ENSMUSG00000045087


Mus musculus

Features
Gene ID: ENSMUSG00000045087
  
Biological name :S1pr5
  
Synonyms : Q91X56 / S1pr5 / Sphingosine 1-phosphate receptor 5
  
Possible biological names infered from orthology : Q9H228
  
Species: Mus musculus
  
Chr. number: 9
Strand: -1
Band: A3
Gene start: 21242912
Gene end: 21248443
  
Corresponding Affymetrix probe sets: 10591494 (MoGene1.0st)   1449365_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000113843
NCBI entrez gene - 94226     See in Manteia.
MGI - MGI:2150641
RefSeq - NM_053190
RefSeq Peptide - NP_444420
swissprot - Q91X56
Ensembl - ENSMUSG00000045087
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 s1pr5bENSDARG00000052192Danio rerio
 S1PR5ENSG00000180739Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
S1pr1 / O08530 / Sphingosine 1-phosphate receptor 1 / P21453*ENSMUSG0000004509242
S1pr2 / P52592 / Sphingosine 1-phosphate receptor 2 / O95136*ENSMUSG0000004389539
S1pr3 / Q9Z0U9 / Sphingosine 1-phosphate receptor 3 / Q99500*ENSMUSG0000006758639
S1pr4 / Q9Z0L1 / Sphingosine 1-phosphate receptor 4 / O95977*ENSMUSG0000004419937
Lpar2 / lysophosphatidic acid receptor 2 / Q9HBW0*ENSMUSG0000003186130
Lpar1 / P61793 / Lysophosphatidic acid receptor 1 / Q92633*ENSMUSG0000003866828
Lpar3 / Q9EQ31 / Lysophosphatidic acid receptor 3 / Q9UBY5*ENSMUSG0000003683225
Gpr12 / P35412 / G-protein coupled receptor 12 / P47775*ENSMUSG0000004146825
Gpr3 / P35413 / G-protein coupled receptor 3 / P46089*ENSMUSG0000004964925
Gpr6 / Q6YNI2 / G-protein coupled receptor 6 / P46095*ENSMUSG0000004692224
Cnr1 / P47746 / Mus musculus cannabinoid receptor 1 (brain) (Cnr1), transcript variant 2, mRNA. / P21554* / cannabinoid receptor 1*ENSMUSG0000004428822
Cnr2 / P47936 / Cannabinoid receptor 2 / P34972*ENSMUSG0000006258521


Protein motifs (from Interpro)
Interpro ID Name
 IPR000276  G protein-coupled receptor, rhodopsin-like
 IPR004061  Sphingosine 1-phosphate receptor
 IPR005386  EDG-8 sphingosine 1-phosphate receptor
 IPR017452  GPCR, rhodopsin-like, 7TM


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0003376 sphingosine-1-phosphate signaling pathway IEA
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007186 G-protein coupled receptor signaling pathway TAS
 biological_processGO:0045664 regulation of neuron differentiation IEA
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0004871 obsolete signal transducer activity IEA
 molecular_functionGO:0004930 G-protein coupled receptor activity TAS
 molecular_functionGO:0038036 sphingosine-1-phosphate receptor activity IEA


Pathways (from Reactome)
Pathway description
G alpha (i) signalling events
Lysosphingolipid and LPA receptors


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0005068 abnormal NK cell morphology/development "anomalous structure, differentiation, or number of non-T, non-B lymphocytes, having a granular morphology and which are important in innate immunity to viruses and other intracellular pathogens; in addition, these cells can kill certain tumor cells" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Scn4atm1.1Cann/Scn4a+
Genetic Background: involves: 129

 MP:0008045 decreased NK cell number "reduction in the number of non-T, non-B lymphocytes, having a granular morphology and which are important in innate immunity to viruses and other intracellular pathogens; in addition, these cells can kill certain tumor cells" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease"]
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Allelic Composition: Scn4atm1.1Cann/Scn4a+
Genetic Background: involves: 129

 MP:0008053 abnormal NK cell differentiation "atypical production of or inability to produce the non-T, non-B lymphocytes, having a granular morphology and which are important in innate immunity to viruses and other intracellular pathogens; in addition, these cells can kill certain tumor cells" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease"]
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Allelic Composition: Tbx21duane/Tbx21duane
Genetic Background: C57BL/6-Tbx21duane

 MP:0008917 abnormal oligodendrocyte physiology "any functional anomaly of the neuroglia of the central nervous system that form the insulating myelin sheath of axons in the CNS" [MESH:A08.637.600]
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Allelic Composition: Lhfpl5hscy/Lhfpl5hscy
Genetic Background: involves: B6(MOR)-Tmhshscy/J * CAST/Ei

 MP:0010766 abnormal NK cell physiology "any functional anomaly of a lymphocyte that can spontaneously kill a variety of target cells without prior antigenic activation via germline encoded activation receptors, and also regulate immune responses via cytokine release and direct contact with other cells" [GOC:add, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", PMID:15771571]
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Allelic Composition: Scn4atm1.1Cann/Scn4a+
Genetic Background: involves: 129

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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