into nonvascular body space as a result of rupture or severance of the blood vessels" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Foxc1tm1Blh/Foxc1tm1Blh,Foxc2tm1Blh/Foxc2tm1Blh
Genetic Background: involves: 129S6/SvEvTac * Black Swiss

 MP:0002651 abnormal sciatic nerve "malformation, absence or misprojection of the nerve which originates in the lumbar and sacral spinal cord (L4 to S3) and supplies motor and sensory innervation to the lower extremity" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Foxc1tm1Blh/Foxc1tm1Blh,Foxc2tm1Blh/Foxc2tm1Blh
Genetic Background: involves: 129S6/SvEvTac * Black Swiss

 MP:0004831 long incisors "increased length of the long pointed teeth; most anterior and prominent in the jaw" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Lpar1tm1Mcox/Lpar1tm1Mcox
Genetic Background: B6.129P2-Lpar1tm1Mcox

 MP:0005322 abnormal serotonin level "anomalous concentration of biochemical messenger and regulator, found in the CNS, g.i. tract, and produced by platelets; it mediates neurotransmission, g.i. motility, hemostasis, and cardiovascular integrity " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Lpar1tm1Mcox/Lpar1tm1Mcox
Genetic Background: B6.129P2-Lpar1tm1Mcox

 MP:0005332 abnormal amino acid level "aberrant concentration of these organic compounds, which, when polymerized, form proteins" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Lpar1tm1Mcox/Lpar1tm1Mcox
Genetic Background: B6.129P2-Lpar1tm1Mcox

 MP:0006086 decreased body mass index "less than normal average of a measure of weight for height " [ncbi:NCBI request, smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Lpar1tm1Mcox/Lpar1tm1Mcox
Genetic Background: B6.129P2-Lpar1tm1Mcox

 MP:0009142 decreased prepulse inhibition "decrease in the ability of a relatively mild stimulus to suppress the response to a strong, startle-eliciting stimulus" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Lpar1tm1Mcox/Lpar1tm1Mcox
Genetic Background: B6.129P2-Lpar1tm1Mcox

 MP:0010025 decreased total body fat amount "less than the normal total amount of connective tissue composed of fat cells within the entire body" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Foxc1tm1Blh/Foxc1tm1Blh,Foxc2tm1Blh/Foxc2tm1Blh
Genetic Background: involves: 129S6/SvEvTac * Black Swiss

 MP:0011086 partial postnatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Foxc1tm1Blh/Foxc1tm1Blh,Foxc2tm1Blh/Foxc2tm1Blh
Genetic Background: involves: 129S6/SvEvTac * Black Swiss

Allelic Composition: Lpar1tm1Mcox/Lpar1tm1Mcox
Genetic Background: B6.129P2-Lpar1tm1Mcox

 MP:0011088 partial neonatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the neonatal period after birth (Mus: P0)" [MGI:csmith]
Show

Allelic Composition: Foxc1tm1Blh/Foxc1tm1Blh,Foxc2tm1Blh/Foxc2tm1Blh
Genetic Background: involves: 129S6/SvEvTac * Black Swiss

 MP:0011090 partial perinatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the perinatal period (Mus: E18.5 through postnatal day 1)" [MGI:csmith]
Show

Allelic Composition: Lpar1tm1Mcox/Lpar1tm1Mcox
Genetic Background: B6.129P2-Lpar1tm1Mcox

 MP:0014143 decreased body fat mass "decreased physical bulk or volume of fat in the whole body" [MGI:csmith]
Show

Allelic Composition: Loxhd1mpc231H/Loxhd1mpc231H
Genetic Background: involves: BALB/c * C3H/HeH * C57BL/6J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
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